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    • 5. 发明申请
    • PRIORITIZING AND DISTRIBUTING WORKLOADS BETWEEN STORAGE RESOURCE CLASSES
    • 存储资源类别之间的重新分配和分配工作量
    • US20160147575A1
    • 2016-05-26
    • US14554430
    • 2014-11-26
    • Ashish Kumar SinghSai Eswar GarapatiVijay Kishore KalakotlaPradeep Kumar Das
    • Ashish Kumar SinghSai Eswar GarapatiVijay Kishore KalakotlaPradeep Kumar Das
    • G06F9/50G06F9/48
    • G06F9/5088
    • A method includes storing a plurality of workloads in a first disk resource associated with a high end disk classification. The method further includes determining a corresponding activity level for each of the plurality of workloads. The method also includes classifying each of the plurality of workloads into a first set indicative of high-priority workloads and a second set indicative of low-priority workloads based on whether the corresponding activity level is greater than a threshold activity level. The method further includes determining whether a second disk resource associated with a low end disk classification can accommodate storage of a first particular workload in the second set based on an available storage capacity of the second disk resource. The method additionally includes migrating the first particular workload from the first disk resource to the second disk resource.
    • 一种方法包括将多个工作负载存储在与高端盘分类相关联的第一磁盘资源中。 所述方法还包括确定所述多个工作负载中的每一个的相应活动级别。 该方法还包括将多个工作负载中的每一个分类为指示高优先级工作负载的第一组,以及基于相应的活动级别是否大于阈值活动级别指示低优先级工作负载的第二组。 该方法还包括基于第二磁盘资源的可用存储容量确定与低端磁盘分类相关联的第二磁盘资源是否可以容纳第二集合中的第一特定工作负载的存储。 该方法还包括将第一特定工作负载从第一磁盘资源迁移到第二磁盘资源。
    • 10. 发明申请
    • PURE FORM OF RAPAMYCIN AND A PROCESS FOR RECOVERY AND PURIFICATION THEREOF
    • RAPAMYCIN的纯化形式及其回收和纯化方法
    • US20100029933A1
    • 2010-02-04
    • US12514356
    • 2006-12-26
    • Nitin Sopanrao PatilSyed Idris HussainiAshish Kumar SinghRakesh Bhaiyyaram Mendhe
    • Nitin Sopanrao PatilSyed Idris HussainiAshish Kumar SinghRakesh Bhaiyyaram Mendhe
    • C07D498/16C12P17/18
    • C07D498/18
    • The present invention relates to a pure form of rapamycin with a total impurity content less than 1.2%; a process for recovery and purification of rapamycin comprising steps of (a) treating the fermentation broth, extracts or solutions containing rapamycin with water immiscible solvent and concentration; (b) addition of a water miscible solvent to effect separation of impurities present; (c) optionally, binding of the solvent containing the product from step (b) to an inert solid, washing the solid with a base and acid, followed by elution; (d) subjecting the elute from step (c) or the solvent containing the product from step (b) to silica gel chromatography; (e) crystallization of the product obtained from step (d); (f) subjecting a solution of the product from step (e) to hydrophobic interaction or reversed phase chromatography; and (g) re-crystallization to afford rapamycin in substantially pure form.
    • 本发明涉及总杂质含量小于1.2%的纯形式的雷帕霉素; 一种回收和纯化雷帕霉素的方法,包括以下步骤:(a)用与水不混溶的溶剂和浓度处理含有雷帕霉素的发酵液,提取物或溶液; (b)加入水混溶性溶剂以分离存在的杂质; (c)任选地,将含有步骤(b)的产物的溶剂与惰性固体结合,用碱和酸洗涤固体,随后洗脱; (d)使来自步骤(c)的洗脱液或含有步骤(b)的产物的溶剂经硅胶色谱法; (e)从步骤(d)获得的产物的结晶; (f)使来自步骤(e)的产物的溶液进行疏水相互作用或反相色谱; 和(g)重结晶以提供基本上纯的形式的雷帕霉素。