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1. 发明授权

US5507795A Catheter with perfusion system 失效
标题翻译：导管与灌注系统
公开(公告)号：US5507795A
公开(公告)日：1996-04-16
申请号：US236485
申请日：1994-04-29
申请人： Andrew L. Chiang , Jeffrey W. Krier , Ron R. Hundertmark , Robert T. Chang , Grace Y. Schulz
发明人： Andrew L. Chiang , Jeffrey W. Krier , Ron R. Hundertmark , Robert T. Chang , Grace Y. Schulz
IPC分类号： A61B17/00 , A61B17/22 , A61M29/02 , A61B17/32 , A61B17/14
CPC分类号： A61B17/320783 , A61B2017/00685 , A61B2017/22038 , A61B2017/22052 , A61B2017/22069 , A61M2025/1097
摘要： Improved atherectomy catheters and methods of use are disclosed. The catheter includes a flexible body with a longitudinal passage therethrough. A housing is mounted at the distal end, with an elongated aperture formed in a lateral side. A drive cable is disposed in the passage of the catheter body, and a working element is disposed in the housing, attached to the distal end of the drive cable. Passages and openings are provided for flowing blood into the housing and for flowing blood from a proximal to a distal side of the cutting blade. An impeller can be provided proximal to the cutting blade to impel blood into the housing and past the blade. Blood flows through the housing and past the blade so as to perfuse tissue downstream from the device.
摘要翻译：公开了改进的粥样斑块切除术导管和使用方法。导管包括具有穿过其中的纵向通道的柔性体。壳体安装在远端，其中形成在侧面的细长孔。驱动电缆设置在导管主体的通道中，并且工作元件设置在壳体中，附接到驱动电缆的远端。提供通道和开口，用于将血液流入壳体并用于使血液从切割刀片的近侧流到远侧。可以在切割刀片附近设置叶轮以将血液推进到壳体中并通过叶片。血液流过壳体并经过刀片，从而将组织向装置下游灌注。

2. 发明授权

US5632754A Universal catheter with interchangeable work element 失效
标题翻译：具有可互换工作元件的通用导管
公开(公告)号：US5632754A
公开(公告)日：1997-05-27
申请号：US363142
申请日：1994-12-23
申请人： Brian Farley , Ron R. Hundertmark , Grace Y. Schulz
发明人： Brian Farley , Ron R. Hundertmark , Grace Y. Schulz
IPC分类号： A61B17/00 , A61B17/22 , A61M25/00 , A61M25/18 , A61M29/02 , A61D17/32
CPC分类号： A61B17/3207 , A61M25/00 , A61B17/320783 , A61B2017/00464 , A61B2017/22075 , A61M2025/1097
摘要： Disclosed herein is an intravascular universal catheter having interchangeable work elements and methods of use thereof. The catheter comprises a flexible catheter body having a distal end, a proximal end and a lumen extending between the ends. A housing having an open interior and an aperture on a lateral side is attached to the distal end of the catheter body by a coupling element. A work element is movably disposed within the housing and operative through the aperture. A work element connector is disposed in a lumen of the catheter body and has a distal end connected to the work element. At least the distal portion of the lumen defines a receiving space within the catheter body, and the coupling element is configured to allow retraction of the work element from the housing through the open proximal end into the receiving space. In a preferred embodiment, perfusion ports are disposed in the catheter body and the housing proximate to the junctional region of the catheter body with the housing. The perfusion ports are in communication with the lumen. The work element may be withdrawn from the housing proximal to the perfusion ports to allow blood to flow into the housing and bypass the work element for perfusion of tissue downstream. Preferably, the lumen is configured to allow the work element to be completely withdrawn from the catheter body, so as to permit interchange of various work elements.
摘要翻译：本文公开了具有可互换的工作元件的血管内通用导管及其使用方法。导管包括具有远端，近端和在端部之间延伸的内腔的柔性导管本体。具有开口内部和外侧的孔的壳体通过联接元件附接到导管主体的远端。工作元件可移动地设置在壳体内并通过孔径操作。工作元件连接器设置在导管主体的内腔中，并具有连接到工作元件的远端。至少管腔的远端部分限定了导管主体内的容纳空间，并且联接元件构造成允许工作元件从壳体通过开放的近端缩回到容纳空间中。在优选实施例中，灌注端口设置在导管主体中，并且壳体靠近导管主体与壳体的连接区域。灌注口与管腔连通。工作元件可以从靠近灌注端口的壳体中取出，以允许血液流入壳体并绕过工作元件以灌注下游的组织。优选地，内腔被配置为允许工作元件从导管主体完全退出，以便允许各种工作元件的交换。

3. 发明申请

US20100106156A1 APPARATUS FOR TREATING VENOUS INSUFFICIENCY 失效
标题翻译：用于治疗呼吸衰竭的装置
公开(公告)号：US20100106156A1
公开(公告)日：2010-04-29
申请号：US12648242
申请日：2009-12-28
申请人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
发明人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
IPC分类号： A61B18/14
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/22051 , A61B2017/22097 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00755 , A61B2018/00797 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.
摘要翻译：导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。将导管引入患者并定位在待治疗的静脉的部分内。电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。电极保持活动，直到静脉充分收缩。静脉收缩的程度可以通过荧光透视法检测。在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

4. 发明授权

US06638273B1 Expandable catheter having improved electrode design, and method for applying energy 失效
标题翻译：具有改进的电极设计的可扩展导管和施加能量的方法
公开(公告)号：US06638273B1
公开(公告)日：2003-10-28
申请号：US09724248
申请日：2000-11-27
申请人： Brian E. Farley , Grace Y. Schulz , Dawn A. Henderson , Mark P. Parker , Arthur W. Zikorus , Gary H. Miller , Jay S. Daulton , Douglas Portnow
发明人： Brian E. Farley , Grace Y. Schulz , Dawn A. Henderson , Mark P. Parker , Arthur W. Zikorus , Gary H. Miller , Jay S. Daulton , Douglas Portnow
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B17/00008 , A61B2017/22051 , A61B2017/22097 , A61B2018/00011 , A61B2018/00029 , A61B2018/00083 , A61B2018/00154 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00702 , A61B2018/00744 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter having expandable electrodes for applying energy to a hollow anatomical structure such as a vein. When used on a vein, the catheter is useful for a minimally invasive treatment of venous insufficiency. The catheter includes conductive end rings to which the electrodes are attached, for mechanically connecting and electrically tying electrodes together to provide for a single wire electrical connection points, for transmitting energy while more evenly spacing the electrodes. Expandable arms are formed of electrically conductive material and insulated along their length except for an intermediate section that functions as the electrode. The arms are tapered to allow more room for wiring and to reduce the possibility of shorting between the ends of the arms. The catheter further includes thermocouples in the electrodes for measuring temperatures on the outer surface of the electrode. Slots are formed in the arms for mounting the thermocouples. The temperature at the hollow anatomical structure is monitored and if a rapid, large temperature decrease of short duration is noted, the power is maintained constant as a fluid flush has been detected.
摘要翻译：具有用于向诸如静脉的中空解剖结构施加能量的可扩张电极的导管。当静脉使用时，导管可用于静脉功能不全的微创治疗。导管包括导电端环，电极附接到该导电端环，用于将电极机械连接并电连接在一起，以提供单线电连接点，用于在更均匀地间隔电极的同时发射能量。可扩展臂由导电材料形成并且沿其长度绝缘，除了用作电极的中间部分之外。臂是锥形的，以允许更多的布线空间并且减少在臂的端部之间短路的可能性。该导管还包括用于测量电极外表面上的温度的电极中的热电偶。插槽形成在用于安装热电偶的臂中。监测中空解剖结构的温度，如果注意到持续时间短的快速，大的温度降低，则检测到流体冲洗时，功率保持恒定。

5. 发明授权

US6036687A Method and apparatus for treating venous insufficiency 失效
公开(公告)号：US6036687A
公开(公告)日：2000-03-14
申请号：US610911
申请日：1996-03-05
申请人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
发明人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
IPC分类号： A61B17/22 , A61B18/08 , A61B18/14 , A61B18/04
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/22051 , A61B2017/22097 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00755 , A61B2018/00797 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.

6. 发明授权

US07967782B2 Apparatus for treating venous insufficiency 失效
标题翻译：用于治疗静脉功能不全的装置
公开(公告)号：US07967782B2
公开(公告)日：2011-06-28
申请号：US12648242
申请日：2009-12-28
申请人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
发明人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
IPC分类号： A61M29/00
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/22051 , A61B2017/22097 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00755 , A61B2018/00797 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.
摘要翻译：导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。将导管引入患者并定位在待治疗的静脉的部分内。电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。电极保持活动，直到静脉充分收缩。静脉收缩的程度可以通过荧光透视法检测。在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

7. 发明授权

US07641633B2 Apparatus for treating venous insufficiency 失效
标题翻译：用于治疗静脉功能不全的装置
公开(公告)号：US07641633B2
公开(公告)日：2010-01-05
申请号：US10396672
申请日：2003-03-25
申请人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
发明人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
IPC分类号： A61F7/12
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/22051 , A61B2017/22097 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00755 , A61B2018/00797 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.
摘要翻译：导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。将导管引入患者并定位在待治疗的静脉的部分内。电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。电极保持活动，直到静脉充分收缩。静脉收缩的程度可以通过荧光透视法检测。在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

8. 发明授权

US06613045B1 Method and apparatus for treating venous insufficiency 失效
标题翻译：用于治疗静脉功能不全的装置
公开(公告)号：US06613045B1
公开(公告)日：2003-09-02
申请号：US09495667
申请日：2000-02-01
申请人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
发明人： Michael D. Laufer , Brian E. Farley , Grace Y. Schulz , Arthur W. Zikorus , Mark P. Parker
IPC分类号： A61B1804
CPC分类号： A61B18/08 , A61B18/1492 , A61B2017/22051 , A61B2017/22097 , A61B2018/00083 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00755 , A61B2018/00797 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter delivers an electrode within a vein for a minimally invasive treatment of varicose veins and venous insufficiency using RF energy. The catheter is introduced into a patient and positioned within the section of the vein to be treated. The electrode radiates high frequency energy towards the vein, and the surrounding venous tissue becomes heated and begins to shrink. The catheter includes a controllable member for limiting the amount of shrinkage of the vein to the diameter of the member. The electrode remains active until there has been sufficient shrinkage of the vein. The extent of shrinkage of the vein may be detected by fluoroscopy. After treating one section of the vein, the catheter and the electrode can be repositioned intraluminally within the vein to treat different sections of the vein until all desired venous sections and valves are repaired and rendered functionally competent.
摘要翻译：导管在静脉内输送电极，以便使用RF能量进行静脉曲张和静脉功能不全的微创治疗。将导管引入患者并定位在待治疗的静脉的部分内。电极向静脉辐射高频能量，周围的静脉组织变热并开始收缩。导管包括可控制的构件，用于限制静脉的收缩量与构件的直径。电极保持活动，直到静脉充分收缩。静脉收缩的程度可以通过荧光透视法检测。在治疗静脉的一部分后，导管和电极可以在静脉内腔内重新定位，以处理静脉的不同部分，直到所有期望的静脉部分和瓣膜被修复并且具有功能上的能力。

9. 发明授权

US6152899A Expandable catheter having improved electrode design, and method for applying energy 失效
公开(公告)号：US6152899A
公开(公告)日：2000-11-28
申请号：US895850
申请日：1997-07-17
申请人： Brian E. Farley , Grace Y. Schulz , Dawn A. Henderson , Mark P. Parker , Arthur W. Zikorus , Gary H. Miller , Jay S. Daulton , Douglas Portnow
发明人： Brian E. Farley , Grace Y. Schulz , Dawn A. Henderson , Mark P. Parker , Arthur W. Zikorus , Gary H. Miller , Jay S. Daulton , Douglas Portnow
IPC分类号： A61B18/04 , A61B17/00 , A61B17/22 , A61B18/00 , A61B18/12 , A61B18/14 , A61F7/12
CPC分类号： A61B18/1492 , A61B17/00008 , A61B2017/22051 , A61B2017/22097 , A61B2018/00011 , A61B2018/00029 , A61B2018/00083 , A61B2018/00154 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00285 , A61B2018/00404 , A61B2018/00488 , A61B2018/00702 , A61B2018/00744 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/1253 , A61B2018/126 , A61B2018/1465 , A61B2018/1497
摘要： A catheter having expandable electrodes for applying energy to a hollow anatomical structure such as a vein. When used on a vein, the catheter is useful for a minimally invasive treatment of venous insufficiency. The catheter includes conductive end rings to which the electrodes are attached, for mechanically connecting and electrically tying electrodes together to provide for a single wire electrical connection points, for transmitting energy while more evenly spacing the electrodes. Expandable arms are formed of electrically conductive material and insulated along their length except for an intermediate section that functions as the electrode. The arms are tapered to allow more room for wiring and to reduce the possibility of shorting between the ends of the arms. The catheter further includes thermocouples in the electrodes for measuring temperatures on the outer surface of the electrode. Slots are formed in the arms for mounting the thermocouples. The temperature at the hollow anatomical structure is monitored and if a rapid, large temperature decrease of short duration is noted, the power is maintained constant as a fluid flush has been detected.

10. 发明授权

US5836957A Large volume atherectomy device 失效
标题翻译：大体积粥样斑块切除装置
公开(公告)号：US5836957A
公开(公告)日：1998-11-17
申请号：US807822
申请日：1997-02-26
申请人： Grace Y. Schulz , Gerri Chatelain , Mark E. Deem , Ferolyn T. Powell
发明人： Grace Y. Schulz , Gerri Chatelain , Mark E. Deem , Ferolyn T. Powell
IPC分类号： A61B17/22 , A61M29/02
CPC分类号： A61B17/320783 , A61B2017/22052 , A61B2017/22055 , A61B2017/22069 , A61M2025/1097
摘要： A side-cutting atherectomy catheter with a housing containing a tissue-removal means, a window on one side, and a large volume inflatable support on the opposite side. The large volume inflatable support has a maximum diameter larger than the diameter of the cutter housing, generating a greater degree of contact with a blood vessel's interior diameter than conventional balloon-housing configurations. This feature stabilizes the cutter housing and improves tissue-removal during the atherectomy procedure. Large volume inflatable supports have a maximum inflated diameter at least 1.1 times, and preferably 1.35 times, greater than the diameter of the housing. The supports may be formed from either elastic or inelastic materials. When formed from inelastic materials, the supports have slack material when uninflated which can extend into and become entangled with the cutter window. To prevent this problem, the large volume inflatable support is constrained when uninflated. The means for constraining the support generally comprises balloon structures, housing structures, or storage or shielding features. In a preferred embodiment, the large volume inflatable support comprises a balloon formed with a plurality of preferential longitudinal folds. When deflated, the folds cause the balloon to form an overlapping flap of material which constrains the slack balloon material from extending around the housing and becoming entangled in the cutter window.
摘要翻译：一种具有壳体的侧切性粥样斑块切除术导管，其包含组织移除装置，一侧上的窗口和相对侧上的大体积可充气支撑件。大体积的可充气支撑件的最大直径大于切割器壳体的直径，与常规球囊壳体构造相比，产生与血管内径更大程度的接触。该功能使切割器壳体稳定，并且可以改善粥样斑块切除术过程中的组织去除。大容积充气支撑件的最大充气直径比壳体的直径大至少1.1倍，优选为1.35倍。支撑件可以由弹性材料或非弹性材料形成。当由非弹性材料形成时，当未膨胀时，支撑件具有松弛的材料，其可以延伸到切割窗口并与切割窗口缠结。为了防止这个问题，当未充气时，大体积的充气支撑被约束。用于约束支撑件的装置通常包括球囊结构，壳体结构或存储或屏蔽特征。在优选实施例中，大体积可充气支撑件包括形成有多个优先纵向折叠的气囊。当放气时，褶皱导致气囊形成重叠的材料折片，其限制松弛球囊材料围绕壳体延伸并且缠结在切割窗口中。

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