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1. 发明授权

US11311731B2 Cardiac resynchronization therapy heart sound response characterization 有权
公开(公告)号：US11311731B2
公开(公告)日：2022-04-26
申请号：US16845730
申请日：2020-04-10
申请人： Cardiac Pacemakers, Inc.
发明人： Yinghong Yu , Krzysztof Z. Siejko , Qi An
IPC分类号： A61N1/365 , A61N1/368 , A61N1/39 , A61N1/372
摘要： This document discusses, among other things, systems and methods to determine a response curve between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), to a set of stimulation signals provided to the subject at different AVD intervals. In certain examples, one or more cardiac resynchronization therapy (CRT) parameters can be determined for the subject using the determined response curve.

2. 发明授权

US11040207B2 Systems and methods for dynamic control of heart failure therapy 有权
公开(公告)号：US11040207B2
公开(公告)日：2021-06-22
申请号：US16007494
申请日：2018-06-13
申请人： Cardiac Pacemakers, Inc.
发明人： David J. Ternes , Yinghong Yu , Jason Humphrey , David L. Perschbacher , Michael James Dufresne , Adam MacEwen , Keith L. Herrmann
IPC分类号： A61N1/362 , A61N1/37 , A61N1/365 , A61N1/368 , A61N1/372 , A61N1/378 , A61N1/39 , A61B5/029
摘要： Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.

3. 发明申请

US20200001092A1 IMPLANTABLE MEDICAL DEVICE WITH GYROSCOPE 审中-公开
公开(公告)号：US20200001092A1
公开(公告)日：2020-01-02
申请号：US16535890
申请日：2019-08-08
申请人： CARDIAC PACEMAKERS, INC.
发明人： Bin Mi , Pramodsingh Hirasingh Thakur , Jeffrey E. Stahmann , Keith R. Maile , Qi An , Brendan Early Koop , Yinghong Yu , Viktoria A. Averina , Michael J. Kane , Krzysztof Z. Siejko
IPC分类号： A61N1/365 , A61B5/00 , A61B5/02 , A61B5/11 , A61N1/375 , G01C19/38 , G06F3/0346
摘要： An implantable medical device (IMD) that includes a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a gyroscope secured relative to the housing. The IMD may include circuitry in the housing in communication with the first electrode, the second electrode, and the gyroscope. The circuitry may be configured to determine and store a plurality of torsion data measurements, from which a representation of a twist profile may be determined.

4. 发明授权

US10478629B2 Leadless cardiac pacemaker for generating cardiac pressure volume loop 有权
公开(公告)号：US10478629B2
公开(公告)日：2019-11-19
申请号：US15630677
申请日：2017-06-22
申请人： CARDIAC PACEMAKERS, INC.
发明人： Qi An , Pramodsingh Hirasingh Thakur , Yinghong Yu , Jeffrey E. Stahmann , Michael J. Kane
IPC分类号： A61N1/375 , A61N1/372 , A61N1/365 , A61N1/05 , A61N1/02 , A61N1/37 , A61B5/00 , A61B5/0215 , A61B5/029 , A61B5/053 , A61B7/00 , A61N1/378
摘要： A leadless cardiac pacemaker (LCP) configured to sense cardiac activity and to pace a patient's heart. The LCP may include a housing, a first electrode secured relative to the housing, a second electrode secured relative to the housing, and a pressure sensor secured relative to the housing and coupled to the environment outside of the housing. The LCP may further include circuitry in the housing in communication with the first electrode, the second electrode, and the pressure sensor. The circuitry may be configured to determine and store a plurality of impedance-pressure data pairs, from which a representation of a pressure-volume loop may be determined.

5. 发明授权

US10350418B2 Multi-sensor based cardiac stimulation 有权
公开(公告)号：US10350418B2
公开(公告)日：2019-07-16
申请号：US15334615
申请日：2016-10-26
申请人： Cardiac Pacemakers, Inc.
发明人： Qi An , Julie A. Thompson , Yinghong Yu , Yi Zhang , Pramodsingh Hirasingh Thakur
IPC分类号： A61N1/365 , A61N1/368 , A61N1/372 , A61N1/362 , A61B7/04
摘要： Devices and methods for improving device therapy such as cardiac resynchronization therapy by determining a value for a device parameter are described. An ambulatory medical device (AMD) can include a sensor circuit to sense a physiological signal and generate two or more signal metrics, and detect an event of worsening cardiac condition using the two or more signal metrics. In response to the detection of worsening cardiac condition, the AMD can determine, for a stimulator, a value of at least one stimulation parameter based on temporal responses of two or more signal metrics. The temporal responses include near-term and long-term responses to the stimulation. The AMD can program the stimulator with the determined parameter value, and generate stimulation according to the determined parameter value to stimulate target tissue.

6. 发明申请

US20180021582A1 METHOD AND SYSTEM FOR DETERMINING A CARDIAC CYCLE PACE TIME IN ACCORDANCE WITH METABOLIC DEMAND IN A LEADLESS CARDIAC PACEMAKER SYSTEM 审中-公开
公开(公告)号：US20180021582A1
公开(公告)日：2018-01-25
申请号：US15654393
申请日：2017-07-19
申请人： CARDIAC PACEMAKERS, INC.
发明人： Qi An , Michael J. Kane , Yinghong Yu , Jeffrey E. Stahmann , Pramodsingh Hirasingh Thakur , Keith R. Maile
IPC分类号： A61N1/365 , A61N1/05 , A61N1/375
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/36535 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/37512 , A61N1/3756
摘要： A leadless cardiac pacemaker (LCP) is configured to sense cardiac activity and to pace a patient's heart and is disposable within a ventricle of the patient's heart. The LCP MAY include a housing, a first electrode and a second electrode that are secured relative to the housing and are spaced apart. A controller is disposed within the housing and is operably coupled to the first electrode and the second electrode such that the controller is capable of receiving, via the first electrode and the second electrode, electrical cardiac signals of the heart. The LCP may include a pressure sensor and/or an accelerometer. The controller may determine a pace time within a cardiac cycle based at least in part upon an indication of metabolic demand.

7. 发明申请

US20180020983A1 PRESSURE SENSOR TO DETECT BODY SOUNDS 审中-公开
公开(公告)号：US20180020983A1
公开(公告)日：2018-01-25
申请号：US15654838
申请日：2017-07-20
申请人： Cardiac Pacemakers, Inc.
发明人： Qi An , Yinghong Yu , Jeffrey E. Stahmann , Pramodsingh Hirasingh Thakur , Michael J. Kane
IPC分类号： A61B5/00 , A61B5/021 , A61B5/0285
CPC分类号： A61B5/6843 , A61B5/02028 , A61B5/0205 , A61B5/021 , A61B5/0285 , A61B5/686 , A61B7/00 , A61B7/003 , A61B7/04 , A61B2562/0247
摘要： This document discusses, among other things, using a pressure sensor to detect body sound information of a patient, such as cardiac murmurs, respiratory sounds, etc.

8. 发明申请

US20170348528A1 METHODS AND SYSTEMS FOR MULTI-SITE STIMULATION 审中-公开
公开(公告)号：US20170348528A1
公开(公告)日：2017-12-07
申请号：US15603720
申请日：2017-05-24
申请人： Cardiac Pacemakers, Inc.
发明人： Yinghong Yu , David J. Ternes , Keith L. Herrmann , Sunipa Saha , Pratik K. Pandya , Jason Humphrey , David L. Perschbacher
IPC分类号： A61N1/368 , A61N1/05 , A61N1/365 , A61N1/372
CPC分类号： A61N1/3684 , A61N1/056 , A61N1/36521 , A61N1/36843 , A61N1/3686 , A61N1/37247 , A61N1/3956
摘要： Systems and methods for multi-site cardiac stimulation are disclosed. The system includes an electrostimulation circuit to deliver electrostimulation to one or more candidate sites of at least one heart chamber. The system may sense a physiological signal including during electrostimulation of the heart, use the physiological signal to determine a first stimulation vector for electrostimulation at a first left ventricular (LV) site and a second stimulation vector for electrostimulation at a different second LV site, and determine a therapy mode including a first chronological order and a first timing offset between stimulations delivered according to the first and second stimulation vectors. The electrostimulation circuit may deliver electrostimulation to the heart in accordance with the first and second stimulation vectors and the therapy mode.

9. 发明申请

US20170173342A1 SYSTEMS AND METHODS FOR FACILITATING SELECTION OF ONE OR MORE VECTORS IN A MEDICAL DEVICE 审中-公开
公开(公告)号：US20170173342A1
公开(公告)日：2017-06-22
申请号：US15454824
申请日：2017-03-09
申请人： Cardiac Pacemakers, Inc.
发明人： Holly E. Rockweiler , Sunipa Saha , Keith L. Herrmann , Yinghong Yu , Joel A. Krueger
IPC分类号： A61N1/37 , A61N1/365 , A61N1/368 , A61B5/04 , A61N1/05
CPC分类号： A61N1/371 , A61B5/04011 , A61N1/056 , A61N1/3622 , A61N1/36521 , A61N1/368 , A61N1/3684 , A61N1/3686
摘要： Systems and methods may facilitate selection of a vector for delivering electrical stimulation to a patient's heart. One illustrative method may include delivering electrical stimulation at a first voltage to each vector in a first set of two or more vectors of a multi-vector medical system, determining whether the delivered electrical stimulation at the first voltage resulted in capture for each of the vectors in the first set of two or more vectors, identifying those vectors of the first set of two or more vectors that were determined to result in capture as a second set of vectors, delivering electrical stimulation at a second voltage that is lower than the first voltage to each vector in the second set of vectors, and determining whether the delivered electrical stimulation at the second voltage resulted in capture for each of the vectors in the second set of vectors.

10. 发明申请

US20160106986A1 METHOD AND APPARATUS FOR OPTIMIZING MULTI-SITE PACING USING HEART SOUNDS 有权
标题翻译：使用心脏声音优化多场景的方法和装置
公开(公告)号：US20160106986A1
公开(公告)日：2016-04-21
申请号：US14882849
申请日：2015-10-14
申请人： Cardiac Pacemakers, Inc.
发明人： Qi An , Pramodsingh Hirasingh Thakur , Yinghong Yu
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36585 , A61N1/056 , A61N1/3627 , A61N1/36578 , A61N1/3684 , A61N1/3686
摘要： An example of a system for pacing through multiple electrodes in a ventricle includes a sensing circuit to sense cardiac signal(s), a pacing output circuit to deliver pacing pulses, a heart sound sensor to sense a heart sound signal, and a control circuit to control the delivery of the pacing pulses. The control circuit includes a heart sound detector to detect heart sounds using the heart sound signal, an electrical event detector to detect cardiac electrical events using the cardiac signal(s), a measurement module to measure an optimization parameter using the detected heart sounds, and an optimization module to approximately optimize one or more pacing parameters using the measured optimization parameter. The one or more pacing parameters include an electrode configuration parameter specifying one or more electrodes selected from the multiple electrodes in the ventricle for delivering ventricular pacing pulses to that ventricle.
摘要翻译：用于起搏通过心室中的多个电极的系统的示例包括用于感测心脏信号的感测电路，用于输送起搏脉冲的起搏输出电路，用于感测心脏声音信号的心脏声音传感器，以及控制电路控制起搏脉冲的输送。控制电路包括使用心音信号检测心音的心脏声音检测器，使用心脏信号检测心脏电气事件的电子事件检测器，使用检测到的心脏声音来测量优化参数的测量模块，以及优化模块，以使用所测量的优化参数近似优化一个或多个起搏参数。一个或多个起搏参数包括指定从心室中的多个电极中选择的一个或多个电极的电极配置参数，用于将心室起搏脉冲输送到心室。

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