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1. 发明授权

US08965531B2 Method for coating devices using electrospinning and melt blowing 有权
标题翻译：使用静电纺丝和熔融吹塑的涂布装置的方法
公开(公告)号：US08965531B2
公开(公告)日：2015-02-24
申请号：US14331393
申请日：2014-07-15
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt , Douglas D. Pagoria , Jeannette C. Polkinghorne
IPC分类号： A61N1/05 , D01D5/00
CPC分类号： A61N1/05 , A61N1/056 , D01D5/0023 , D01D5/0084 , D10B2321/08 , D10B2331/06 , Y10T29/4922 , Y10T29/49224
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from a non-conductive polycarbonate polyurethane polymer.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由非导电聚碳酸酯聚氨酯聚合物形成。

2. 发明授权

US08825179B2 Implantable medical device lead including a unifilar coiled cable 有权
标题翻译：可植入医疗器械引线，包括单丝线圈
公开(公告)号：US08825179B2
公开(公告)日：2014-09-02
申请号：US13866791
申请日：2013-04-19
申请人： Cardiac Pacemakers, Inc.
发明人： Joseph Walker , G. Shantanu Reddy , Devon N. Arnholt , Benjamin J. Haasl
IPC分类号： A61N1/05 , A61B18/14
CPC分类号： A61B18/1492 , A61N1/05 , A61N1/056 , A61N1/086
摘要： A medical device lead includes a flexible body having a proximal region with a proximal end, and a distal region with a distal end. A connector is coupled to the proximal end of the flexible body of the lead to electrically and mechanically connect the lead to an implantable pulse generator. The medical device lead also includes an electrode in the distal region of the flexible body, and a cable conductor having a proximal end electrically coupled to the connector and a distal end electrically coupled to the electrode. The cable conductor consists of a single helically coiled filar including a plurality of co-radial turns and having an outer diameter of less than about 0.020 inch (0.508 mm).
摘要翻译：医疗装置引线包括具有近端区域的柔性主体和具有远端的远侧区域。连接器耦合到引线的柔性体的近端，以电和机械地将引线连接到可植入脉冲发生器。医疗装置引线还包括在柔性体的远端区域中的电极，以及具有电连接到连接器的近端的电缆导体和电耦合到电极的远端。电缆导体由包括多个共同径向匝并具有小于约0.020英寸（0.508mm）的外径的单个螺旋线圈的丝状体组成。

3. 发明申请

US20140109404A1 LEAD ASSEMBLY AND RELATED METHODS 有权
标题翻译：铅装配及相关方法
公开(公告)号：US20140109404A1
公开(公告)日：2014-04-24
申请号：US14144076
申请日：2013-12-30
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt
IPC分类号： A61N1/05 , A61L31/10
CPC分类号： A61N1/0563 , A61L31/10 , A61N1/0568 , A61N2001/0578 , H01R2201/12 , Y10T29/49117 , Y10T29/49224
摘要： Defibrillator lead designs and methods for manufacturing a lead having attachment between a fibrosis-limiting material covering, a shocking coil electrode, and an implantable lead body are disclosed herein. An electrode coil fitting is disposed within the shocking coil electrode. In an option, the fibrosis limiting material extends past the ends of the electrode coil, and is wrapped between the coil electrode and the electrode coil member.
摘要翻译：本文公开了用于制造具有纤维化限制材料覆盖物，冲击性线圈电极和可植入引线体之间的附着物的引线的除颤器引线设计和方法。电极线圈配件设置在震动线圈电极内。在一种选择中，纤维化限制材料延伸超过电极线圈的端部，并且被包裹在线圈电极和电极线圈构件之间。

4. 发明公开

US20240157130A1 IMPLANTABLE MEDICAL SYSTEMS FOR CANCER TREATMENT WITH THERMAL MANAGEMENT FEATURES 审中-公开
公开(公告)号：US20240157130A1
公开(公告)日：2024-05-16
申请号：US18386895
申请日：2023-11-03
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt , Michael J. Kane , Brian L. Schmidt
IPC分类号： A61N1/36 , A61N1/02 , A61N1/05 , A61N1/20
CPC分类号： A61N1/36002 , A61N1/025 , A61N1/05 , A61N1/205
摘要： Embodiments herein relate to implantable systems for cancer treatment and related methods. In an embodiment, an implantable system for cancer treatment can be included having a therapy output circuit configured to generate an electrical output for one or more electrodes to create one or more electric fields. The implantable system can include control circuitry that causes the therapy output circuit to generate the one or more electric fields at frequencies between 10 kHz and 1 MHz within a bodily tissue. The one or more electric fields can be effective to prevent and./or disrupt cellular mitosis in a cell. The implantable system can further include a therapy zone temperature sensor. The implantable system can be configured to measure the temperature and/or record the temperature data of a patient over time. The temperature data can include tissue temperature and time stamps of the same. Other embodiments are also included herein.

5. 发明申请

US20140073194A1 TERMINAL CONNECTOR ASSEMBLY FOR A MEDICAL ELECTRICAL LEAD 审中-公开
标题翻译：医用电气接线端子连接器总成
公开(公告)号：US20140073194A1
公开(公告)日：2014-03-13
申请号：US14082516
申请日：2013-11-18
申请人： Cardiac Pacemakers, Inc.
发明人： Lily Lim , Ronald W. Kunkel , Joseph C. Walker , Peter C. Hall , Steven E. Schultz , Devon N. Arnholt , Angelo Fruci
IPC分类号： H01R24/58 , H01R43/00
CPC分类号： H01R24/58 , A61N1/3752 , H01R43/00 , Y10T29/49171 , Y10T29/49172 , Y10T29/49208
摘要： An IS-4 terminal connector assembly includes three terminal electrodes positioned over an inner tubular member such that they are radially offset from one another. Each of the terminal ring electrodes are configured such that they can withstand both tensile and cyclical bending loads with minimal compromise in their outer geometry. Additionally, each of the terminal electrodes is configured such that they have both an inner and outer geometry that facilitates adequate insulation between a select terminal electrode and an adjacent conductor. Additionally, each of the terminal ring electrodes is configured such that they facilitate an external approach to staking a cable conductor.
摘要翻译： IS-4端子连接器组件包括位于内部管状构件上方的三个端子电极，使得它们彼此径向偏移。每个端子环电极被构造成使得它们能够承受拉伸和循环弯曲载荷，并且在其外部几何形状中具有最小的损害。此外，每个端子电极被配置成使得它们具有促进选择端子电极和相邻导体之间的充分绝缘的内外几何形状。此外，每个端子环电极被构造成使得它们有助于外部接近来铆接电缆导体。

6. 发明公开

US20230414161A1 INTERACTIVE MEDICAL VISUALIZATION SYSTEM AND METHODS FOR VISUALIZING STIMULATION LEAD PLACEMENT 审中-公开
公开(公告)号：US20230414161A1
公开(公告)日：2023-12-28
申请号：US18214065
申请日：2023-06-26
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt , Michael J. Kane , Brian L. Schmidt
IPC分类号： A61B5/00 , A61N1/36
CPC分类号： A61B5/4064 , A61B5/0022 , A61N1/3606 , A61B5/055
摘要： Embodiments herein relate to interactive medical visualization systems for visualizing stimulation lead placements and related methods. In an embodiment, a medical visualization system can be included having a video processing circuit, a central processing circuit in communication with the video processing circuit, and a user interface. The user interface can be generated by the video processing circuit and can include a three-dimensional model. The three-dimensional model can include at least a portion of a subject's anatomy and a graphic representation including at least one cancer therapy stimulation lead, and a visual thermal heating zone associated with the graphic representation of the at least one cancer therapy stimulation lead and/or a visual electrical field strength zone associated with the graphic representation of the at least one cancer therapy stimulation lead. Other embodiments are also included herein.

7. 发明授权

US09415206B2 Method for coating devices using electrospinning 有权
标题翻译：使用静电纺丝装置的方法
公开(公告)号：US09415206B2
公开(公告)日：2016-08-16
申请号：US14825166
申请日：2015-08-12
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt , Douglas D. Pagoria , Jeannette C. Polkinghorne , Joseph T. Delaney, Jr.
IPC分类号： A61N1/05 , D01D5/00
CPC分类号： A61N1/05 , A61N1/056 , D01D5/0023 , D01D5/0084 , D10B2321/08 , D10B2331/06 , Y10T29/4922 , Y10T29/49224
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from polyether polyurethane.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚醚聚氨酯形成。

8. 发明授权

US09216281B2 Implantable medical leads having oscillating cable conductor lumens 有权
标题翻译：具有振荡电缆导体流明的植入式医疗引线
公开(公告)号：US09216281B2
公开(公告)日：2015-12-22
申请号：US14508087
申请日：2014-10-07
申请人： Cardiac Pacemakers, Inc.
发明人： Lily Lim , Devon N. Arnholt , Joel T. Eggert , Andrew L. De Kock , Paul E. Zarembo , Christopher A. Hartemink
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , B29C45/14065 , B29C45/14262 , B29C45/14819 , Y10T29/49204
摘要： An electrical implantable lead includes an elongated lead body having a plurality of lumens therein, including at least one linear lumen and at least one planar, non-linear lumen and a plurality of conductor cables disposed within the plurality of lumens. The electrical implantable lead further includes a terminal connector coupled to a proximal end of the lead body, the terminal connector being in electrical communication with at least one of the plurality of conductor cables. Further, the electrical implantable lead includes at least one electrode coupled to the lead body, the at least one electrode in electrical communication with at least one of the plurality of conductor cables. In accordance with various embodiments, the at least one non-linear lumen extends longitudinally along a portion of the lead body and includes a plurality or crests and a plurality of troughs.
摘要翻译：电可植入引线包括在其中具有多个腔的细长引线主体，其包括至少一个线性内腔和至少一个平面非线性内腔和设置在所述多个腔内的多个导体电缆。电可植入引线还包括耦合到引线本体的近端的端子连接器，所述端子连接器与多个导体电缆中的至少一个电连通。此外，电可植入引线包括耦合到引线主体的至少一个电极，所述至少一个电极与多个导体电缆中的至少一个电连通。根据各种实施例，所述至少一个非线性腔沿着引线主体的一部分纵向延伸并且包括多个或顶部和多个槽。

9. 发明授权

US09132269B2 Method for coating devices using electrospinning 有权
标题翻译：使用静电纺丝装置的方法
公开(公告)号：US09132269B2
公开(公告)日：2015-09-15
申请号：US14556818
申请日：2014-12-01
申请人： Cardiac Pacemakers, Inc.
发明人： Devon N. Arnholt , Douglas D. Pagoria , Jeannette C. Polkinghorne , Joseph T. Delaney, Jr.
IPC分类号： A61N1/05 , D01D5/00
CPC分类号： A61N1/05 , A61N1/056 , D01D5/0023 , D01D5/0084 , D10B2321/08 , D10B2331/06 , Y10T29/4922 , Y10T29/49224
摘要： A medical electrical lead may include an insulative lead body, a conductor disposed within the insulative lead body, an electrode disposed on the insulative lead body and in electrical contact with the conductor and a fibrous matrix disposed at least partially over the electrode. The fibrous matrix may be formed from polytetrafluoroethylene.
摘要翻译：医疗电引线可以包括绝缘引线体，布置在绝缘引线体内的导体，设置在绝缘引线体上并与导体电接触的电极和至少部分地布置在电极上的纤维基质。纤维基质可以由聚四氟乙烯形成。

10. 发明授权

US08958889B2 MRI compatible lead coil 有权
标题翻译： MRI兼容线圈
公开(公告)号：US08958889B2
公开(公告)日：2015-02-17
申请号：US14015972
申请日：2013-08-30
申请人： Cardiac Pacemakers, Inc.
发明人： Joseph Walker , G. Shantanu Reddy , Devon N. Arnholt , Masoud Ameri
IPC分类号： A61N1/00 , A61N1/05 , A61N1/08
CPC分类号： A61N1/056 , A61N1/08 , A61N1/086
摘要： Various embodiments concern leads having low peak MRI heating for improved MRI compatibility. Various leads include a lead body having at least one lumen, a proximal end configured to interface with an implantable medical device, and a distal end. Such leads can further include a conductor extending along at least a portion of the lead body within the at least one lumen and a defibrillation coil extending along an exterior portion of the lead body and in electrical connection with the conductor, wherein at least a section of the defibrillation coil is under longitudinal compression. The longitudinal compression can lower peak MRI heating along the defibrillation coil. The longitudinal compression may maintain circumferential contact between adjacent turns of the section of the defibrillation coil.
摘要翻译：各种实施例涉及具有低峰值MRI加热以提高MRI兼容性的引线。各种引线包括具有至少一个内腔，配置成与可植入医疗装置接合的近端和远端的引线体。这样的引线还可以包括沿着至少一个管腔内的引线主体的至少一部分延伸的导体，以及沿引线主体的外部部分延伸并与导体电连接的除颤线圈，其中至少一部分除颤线圈处于纵向压缩状态。纵向压缩可以降低沿除颤线圈的峰值MRI加热。纵向压缩可以保持除颤线圈的部分的相邻匝之间的圆周接触。

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