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1. 发明申请

US20150148867A1 SYSTEMS AND METHODS FOR MONITORING NEUROSTIMULATION DOSING 审中-公开
标题翻译：用于监测神经调节剂量的系统和方法
公开(公告)号：US20150148867A1
公开(公告)日：2015-05-28
申请号：US14612799
申请日：2015-02-03
申请人： Cardiac Pacemakers, Inc.
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/372 , A61N1/378
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data fir the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does riot favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录所输送的神经刺激疗法的监测剂量的数据，并且如果所监测的剂量与神经刺激疗法的期望剂量相比有利地相比，则宣告出现故障。

2. 发明授权

US10814135B2 Systems and methods for monitoring neurostimulation dosing 有权
公开(公告)号：US10814135B2
公开(公告)日：2020-10-27
申请号：US15278113
申请日：2016-09-28
申请人： Cardiac Pacemakers, Inc.
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/372 , A61N1/378 , A61N1/36
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy to stimulate tissue. A prescribed dose of the neurostimulation therapy relates to a therapeutically-effective and safe amount of charge delivered to the stimulated tissue over a period of time. The neural stimulator may include a power supply used to deliver the neurostimulation therapy, and a charge/current monitor configured to monitor a delivered dose of the neurostimulation therapy with respect to the prescribed dose to determine whether the delivered dose is delivering the therapeutically-effective and safe amount of charge to the stimulated tissue over the period of time.

3. 发明授权

US08965521B2 Systems and methods for monitoring neurostimulation dosing 有权
标题翻译：用于监测神经刺激剂量的系统和方法
公开(公告)号：US08965521B2
公开(公告)日：2015-02-24
申请号：US13780903
申请日：2013-02-28
申请人： Cardiac Pacemakers, Inc.
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/37 , A61N1/36
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data for the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录所输送的神经刺激疗法的监测剂量的数据，并且如果所监测的剂量与用于神经刺激疗法的期望剂量不利地相比较，则声明故障。

4. 发明申请

US20170080237A1 MEDICAL DEVICE WITH CONVERTIBLE SOLID 审中-公开
公开(公告)号：US20170080237A1
公开(公告)日：2017-03-23
申请号：US15365319
申请日：2016-11-30
申请人： Cardiac Pacemakers, Inc.
发明人： Scott Dahl , John H. Tangren , Kevin Ely , Douglas J. Brandner , William J. Linder
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/362 , A61N1/3968
摘要： Embodiments of the invention are related to medical devices filled with a liquid composition, amongst other things. In an embodiment, the invention includes a hermetically sealed housing defining an interior volume, a component module disposed within the interior volume, the component module comprising a circuit board, the component module displacing a portion of the interior volume. A liquid composition can be disposed within the housing, the liquid composition filling at least 80% of the interior volume not displaced by the component module. Other embodiments are also included herein.

5. 发明授权

US09457192B2 Systems and methods for monitoring neurostimulation dosing 有权
标题翻译：用于监测神经刺激剂量的系统和方法
公开(公告)号：US09457192B2
公开(公告)日：2016-10-04
申请号：US14612799
申请日：2015-02-03
申请人： Cardiac Pacemakers, Inc.
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/375 , A61N1/372 , A61N1/36 , A61N1/378
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data fir the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录数据，冷却所传递的神经刺激疗法的监测剂量，并且如果所监测的剂量与用于神经刺激疗法的期望剂量不利地相比较，则报告错误。

6. 发明授权

US08688213B2 Managing cross therapy sensing in a multiple therapy implantable device 有权
标题翻译：在多种治疗植入式装置中管理交叉治疗感测
公开(公告)号：US08688213B2
公开(公告)日：2014-04-01
申请号：US13660388
申请日：2012-10-25
申请人： Cardiac Pacemakers, Inc.
发明人： David J. Ternes , Douglas J. Brandner , Ramprasad Vijayagopal , Nicholas J. Stessman , William J. Linder , Keith R. Maile , Abhi V. Chavan
IPC分类号： A61N1/00
CPC分类号： A61N1/3605 , A61B5/0428 , A61B5/4836 , A61B5/686 , A61B5/7217 , A61N1/36142 , A61N1/3704
摘要： An apparatus comprises a cardiac signal sensing circuit configured to sense an electrical cardiac signal from at least one of an atrium or ventricle of a heart of a subject, a therapy circuit configured to provide electrical pacing therapy and electrical autonomic neural modulation therapy to the subject, and a control circuit. The control circuit is configured to initiate delivery of the autonomic modulation neural therapy, and the control circuit includes a signal detection circuit configured to detect delivery of the autonomic neural modulation therapy in the sensed cardiac signal. The control circuit is configured to change, in response to detecting the delivery, a sensitivity of the cardiac signal sensing circuit during delivery of the autonomic neural modulation therapy.
摘要翻译：一种装置包括心脏信号感测电路，其被配置为感测来自受试者心脏的心房或心室中的至少一个的电心脏信号，被配置为向受试者提供电起搏治疗和电自主神经调节疗法的治疗电路，和控制电路。控制电路被配置为启动自主调制神经治疗的传递，并且控制电路包括被配置为检测所感测的心脏信号中的自主神经调节治疗的传递的信号检测电路。控制电路被配置为响应于检测到传送而改变在传送自主神经调制疗法期间心脏信号感测电路的灵敏度。

7. 发明授权

US11147975B2 Medical device with convertible solid 有权
公开(公告)号：US11147975B2
公开(公告)日：2021-10-19
申请号：US15365319
申请日：2016-11-30
申请人： Cardiac Pacemakers, Inc.
发明人： Scott Dahl , John H. Tangren , Kevin Ely , Douglas J. Brandner , William J. Linder
IPC分类号： A61N1/375 , A61N1/362 , A61N1/39
摘要： Embodiments of the invention are related to medical devices filled with a liquid composition, amongst other things. In an embodiment, the invention includes a hermetically sealed housing defining an interior volume, a component module disposed within the interior volume, the component module comprising a circuit board, the component module displacing a portion of the interior volume. A liquid composition can be disposed within the housing, the liquid composition filling at least 80% of the interior volume not displaced by the component module. Other embodiments are also included herein.

8. 发明申请

US20170014634A1 SYSTEMS AND METHODS FOR MONITORING NEUROSTIMULATION DOSING 审中-公开
标题翻译：用于监测神经调节剂量的系统和方法
公开(公告)号：US20170014634A1
公开(公告)日：2017-01-19
申请号：US15278113
申请日：2016-09-28
申请人： Cardiac Pacemakers, Inc.
发明人： Doug M. Birkholz , Douglas J. Brandner , Douglas J. Gifford , David J. Ternes , William J. Linder
IPC分类号： A61N1/372 , A61N1/378 , A61N1/36
CPC分类号： A61N1/3727 , A61N1/3605 , A61N1/36082 , A61N1/36125 , A61N1/36142 , A61N1/36178 , A61N1/378
摘要： Various implantable device embodiments may comprise a neural stimulator configured to deliver a neurostimulation therapy with stimulation ON times and stimulation OFF times where a dose of the neurostimulation therapy is provided by a number of neurostimulation pulses over a period of time. The neural stimulator may be configured to monitor the dose of the delivered neurostimulation therapy against dosing parameters. The neural stimulator may be configured to declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy, or may be configured to record data for the monitored dose of the delivered neurostimulation therapy, or may be configured to both record data for the monitored dose of the delivered neurostimulation therapy and declare a fault if the monitored dose does not favorably compare to a desired dose for the neurostimulation therapy.
摘要翻译：各种可植入装置实施例可以包括神经刺激器，所述神经刺激器被配置为在刺激ON次数和刺激OFF时间递送神经刺激疗法，其中神经刺激疗法的剂量在一段时间内由许多神经刺激脉冲提供。神经刺激器可以被配置为监测所输送的神经刺激疗法针对给药参数的剂量。如果所监测的剂量与用于神经刺激疗法的期望剂量不利地比较，则神经刺激器可以被配置为宣告故障，或者可被配置为记录所输送的神经刺激疗法的监测剂量的数据，或者可以被配置为两者记录所输送的神经刺激疗法的监测剂量的数据，并且如果所监测的剂量与用于神经刺激疗法的期望剂量不利地相比较，则声明故障。

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