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1. 发明申请

US20220023484A1 Wound Dressings and Applications Thereof 有权
公开(公告)号：US20220023484A1
公开(公告)日：2022-01-27
申请号：US17499221
申请日：2021-10-12
申请人： THE PENN STATE RESEARCH FOUNDATION , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jian Yang , Kytai T. Nguyen , Zhiwei Xie
IPC分类号： A61L15/22 , A61L15/64 , A61L15/26 , A61L15/42 , A61L15/44
摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

2. 发明授权

US11173227B2 Wound dressings and applications thereof 有权
公开(公告)号：US11173227B2
公开(公告)日：2021-11-16
申请号：US14891862
申请日：2014-05-21
申请人： THE PENN STATE RESEARCH FOUNDATION , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jian Yang , Kytai T. Nguyen , Zhiwei Xie
IPC分类号： A61L15/22 , A61L15/44 , A61L15/28 , A61L15/42 , A61L15/26 , A61L15/64 , A61L31/14 , A61L31/04 , A61L31/16 , A61L31/06 , A61L31/12 , C08L67/04
摘要： In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

3. 发明申请

US20170274115A1 Methods of Making and Using Bioadhesive Compositions 审中-公开
公开(公告)号：US20170274115A1
公开(公告)日：2017-09-28
申请号：US15474611
申请日：2017-03-30
申请人： Board of Regents, The University of Texas System
发明人： Jian Yang , Reza Medizad
IPC分类号： A61L24/04 , A61L27/52 , A61L27/58 , A61L24/00 , C08G63/668 , C08G63/685
CPC分类号： A61L24/046 , A61L24/0031 , A61L24/0042 , A61L27/52 , A61L27/58 , A61L2400/12 , C08G63/668 , C08G63/6854
摘要： In one aspect, methods of making a composition are described herein. In some embodiments, a method of making a composition comprises providing a polycarboxylic acid; providing an alcohol; combining the polycarboxylic acid with the alcohol; adding a catechol-containing species to the combination of the polycarboxylic acid and the alcohol; and forming a polymer or oligomer from the polycarboxylic acid, the alcohol, and the catechol-containing species. In some embodiments, the catechol-containing species comprises an amine moiety, a carboxylic acid moiety, or a hydroxyl moiety that is not part of the catechol group.

4. 发明授权

US09248147B2 Methods for endoscopic mucosal resection and endoscopic submucosal dissection 有权
标题翻译：内窥镜粘膜切除术和内窥镜粘膜下剥离方法
公开(公告)号：US09248147B2
公开(公告)日：2016-02-02
申请号：US14084935
申请日：2013-11-20
申请人： Board Of Regents, The University of Texas System
发明人： Jian Yang , Minh-Tuan Richard Tran , Michael W Palmer , Shou-Jiang Tang
IPC分类号： A61P41/00 , A61K31/745 , A61F2/02 , A61K31/765 , G01N33/50
CPC分类号： A61K31/765 , G01N33/5088
摘要： In one aspect, methods for separating biological tissue are described herein. In some embodiments, a method for separating tissue comprises providing a first composition comprising a polymerizable material, providing a second composition comprising a polymerization initiator, disposing the first composition at a first site beneath a first tissue layer, disposing the second composition at the first site, polymerizing the polymerizable material at the first site, and separating the first tissue layer from a second tissue layer.
摘要翻译：在一个方面，本文描述了用于分离生物组织的方法。在一些实施方案中，用于分离组织的方法包括提供包含可聚合材料的第一组合物，提供包含聚合引发剂的第二组合物，将第一组合物设置在第一组织层下方的第一位点，将第二组合物设置在第一部位在第一位置处聚合可聚合材料，并将第一组织层与第二组织层分离。

5. 发明申请

US20140086866A1 Methods For Endoscopic Mucosal Resection And Endoscopic Submucosal Dissection 有权
标题翻译：内镜粘膜切除术和内镜粘膜下剥离术
公开(公告)号：US20140086866A1
公开(公告)日：2014-03-27
申请号：US14084935
申请日：2013-11-20
申请人： Board Of Regents, The University of Texas System
发明人： Jian Yang , Minh-Tuan Richard Tran , Michael W. Palmer , Shou-Jiang Tang
IPC分类号： A61K31/765
CPC分类号： A61K31/765 , G01N33/5088
摘要： In one aspect, methods for separating biological tissue are described herein. In some embodiments, a method for separating tissue comprises providing a first composition comprising a polymerizable material, providing a second composition comprising a polymerization initiator, disposing the first composition at a first site beneath a first tissue layer, disposing the second composition at the first site, polymerizing the polymerizable material at the first site, and separating the first tissue layer from a second tissue layer.
摘要翻译：在一个方面，本文描述了用于分离生物组织的方法。在一些实施方案中，用于分离组织的方法包括提供包含可聚合材料的第一组合物，提供包含聚合引发剂的第二组合物，将第一组合物设置在第一组织层下方的第一位点，将第二组合物设置在第一部位在第一位置处聚合可聚合材料，并将第一组织层与第二组织层分离。

6. 发明授权

US09642933B2 Compositions comprising bioadhesives and methods of making the same 有权
公开(公告)号：US09642933B2
公开(公告)日：2017-05-09
申请号：US13753683
申请日：2013-01-30
申请人： The Board of Regents, The University of Texas System
发明人： Jian Yang , Mohammadreza Mehdizadeh
IPC分类号： A61L24/04 , C08G63/685 , C08G63/668 , A61L27/52 , A61L27/58 , A61L24/00
CPC分类号： A61L24/046 , A61L24/0031 , A61L24/0042 , A61L27/52 , A61L27/58 , A61L2400/12 , C08G63/668 , C08G63/6854
摘要： In one aspect, compositions are described herein. In some embodiments, a composition comprises a polymer or oligomer formed from one or more polycarboxylic acids, one or more alcohols, and one or more catechol-containing species. In another aspect, methods of making a composition are described herein. In some embodiments, a method of making a composition comprises providing a polycarboxylic acid; providing an alcohol; combining the polycarboxylic acid with the alcohol; adding a catechol-containing species to the combination of the polycarboxylic acid and the alcohol; and forming a polymer or oligomer from the polycarboxylic acid, the alcohol, and the catechol-containing species. In some embodiments, the catechol-containing species comprises an amine moiety, a carboxylic acid moiety, or a hydroxyl moiety that is not part of the catechol group.

7. 发明授权

US09611354B2 Biodegradable photoluminescent polymers 有权
公开(公告)号：US09611354B2
公开(公告)日：2017-04-04
申请号：US14863889
申请日：2015-09-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jian Yang , Santosh Gautam
IPC分类号： C08G63/91 , C08J5/18 , C08G18/42 , A61L27/18 , A61L27/38 , A61L27/50 , C08F283/00 , C08F289/00 , C08F290/00 , C08G18/46 , C08G18/73 , C08G63/685 , C12N5/071
CPC分类号： C08G63/914 , A61L27/18 , A61L27/3891 , A61L27/50 , A61L27/507 , C08F283/00 , C08F283/006 , C08F289/00 , C08F290/00 , C08G18/4236 , C08G18/4283 , C08G18/4646 , C08G18/4676 , C08G18/73 , C08G63/6854 , C08G63/6858 , C08G2230/00 , C08J5/18 , C08J2367/04 , C12N5/0691 , C12N2533/30
摘要： Biodegradable photoluminescent polymer (BPLP) which comprises an oligomer synthesized from a multifunctional monomer, a diol, and an amino acid by reacting (i) a multifunctional monomer comprising citric acid or triethyl citrate with (ii) a diol to form a reaction product, and further reacting the reaction product with (iii) an amino acid, wherein the amino acid is linked as a side group to the oligomer backbone. The BPLP of the present invention poses tunable fluorescence emission characteristics and are cell-compatible and biodegradable. The BPLP can serve as both implant materials and bioimaging probes.

8. 发明申请

US20160137776A1 Fluorescent Polymers and Applications Thereof 有权
标题翻译：荧光聚合物及其应用
公开(公告)号：US20160137776A1
公开(公告)日：2016-05-19
申请号：US14903181
申请日：2014-07-08
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , THE PENN STATE RESEARCH FOUNDATION
发明人： Jian Yang , Zhiwei Xie
IPC分类号： C08G63/91 , A61K9/107
CPC分类号： C08G63/914 , A61K9/107 , A61K9/1075 , A61K47/34 , C08G63/6854
摘要： In one aspect, block copolymers are described herein. A block copolymer described herein, in some embodiments, comprises a first block comprising a polymer or oligomer formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid; and a second block comprising a polymer or oligomer that differs from the polymer or oligomer of the first block. In some cases, the polycarboxylic acid or polycarboxylic acid equivalent comprises citric acid, a citrate, or an ester of citric acid. The polyol can comprise an α,ω-n-alkane diol, poly(ethylene glycol), or poly(propylene glycol). In some embodiments, the amino acid forms a pendant group of the polymer or oligomer of the first block and/or forms a luminescent 6-membered ring with the polycarboxylic acid or polycarboxylic acid equivalent. The second block of a block copolymer described herein, in some embodiments, comprises a polylactone.
摘要翻译：一方面，本文描述了嵌段共聚物。在一些实施方案中，本文描述的嵌段共聚物包含第一嵌段，其包含由（i）多元羧酸或多元羧酸当量的反应产物形成的聚合物或低聚物，（ii）多元醇，和（iii）氨基酸 ; 和包含与第一嵌段的聚合物或低聚物不同的聚合物或低聚物的第二嵌段。在一些情况下，多元羧酸或多元羧酸当量包括柠檬酸，柠檬酸盐或柠檬酸酯。多元醇可以包含α，ω-正烷烃二醇，聚（乙二醇）或聚（丙二醇）。在一些实施方案中，氨基酸形成第一嵌段的聚合物或低聚物的侧基和/或与多元羧酸或多元羧酸当量形成发光的6-元环。在一些实施方案中，本文所述的嵌段共聚物的第二嵌段包含聚内酯。

9. 发明申请

US20160075822A1 BIODEGRADABLE PHOTOLUMINESCENT POLYMERS 有权
标题翻译：可生物降解的光致聚合物
公开(公告)号：US20160075822A1
公开(公告)日：2016-03-17
申请号：US14863889
申请日：2015-09-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： Jian Yang , Santosh Gautam
IPC分类号： C08G63/91 , C08J5/18
CPC分类号： C08G63/914 , A61L27/18 , A61L27/3891 , A61L27/50 , A61L27/507 , C08F283/00 , C08F283/006 , C08F289/00 , C08F290/00 , C08G18/4236 , C08G18/4283 , C08G18/4646 , C08G18/4676 , C08G18/73 , C08G63/6854 , C08G63/6858 , C08G2230/00 , C08J5/18 , C08J2367/04 , C12N5/0691 , C12N2533/30
摘要： The present invention describes a novel elastomeric biodegradable photoluminescent polymer (BPLP). The BPLPs of the present invention possess great processability and tunable fluorescence emission characteristics and are cell-compatible and biodegradable. The BPLPs of the present invention can serve as both implant materials and bioimaging probes.
摘要翻译：本发明描述了一种新的弹性体可生物降解的光致发光聚合物（BPLP）。本发明的BPLP具有很好的加工性和可调谐的荧光发射特性，并且是细胞相容的和可生物降解的。本发明的BPLP可以用作植入材料和生物成像探针。

10. 发明申请

US20130217790A1 Compositions Comprising Bioadhesives And Methods Of Making The Same 有权
标题翻译：组合包括生物粘合剂和制作方法
公开(公告)号：US20130217790A1
公开(公告)日：2013-08-22
申请号：US13753683
申请日：2013-01-30
申请人： The Board of Regents, The University of Texas System
发明人： Jian Yang , Mohammadreza Mehdizadeh
IPC分类号： A61L24/04 , C08G63/685
CPC分类号： A61L24/046 , A61L24/0031 , A61L24/0042 , A61L27/52 , A61L27/58 , A61L2400/12 , C08G63/668 , C08G63/6854
摘要： In one aspect, compositions are described herein. In some embodiments, a composition comprises a polymer or oligomer formed from one or more polycarboxylic acids, one or more alcohols, and one or more catechol-containing species. In another aspect, methods of making a composition are described herein. In some embodiments, a method of making a composition comprises providing a polycarboxylic acid; providing an alcohol; combining the polycarboxylic acid with the alcohol; adding a catechol-containing species to the combination of the polycarboxylic acid and the alcohol; and forming a polymer or oligomer from the polycarboxylic acid, the alcohol, and the catechol-containing species. In some embodiments, the catechol-containing species comprises an amine moiety, a carboxylic acid moiety, or a hydroxyl moiety that is not part of the catechol group.
摘要翻译：在一个方面，本文描述了组合物。在一些实施方案中，组合物包含由一种或多种多元羧酸，一种或多种醇和一种或多种含邻苯二酚的物质形成的聚合物或低聚物。在另一方面，本文描述了制备组合物的方法。在一些实施方案中，制备组合物的方法包括提供多元羧酸; 提供酒精; 将多元羧酸与醇组合; 向所述多元羧酸和所述醇的组合中加入含邻苯二酚的物质; 以及从多元羧酸，醇和含邻苯二酚的物质形成聚合物或低聚物。在一些实施方案中，含儿茶酚的物质包含不属于儿茶酚基团的胺部分，羧酸部分或羟基部分。

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