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    • 6. 发明申请
    • PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS WITH METAL ALCOHOLATES
    • 具有金属醇的氨基醇的加成方法
    • US20160194273A1
    • 2016-07-07
    • US14987960
    • 2016-01-05
    • BASF SE
    • Melanie WEINGARTENWolfgang SIEGEL
    • C07C213/06
    • C07C213/06C07B2200/07C07C217/08
    • Process for the etherification of amino alcohols with metal alcoholatesA process for the preparation of the ether of formula I where R1 and R2 independently from one another are hydrogen or an alkyl group with 1 to 10 C atoms, R3 is an alkyl group with 1 to 10 carbon atoms andX is a bond or a hydrocarbon group with 1 to 10 carbon atomscomprisinga) deprotonating the amino alcohol of formula II where R1, R2 and X have the meaning abovewith a metal alcoholate as deprotonating agent to give the anion of formula III where R1, R2 and X have the meaning aboveandb) alkylation of the anion obtained in step a) with an alkylation agent to give the ether of formula I,wherein the deprotonating agent in step a) is used in equimolar or less than equimolar amounts compared to the amino alcohol andthe alkylation agent in step b) is used in equimolar or less than equimolar amounts compared to the anion of formula III.
    • 氨基醇与金属醇化物醚化的方法制备其中R 1和R 2彼此独立地为氢或具有1至10个C原子的烷基的式I的醚的方法,R 3是具有1至 10个碳原子,X是具有1至10个碳原子的键或烃基,包括a)使式II的氨基醇去质子化,其中R 1,R 2和X具有上述含义,用金属醇化物作为去质子化剂,得到 式III其中R 1,R 2和X具有上述含义,和b)用烷基化剂在步骤a)中获得的阴离子烷基化得到式I的醚,其中步骤a)中的去质子化剂以等摩尔或更少 与步骤b)中的氨基醇和烷基化剂相比,等摩尔量与式III的阴离子等摩尔或小于等摩尔量使用。