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1. 发明申请

US20120117298A1 Managing Memory Across a Network of Cloned Virtual Machines 有权
标题翻译：管理跨越克隆虚拟机网络的内存
公开(公告)号：US20120117298A1
公开(公告)日：2012-05-10
申请号：US12942045
申请日：2010-11-09
申请人： Adin Scannell , Timothy Smith , Vivek Lakshmanan , David Scannell , Kannan Vijayan , Jing Su
发明人： Adin Scannell , Timothy Smith , Vivek Lakshmanan , David Scannell , Kannan Vijayan , Jing Su
IPC分类号： G06F12/02
CPC分类号： G06F12/08 , G06F9/45558 , G06F9/5016 , G06F12/12 , G06F2009/45583 , G06F2212/152 , G06F2212/254
摘要： A method and system manages memory in a network of virtual machines, including a copy of a master virtual machine (VM) memory system, the copy accessible to a memory server. The method includes determining whether a memory page requested by a clone VM memory system is fetchable from the memory server, the clone VM memory system hosted in a host memory system; if the memory page is fetchable from the memory server, fetching the memory page from the memory server; determining whether there is sufficient space in the host memory system to load the memory page; if there is insufficient space in the host memory system, evicting a selected memory page from the host memory system; and loading the memory page into the host memory system and the clone VM memory system.
摘要翻译：一种方法和系统管理虚拟机网络中的存储器，包括主虚拟机（VM）存储器系统的副本，存储器服务器可访问的副本。所述方法包括确定克隆VM存储器系统请求的存储器页是否可从存储器服务器获取，所述存储器存储系统托管在主存储器系统中; 如果从存储器服务器获取存储器页面，则从存储器服务器获取存储器页面; 确定主机存储器系统中是否有足够的空间来加载存储器页面; 如果在主机存储器系统中没有足够的空间，则从主机存储器系统中驱逐选定的存储器页面; 并将内存页面加载到主机内存系统和克隆VM内存系统中。

2. 发明授权

US08601201B2 Managing memory across a network of cloned virtual machines 有权
标题翻译：通过克隆的虚拟机网络管理内存
公开(公告)号：US08601201B2
公开(公告)日：2013-12-03
申请号：US12942045
申请日：2010-11-09
申请人： Adin Scannell , Timothy Smith , Vivek Lakshmanan , David Scannell , Kannan Vijayan , Jing Su
发明人： Adin Scannell , Timothy Smith , Vivek Lakshmanan , David Scannell , Kannan Vijayan , Jing Su
IPC分类号： G06F13/00 , G06F13/28 , G06F21/00
CPC分类号： G06F12/08 , G06F9/45558 , G06F9/5016 , G06F12/12 , G06F2009/45583 , G06F2212/152 , G06F2212/254
摘要： A method and system manages memory in a network of virtual machines, including a copy of a master virtual machine (VM) memory system, the copy accessible to a memory server. The method includes determining whether a memory page requested by a clone VM memory system is fetchable from the memory server, the clone VM memory system hosted in a host memory system; if the memory page is fetchable from the memory server, fetching the memory page from the memory server; determining whether there is sufficient space in the host memory system to load the memory page; if there is insufficient space in the host memory system, evicting a selected memory page from the host memory system; and loading the memory page into the host memory system and the clone VM memory system.
摘要翻译：一种方法和系统管理虚拟机网络中的存储器，包括主虚拟机（VM）存储器系统的副本，存储器服务器可访问的副本。所述方法包括确定克隆VM存储器系统请求的存储器页是否可从存储器服务器获取，所述存储器存储系统托管在主存储器系统中; 如果从存储器服务器获取存储器页面，则从存储器服务器获取存储器页面; 确定主机存储器系统中是否有足够的空间来加载存储器页面; 如果在主机存储器系统中没有足够的空间，则从主机存储器系统中驱逐选定的存储器页面; 并将内存页加载到主机内存系统和克隆VM内存系统中。

3. 发明申请

US20180290987A1 OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS 审中-公开
公开(公告)号：US20180290987A1
公开(公告)日：2018-10-11
申请号：US15766395
申请日：2016-10-17
申请人： Mihir B. MANDAL , David B. OLSEN , Jing SU , Lihu YANG , Katherine YOUNG , Takao SUZUKI , Lanying YOU , Merck Sharp & Dohme Corp.
发明人： Mihir B. Mandal , David B. Olsen , Jing Su , Lihu Yang , Katherine Young , Takao Suzuki , Lanying You
IPC分类号： C07D263/20 , C07D471/04 , C07D413/10 , C07D417/10 , C07D413/04 , C07D487/04 , C07D413/06 , C07D417/14 , C07D413/14 , A61K31/421 , A61K31/437 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/553 , A61K31/4985 , A61K31/541 , A61K31/5377 , A61K45/06
摘要： The present invention relates to oxazolidinone compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

4. 发明授权

US08326914B2 Network system extensible by users 有权
标题翻译：用户可扩展的网络系统
公开(公告)号：US08326914B2
公开(公告)日：2012-12-04
申请号：US13112540
申请日：2011-05-20
申请人： Danny Lange , Barbara Nelson , Jing Su , James E. White
发明人： Danny Lange , Barbara Nelson , Jing Su , James E. White
IPC分类号： G06F15/16 , G06F15/173
CPC分类号： H04L67/125 , H04L63/0209 , H04L63/10 , H04L63/1408 , H04L67/28 , H04L67/2823 , H04L67/34
摘要： In one aspect, a network system includes a user interface which allows a user to interact with the network system. An agent server is coupled to the user interface. The agent server manages the operation of the network system. Furthermore, the agent server in conjunction with the user interface is operable to create or modify an agent in response to interaction by the user. In another aspect, a network system includes an agent server which manages the operation of the network system. An agent is operable to utilize a service within the network system. A service wrapper, associated with the service, cooperates with the agent server to mediate interaction between the service and the agent.
摘要翻译：一方面，网络系统包括允许用户与网络系统交互的用户界面。代理服务器耦合到用户界面。代理服务器管理网络系统的操作。此外，代理服务器与用户界面一起可操作以响应于用户的交互来创建或修改代理。在另一方面，网络系统包括管理网络系统的操作的代理服务器。代理可操作以利用网络系统内的服务。与服务相关联的服务包装器与代理服务器协作来调解服务和代理之间的交互。

5. 发明申请

US20120172303A1 Growth Hormones with Prolonged In-Vivo Efficacy 有权
标题翻译：生长激素具有延长的体内功效
公开(公告)号：US20120172303A1
公开(公告)日：2012-07-05
申请号：US13389180
申请日：2010-08-06
申请人： Nils Langeland Johansen , Henrik Sune Andersen , Jens Buchardt , Carsten Behrens , Leif Norskov-Lauritsen , Jing Su
发明人： Nils Langeland Johansen , Henrik Sune Andersen , Jens Buchardt , Carsten Behrens , Leif Norskov-Lauritsen , Jing Su
IPC分类号： A61K38/27 , A61P5/00 , C07K19/00
CPC分类号： A61K47/64 , A61K47/54 , A61K47/542 , A61K47/543 , A61K47/545 , A61K47/60
摘要： The present invention relates to polypeptide compound optimized for subcutaneous administration, exemplified by growth hormone conjugates having a linker providing non-covalent binding to albumin.
摘要翻译：本发明涉及针对皮下给药优化的多肽化合物，例如具有提供与白蛋白非共价结合的接头的生长激素缀合物。

6. 发明申请

US20080064630A1 Osteogenic Growth Peptide Fusion Proteins 审中-公开
标题翻译：成骨生长肽融合蛋白
公开(公告)号：US20080064630A1
公开(公告)日：2008-03-13
申请号：US11578629
申请日：2005-04-14
申请人： Niels Blume , Jing Su , Kjeld Madsen , Nils Johansen , Lars Iversen
发明人： Niels Blume , Jing Su , Kjeld Madsen , Nils Johansen , Lars Iversen
IPC分类号： A61K38/00 , A61P43/00 , C07H21/04 , C07K16/00 , C12N15/00 , C12N5/00 , C12P21/04
CPC分类号： C12N15/62 , C07K2319/31
摘要： Fusion protein comprising a protein to be fused, e.g. a therapeutic protein fused to the C-terminal of osteogenic growth peptide (OGP). The fusion proteins have a prolonged circulation time.
摘要翻译：包含待融合的蛋白质的融合蛋白，例如与成骨生长肽（OGP）的C端融合的治疗性蛋白质。融合蛋白具有延长的循环时间。

7. 发明申请

US20070066630A1 Nitrogen-containing heterocyclic compounds and methods of use thereof 有权
标题翻译：含氮杂环化合物及其使用方法
公开(公告)号：US20070066630A1
公开(公告)日：2007-03-22
申请号：US11600216
申请日：2006-11-15
申请人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying Huang , Robert Aslanian , Brian McKittrick , Sylvia Degrado
发明人： Anandan Palani , Jing Su , Dong Xiao , Xianhai Huang , Ashwin Rao , Xiao Chen , Haiqun Tang , Jun Qin , Ying Huang , Robert Aslanian , Brian McKittrick , Sylvia Degrado
IPC分类号： A61K31/519 , C07D491/02
CPC分类号： C07D491/052
摘要： The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，溶剂合物，酯和互变异构体，其中：Q选自：L选自：包含一种或多种式（I）化合物和使用式（I）化合物的方法。

8. 发明申请

US20060138083A1 Patterning and alteration of molecules 审中-公开
标题翻译：分子的形成和改变
公开(公告)号：US20060138083A1
公开(公告)日：2006-06-29
申请号：US11222500
申请日：2005-09-08
申请人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
发明人： Declan Ryan , Babak Amirparviz , Vincent Linder , Vincent Semetey , Samuel Sia , Jing Su , Milan Mrksich , George Whitesides
IPC分类号： C23F1/00 , B44C1/22 , C03C25/68 , G03F1/00
CPC分类号： G03F7/165 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B82Y5/00 , B82Y30/00 , C03C17/28 , C03C23/0005 , C03C2218/32 , C40B80/00 , G03F7/203
摘要： The present invention provides a series of methods, compositions, and articles for patterning a surface with multiple, aligned layers of molecules, by exposing the molecules to electromagnetic radiation. In certain embodiments, a single photomask acts as an area-selective filter for light at multiple wavelengths. A single set of exposures of multiple wavelengths through this photomask may make it possible to fabricate a pattern comprising discontinuous multiple regions, where the regions differ from each other in at least one chemical and/or physical property, without acts of alignment between the exposures. In certain embodiments, the surface includes molecules attached thereto that can be photocleaved upon exposure to a certain wavelength of radiation, thereby altering the chemical composition on at least a portion of the surface. In some embodiments, the molecules attached to the surface may include thiol moieties (e.g., as in alkanethiol), by which the molecule can become attached to the surface. In some embodiments, the molecules may be terminated at the unattached end with photocleavable groups. In other embodiments, a molecule that was photocleaved may be exposed to another molecule that binds to the photocleaved molecule. In certain cases, the molecules may be terminated at the unattached end with hydrophilic groups that may, for example, be resistant to the adsorption of proteins. In other cases, the molecules may be terminated at the unattached end with end groups that are not resistant to the adsorption of proteins. In certain embodiments, the techniques are used to pattern simultaneously two different regions that are resistant to the adsorption of proteins, and a third region that does not resist the adsorption of proteins.
摘要翻译：本发明通过将分子暴露于电磁辐射来提供一系列方法，组合物和用于图案化具有多个对准的分子层的表面的制品。在某些实施例中，单个光掩模用作多个波长的光的区域选择滤光器。通过该光掩模的多组波长的一组曝光可以使得可以制造包括不连续多个区域的图案，其中区域在至少一种化学和/或物理性质上彼此不同，而不影响曝光之间的对准。在某些实施方案中，表面包括附着于其上的分子，其可以在暴露于一定波长的辐射时被光刻，从而改变表面的至少一部分上的化学组成。在一些实施方案中，连接到表面的分子可以包括硫醇部分（例如，如在链烷硫醇中），分子可以通过该分子附着到表面。在一些实施方案中，分子可以在不附着的端部用可光致发光的基团终止。在其它实施方案中，被光致剪切的分子可以暴露于结合光刻分子的另一个分子。在某些情况下，分子可以在亲水基团的末端被终止，所述亲水基团例如可以抵抗蛋白质的吸附。在其他情况下，分子可以在不附着于不附着蛋白质的端基的端基处终止。在某些实施方案中，所述技术用于同时模拟对蛋白质的吸附具有抗性的两个不同区域，以及不抵抗蛋白质吸附的第三区域。

9. 发明授权

US06839733B1 Network system extensible by users 有权
公开(公告)号：US06839733B1
公开(公告)日：2005-01-04
申请号：US09712712
申请日：2000-11-14
申请人： Danny Lange , Barbara Nelson , Jing Su , James E. White
发明人： Danny Lange , Barbara Nelson , Jing Su , James E. White
IPC分类号： H04L29/06 , H04L29/08 , G06F15/16
CPC分类号： H04L67/125 , H04L63/0209 , H04L63/10 , H04L63/1408 , H04L67/28 , H04L67/2823 , H04L67/34
摘要： In one aspect, a network system includes a user interface which allows a user to interact with the network system. An agent server is coupled to the user interface. The agent server manages the operation of the network system. Furthermore, the agent server in conjunction with the user interface is operable to create or modify an agent in response to interaction by the user. In another aspect, a network system includes an agent server which manages the operation of the network system. An agent is operable to utilize a service within the network system. A service wrapper, associated with the service, cooperates with the agent server to mediate interaction between the service and the agent.

10. 发明授权

US11141403B2 Benzimidazoles and indoles as taro inhibitors 有权
公开(公告)号：US11141403B2
公开(公告)日：2021-10-12
申请号：US16061481
申请日：2016-12-13
申请人： MERCK SHARP & DOHME CORP. , John P. Caldwell , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Jianping Pan , Weidong Pan , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Hao Wang , Christine Yang , Shu-Wei Yang
发明人： John P. Caldwell , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Jianping Pan , Weidong Pan , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Hao Wang , Christine Yang , Shu-Wei Yang
IPC分类号： A61K31/397 , A61P31/04 , A61K31/407 , C07D235/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

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