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1. 发明授权

US08795174B2 Adherent device with multiple physiological sensors 有权
标题翻译：具有多个生理传感器的粘附装置
公开(公告)号：US08795174B2
公开(公告)日：2014-08-05
申请号：US13598238
申请日：2012-08-29
申请人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
发明人： Yatheendhar D. Manicka , Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/00 , G06F19/00 , A61B5/053
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a hydration signal of the patient. Electrocardiogram circuitry is coupled to at least two of the at least four electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate a signal in response to at least one of an activity or a position of the patient.
摘要翻译：用于监测患者的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的水合信号。心电图电路耦合到至少四个电极中的至少两个，以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生信号。

2. 发明授权

US08630709B2 Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权
标题翻译：用于选择治疗慢性心脏功能障碍的颈部迷走神经电刺激治疗方案的计算机实现系统和方法
公开(公告)号：US08630709B2
公开(公告)日：2014-01-14
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译：提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。外部编程器包括存储在存储器中的多个治疗简档。治疗概况包括不同组的刺激参数，其协作地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极治疗性地刺激颈部迷走神经。

3. 发明授权

US07664548B2 Distributed neuromodulation system for treatment of cardiovascular disease 有权
标题翻译：分布式神经调节系统治疗心血管疾病
公开(公告)号：US07664548B2
公开(公告)日：2010-02-16
申请号：US11539301
申请日：2006-10-06
申请人： Badri Amurthur , Steven D. Girouard , Imad Libbus
发明人： Badri Amurthur , Steven D. Girouard , Imad Libbus
IPC分类号： A61N1/362
CPC分类号： A61N1/37288 , A61N1/36114 , A61N1/37247 , A61N1/3787
摘要： A distributed system is described that employs electrical neural stimulation to modulate autonomic activity and which allows titration of the neural stimulation therapy in accordance with physiological measurements reflective of autonomic activity and/or physiological variables affected by the neural stimulation. Such a system may include a plurality of implantable neuromodulation units that communicate with one another over a network.
摘要翻译：描述了一种使用电神经刺激来调节自主活动的分布式系统，并且其允许根据反映受神经刺激影响的自主活动和/或生理变量的生理测量来滴定神经刺激疗法。这样的系统可以包括通过网络彼此通信的多个可植入神经调节单元。

4. 发明申请

US20090076363A1 Adherent Device with Multiple Physiological Sensors 有权
标题翻译：具有多个生理传感器的粘附装置
公开(公告)号：US20090076363A1
公开(公告)日：2009-03-19
申请号：US12209273
申请日：2008-09-12
申请人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/04
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient for an extended period comprises a breathable tape. The breathable tape comprises a porous material with an adhesive coating to adhere the breathable tape to a skin of the patient. At least one electrode is affixed to the breathable tape and capable of electrically coupling to a skin of the patient. A printed circuit board is connected to the breathable tape to support the printed circuit board with the breathable tape when the tape is adhered to the patient. Electronic components electrically are connected to the printed circuit board and coupled to the at least one electrode to measure physiologic signals of the patient. A breathable cover and/or an electronics housing is disposed over the circuit board and electronic components and connected to at least one of the electronics components, the printed circuit board or the breathable tape.
摘要翻译：用于长时间监视患者的附着装置包括透气带。透气带包括具有粘合剂涂层以将透气带粘附到患者皮肤的多孔材料。至少一个电极固定在透气带上并且能够电耦合到患者的皮肤。印刷电路板连接到透气带上，以便当带子粘附到患者时，用透气带支撑印刷电路板。电气部件电连接到印刷电路板并且耦合到至少一个电极以测量患者的生理信号。透气盖和/或电子壳体设置在电路板和电子部件上方并连接到电子部件，印刷电路板或透气带中的至少一个。

5. 发明申请

US20090076342A1 Adherent Multi-Sensor Device with Empathic Monitoring 审中-公开
标题翻译：具有同步监测的粘附多传感器设备
公开(公告)号：US20090076342A1
公开(公告)日：2009-03-19
申请号：US12209271
申请日：2008-09-12
申请人： Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Badri Amurthur , Mark J. Bly , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/00
CPC分类号： A61B5/0002 , A61B5/6833 , A61B2560/0412
摘要： A system and methods are provided for physiological monitoring and prediction. The system includes a detecting system and a remote monitoring system. The detecting system includes, (i) an adherent device with a plurality of sensors that provide an indication of at least one physiological event of a patient, the adherent device being coupled to the patient's thorax and (ii) a wireless communication device coupled to the plurality of sensors and configured to transfer patient data directly or indirectly from the plurality of sensors to a remote monitoring system. The remote monitoring system is coupled to the wireless communication device. Logic resources may be provided at the remote monitoring system to determine the physiological event of the patient.
摘要翻译：提供了一种用于生理监测和预测的系统和方法。该系统包括检测系统和远程监控系统。所述检测系统包括：（i）具有多个传感器的粘附装置，所述多个传感器提供患者的至少一个生理事件的指示，所述粘附装置耦合到患者的胸部，以及（ii）耦合到所述患者的胸部的无线通信装置多个传感器并且被配置为将患者数据直接或间接地从多个传感器传送到远程监视系统。远程监控系统耦合到无线通信设备。可以在远程监控系统处提供逻辑资源以确定患者的生理事件。

6. 发明授权

US08755892B2 Systems for stimulating neural targets 有权
标题翻译：刺激神经靶点的系统
公开(公告)号：US08755892B2
公开(公告)日：2014-06-17
申请号：US11749500
申请日：2007-05-16
申请人： Badri Amurthur , Imad Libbus
发明人： Badri Amurthur , Imad Libbus
IPC分类号： A61N1/04 , A61N1/36
CPC分类号： A61N1/36017 , A61B5/021 , A61B5/02405 , A61B5/02416 , A61B5/026 , A61B5/14532 , A61B5/1455 , A61B5/4041 , A61B5/6815 , A61B5/6826 , A61B5/6838 , A61B8/06 , A61N1/0452 , A61N1/0456 , A61N1/0492 , A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a method for stimulating neural targets in the vicinity of a human ear. According to an embodiment, a device is clipped on a patient ear lobe, the device including a neural stimulation electrode. A neural stimulation signal is applied to the electrode to transcutaneously stimulate neural targets in the vicinity of the ear lobe, according to an embodiment. A physiological parameter is sensed using a sensor connected to the device. According to an embodiment, the neural stimulation signal is adjusted in response to the sensed parameter. The method is used is a variety of treatment regimens, including anti-hypertensive and cardiac improvement therapy.
摘要翻译：本文公开了一种用于刺激人耳附近的神经靶的方法。根据实施例，将装置夹在患者耳垂上，该装置包括神经刺激电极。根据实施例，神经刺激信号被施加到电极以经皮刺激耳垂附近的神经靶。使用连接到该装置的传感器感测生理参数。根据实施例，响应于所感测的参数来调整神经刺激信号。使用的方法是多种治疗方案，包括抗高血压和心脏改善治疗。

7. 发明授权

US08571654B2 Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction 有权
标题翻译：迷走神经神经刺激器具有多种患者可选择的治疗慢性心脏功能障碍的模式
公开(公告)号：US08571654B2
公开(公告)日：2013-10-29
申请号：US13352244
申请日：2012-01-17
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/0551 , A61N1/36053 , A61N1/36114 , A61N1/3727
摘要： A vagus nerve neurostimulator system with multiple patient-selectable modes for treating chronic cardiac dysfunction is provided. An implantable neurostimulator includes a pulse generator coupled to a therapy lead terminated by a pair of helical electrodes positioned over a cervical vagus nerve. The pulse generator is configured to deliver through the helical electrodes continuously-cycling, intermittent and periodic electrical stimulation that is parametrically defined to bi-directionally propagate through nerve fibers in the cervical vagus nerve. The implantable neurostimulator includes a magnetic switch configured to switch the pulse generator between a plurality of operating modes that are each separately selectable in response to a unique and remotely-applied magnetic signal. An external controller includes patient-actuatable controls configured to enable selection of one of the operating modes of the pulse generator. The external controller includes an electromagnetic transmitter configured to output the magnetic signal uniquely associated with the operating mode as selected with the controls.
摘要翻译：提供了一种具有多种患者可选择的用于治疗慢性心脏功能障碍的模式的迷走神经神经刺激器系统。可植入的神经刺激器包括一个脉冲发生器，该脉冲发生器耦合到由位于颈部迷走神经上的一对螺旋电极终止的治疗引线。脉冲发生器被配置为通过螺旋电极连续循环，间歇和周期性电刺激传递，其被参数限定以通过颈部迷走神经中的神经纤维双向传播。可植入神经刺激器包括磁开关，其被配置为在多个操作模式之间切换脉冲发生器，所述多个操作模式可以响应于独特的和远程施加的磁信号而分别可选择。外部控制器包括被配置为能够选择脉冲发生器的一个操作模式的患者致动控制。外部控制器包括电磁发射机，其被配置为输出与通过控制选择的操作模式唯一相关联的磁信号。

8. 发明授权

US08116841B2 Adherent device with multiple physiological sensors 有权
公开(公告)号：US08116841B2
公开(公告)日：2012-02-14
申请号：US12209273
申请日：2008-09-12
申请人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/04 , A61B5/0408
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient for an extended period comprises a breathable tape. The breathable tape comprises a porous material with an adhesive coating to adhere the breathable tape to a skin of the patient. At least one electrode is affixed to the breathable tape and capable of electrically coupling to a skin of the patient. A printed circuit board is connected to the breathable tape to support the printed circuit board with the breathable tape when the tape is adhered to the patient. Electronic components electrically are connected to the printed circuit board and coupled to the at least one electrode to measure physiologic signals of the patient. A breathable cover and/or an electronics housing is disposed over the circuit board and electronic components and connected to at least one of the electronics components, the printed circuit board or the breathable tape.

9. 发明申请

US20090076405A1 Adherent Device for Respiratory Monitoring 有权
标题翻译：用于呼吸监测的粘附装置
公开(公告)号：US20090076405A1
公开(公告)日：2009-03-19
申请号：US12209268
申请日：2008-09-12
申请人： Badri Amurthur , Mark J. Bly , Imad Libbus , Yatheendhar D. Manicka
发明人： Badri Amurthur , Mark J. Bly , Imad Libbus , Yatheendhar D. Manicka
IPC分类号： A61B5/08 , A61B5/053
CPC分类号： A61B5/4818 , A61B5/0002 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/0809 , A61B5/11 , A61B5/14551 , A61B5/6832 , A61B5/6833 , A61B5/7282 , A61B2560/0412 , A61B2562/164
摘要： A respiratory monitoring system is provided. A measuring system is provided that includes, (i) an adherent device configured to be coupled to a patient, the adherent device including a plurality of sensors that monitor respiratory status, at least one of the sensors configured to monitor the patient's respiration, and (ii) a wireless communication device coupled to the plurality of sensors and configured to transfer patient data directly or indirectly from the plurality of sensors to a remote monitoring system. A remote monitoring system is coupled to the wireless communication device.
摘要翻译：提供呼吸监测系统。提供了一种测量系统，其包括：（i）被配置为耦合到患者的粘附装置，所述粘附装置包括监测呼吸状态的多个传感器，配置成监测患者呼吸的至少一个传感器，以及（ ii）耦合到所述多个传感器并被配置为将患者数据直接或间接地从所述多个传感器传送到远程监控系统的无线通信设备。远程监控系统耦合到无线通信设备。

10. 发明申请

US20090076397A1 Adherent Emergency Patient Monitor 审中-公开
标题翻译：贴近紧急病人监护仪
公开(公告)号：US20090076397A1
公开(公告)日：2009-03-19
申请号：US12209259
申请日：2008-09-12
申请人： Imad Libbus , Badri Amurthur , Mark J. Bly , Kristofer J. James , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
发明人： Imad Libbus , Badri Amurthur , Mark J. Bly , Kristofer J. James , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/02 , A61B5/0402 , A61B5/08
CPC分类号： A61B5/04087 , A61B5/6833
摘要： An adherent device comprises an adhesive patch to adhere to a skin of the patient. At least two electrodes are connected to the patch and capable of electrically coupling to the patient. Electrocardiogram circuitry can be coupled to at the least two electrodes to measure an electrocardiogram signal of the patient. An accelerometer can be mechanically coupled to the adhesive patch to generate an accelerometer signal in response to at least one of an activity or a position of the patient. A processor comprising a tangible medium can be configured to communicate with the electrocardiogram circuitry and the accelerometer to generate an alarm signal in response to the electrocardiogram signal and the accelerometer signal.
摘要翻译：粘附装置包括粘附到患者皮肤上的粘贴剂。至少两个电极连接到贴片并且能够电耦合到患者。心电图电路可耦合到至少两个电极以测量患者的心电图信号。加速度计可以机械耦合到粘合贴片，以响应于患者的活动或位置中的至少一个来产生加速度计信号。包括有形介质的处理器可以被配置为与心电图电路和加速度计通信，以响应于心电图信号和加速度计信号产生报警信号。

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