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1. 发明申请

US20120138484A1 Analyte Sensors Comprising Thickeners, Enzyme Stabilizers and Osmium Boronates 审中-公开
标题翻译：分析物传感器，包括增稠剂，酶稳定剂和锇硼酸盐
公开(公告)号：US20120138484A1
公开(公告)日：2012-06-07
申请号：US13298020
申请日：2011-11-16
申请人： Balasubrahmanya S. Bommakanti , Udo Hoss , Gary Sandhu
发明人： Balasubrahmanya S. Bommakanti , Udo Hoss , Gary Sandhu
IPC分类号： G01N33/50 , B05D5/00 , G01N27/26
CPC分类号： C12Q1/006
摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution and/or improved sensitivity and/or reduced sensitivity variation of the sensing layer by inclusion of a thickener and/or an enzyme stabilizer in the sensing layer. Embodiments of the present disclosure also relate to transition metal complexes having at least one pyridine boronic acid ligand are also described. Aspects of the disclosure include transition metal complexes chemically bonded to a polymer, such as a sensing layer polymer. The sensing layer is disposed on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：本公开的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包含增稠剂和/或（例如，电化学分析物监测系统）具有改善的分布均匀性和/或改善的灵敏度和/或降低感测层的灵敏度变化酶稳定剂在感应层。还描述了本公开的实施方案涉及具有至少一个吡啶硼酸配体的过渡金属络合物。本公开的方面包括化学键合到聚合物上的过渡金属络合物，例如感测层聚合物。感测层设置在体内和/或体外分析物传感器的工作电极上，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

2. 发明申请

US20110124993A1 Analyte Sensors Comprising Self-Polymerizing Hydrogels 审中-公开
标题翻译：包含自聚合水凝胶的分析物传感器
公开(公告)号：US20110124993A1
公开(公告)日：2011-05-26
申请号：US12624767
申请日：2009-11-24
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： A61B5/1468 , G01N27/26
CPC分类号： A61B5/1473 , C12Q1/006
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a self-polymerizing hydrogel, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本公开的实施方案涉及通过包含自聚合水凝胶而具有改进的感测层分布均匀性的分析物确定方法和装置（例如，电化学分析物监测系统），其中感测层设置在接近于体内和/或体外分析物传感器的工作电极，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

3. 发明申请

US20100030052A1 ANALYTE SENSORS COMPRISING PLASTICIZERS 审中-公开
标题翻译：包含增塑剂的分析仪传感器
公开(公告)号：US20100030052A1
公开(公告)日：2010-02-04
申请号：US12183602
申请日：2008-07-31
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Phu Le , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Phu Le , Udo Hoss
IPC分类号： A61B5/145 , G01N27/26
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/6849 , G01N27/3272
摘要： A method and analyte-measurement device adapted to determine the concentration of an analyte in a fluid from a measurement site within a body, including an animal body, a mammalian body, or a human body. The invention further relates to the use of partially or fully implantable glucose-monitoring devices, including transcutaneous or subcutaneous glucose-monitoring devices. Devices, systems and kits making use of the aforementioned method are provided as well.
摘要翻译：一种适于确定来自体内（包括动物体，哺乳动物体或人体）内的测量部位的流体中分析物浓度的方法和分析物测量装置。本发明还涉及部分或完全可植入的葡萄糖监测装置（包括经皮或皮下葡萄糖监测装置）的用途。还提供了利用上述方法的设备，系统和套件。

4. 发明授权

US08354013B2 Analyte sensors comprising high-boiling point solvents 有权
公开(公告)号：US08354013B2
公开(公告)日：2013-01-15
申请号：US12625185
申请日：2009-11-24
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss , Geoffrey V. McGarraugh
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss , Geoffrey V. McGarraugh
IPC分类号： G01N27/327
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/4839 , A61B5/6847 , A61B5/742 , A61B5/746 , A61K38/28 , C12Q1/004 , C12Q1/006 , G01N27/3271 , G01N27/3272
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a high-boiling point solvent, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

5. 发明申请

US20110124994A1 Analyte Sensors Comprising Hydrogel Membranes 有权
标题翻译：包含水凝胶膜的分析物传感器
公开(公告)号：US20110124994A1
公开(公告)日：2011-05-26
申请号：US12625208
申请日：2009-11-24
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： A61B5/1468 , G01N27/26
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/145 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/742 , A61B5/746
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of a coating including a hydrogel, a crosslinker, and a swelling modulator, where the coating is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本公开的实施方案涉及通过包括包含水凝胶，交联剂和溶胀调节剂的涂层而具有改善的信号响应和稳定性的分析物确定方法和装置（例如，电化学分析物监测系统），其中涂层为设置在体内和/或体外分析物传感器的工作电极附近，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

6. 发明申请

US20110120865A1 Analyte Sensors Comprising High-Boiling Point Solvents 有权
标题翻译：包含高沸点溶剂的分析物传感器
公开(公告)号：US20110120865A1
公开(公告)日：2011-05-26
申请号：US12625185
申请日：2009-11-24
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss , Geoffrey McGarraugh
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss , Geoffrey McGarraugh
IPC分类号： G01N33/50
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/1473 , A61B5/1495 , A61B5/4839 , A61B5/6847 , A61B5/742 , A61B5/746 , A61K38/28 , C12Q1/004 , C12Q1/006 , G01N27/3271 , G01N27/3272
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a high-boiling point solvent, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本公开的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包含高沸点溶剂来改善感测层的分布均匀性，其中感测层设置在接近体内和/或体外分析物传感器的工作电极，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

7. 发明申请

US20100081905A1 ANALYTE SENSORS COMPRISING LEVELING AGENTS 有权
标题翻译：分析传感器包括水平试剂
公开(公告)号：US20100081905A1
公开(公告)日：2010-04-01
申请号：US12242780
申请日：2008-09-30
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： A61B5/1473 , G01N27/416
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/0022 , A61B5/14532 , A61B5/14542 , C12Q1/001 , C12Q1/006 , G01N27/327
摘要： Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本发明的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包含低表面张力聚合物流平剂（其中组分是）可以改善传感器的一个或多个组分的分布均匀性设置在体内和/或体外分析物传感器的工作电极附近，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

8. 发明授权

US09042954B2 Analyte sensors comprising hydrogel membranes 有权
标题翻译：含有水凝胶膜的分析物传感器
公开(公告)号：US09042954B2
公开(公告)日：2015-05-26
申请号：US12625208
申请日：2009-11-24
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： A61B5/05 , A61B5/1473 , A61B5/145 , A61B5/1486
CPC分类号： A61B5/14865 , A61B5/0004 , A61B5/145 , A61B5/14532 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/742 , A61B5/746
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved signal response and stability by inclusion of a coating including a hydrogel, a crosslinker, and a swelling modulator, where the coating is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本公开的实施方案涉及通过包括包含水凝胶，交联剂和溶胀调节剂的涂层而具有改善的信号响应和稳定性的分析物确定方法和装置（例如，电化学分析物监测系统），其中涂层为靠近体内和/或体外分析物传感器的工作电极设置，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

9. 发明授权

US08983568B2 Analyte sensors comprising leveling agents 有权
标题翻译：分析物传感器包括流平剂
公开(公告)号：US08983568B2
公开(公告)日：2015-03-17
申请号：US12242780
申请日：2008-09-30
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： A61B5/05 , C12Q1/00 , A61B5/145 , A61B5/1486 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/0022 , A61B5/14532 , A61B5/14542 , C12Q1/001 , C12Q1/006 , G01N27/327
摘要： Generally, embodiments of the invention relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of one or more components of the sensor by inclusion of a low surface tension polymer leveling agent, where the components are disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本发明的实施方案涉及分析物确定方法和装置（例如，电化学分析物监测系统），其通过包含低表面张力聚合物流平剂（其中组分是）可以改善传感器的一个或多个组分的分布均匀性设置在体内和/或体外分析物传感器的工作电极附近，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

10. 发明申请

US20130004649A1 Analyte Sensors Comprising Self-Polymerizing Hydrogels 审中-公开
标题翻译：包含自聚合水凝胶的分析物传感器
公开(公告)号：US20130004649A1
公开(公告)日：2013-01-03
申请号：US13612489
申请日：2012-09-12
申请人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
发明人： Balasubrahmanya S. Bommakanti , Gary Sandhu , Udo Hoss
IPC分类号： G01N1/00
CPC分类号： A61B5/1473 , C12Q1/006
摘要： Generally, embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have improved uniformity of distribution of the sensing layer by inclusion of a self-polymerizing hydrogel, where the sensing layer is disposed proximate to a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
摘要翻译：通常，本公开的实施方案涉及通过包含自聚合水凝胶而具有改进的感测层分布均匀性的分析物确定方法和装置（例如，电化学分析物监测系统），其中感测层设置在接近于体内和/或体外分析物传感器的工作电极，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。

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