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1. 发明授权

US11160840B2 Composition for improvement of muscle function containing 3,5-dicaffeoylquinic acid or chrysanthemum extract 有权
公开(公告)号：US11160840B2
公开(公告)日：2021-11-02
申请号：US16474528
申请日：2017-11-30
申请人： Industry-Academic Cooperation Foundation, Yonsei University , Cosmax NBT, Inc. , Cosmax NS, Inc.
发明人： Jae Kwan Hwang , Jun Gon Yun , Mi Bo Kim , Chang Hee Kim , Joon Hyung Lee , Do Wan Kwon , Su Young Choi , Jin Hak Kim , Ji Hwan Jang , Jeong Ho Geum , Min Son Kweon
IPC分类号： A61K36/287 , A23L33/105 , A61K8/9789 , A61K8/37 , A61K31/216
摘要： The present invention relates to a composition for preventing or treating a muscle disorder, which includes a chrysanthemum extract or 3,5-dicaffeoylquinic acid as an active ingredient, and specifically, it may be used to reduce mRNA expression of atrogin-1 and MuRF1, which are main biomarkers involved in muscle protein degradation and increase mRNA expression of the mTOR protein, which is a main biomarker involved in muscle protein formation, and myogenin and MyoD, which are biomarkers related to muscle differentiation, thereby reducing muscle loss, and thus the chrysanthemum extract or 3,5-dicaffeoylquinic acid can be used in prevention and treatment of a muscle disorder, or improvement in muscle function. In addition, the chrysanthemum extract or 3,5-dicaffeoylquinic acid increases the activity of SIRT1 and PGC-1α, which are the main biomarkers involved in exercise performance, thereby excellently enhancing exercise performance. In addition, the present invention is a natural substance and may be safely used without a side effect, and therefore may be used as a medication, food or a cosmetic.

2. 发明授权

US11980649B2 Composition for the prevention or treatment of respiratory diseases caused by fine dust comprising 有权
公开(公告)号：US11980649B2
公开(公告)日：2024-05-14
申请号：US17257529
申请日：2020-05-21
申请人： Cosmax NBT, Inc. , Cosmax NS, Inc.
发明人： Jeong Ho Geum , Hye Rim Kim , Jin Hak Kim , Su Young Choi
IPC分类号： A61K36/00 , A23L33/105 , A61K36/484 , A61K36/532
CPC分类号： A61K36/532 , A23L33/105 , A61K36/484
摘要： The Agastache rugosa and licorice complex mixture of the present invention has the synergy effects for the efficacies of reducing cough through inhibition of TRPV1 activity, reducing lung inflammation through inhibition of CXCR1 and CXCR2 activities and GR-1+CD11b+ cell ratio reduction, and suppressing sputum production through inhibition of MUC5AC activity and therefore it can be widely utilized as a composition for the prevention or treatment of respiratory diseases.

3. 发明授权

US10682384B2 Composition comprising natural complex extract as active ingredient 有权
公开(公告)号：US10682384B2
公开(公告)日：2020-06-16
申请号：US15866673
申请日：2018-01-10
申请人： COSMAX NS, INC. , COSMAX NBT, INC.
发明人： Jin Hak Kim , Kwang Soo Baek , Yong Jun Jo , Hyeon Yeong Ahn , Young Min Park , Hyun Ji Kim , Jae Seok Shim , Su Young Choi , Jin Woo Lee , Sang Woo Kim , Mann-Seok Yoon , Jin Hyouk Kwon
IPC分类号： A61K36/60 , A61Q19/02 , A61K36/815 , A61K36/532 , A61K8/9789 , A61Q19/08 , A61K36/44 , A61K36/534
摘要： The present invention relates to a composition comprising a natural complex extract. It is confirmed that the composition has synergistic effects on antioxidant activity, immune enhancement, whitening, anti-wrinkle and collagenase inhibition with low cytotoxicity, and therefore, the composition is suitable for uses of antioxidation, immune, whitening and skin anti-wrinkle.

4. 发明授权

US11628195B2 Method for preparing iridoid-rich noni fruit extract or fraction thereof, method for preparing immune-enhancing active material-rich noni fruit extract or fraction thereof and use of noni fruit extract or fraction thereof 有权
$Method for preparing iridoid-rich noni fruit extract or fraction thereof, method for preparing immune-enhancing active material-rich noni fruit extract or fraction thereof and use of noni fruit extract or fraction thereof$
公开(公告)号：US11628195B2
公开(公告)日：2023-04-18
申请号：US17257222
申请日：2020-06-02
申请人： Cosmax NBT, Inc. , Cosmax NS, Inc.
发明人： Ji Hwan Jang , Jin Hak Kim , Bo Ra Jin , Su Young Choi , Hyun Ji Kim
IPC分类号： A61K36/746 , A61P37/04 , A61K31/7048
摘要： The present invention relates to a method of preparing a noni fruit extract containing a high iridoid content or a fraction thereof, a method of preparing a noni fruit extract containing a high content of an immune-enhancing active substance or a fraction thereof, and a use of a noni fruit extract or a fraction thereof, and more specifically, the present invention provides a method of preparing a noni fruit extract containing a high iridoid content or a fraction thereof, including preparing a noni fruit extract by using ethanol in a specific concentration range as an extraction solvent, a method of preparing a noni fruit extract containing a high content of an immune-enhancing active substance or a fraction thereof, a pharmaceutical composition for enhancing immunity including the extract or a fraction thereof, a health functional food composition including the same constitution, a method of enhancing immunity using the extract or a fraction thereof, and a use of the extract or a fraction thereof in preparation of medicine for preventing or treating a disease associated with immune enhancement or reduced immunity.

5. 发明授权

US11779626B2 Composition for enhancing immunity or preventing or treating neurodegenerative diseases by using goji berries, mulberries and jujubes 有权
公开(公告)号：US11779626B2
公开(公告)日：2023-10-10
申请号：US17868704
申请日：2022-07-19
申请人： COSMAX NS, INC.
发明人： Kwang Soo Baek , Hyunji Kim , Su Young Choi , Jin Hak Kim , Jae Seok Shim , Young Min Park , Sang Woo Kim , Mann-Seok Yoon , Yoon Jong Lee
IPC分类号： A61K36/815 , A23L33/105 , A61K36/605 , A61K36/725
CPC分类号： A61K36/815 , A23L33/105 , A61K36/605 , A61K36/725 , A61K2236/51
摘要： The present invention relates to a composition for enhancing immunity or a composition for preventing or ameliorating neurodegenerative diseases, both of which contain, as an active ingredient, a mixture extract of goji berries, mulberries and jujubes or an extract mixture thereof.

6. 发明申请

US20200061146A1 METHOD FOR PREPARING CURCUMA XANTHORRHIZA ROXB. EXTRACT 审中-公开
公开(公告)号：US20200061146A1
公开(公告)日：2020-02-27
申请号：US16461613
申请日：2017-11-02
申请人： COSMAX NS, INC.
发明人： Jin Hak Kim , Jae Kwan Hwang , Su Young Choi
IPC分类号： A61K36/9066
摘要： The present invention relates to a method for preparing a Curcuma xanthorrhiza Roxb. extract. Further, the present invention provides a method for preparing a Curcuma xanthorrhiza Roxb. extract comprising the following steps of: subjecting Curcuma xanthorrhiza Roxb. to supercritical extraction to obtain an extract containing xanthorrhizol as an active ingredient; subjecting the supercritical extraction residue to ethanol extraction or supercritical extraction to obtain an extract containing curcumin as an active ingredient; subjecting the ethanol extraction or supercritical extraction residue to enzyme treatment to obtain immune polysaccharides having average molecular weight 33,000 Da; and obtaining a insoluble dietary fiber from the enzyme treatment residue, an extract containing xanthorrhizol, curcumin, immune polysaccharides and insoluble dietary fiber obtained by the said preparing method, and general food, health functional food, cosmetic, pharmaceutical compositions and the like containing the extracts as an active ingredient. Since the Curcuma xanthorrhiza Roxb. extraction method according to the present invention can obtain various kinds of natural extracts from one raw material by applying a variety of extraction methods, the method can be very useful for the production of extracts using natural products.

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