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1. 发明授权

US07880456B2 DC/DC voltage regulator with automatic current sensing selectability for linear and switch mode operation utilizing a single voltage reference 有权
标题翻译： DC / DC电压调节器，具有自动电流检测选择性，用于使用单个参考电压的线性和开关模式操作
公开(公告)号：US07880456B2
公开(公告)日：2011-02-01
申请号：US12724289
申请日：2010-03-15
申请人： Christopher T. Falvey , Andrew Wu
发明人： Christopher T. Falvey , Andrew Wu
IPC分类号： G05F1/618
CPC分类号： H02M3/158 , H02M2001/0009 , H02M2001/0045
摘要： A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.
摘要翻译：开关模式DC / DC转换器和线性低压降（LDO）DC / DC调节器并联连接以驱动单个负载。两个稳压器都有一个共同的参考电压，反馈网络，输入电源和输出，使得每个工作模式下的稳压电压相同。在重负载期间，开关模式稳压器处于工作状态，线性稳压器被禁用，以实现最高的效率。相反，轻负载时，线性稳压器工作在禁用开关模式调节器的同时，也使效率最大化。每个调节器感测负载电流，以在固定负载电流水平下自适应在适当的稳压器之间转换。本发明还包括电压调节器的断开前转换方案以使电压瞬变最小化。

2. 发明申请

US20100231190A1 DC/DC VOLTAGE REGULATOR WITH AUTOMATIC CURRENT SENSING SELECTABILITY FOR LINEAR AND SWITCH MODE OPERATION UTILIZING A SINGLE VOLTAGE REFERENCE 有权
标题翻译：具有自动电流传感选择性的直流/直流电压调节器，用于线性和开关模式操作，使用单电压参考
公开(公告)号：US20100231190A1
公开(公告)日：2010-09-16
申请号：US12724289
申请日：2010-03-15
申请人： Christopher T. Falvey , Andrew Wu
发明人： Christopher T. Falvey , Andrew Wu
IPC分类号： G05F1/10
CPC分类号： H02M3/158 , H02M2001/0009 , H02M2001/0045
摘要： A switch-mode DC/DC converter and a linear low drop out (LDO) DC/DC regulator are connected in parallel to drive a single load. Both regulators share a common voltage reference, feedback network, input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator disabled, also maximizing the efficiency. Each regulator senses load current to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators to minimize the voltage transients.
摘要翻译：开关模式DC / DC转换器和线性低压降（LDO）DC / DC调节器并联连接以驱动单个负载。两个稳压器都有一个共同的参考电压，反馈网络，输入电源和输出，使得每个工作模式下的稳压电压相同。在重负载期间，开关模式稳压器处于工作状态，线性稳压器被禁用，以实现最高的效率。相反，轻负载时，线性稳压器工作在禁用开关模式调节器的同时，也使效率最大化。每个调节器感测负载电流，以在固定负载电流水平下自适应在适当的稳压器之间转换。本发明还包括电压调节器的断开前转换方案以使电压瞬变最小化。

3. 发明授权

US07679350B2 DC/DC voltage regulator with automatic current sensing selectability for linear and switch mode operation utilizing a single voltage reference 有权
标题翻译： DC / DC电压调节器，具有自动电流检测选择性，用于使用单个参考电压的线性和开关模式操作
公开(公告)号：US07679350B2
公开(公告)日：2010-03-16
申请号：US10587785
申请日：2004-02-05
申请人： Christopher T. Falvey , Andrew Wu
发明人： Christopher T. Falvey , Andrew Wu
IPC分类号： G05F1/618
CPC分类号： H02M3/158 , H02M2001/0009 , H02M2001/0045
摘要： A switch-mode DC/DC converter (101) and linear low drop out (LIDO) DC/DC regulator (105) are connected in parallel to drive a single load Both regulators share a common voltage reference, feedback network (103), input supply and output such that the regulated voltage is identical during each mode of operation. During heavy loads the switch-mode regulator (107) is in operation and the linear regulator is disabled for the highest efficiency possible. Conversely at light loads the linear regulator is in operation with the switch-mode regulator (107) disabled, also maximizing the efficiency. Each regulator senses load current (131) to automatically transition between the appropriate voltage regulators at fixed load current levels. The presented invention also includes a make before break transition scheme of the voltage regulators (103) to minimize the voltage transients.
摘要翻译：开关模式DC / DC转换器（101）和线性低压降（LIDO）DC / DC稳压器（105）并联连接以驱动单个负载。两个稳压器共享公共参考电压，反馈网络（103），输入供应和输出，使得在每个操作模式期间调节电压相同。在重负载期间，开关模式稳压器（107）处于工作状态，线性稳压器被禁用，以实现最高的效率。相反，轻负载时，线性稳压器在开关模式稳压器（107）禁用的情况下运行，同时也使效率最大化。每个调节器感测负载电流（131），以在固定负载电流水平下自适应在适当的电压调节器之间转换。本发明还包括电压调节器（103）的断开前转换方案以最小化电压瞬变。

4. 发明授权

US10258791B2 Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods 有权
公开(公告)号：US10258791B2
公开(公告)日：2019-04-16
申请号：US13458877
申请日：2012-04-27
申请人： Neil C. Barman , Robert J. Beetel , Benjamin J. Clark , Andrew Wu , Maria G. Aboytes , Denise Zarins
发明人： Neil C. Barman , Robert J. Beetel , Benjamin J. Clark , Andrew Wu , Maria G. Aboytes , Denise Zarins
IPC分类号： A61B18/14 , A61N1/05 , A61N1/36
摘要： Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point.

5. 发明授权

US09066720B2 Devices, systems and methods for evaluation and feedback of neuromodulation treatment 有权
标题翻译：用于评估和反馈神经调节治疗的装置，系统和方法
公开(公告)号：US09066720B2
公开(公告)日：2015-06-30
申请号：US13281269
申请日：2011-10-25
申请人： Sowmya Ballakur , Robert Beetel , Paul Friedrichs , Andrew Wu , Denise Zarins , David Herzfeld , Mark S. Leung
发明人： Sowmya Ballakur , Robert Beetel , Paul Friedrichs , Andrew Wu , Denise Zarins , David Herzfeld , Mark S. Leung
IPC分类号： A61B18/10 , A61B18/12 , A61B18/14 , A61B17/00 , A61B18/00
CPC分类号： A61B18/1206 , A61B18/10 , A61B18/1492 , A61B2017/00075 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00648 , A61B2018/00672 , A61B2018/00678 , A61B2018/00702 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00863 , A61B2018/00875 , A61F7/12 , A61F2007/0093 , A61F2007/126
摘要： The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.
摘要翻译：本公开涉及用于评估应用于患者组织的治疗成功的装置，系统和方法，例如用于神经调节与肾动脉相关的神经的射频消融治疗。系统监视在治疗过程中产生的参数或值。提供给运营商的反馈是基于监测值，并且涉及对完成的处理在技术上成功的可能性的评估。在其他实施例中，可以评估在不完全处理过程中产生的参数或值（例如由于高温或高阻抗条件），以向操作者提供额外的指令或反馈。

6. 发明申请

US20140114305A1 METHODS AND APPARATUS FOR THERMALLY-INDUCED RENAL NEUROMODULATION 审中-公开
标题翻译：用于热诱导的肾脏神经调节的方法和装置
公开(公告)号：US20140114305A1
公开(公告)日：2014-04-24
申请号：US14094330
申请日：2013-12-02
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61N1/32
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

7. 发明授权

US08626300B2 Methods and apparatus for thermally-induced renal neuromodulation 有权
标题翻译：热诱导肾神经调节的方法和装置
公开(公告)号：US08626300B2
公开(公告)日：2014-01-07
申请号：US13046595
申请日：2011-03-11
申请人： Denise Demarais , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Demarais , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61F7/12 , A61N1/18
CPC分类号： A61B18/1492 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61F7/123 , A61F2007/126 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/28 , A61N1/32 , A61N1/326 , A61N1/36007 , A61N1/36017 , A61N1/36114 , A61N1/36117 , A61N1/3627 , A61N1/403 , A61N5/045 , A61N7/02 , A61N2007/003
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。在一些实施方案中，热诱导的肾神经调节通过脉冲热疗法的递送来实现。

8. 发明授权

US08454594B2 Apparatus for performing a non-continuous circumferential treatment of a body lumen 有权
标题翻译：用于对身体腔进行非连续周边处理的装置
公开(公告)号：US08454594B2
公开(公告)日：2013-06-04
申请号：US12539390
申请日：2009-08-11
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.
摘要翻译：提供了用于不间断地周围处理体腔的方法和装置。装置可以定位在患者的体腔内，并且可以在第一纵向和角位置处递送能量，以在第一位置处产生小于整个圆周的处理区域。该装置还可以在体腔内的一个或多个附加的纵向和角度位置处递送能量，以在一个或多个附加位置处创建小于整个圆周处理区域，该一个或多个附加位置从第一处理区域纵向和角度偏移。第一处理区和一个或多个另外的处理区的叠置限定非连续的圆周处理区而不形成连续的周向损伤。提供了用于实现这种非连续圆周处理的方法和装置的各种实施例。

9. 发明授权

US08444640B2 Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen 有权
公开(公告)号：US08444640B2
公开(公告)日：2013-05-21
申请号：US13620173
申请日：2012-09-14
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Nicolas Zadno , Benjamin J. Clark , Andrew Wu , Kenneth J. Michlitsch
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/18 , A61B2018/00023 , A61B2018/00077 , A61B2018/0016 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00648 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1435 , A61B2018/1465 , A61N1/0551 , A61N1/32 , A61N1/327 , A61N1/36007 , A61N7/022
摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

10. 发明申请

US20120143293A1 CATHETER APPARATUSES HAVING MULTI-ELECTRODE ARRAYS FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20120143293A1
公开(公告)日：2012-06-07
申请号：US13281395
申请日：2011-10-25
申请人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
发明人： Kevin Mauch , Mario Alvarado , Robert Beetel , William Chang , Justin Goshgarian , Leonila Rivera , Sukyoung Shin , Michele Silver , Sina Som , Andrew Wu , Denise Zarins , Juanita Sanchez-Cole , Maria G. Aboytes
IPC分类号： A61N1/18 , A61F7/12
CPC分类号： A61B18/1492 , A61B2018/00023 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61B2018/1467 , A61M25/0041 , A61M25/0074 , A61M25/0133 , A61M25/0138 , A61M25/0147
摘要： Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel. The array is selectively transformable between a delivery or low-profile state (e.g., a generally straight shape) and a deployed state (e.g., a radially expanded, generally helical shape). The multi-electrode array is sized and shaped so that the electrodes or energy delivery elements contact an interior wall of the renal blood vessel when the array is in the deployed (e.g., helical) state. The electrodes or energy delivery elements are configured for direct and/or indirect application of thermal and/or electrical energy to heat or otherwise electrically modulate neural fibers that contribute to renal function or of vascular structures that feed or perfuse the neural fibers.

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