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1. 发明授权

US11613461B2 Textiles having a microstructured surface and garments comprising the same 有权
公开(公告)号：US11613461B2
公开(公告)日：2023-03-28
申请号：US15285529
申请日：2016-10-05
申请人： BVW Holding AG
发明人： Michael Milbocker , Lukas Bluecher
IPC分类号： B81B3/00 , B81C1/00 , D06M23/16 , A61B42/10 , A41D19/015 , A41D31/12
摘要： The present invention relates to textile articles and clothing such as outdoor garments, indoor garments, and commercial protective wear exposed to contact mixtures of water and oil, swimwear and winter wear exposed to mixtures of water and air. At least part of these textile articles possess a surface provided with at least one of 1) a high surface area, 2) hierarchical pattern, 3) contact angles such that hydrophilic portion of a contact mixture possesses a high contact angle and the hydrophobic portion of a contact mixture possesses a low contact angle, and 4) hysteresis angle greater than 5 degrees. Hydrophobic/Hydrophilic contact mixtures of the present invention can be surfaces where water and or ice are present in combination with oil and or air. The textile articles of the present invention resist slippage on surfaces possessing hydrophobic/hydrophilic contact mixtures.

2. 发明授权

US11419711B2 Implantable superhydrophobic surfaces 有权
公开(公告)号：US11419711B2
公开(公告)日：2022-08-23
申请号：US17389046
申请日：2021-07-29
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A61F2/02 , A61L27/50 , A61F2/00 , A61L27/34 , A61L31/10 , A61L31/14 , A61L27/56 , B29C33/38
摘要： Bio-adhesive textured surfaces are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein.

3. 发明申请

US20220161301A1 SELECTIVE TERMINATION OF SUPERHYDROPHOBIC SURFACES 有权
公开(公告)号：US20220161301A1
公开(公告)日：2022-05-26
申请号：US17669091
申请日：2022-02-10
申请人： BVW Holding AG
发明人： Michael Milbocker , Lukas Bluecher
IPC分类号： B08B17/06 , C23C16/04 , B29C39/02 , B81C1/00 , A61L27/50 , A61L31/14 , A61L29/14
摘要： Provided herein is a hierarchical superhydrophobic surface comprising an array of first geometrical features disposed on a substrate comprising a first material and a terminal level disposed on the second features, wherein the terminal level comprises a second material, the second material being different from the first material. The second material has a hydrophilicity different from the hydrophilicity of at least one of 1) the hydrophilicity of the second material and 2) hydrophilicity induced by the hierarchical structure. The present disclosure further includes methods of preparing hierarchical superhydrophobic surfaces and medical devices comprising the hierarchical superhydrophobic surfaces.

4. 发明授权

US11298440B2 Microstructured haptotaxic implant 有权
公开(公告)号：US11298440B2
公开(公告)日：2022-04-12
申请号：US17236738
申请日：2021-04-21
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A61L27/26 , A61L27/56 , A61L27/58 , A61F2/00 , A61L27/48 , A61L27/50
摘要： The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.

5. 发明申请

US20210353400A1 IMPLANTABLE SUPERHYDROPHOBIC SURFACES 有权
公开(公告)号：US20210353400A1
公开(公告)日：2021-11-18
申请号：US17389040
申请日：2021-07-29
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A61F2/02 , A61L27/50 , A61L27/56 , A61F2/00 , A61L27/34 , A61L31/10 , A61L31/14
摘要： Bio-adhesive textured surfaces and methods of making the same are described which allow implants to be localized within a living body. Hierarchical levels of texture on an implantable medical device, some capable of establishing a Wenzel state and others a Cassie state, may be employed to interface with living structures to provide resistance to device migration. Since a gaseous state is traditionally required to establish a Cassie or Wenzel state, and gases do not remain long in living tissue, described herein are tissue/device interactions analogous to the above states with the component normally represented by a gas replaced by a bodily constituent, wherein separation of tissue constituents develops and an analogous Cassie, Wenzel, or Cassie-Wenzel state evolves. Further methods of making molds to produce said devices are described herein.

6. 发明申请

US20210290820A1 MICROSTRUCTURED HAPTOTAXIC IMPLANT 有权
公开(公告)号：US20210290820A1
公开(公告)日：2021-09-23
申请号：US17236738
申请日：2021-04-21
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A61L27/26 , A61L27/56 , A61L27/58 , A61F2/00 , A61L27/48 , A61L27/50
摘要： The invention relates to the field of tissue engineering and regenerative medicine, and particularly to a three-dimensional biomimetic tissue scaffold that exploits the use of three-dimensional print technology. Surface energy is controlled by precisely placing polymers with differing surface chemistry, and using surface texture and bulk composition to pattern absorbable and non-absorbable polymers for the purpose of promoting functional healing in a mammalian body.

7. 发明申请

US20210290241A1 MICROSTRUCTURED HEMOSTAT 有权
公开(公告)号：US20210290241A1
公开(公告)日：2021-09-23
申请号：US16823009
申请日：2020-03-18
申请人： BVW Holding AG
发明人： Michael Milbocker , Lukas Bluecher
IPC分类号： A61B17/12 , A61L31/04
摘要： A microstructured hemostat comprising multiple layers of microstructure, each layer characterized by one or more length scales, is described. Microstructured hemostats of the present invention, can reduce the time for blood coagulation, control the morphology of the coagulation, and provide a novel diagnostic platform for evaluation of coagulation function from a morphological perspective.

8. 发明申请

US20200113933A1 COPOLYMERS OF HYDROPHOBIC AND HYDROPHILIC SEGMENTS THAT REDUCE PROTEIN ADSORPTION 审中-公开
公开(公告)号：US20200113933A1
公开(公告)日：2020-04-16
申请号：US16656134
申请日：2019-10-17
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A61K31/785 , C08G18/66 , C08G18/12 , C08G18/64 , C08G18/42 , C08G18/75 , C08G18/10
摘要： The present disclosure relates to compositions A composition comprising a polymerization product of an anionic polysaccharide, a diisocyanate, and a linker, wherein the linker comprises i) an ether group, an ester group, or a combination thereof and, ii) a chain extender comprising a hydroxyl group, a thiol group, an amine group, or a combination thereof. The disclosure further relates to medical devices comprising the aforementioned compositions, and to methods of using the compositions and devices. More particularly, the compositions, devices and methods described herein are useful for preventing protein adhesions in vivo, particularly the Vroman effect.

9. 发明授权

US10433924B2 Wenzel-cassie glove 有权
公开(公告)号：US10433924B2
公开(公告)日：2019-10-08
申请号：US15616919
申请日：2017-06-08
申请人： BVW Holding AG
发明人： Lukas Bluecher , Michael Milbocker
IPC分类号： A41D19/015 , A61B42/10 , A41D19/00 , A61B42/00 , A41D31/12
摘要： A glove with an enhanced gripping textured surface is disclosed herein. In preferred embodiments, the glove contains a palm region adapted to cover the palm of a person's hand, a thumb region extending outwardly from the palm region, an index finger region disposed adjacent the thumb region, a middle finger region adjacent the index finger region, a ring finger region adjacent the middle finger region, and a little finger region adjacent the ring finger region with each region containing a textured surface. In preferred embodiments, the textured surface is formed by a plurality of dimensionally hierarchical structures superimposed in layers. The textured surface of the invention, when in contact with wet tissue, repels water at a first texture layer and traps tissue at a second texture layer, such that when in tissue contact, especially exudative tissue, tissue fixatively localizes to the glove surface.

10. 发明申请

US20190133222A1 Device for Dynamic Fluid Pinning 审中-公开
公开(公告)号：US20190133222A1
公开(公告)日：2019-05-09
申请号：US16146877
申请日：2018-09-28
申请人： BVW Holding AG
发明人： Michael Milbocker , Lukas Bluecher
IPC分类号： A41D19/00
摘要： The present disclosure provides microstructured hydrophobic surfaces and devices for gripping wet deformable surfaces. The surfaces and devices disclosed herein utilize a split contact Wenzel-Cassie mechanism to develop multi-level Wenzel-Cassie structures. The Wenzel-Cassie structures are separated with a spatial period corresponding to at least one wrinkle eigenmode of a wet deformable surface to which the microstructure or device is designed to contact, allowing grip of the deformable surface without slippage. Microstructures of the present invention are specifically designed to prevent the formation of Shallamach waves when a shear force is applied to a deformable surface. The multi-level Wenzel-Cassie states of the present disclosure develop temporally, and accordingly are characterized by hierarchical fluid pinning, both in the instance of slippage, and more importantly in the instance of localization. This temporal aspect to the multi-level Wenzel-Cassie state delays or prevents the transition from a wrinkled eigenmode state in a deformable surface to a buckled state in a deformable surface.

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