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1. 发明申请

US20230036048A1 TUNABLE HYBRID III-V/IV LASER SENSOR SYSTEM-ON-A CHIP FOR REAL-TIME MONITORING OF A BLOOD CONSTITUENT CONCENTRATION LEVEL 有权
公开(公告)号：US20230036048A1
公开(公告)日：2023-02-02
申请号：US17887974
申请日：2022-08-15
申请人： Brolis Sensor Technology, UAB , Universiteit Gent , IMEC VZW
发明人： Augustinas Vizbaras , Kristijonas Vizbaras , Ieva Simonyte , Günther Roelkens
IPC分类号： A61B5/1455 , G01N21/39
摘要： A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGal-nAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

2. 发明申请

US20210353183A1 TUNABLE HYBRID III-V/ IV LASER SENSOR SYSTEM-ON-A-CHIP FOR REAL-TIME MONITORING OF A BLOOD CONSTITUENT CONCENTRATION LEVEL 有权
公开(公告)号：US20210353183A1
公开(公告)日：2021-11-18
申请号：US17369517
申请日：2021-07-07
申请人： Brolis Sensor Technology, UAB , Universiteit Gent , IMEC VZW
发明人： Augustinas Vizbaras , Kristijonas Vizbaras , Ieva Simonyte , Günther Roelkens
IPC分类号： A61B5/1455 , G01N21/39
摘要： A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGaInAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

3. 发明申请

US20230047997A1 TUNABLE HYBRID III-V/IV LASER SENSOR SYSTEM-ON-A CHIP FOR REAL-TIME MONITORING OF A BLOOD CONSTITUENT CONCENTRATION LEVEL 有权
公开(公告)号：US20230047997A1
公开(公告)日：2023-02-16
申请号：US17887981
申请日：2022-08-15
申请人： Brolis Sensor Technology, UAB , Universiteit Gent , IMEC VZW
发明人： Augustinas Vizbaras , Kristijonas Vizbaras , Ieva Simonyte , Günther Roelkens
IPC分类号： A61B5/1455 , G01N21/39
摘要： A spectroscopic laser sensor based on hybrid lll-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a lll-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGalnAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

4. 发明授权

US11298057B2 Tunable hybrid III-V/IV laser sensor system-on-a-chip for real-time monitoring of a blood constituent concentration level 有权
公开(公告)号：US11298057B2
公开(公告)日：2022-04-12
申请号：US17369517
申请日：2021-07-07
申请人： Brolis Sensor Technology, UAB , Universiteit Gent , IMEC VZW
发明人： Augustinas Vizbaras , Kristijonas Vizbaras , Ieva {hacek over (S)}imonytė , Günther Roelkens
IPC分类号： A61B5/1455 , H01S5/026 , G01N21/39 , H01S5/125 , H01S5/20
摘要： A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGaInAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

5. 发明申请

US20150268419A1 METHOD FOR OPTICAL COUPLING BETWEEN A PHOTONIC INTEGRATED CIRCUIT AND AN EXTERNAL OPTICAL ELEMENT 有权
标题翻译：光电集成电路与外部光学元件之间的光耦合方法
公开(公告)号：US20150268419A1
公开(公告)日：2015-09-24
申请号：US14664673
申请日：2015-03-20
申请人： IMEC VZW , Universiteit Gent
发明人： Geert Van Steenberge , Dries Van Thourhout , Günther Roelkens
IPC分类号： G02B6/26 , C03C23/00 , C03C15/00 , G02B6/12
CPC分类号： G02B6/30 , C03C13/04 , C03C15/00 , C03C23/0025 , G02B6/1228 , G02B6/13 , G02B6/305 , G02B6/42
摘要： The present disclosure generally relates to a method of optically coupling a photonic integrated circuit and an external optical component. In one aspect, a method comprises: providing a photonic integrated circuit comprising at least one integrated optical waveguide, the photonic integrated circuit having a cover layer; providing at least one optical component external to the photonic integrated circuit, the at least one optical component having an optical coupling facet and configured to be optically coupled to the at least one integrated optical waveguide, thereby forming an assembly; determining a position of the optical coupling facet of the at least one optical component in the assembly; determining a position of the at least one integrated optical waveguide; designing an optical interface pattern between the optical coupling facet of the at least one optical component in the assembly and the at least one integrated optical waveguide; and writing the interface pattern in the cover layer of the photonic integrated circuit by means of a femtosecond laser, thereby forming an optical interface for optically coupling the optical coupling facet and the at least one integrated optical waveguide.
摘要翻译：本公开一般涉及光学耦合光子集成电路和外部光学部件的方法。一方面，一种方法包括：提供包括至少一个集成光波导的光子集成电路，所述光子集成电路具有覆盖层; 在所述光子集成电路外部提供至少一个光学部件，所述至少一个光学部件具有光学耦合小面并且被配置为光耦合到所述至少一个集成光波导，从而形成组件; 确定所述组件中所述至少一个光学部件的所述光学耦合小面的位置; 确定所述至少一个集成光波导的位置; 在所述组件中的所述至少一个光学部件的光耦合面与所述至少一个集成光波导之间设计光学接口图案; 以及通过飞秒激光将所述界面图案写入所述光子集成电路的覆盖层中，从而形成用于光耦合所述光耦合面和所述至少一个集成光波导的光学接口。

6. 发明授权

US09529154B2 Method for optical coupling between a photonic integrated circuit and an external optical element 有权
标题翻译：光子集成电路与外部光学元件之间的光耦合方法
公开(公告)号：US09529154B2
公开(公告)日：2016-12-27
申请号：US14664673
申请日：2015-03-20
申请人： IMEC VZW , Universiteit Gent
发明人： Geert Van Steenberge , Dries Van Thourhout , Günther Roelkens
IPC分类号： G02B6/30 , C03C23/00 , C03C15/00 , G02B6/42 , G02B6/122 , C03C13/04 , G02B6/13
CPC分类号： G02B6/30 , C03C13/04 , C03C15/00 , C03C23/0025 , G02B6/1228 , G02B6/13 , G02B6/305 , G02B6/42
摘要： The present disclosure generally relates to a method of optically coupling a photonic integrated circuit and an external optical component. In one aspect, a method comprises: providing a photonic integrated circuit comprising at least one integrated optical waveguide, the photonic integrated circuit having a cover layer; providing at least one optical component external to the photonic integrated circuit, the at least one optical component having an optical coupling facet and configured to be optically coupled to the at least one integrated optical waveguide, thereby forming an assembly; determining a position of the optical coupling facet of the at least one optical component in the assembly; determining a position of the at least one integrated optical waveguide; designing an optical interface pattern between the optical coupling facet of the at least one optical component in the assembly and the at least one integrated optical waveguide; and writing the interface pattern in the cover layer of the photonic integrated circuit by means of a femtosecond laser, thereby forming an optical interface for optically coupling the optical coupling facet and the at least one integrated optical waveguide.
摘要翻译：本公开一般涉及光学耦合光子集成电路和外部光学部件的方法。一方面，一种方法包括：提供包括至少一个集成光波导的光子集成电路，所述光子集成电路具有覆盖层; 在所述光子集成电路外部提供至少一个光学部件，所述至少一个光学部件具有光学耦合小面并且被配置为光耦合到所述至少一个集成光波导，从而形成组件; 确定所述组件中所述至少一个光学部件的所述光学耦合小面的位置; 确定所述至少一个集成光波导的位置; 在所述组件中的所述至少一个光学部件的光耦合面与所述至少一个集成光波导之间设计光学接口图案; 以及通过飞秒激光将所述界面图案写入所述光子集成电路的覆盖层中，由此形成用于光耦合所述光耦合面和所述至少一个集成光波导的光学接口。

7. 发明授权

US10338313B2 On-chip broadband light source 有权
公开(公告)号：US10338313B2
公开(公告)日：2019-07-02
申请号：US15753700
申请日：2016-08-22
申请人： UNIVERSITEIT GENT , IMEC VZW
发明人： Roeland Baets , Günther Roelkens , Andreas De Groote , Paolo Cardile , Ananth Subramanian
IPC分类号： G02B6/12 , G02B6/122 , H01L33/00 , H01L33/58 , H01L33/30 , H01S5/026 , G02B6/13
摘要： An on-chip broadband radiation source, and methods for its manufacture such that a photonics IC comprises an optical waveguide such as a semiconductor waveguide, a thin III-V material membrane with absorption capability for absorbing an optical pump signal induced in the waveguide. The III-V membrane comprises a LED implemented therein. The photonics IC also comprises a coupling means between the waveguide and the membrane. The device provides a broadband radiation source at a wavelength longer than the wavelength of the transferred radiation. The broadband signal can then be coupled out through the waveguide and used in the chip.

8. 发明授权

US10036625B2 Integrated spectrometers with single pixel detector 有权
公开(公告)号：US10036625B2
公开(公告)日：2018-07-31
申请号：US15305713
申请日：2015-04-23
申请人： UNIVERSITEIT GENT , IMEC VZW
发明人： Roeland Baets , Danaë Delbeke , Günther Roelkens , Wim Bogaerts
IPC分类号： G01J3/28 , G01B9/02 , G01J3/02 , G01J3/18 , G01J3/32 , G01J3/433 , G01N21/35 , G02B6/12
CPC分类号： G01B9/02051 , G01B9/02044 , G01J3/0218 , G01J3/0256 , G01J3/0259 , G01J3/18 , G01J3/1895 , G01J3/32 , G01J3/433 , G01N21/35 , G02B6/12019
摘要： An integrated waveguide based spectrometer is described. The spectrometer comprises a sensing region for receiving multi-wavelength radiation for irradiating a sample in the sensing region, a wavelength demultiplexing element arranged for capturing said multi-wavelength radiation after interaction with the sample and for providing a number of wavelength demultiplexed radiation outputs or a number of different groups of wavelength demultiplexed radiation outputs, an integrated modulator for differently modulating the different demultiplexed radiation outputs or different groups of demultiplexed radiation outputs, and a multiplexer element for multiplexing the differently modulated demultiplexed radiation outputs or the differently grouped demultiplexed radiation outputs.

9. 发明申请

US20200069225A1 TUNABLE HYBRID II-V IV LASER SENSOR SYSTEM-ON-A CHIP FOR REAL-TIME MONITORING OF A BLOOD CONSTITUENT CONCENTRATION LEVEL 审中-公开
公开(公告)号：US20200069225A1
公开(公告)日：2020-03-05
申请号：US16609355
申请日：2018-05-21
申请人： Brolis Sensor Techonology, UAB , Universiteit Gent
发明人： Augustinas Vizbaras , Kristijonas Vizbaras , leva Simonyte , Günther Roelkens
IPC分类号： A61B5/1455 , G01N21/39
摘要： A spectroscopic laser sensor based on hybrid lll-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a lll-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGal-nAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

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