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1. 发明授权

US11001627B2 Correctly folded etanercept in high purity and excellent yield 有权
公开(公告)号：US11001627B2
公开(公告)日：2021-05-11
申请号：US15720291
申请日：2017-09-29
申请人： Coherus Biosciences, Inc.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K14/705 , C07K1/16 , A61K39/395
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

2. 发明授权

US10954295B2 Correctly folded etanercept in high purity and excellent yield 有权
公开(公告)号：US10954295B2
公开(公告)日：2021-03-23
申请号：US16443721
申请日：2019-06-17
申请人： COHERUS BIOSCIENCES, INC.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K14/705 , C07K1/16 , A61K39/395
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

3. 发明授权

US10954294B2 Correctly folded etanercept in high purity and excellent yield 有权
公开(公告)号：US10954294B2
公开(公告)日：2021-03-23
申请号：US16443594
申请日：2019-06-17
申请人： COHERUS BIOSCIENCES, INC.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K14/705 , C07K1/16 , A61K39/395
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

4. 发明授权

US10947306B2 Correctly folded etanercept in high purity and excellent yield 有权
公开(公告)号：US10947306B2
公开(公告)日：2021-03-16
申请号：US16443688
申请日：2019-06-17
申请人： COHERUS BIOSCIENCES, INC.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K14/705 , C07K1/16 , A61K39/395
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

5. 发明申请

US20180037642A1 CORRECTLY FOLDED ETANERCEPT IN HIGH PURITY AND EXCELLENT YIELD 审中-公开
公开(公告)号：US20180037642A1
公开(公告)日：2018-02-08
申请号：US15720291
申请日：2017-09-29
申请人： Coherus Biosciences, Inc.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： C07K16/24 , C07K1/16 , C07K14/705
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

6. 发明授权

US10954293B2 Correctly folded etanercept in high purity and excellent yield 有权
公开(公告)号：US10954293B2
公开(公告)日：2021-03-23
申请号：US16443514
申请日：2019-06-17
申请人： COHERUS BIOSCIENCES, INC.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： A61K39/00 , C07K16/00 , C12P21/08 , C07K16/24 , C07K14/705 , C07K1/16 , A61K39/395
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.

7. 发明申请

US20140072560A1 CORRECTLY FOLDED ETANERCEPT IN HIGH PURITY AND EXCELLENT YIELD 审中-公开
标题翻译：正确折叠的ETANERCEPT在高品质和卓越的产量
公开(公告)号：US20140072560A1
公开(公告)日：2014-03-13
申请号：US14023736
申请日：2013-09-11
申请人： COHERUS BIOSCIENCES, INC.
发明人： Tsutomu Arakawa , Douglas Farrar
IPC分类号： C07K16/24 , C07K14/705
摘要： A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly folded etanercept from incorrectly folded etanercept and aggregates in commercially attractive yields capable of affording etanercept preparations having very high purity in terms of correctly folded etanercept versus incorrectly folded etanercept. The invention is further directed to protein preparations and formulations comprising correctly folded proteins obtained using the present methods, and methods of treatment using the high purity preparations obtained from the mixed mode method.
摘要翻译：提供了一种用于从给定蛋白质的错误折叠构象正确折叠的混合模式色谱法。该方法非常有效地将正确折叠的依那西普与错误地折叠的依那西普和聚集体以商业上有吸引力的产率分离，其能够提供具有非常高纯度的依那西普制剂，就正确折叠的依那西普与错误地折叠的依那西普而言。本发明还涉及包含使用本发明方法获得的正确折叠蛋白质的蛋白质制剂和制剂，以及使用从混合模式法获得的高纯度制剂的处理方法。

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