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1. 发明申请

US20210059142A1 PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS 有权
公开(公告)号：US20210059142A1
公开(公告)日：2021-03-04
申请号：US17098210
申请日：2020-11-13
申请人： CELLECTIS SA , MEDICAGO INC.
发明人： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
IPC分类号： A01H1/06 , C12N15/82 , C12N15/01 , C12N9/22 , C12P21/00
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

2. 发明授权

US11576317B2 Mutant Nicotiana benthamiana plant or cell with reduced XylT and FucT 有权
公开(公告)号：US11576317B2
公开(公告)日：2023-02-14
申请号：US17098210
申请日：2020-11-13
申请人： CELLECTIS SA , MEDICAGO INC.
发明人： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
IPC分类号： A01H1/06 , A01H6/82 , A01H5/12 , C12N15/82 , C12N15/01 , C12N9/22 , C12P21/00
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

3. 发明授权

US11555198B2 Method for making nicotiana plants with mutations in XylT and FucT alleles using rare-cutting endonucleases 有权
公开(公告)号：US11555198B2
公开(公告)日：2023-01-17
申请号：US14439420
申请日：2013-10-31
申请人： CELLECTIS SA , MEDICAGO INC.
发明人： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
IPC分类号： A01H1/06 , C12N15/82 , C12N15/01 , C12N9/22 , C12P21/00
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

4. 发明申请

US20150272076A1 PLANTS FOR PRODUCTION OF THERAPEUTIC PROTEINS 审中-公开
标题翻译：用于生产治疗性蛋白质的植物
公开(公告)号：US20150272076A1
公开(公告)日：2015-10-01
申请号：US14439420
申请日：2013-10-31
申请人： CELLECTIS SA , MEDICAGO INC.
发明人： Luc Mathis , Daniel F. Voytas , Jin Li , Feng Zhang , Thomas Stoddard , Marc-Andre D'Aoust
IPC分类号： A01H5/12 , A01H1/06 , C12P21/00
CPC分类号： A01H5/12 , A01H1/06 , C12N9/22 , C12N15/01 , C12N15/8218 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12P21/005
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
摘要翻译：提供材料和方法用于制造适合于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。

5. 发明授权

US10590173B2 Picornavirus-like particle production in plants 有权
公开(公告)号：US10590173B2
公开(公告)日：2020-03-17
申请号：US16228091
申请日：2018-12-20
申请人： MEDICAGO INC.
发明人： Marc-Andre D'Aoust , Pierre-Olivier Lavoie , Manon Couture , Lucie Poulin , Louis-Philippe Vezina
IPC分类号： C12N7/00 , C07K14/005 , C07K16/10 , C12N15/82 , A61K39/125 , A61K39/13
摘要： A method of producing a picornavirus-like particle (PVLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, portion of the plant, or a plant cell. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding a polyprotein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more protease. The plant, portion of the plant, or plant cell is incubated under conditions that permit the expression of the nucleic acids, thereby producing the PVLP. A PVLP comprising the polyprotein is also provided.

6. 发明授权

US10358652B2 Influenza virus-like particle production in plants 有权
公开(公告)号：US10358652B2
公开(公告)日：2019-07-23
申请号：US14779423
申请日：2014-03-28
申请人： MEDICAGO INC.
发明人： Manon Couture , Marc-Andre D'Aoust , Louis-Philippe Vezina
IPC分类号： C12N7/00 , C12N15/82 , A61K39/12 , A61K39/145 , C07K14/005 , A61K39/00
摘要： A method of producing a virus like particle (VLP) in a plant comprising modified hemagglutinin is provided. The method comprises introducing a nucleic acid comprising a regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a modified influenza hemagglutinin (HA) protein into the plant, or portion of the plant, the modified HA protein comprises a modified proteolytic loop. Followed by incubating the plant or portion of the plant under conditions that permit the expression of the nucleic acids, thereby producing the VLP. The modified proteolytic loop may comprise one or more protease cleavage sites exhibiting reduced or abolished cleavage by a protease. The nucleotide sequence encoding the HA may be selected from the group consisting of B HA, C, H1, H2, H3, H4, H5, H6, H7, H8, H9, H10, H11, H12, H13, H14, H15, and H16. Also described is a virus like particle (VLP) produced by the method, and plants expressing the VLP. The virus like particle (VLP) may comprise plant-specific N-glycans, or modified N-glycans.

7. 发明申请

US20150216961A1 ROTAVIRUS-LIKE PARTICLE PRODUCTION IN PLANTS 审中-公开
标题翻译：在植物中的旋风样颗粒生产
公开(公告)号：US20150216961A1
公开(公告)日：2015-08-06
申请号：US14398650
申请日：2013-05-10
申请人： MEDICAGO INC. , MITSUBISHI TANABE PHARMA CORPORATION
发明人： Marc-Andre D'Aoust , Nathalie Landry , Pierre-Olivier Lavoie , Masaaki Arai , Naomi Asahara , David Levi Rutendo Mutepfa , Inga Isabel Hitzeroth , Edward Peter Rybicki
IPC分类号： A61K39/15 , C07K14/005 , C12N7/00
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N7/02 , C12N15/8203 , C12N15/8214 , C12N15/8216 , C12N15/8218 , C12N15/8221 , C12N15/8258 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸引入植物或植物的一部分。所述第一核酸包含在植物中活性的第一调节区，其可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP2）的核苷酸序列。核苷酸序列还可以包含一个或多于一个扩增元件和/或隔室靶向序列。可以将第二种核酸引入植物或植物的一部分。第二核酸包含在植物中有活性的第二调控区，并可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP6）的核苷酸序列。任选地，第三核酸和/或第四核酸可以被引入植物或植物的一部分。第三核酸包含在植物中活性的第三调节区，并且与编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP4）的核苷酸序列可操作地连接。第四核酸包含在植物中活性的第四调节区，并且可操作地连接于编码一种或多种轮状病毒结构蛋白（例如但不限于轮状病毒蛋白VP7）的核苷酸序列。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

8. 发明申请

US20150104480A1 INCREASING VIRUS-LIKE PARTICLE YIELD IN PLANTS 审中-公开
标题翻译：在植物中增加病毒样颗粒物
公开(公告)号：US20150104480A1
公开(公告)日：2015-04-16
申请号：US14347804
申请日：2012-09-28
申请人： MEDICAGO INC.
发明人： Marc-Andre D'Aoust , Manon Couture , Louis-Philippe Vezina
IPC分类号： C07K14/005 , C07K16/10 , A61K39/145 , C12N15/82 , C12N7/00
摘要： A method of producing a virus like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid and a second nucleic acid into the plant, or portion of the plant. The first nucleic acid comprises a first regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a structural virus protein. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding a channel protein, for example but not limited to a proton channel protein. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
摘要翻译：提供了一种在植物中生产病毒样颗粒（VLP）的方法。该方法包括将第一核酸和第二核酸引入植物或植物的一部分。第一核酸包含在植物中有活性的第一调节区，并与编码结构病毒蛋白的核苷酸序列有效连接。第二核酸包含在植物中有活性的第二调节区，并可操作地连接于编码通道蛋白的核苷酸序列，例如但不限于质子通道蛋白。将植物或植物的一部分在允许核酸表达的条件下温育，从而产生VLP。

9. 发明授权

US11759512B2 Modified norovirus VP1 proteins and VLPs comprising modified norovirus VP1 proteins 有权
公开(公告)号：US11759512B2
公开(公告)日：2023-09-19
申请号：US17259789
申请日：2018-11-30
申请人： MEDICAGO INC.
发明人： Marc-Andre D'Aoust , Pierre-Olivier Lavoie
IPC分类号： A61K39/12 , C07K14/085 , C12N15/82
CPC分类号： A61K39/12 , C07K14/085 , C12N15/82 , C12N2770/16023 , C12N2770/16034
摘要： Nucleic acids encoding modified norovirus VP1 proteins, and VLPs comprising one or more of the modified norovirus VP1 proteins are provided. Methods for modified norovirus VP1 protein, and norovirus VLP, production in plants, portions of the plant or a plant cell, are also described.

10. 发明公开

US20230149531A1 Suprastructure Comprising Modified Influenza Hemagglutinin With Reduced Interaction With Sialic Acid 审中-公开
公开(公告)号：US20230149531A1
公开(公告)日：2023-05-18
申请号：US17920625
申请日：2021-04-22
申请人： Hilary E. Hendin , Brian J. Ward , Medicago Inc.
发明人： Pierre-Olivier Lavoie , Hilary E. Hendin , Brian J. Ward , Nathalie Landry , Marc-Andre D'Aoust , Mikael Bedard , Pooja Saxena
IPC分类号： A61K39/145 , C12N7/00 , A61P31/16 , C07K14/005
CPC分类号： A61K39/145 , C12N7/00 , A61P31/16 , C07K14/005 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16152 , A61K2039/5258
摘要： A suprastructure comprising a modified influenza hemagglutinin (HA) is provided. The modified HA may comprise one or more than one alteration that reduces non-cognate binding of the modified HA to sialic acid (SA) on the surface of a cell, while maintaining cognate interaction with the cell, such as a B cell. A composition comprising the suprastructure and modified HA and a pharmaceutically acceptable carrier is also described. A method of increasing an immunological response or inducing immunity in response to a vaccine comprising the suprastructure and modified HA is also provided.

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