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    • 5. 发明授权
    • Housing block
    • 住房块
    • US06176266B1
    • 2001-01-23
    • US09381379
    • 1999-09-20
    • Hubert HuberArne RoeschMarkus Wolf
    • Hubert HuberArne RoeschMarkus Wolf
    • B21D2810
    • B60T17/04B21J9/025B60T8/3615B60T8/3675Y10T137/9247
    • A housing block for receiving valves, for example piston pumps and storage chambers for use in hydraulic vehicle brake systems. The invention uses a wobble tool to deform material of the housing block at a beginning of a hole essentially in the longitudinal direction of the hole, so that with the insertion of the wobble tool into the housing block in the vicinity of the beginning of the hole, first opening narrowed in relation to the diameter of the hole is produced. The hole becomes narrower with further continuation of the wobbling process and finally disappears. Then the material, which has produced the increased narrowing of the opening and finally its disappearance, forms a closure. The production of plug bodies in accordance with the prior art and the production of assembly devices are eliminated.
    • 用于接收阀的壳体块,例如用于液压车辆制动系统中的活塞泵和储存室。 本发明使用摆动工具来在基本上在孔的纵向方向上在孔的开始处使壳体块的材料变形,使得当摆动工具在孔的开始附近插入到壳体块中时 产生相对于孔的直径变窄的第一开口。 随着摇摆过程的进一步延续,孔变窄,最终消失。 那么导致开口变窄并最终消失的材料形成一个闭合。 消除了根据现有技术的生产插头体和组装装置的生产。
    • 8. 发明申请
    • Polyamine-substituted ligands for use as contrast agents
    • 用作造影剂的多胺取代的配体
    • US20070202047A1
    • 2007-08-30
    • US11649503
    • 2007-01-04
    • Markus WolfUlrike Bauder-WustUwe HaberkornMichael EisenhutWalter Mier
    • Markus WolfUlrike Bauder-WustUwe HaberkornMichael EisenhutWalter Mier
    • A61K49/10C07F5/00C07D257/02
    • C07D257/02A61K49/103A61K49/106
    • The present invention relates to a polyamine-substituted ligand for the preparation of a contrast agent derived from a chelating molecule selected from the group consisting of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and diethylentriamine-pentaacetic acid (DTPA), wherein at least one of the carboxylic groups of the chelating molecule is reacted with an amine of formula HNR1R2 to form an amide bond, wherein R1, R2 are independently selected from the group consisting of H; (CH2)n—NR3R4; and R5; R3, R4 are independently selected from the group consisting of H; (CH2)m—NR6R7; and (CH2)m-1—CH3; R6, R7 are independently selected from the group consisting of H; and (CH2)o-1—CH3; n, m, o are independently 2, 3, or 4; R5 is of formula and optionally at least one of the carboxylic groups of the chelating molecule is further reacted with a monoalkylamine having 1 to 18 carbon atoms to form an amide bond; provided that at least one of R1, R2 is other than H. Furthermore, the invention relates to contrast agents for magnetic resonance imaging (MRI) comprising said ligands and in-vivo diagnostic methods based on MRI using said contrast agents.
    • 本发明涉及用于制备衍生自螯合分子的造影剂的多胺取代配体,所述螯合分子选自1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸(DOTA )和二乙基三胺五乙酸(DTPA),其中螯合分子的至少一个羧基与式HNR 1 R 2的胺反应形成 酰胺键,其中R 1,R 2,R 2独立地选自H; (CH 2)n - NR 3 - 3 - - - - - - - 和R 5; R 3,R 4,R 4独立地选自H; (CH 2 CH 2)m -NR 6 R 6 R 7 R 7, 和(CH 2 CH 2)m-1 -CH 3 3; R 6,R 7,R 7独立地选自H; 和(CH 2)2 -O-1 -CH 3; n,m,o分别为2,3或4; R 5是下式,并且任选地,螯合分子的至少一个羧酸基团与具有1至18个碳原子的单烷基胺进一步反应以形成酰胺键; 条件是R 1,R 2和R 2中的至少一个不是H.此外,本发明涉及用于包含所述配体的磁共振成像(MRI)的造影剂,并且在 - 使用所述造影剂的基于MRI的体内诊断方法。
    • 10. 发明授权
    • Electronic braking system and method for drawbar trailers
    • 牵引车拖车电子制动系统及方法
    • US08267485B2
    • 2012-09-18
    • US12386963
    • 2009-04-23
    • Holger BarlsenAxel StenderIngo ThaNorbert WitteMarkus Wolf
    • Holger BarlsenAxel StenderIngo ThaNorbert WitteMarkus Wolf
    • B60T13/74B60T8/18B60T7/20
    • B60T7/20B60T8/1887B60T8/323B60T8/327B60T2240/06
    • A system and method for braking a drawbar trailer having a front axle and one or more further axles, each axle having at least two wheels, includes first sensors which sense the axle load of at least one axle, and second sensors which sense the rotational wheel speeds. Brakes actuatable with a pneumatic brake pressure brake the trailer. Brake signals generated in the towing vehicle are transmitted between the towing vehicle and the trailer. A control unit receives these brake signals and the sensor signals, and determines the axle load. The operating pressure is adapted to the brake pressure which is fed to the brakes. The control unit detects the brake pressure value as a function of (i) the specific axle loads of the front axle and the other axles and (ii) the received brake signals, and actuates the brakes such that the detected brake pressure is made available.
    • 一种用于制动具有前轴和一个或多个其它轴的牵引杆拖车的系统和方法,每个轴具有至少两个轮,包括感测至少一个轴的轴负载的第一传感器,以及感测所述旋转轮的第二传感器 速度。 制动器可用气动制动器制动拖车。 牵引车中产生的制动信号在牵引车和拖车之间传递。 控制单元接收这些制动信号和传感器信号,并确定轴负载。 工作压力适应于供给制动器的制动压力。 控制单元根据(i)前轴和其他轴的特定车轴负载和(ii)接收到的制动信号来检测制动压力值,并致动制动器,使得检测到的制动压力可用。