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1. 发明授权

US08131376B1 Method of inspection of materials for defects 有权
标题翻译：材料缺陷检查方法
公开(公告)号：US08131376B1
公开(公告)日：2012-03-06
申请号：US12209068
申请日：2008-09-11
申请人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.
摘要翻译：本发明是一种在密封包装中检查粘合剂，特别是钎焊粘合剂的非破坏性方法。本发明涉及适用于超声波检查的独特的密封包装设计和检查包装的方法。该包装和非破坏性检查过程在可植入的神经刺激器如视觉假体中特别有用。

2. 发明授权

US08391987B2 Implantable package to facilitate inspection 有权
公开(公告)号：US08391987B2
公开(公告)日：2013-03-05
申请号：US13360480
申请日：2012-01-27
申请人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.

3. 发明申请

US20120136415A1 Method for Inspection of Materials for Defects 有权
标题翻译：检测缺陷材料的方法
公开(公告)号：US20120136415A1
公开(公告)日：2012-05-31
申请号：US13360480
申请日：2012-01-27
申请人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Boozarjomehr Faraji , Kevin Jun Ha , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/375 , B65D6/00 , G01N29/04 , A61F9/08
CPC分类号： A61N1/0543 , A61N1/0526 , A61N1/36046 , A61N1/375 , G01N29/00 , G01N29/26
摘要： The present invention is a non-destructive method of inspecting a bond, particularly a braze bond, in a hermetic package. The invention involves a unique hermetic package design adapted for ultrasonic inspection and a method of inspecting the package. This package and non-destructive inspection process are particularly useful in implantable neural stimulators such as visual prostheses.
摘要翻译：本发明是一种在密封包装中检查粘合剂，特别是钎焊粘合剂的非破坏性方法。本发明涉及适用于超声波检查的独特的密封包装设计和检查包装的方法。该包装和非破坏性检查过程在可植入的神经刺激器如视觉假体中特别有用。

4. 发明申请

US20110270067A1 Biocompatible Bonding Method 审中-公开
标题翻译：生物相容性粘合法
公开(公告)号：US20110270067A1
公开(公告)日：2011-11-03
申请号：US13097399
申请日：2011-04-29
申请人： Boozarjomehr Faraji , Robert J. Greenberg , James S. Little , Jerry Ok , Neil Hamilton Talbot , David Daomin Zhou
发明人： Boozarjomehr Faraji , Robert J. Greenberg , James S. Little , Jerry Ok , Neil Hamilton Talbot , David Daomin Zhou
IPC分类号： A61B5/04 , H05K13/04 , B32B38/00 , B32B37/12 , B32B37/16 , A61N1/36 , B32B37/02
CPC分类号： H01L21/563 , A61B5/04001 , A61B2562/125 , A61N1/0543 , A61N1/36046 , A61N1/3752 , H01L24/29 , H01L24/32 , H01L24/83 , H01L2224/16225 , H01L2224/2919 , H01L2224/32225 , H01L2224/45169 , H01L2224/48091 , H01L2224/48465 , H01L2224/73203 , H01L2224/73204 , H01L2224/73265 , H01L2224/81193 , H01L2224/81801 , H01L2224/838 , H01L2224/92125 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01041 , H01L2924/01045 , H01L2924/01047 , H01L2924/01073 , H01L2924/01074 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/0665 , H01L2924/0781 , H01L2924/12042 , H01L2924/14 , H01L2924/15787 , H01L2924/19107 , H01L2924/3011 , Y10T156/10 , H01L2924/00014 , H01L2924/00 , H01L2924/3512
摘要： The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as etching or applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.
摘要翻译：本发明是一种用于将密封包装连接到诸如用于可植入装置中的电极阵列的柔性电路的装置和方法。通过导电粘合剂将柔性电路上的金属焊盘连接到密封设备上的金属焊盘是已知的。光滑的金属，如铂，不能很好地粘结到导电环氧树脂上。本发明提供了粗糙化的表面，例如蚀刻或施加高表面积的白金灰，以改善与铂或其它金属垫的粘合性。

5. 发明授权

US09643002B2 Method of manufacturing a flexible circuit electrode array with at least one tack opening 有权
公开(公告)号：US09643002B2
公开(公告)日：2017-05-09
申请号：US13167074
申请日：2011-06-23
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
IPC分类号： A61N1/05 , A61N1/36 , H05K1/11 , H05K3/00
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on the polymer base layer and the metal traces at least one tack opening. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on the polymer base layer; patterning the metal to form metal traces; depositing a polymer top layer on the polymer base layer and the metal traces; and preparing at least one tack opening.

6. 发明授权

US08738149B2 Flexible circuit electrode array device and a method for backside processing of a flexible circuit electrode device 有权
标题翻译：柔性电路电极阵列器件及柔性电路电极器件的背面处理方法
公开(公告)号：US08738149B2
公开(公告)日：2014-05-27
申请号：US13397604
申请日：2012-02-15
申请人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
发明人： Qingfang Yao , Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/04
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , B23K26/361 , B23K26/362
摘要： The invention involves a flexible circuit electrode array device comprising: a polymer layer; wherein the polymer layer includes one or more metal traces, an electrode array; one or more bond pads; and the electrode array is located on the opposite side of the polymer layer.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: applying polymer film on a substrate; processing the front side; releasing the polymer film from substrate; flipping over the polymer film and fixing it onto the substrate; processing the backside; and final releasing of the polymer film from the substrate.The invention further involves a method for backside processing of a flexible circuit electrode device, comprising: processing the front side without releasing the polymer; processing the backside by sacrificial substrate method, or by laser drilling method; and releasing the polymer film from the substrate.
摘要翻译：本发明涉及一种柔性电路电极阵列器件，包括：聚合物层; 其中所述聚合物层包括一个或多个金属迹线，电极阵列; 一个或多个接合垫; 并且电极阵列位于聚合物层的相对侧上。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：在基底上施加聚合物膜; 正面加工; 从基材中释放聚合物膜; 翻转在聚合物膜上并将其固定在基底上; 处理背面; 并从基底中最终释放聚合物膜。本发明还涉及一种用于柔性电路电极器件的背面处理的方法，包括：处理前侧而不释放聚合物; 通过牺牲基板方法或通过激光钻孔方法处理背面; 并从基板上释放聚合物膜。

7. 发明授权

US08180460B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08180460B2
公开(公告)日：2012-05-15
申请号：US11934627
申请日：2007-11-02
申请人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

8. 发明授权

US07937153B2 Electrode with increased stability and method of manufacturing the same 有权
标题翻译：增加稳定性的电极及其制造方法
公开(公告)号：US07937153B2
公开(公告)日：2011-05-03
申请号：US11820744
申请日：2007-06-19
申请人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. An implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.
摘要翻译：具有增加的稳定性的可植入电极具有聚集结构，其中电极的表面被包括充满棒或柱的开口的材料覆盖。具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

9. 发明授权

US07631424B2 Method of making electrode array with a tack opening 有权
标题翻译：制作具有开口的电极阵列的方法
公开(公告)号：US07631424B2
公开(公告)日：2009-12-15
申请号：US11928698
申请日：2007-10-30
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
IPC分类号： H01R41/00 , A61B5/04 , A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape.The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.
摘要翻译：本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

10. 发明申请

US20090118805A1 Return Electrode for a Flexible Circuit Electrode Array 审中-公开
标题翻译：用于柔性电路电极阵列的返回电极
公开(公告)号：US20090118805A1
公开(公告)日：2009-05-07
申请号：US12168740
申请日：2008-07-07
申请人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
发明人： Robert J. Greenberg , Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Kelly H. McClure , Brian V. Mech , Rongqing Dai , David Daomin Zhou , Gaillard R. Nolan
IPC分类号： A61F9/08 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large.The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes.The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
摘要翻译：在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。为了避免用返回电极刺激组织，如果电极很大，则是有利的。本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极从所述刺激电极。柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

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