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1. 发明申请

US20080138287A1 3-SUBSTITUTED-2(ARYLALKYL)-1- AZABICYCLOALKANES AND METHODS OF USE THEREOF 有权
标题翻译： 3-取代-2（芳基）-1-氮杂环丁烷及其使用方法
公开(公告)号：US20080138287A1
公开(公告)日：2008-06-12
申请号：US12026847
申请日：2008-02-06
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A61K49/00 , C07D221/22
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds, and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 1-4烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

2. 发明授权

US06953855B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof 有权
标题翻译： 3-取代-2（芳基烷基）-1-氮杂双环烷烃及其使用方法
公开(公告)号：US06953855B2
公开(公告)日：2005-10-11
申请号：US10372642
申请日：2003-02-21
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A61K51/00 , C07D453/02 , C07D453/04 , C07D471/08 , C07D487/08
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 1-4烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

3. 发明申请

US20100240696A1 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF 有权
标题翻译： 3-取代-2（芳基）-1-亚氨基二醇及其使用方法
公开(公告)号：US20100240696A1
公开(公告)日：2010-09-23
申请号：US12793773
申请日：2010-06-04
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A61K31/46 , A61P25/18
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 1-4烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

4. 发明授权

US08084462B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof 有权
标题翻译： 3-取代-2（芳基烷基）-1-氮杂双环烷烃及其使用方法
公开(公告)号：US08084462B2
公开(公告)日：2011-12-27
申请号：US12793773
申请日：2010-06-04
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to the pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.
摘要翻译：本发明涉及包含能够影响烟碱乙酰胆碱能受体（nAChR）的化合物的药物组合物，例如作为特定烟碱型受体亚型（特别是α7nAChR亚型）的调节剂。本发明还涉及用于治疗各种各样的病症和疾病的方法，特别是与中枢神经系统和自主神经系统的功能障碍有关的方法。

5. 发明授权

US07754189B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof 有权
标题翻译： 3-取代-2（芳基烷基）-1-氮杂双环烷烃及其使用方法
公开(公告)号：US07754189B2
公开(公告)日：2010-07-13
申请号：US12026847
申请日：2008-02-06
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A61K49/00 , C07D221/02
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds, and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

6. 发明授权

US07425561B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof 有权
标题翻译： 3-取代-2（芳基烷基）-1-氮杂双环烷烃及其使用方法
公开(公告)号：US07425561B2
公开(公告)日：2008-09-16
申请号：US11458231
申请日：2006-07-18
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao , Angela S. Seamans , Teresa Youngpeter Phillips , Jeffrey Daniel Schmitt , Craig Harrison Miller
IPC分类号： A61K31/44 , C07D415/00 , C07D413/00 , C07D253/08
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 1-4烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

7. 发明申请

US20110071189A1 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF 有权
公开(公告)号：US20110071189A1
公开(公告)日：2011-03-24
申请号：US12862416
申请日：2010-08-24
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
IPC分类号： A61K31/439 , C07D453/02 , A61K31/444 , A61P25/00
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.

8. 发明申请

US20110071187A1 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF 有权
标题翻译： 3-取代-2（芳基）-1-亚氨基二醇及其使用方法
公开(公告)号：US20110071187A1
公开(公告)日：2011-03-24
申请号：US12862373
申请日：2010-08-24
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
IPC分类号： A61K31/439 , C07D453/02 , A61P25/00 , A61K31/4545
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C1-4 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), particularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 1-4烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs），特别是α7nAChR亚型中表现出活性，并且可用于调节神经传递和涉及神经传递的配体释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

9. 发明申请

US20110071188A1 3-SUBSTITUTED-2(ARYLALKYL)-1-AZABICYCLOALKANES AND METHODS OF USE THEREOF 有权
标题翻译： 3-取代-2（芳基）-1-亚氨基二醇及其使用方法
公开(公告)号：US20110071188A1
公开(公告)日：2011-03-24
申请号：US12862388
申请日：2010-08-24
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
IPC分类号： A61K31/444 , C07D453/02 , A61K31/439 , A61P25/00
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to 3-substituted-2-(arylalkyl)-1-azabicycloalkanes, methods of preparing the compounds and methods of treatment using the compounds. The azabicycloalkanes generally are azabicycloheptanes, azabicyclooctanes, or azabicyclononanes. The aryl group in the arylalkyl moiety is a 5- or 6-membered ring heteroaromatic, preferably 3-pyridinyl and 5-pyrimidinyl moieties, and the alkyl group is typically a C14 alkyl. The substituent at the 3-position of the 1-azabicycloalkane is a carbonyl group-containing moiety, such as an amide, carbamate, urea, thioamide, thiocarbamate, thiourea or similar functionality. The compounds exhibit activity at nicotinic acetylcholine receptors (nAChRs), partidularly the α7 nAChR subtype, and are useful towards modulating neurotransmission and the release of ligands involved in neurotransmission. Methods for preventing or treating conditions and disorders, including central nervous system (CNS) disorders, which are characterized by an alteration in normal neurotransmission, are also disclosed. Also disclosed are methods for treating inflammation, autoimmune disorders, pain and excess neovascularization, such as that associated with tumor growth.
摘要翻译：本发明涉及3-取代-2-（芳基烷基）-1-氮杂双环烷烃，制备化合物的方法和使用该化合物的处理方法。氮杂双环烷烃通常是氮杂双环庚烷，氮杂双环辛烷或氮杂双环壬烷。芳基烷基部分中的芳基是5-或6-元环杂芳族，优选3-吡啶基和5-嘧啶基部分，并且烷基通常是C 14烷基。 1-氮杂双环烷烃3-位上的取代基是含羰基的部分，例如酰胺，氨基甲酸酯，脲，硫代酰胺，硫代氨基甲酸酯，硫脲或类似官能团。该化合物在烟碱乙酰胆碱受体（nAChRs）上表现出活性，分散在α7nAChR亚型上，可用于调节神经传递和涉及神经传递的配体的释放。还公开了预防或治疗包括中枢神经系统（CNS）病症在内的病症和障碍的方法，其特征在于正常神经传递的改变。还公开了用于治疗炎症，自身免疫疾病，疼痛和过量新生血管形成（例如与肿瘤生长相关的）的方法。

10. 发明授权

US08124619B2 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof 有权
公开(公告)号：US08124619B2
公开(公告)日：2012-02-28
申请号：US12862388
申请日：2010-08-24
申请人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
发明人： Anatoly A. Mazurov , Jozef Klucik , Lan Miao
IPC分类号： A01N43/90 , A61K31/44 , C07D453/02
CPC分类号： C07D471/08 , A61K51/0455 , C07D453/02 , C07D487/08
摘要： The present invention relates to pharmaceutical compositions incorporating compounds capable of affecting nicotinic acetylcholinergic receptors (nAChRs), for example, as modulators of specific nicotinic receptor subtypes (specifically, the α7 nAChR subtype). The present invention also relates to methods for treating a wide variety of conditions and disorders, particularly those associated with dysfunction of the central and autonomic nervous systems.

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