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1. 发明授权

US5767206A Use, as antiadhesives agent and/or water repellents, of grafted functionalized polyorganosiloxanes 失效
标题翻译：作为抗粘剂剂和/或拒水剂，使用接枝官能化聚有机硅氧烷
公开(公告)号：US5767206A
公开(公告)日：1998-06-16
申请号：US862423
申请日：1997-05-23
申请人： Daniel Ariagno , Andre Lievre , Theresa Michael , Joel Richard
发明人： Daniel Ariagno , Andre Lievre , Theresa Michael , Joel Richard
IPC分类号： B05D5/08 , B05D7/24 , C08F283/12 , C08G77/14 , C08G77/22 , C08G77/26 , C08G77/28 , C08G77/442 , C08L83/04 , C08L83/10 , C09D151/08 , C09D183/04 , C09D183/06 , C09D183/08 , C09D183/10 , C09J7/02 , C09J7/04 , C09K3/18 , D21H19/32 , D21H27/00 , C08F283/00 , C08G77/04
CPC分类号： C09J7/0228 , C08F283/12 , C08G77/442 , C09D151/08 , C09D183/10 , D21H19/32 , D21H27/001 , C08L83/04 , C08L83/10 , C09J2400/263 , C09J2400/283 , C09J2451/005 , C09J2483/005
摘要： The present invention relates to the use, as antiadhesive agents and/or water repellents, of grafted functionalized polyorganosiloxanes consisting of grafted copolymer moieties, derived from at least one ethylenically unsaturated monomer which may be polymerized via a radical route and from a functionalized polyorganosiloxane (I) containing similar or different moieties (I) of formula (I) R.sub.a Y.sub.b X.sub.c Si O.sub.(4-a-b-c)/2 (I) in which formula: R=C.sub.1 -C.sub.18 alkyl, X=C.sub.1 -C.sub.20 alkylated epoxyfunctional residue, Y=acrylate, and a, b, c=0, 1, 2 or 3 with a +b+c=0, 1, 2 or 3. These grafted functionalized POSs are used in the form of an aqueous dispersion for the production of an antiadhesive coating on a solid support, preferably chosen from sheets of polymer material or of paper, cardboard or the like, from tapes which are adhesive on their non-adhesive side, from intercalating films of double-sided adhesive tapes or from woven or nonwoven fibrous supports and/or composites or non-composites.
摘要翻译：本发明涉及作为抗粘附剂和/或防水剂的由接枝的共聚物部分组成的接枝官能化聚有机硅氧烷，其衍生自可通过自由基途径聚合的至少一种烯属不饱和单体和官能化聚有机硅氧烷（I ），其中R = C 1 -C 18烷基，X = C 1 -C 20烷基化环氧官能残基，Y =丙烯酸酯，式（I）的相似或不同部分（I）RaYbXcSi O（4-abc）/ 2 和a，b，c = 0,1,2或3，其中a + b + c = 0,1,2或3.这些接枝的官能化POS以水分散体的形式用于生产防粘涂层固体支持物，优选选自聚合物材料片或纸，纸板或类似物，从其非粘合剂侧粘合的胶带，双面胶带的插入膜或来自织造或非织造纤维支撑体和/ 或复合材料或非复合材料。

2. 发明申请

US20050133764A1 Latex dispersions containing a hydroxyl functional group and a carboxylic functional group and their use for the manufacture of coatings 审中-公开
标题翻译：含有羟基官能团和羧基官能团的胶乳分散体及其用于制造涂料的用途
公开(公告)号：US20050133764A1
公开(公告)日：2005-06-23
申请号：US11062092
申请日：2005-02-18
申请人： Mathieu Joanicot , Bruno Langlois , Theresa Michael , Joel Richard
发明人： Mathieu Joanicot , Bruno Langlois , Theresa Michael , Joel Richard
IPC分类号： C08F220/04 , C08F220/12 , C08G18/62 , C08G18/70 , C08G18/80 , C08G18/81 , C09D133/06 , B01F1/00
CPC分类号： C08G18/6254 , C08F220/04 , C08F220/12 , C08G18/706 , C08G18/8077 , C08G18/8175 , C09D133/066
摘要： The present invention relates to dispersions in an aqueous phase of forming coatings after curing. The composition which can be used for paint and varnish, made up of a dispersion comprising at least one aqueous phase and a population A of particles of (co)polymer(s) whose size is between 10 and 1000 nanometres, in which the particles have an accessible acidic (advantageously carboxylic) functional group content of between 0.2 and 1.2 milliequivalents/gram of solid matter and have an accessible alcoholic functional group content of between 0.3 and 1.5 milliequivalents/gram. Application to paint.
摘要翻译：本发明涉及固化后形成涂层的水相中的分散体。可用于油漆和清漆的组合物由包含至少一种水相的分散体和尺寸为10至1000纳米的（共）聚合物颗粒的群体A组成，其中颗粒具有 0.2到1.2毫当量/克固体物质的可接近的酸性（有利的羧酸）官能团含量，并且具有0.3至1.5毫当量/克的可接近的官能团含量。应用于油漆。

3. 发明授权

US09138403B2 PEG-interferon-beta formulations 有权
标题翻译： PEG-干扰素-β制剂
公开(公告)号：US09138403B2
公开(公告)日：2015-09-22
申请号：US12738375
申请日：2008-12-18
申请人： Alessandra Del Rio , Joel Richard
发明人： Alessandra Del Rio , Joel Richard
IPC分类号： A61K38/21 , A61K47/26 , A61K47/34 , A61K38/00 , C07K14/565 , A61K9/00 , C07K14/555 , A61K47/48
CPC分类号： A61K9/0019 , A61K38/21 , A61K38/215 , A61K47/26 , A61K47/34 , A61K47/60 , A61K2300/00 , C07K14/555 , C07K14/565
摘要： The invention relates to a liquid pharmaceutical composition comprising a pegylated IFN-β (PEG-IFN-β), an excipient, a surfactant and a buffer wherein said excipient is a polyol, wherein said surfactant is a non-ionic surfactant and wherein said buffer is a sodium acetate buffer.
摘要翻译：本发明涉及一种液体药物组合物，其包含聚乙二醇化的IFN- （PEG-IFN-和bgr），赋形剂，表面活性剂和缓冲液，其中所述赋形剂是多元醇，其中所述表面活性剂是非离子表面活性剂，其中所述缓冲液是乙酸钠缓冲液。

4. 发明申请

US20100310649A1 SOLID LIPID MICROCAPSULES CONTAINING GROWTH HORMONE INNER CORE MICROPARTICLES 有权
标题翻译：含有生长激素内核微生物的固体脂质微球
公开(公告)号：US20100310649A1
公开(公告)日：2010-12-09
申请号：US12809397
申请日：2008-11-21
申请人： Joel Richard , Helen Baldascini , Rita Agostinetto , Luisa De Angelis , Frantz Deschamps
发明人： Joel Richard , Helen Baldascini , Rita Agostinetto , Luisa De Angelis , Frantz Deschamps
IPC分类号： A61K9/48 , A61K38/27 , A61P5/06
CPC分类号： A61K9/5015 , A61K9/127 , A61K38/27
摘要： The invention relates to growth hormone (GH) formulations having sustained-release properties, in particular human growth hormone (hGH) and methods for their preparation. The growth hormone formulations can be manufactured without denaturing of the protein and can conveniently be administrated to the person in need thereof by using a conventional syringe via a needle having a small diameter.
摘要翻译：本发明涉及具有缓释性质的生长激素（GH）制剂，特别是人生长激素（hGH）及其制备方法。可以在不使蛋白质变性的情况下制造生长激素制剂，并且可以通过使用具有小直径的针的常规注射器方便地向有需要的人施用生长激素制剂。

5. 发明授权

US5976426A Latex of calibrated monodisperse magnetizable microspheres, process of preparation and use of the said latex in chemistry or in biology 失效
标题翻译：校准的单分散可磁化微球的乳胶，在化学或生物学中制备和使用所述胶乳的方法
公开(公告)号：US5976426A
公开(公告)日：1999-11-02
申请号：US793352
申请日：1997-02-24
申请人： Joel Richard , Sophie Vaslin
发明人： Joel Richard , Sophie Vaslin
IPC分类号： G01N33/553 , B01J13/00 , B01J13/14 , B01J20/281 , B01J20/285 , C08F2/14 , C08F2/44 , C08F297/00 , C08K3/22 , G01N30/88 , G01N33/543
CPC分类号： C08K3/22 , C08F2/44 , G01N33/5434 , G01N2446/20 , G01N2446/40
摘要： Latices of monodisperse magnetizable microspheres contain a hydrophobic polymer matrix and magnetizable fillers. The microspheres have a calibrated particle-size distribution and a size of around 0.1-5 micrometers, and the polymer matrix, produced by a dispersion polymerization method, includes polymer chains derived from at least one vinyl monomer. The latices are useful in biology, in particular, for diagnostic and affinity chromatography methods.
摘要翻译： PCT No.PCT / FR96 / 00957 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1996年6月20日PCT公布。公开号WO97 / 00896 日期1997年1月9日单分散可磁化微球含有疏水性聚合物基质和可磁化填料。微球具有校准的粒度分布和约0.1-5微米的尺寸，并且通过分散聚合法产生的聚合物基质包括衍生自至少一种乙烯基单体的聚合物链。胶乳可用于生物学，特别是诊断和亲和层析方法。

6. 发明授权

US5872189A Water-redispersible powders of film-forming polymers with a "core/shell" structure 失效
标题翻译：具有“核/壳”结构的成膜聚合物的水可再分散粉末
公开(公告)号：US5872189A
公开(公告)日：1999-02-16
申请号：US860204
申请日：1997-09-08
申请人： Bill Bett , Joel Richard
发明人： Bill Bett , Joel Richard
IPC分类号： C08F2/24 , C08F279/02 , C09D151/04 , C09J151/04 , D21H19/58
CPC分类号： D21H19/58 , C08F279/02 , C09D151/04 , C09J151/04 , Y10S977/70
摘要： The present invention relates to a water-redispersible powder based on film-forming polymers which are substantially water-insoluble and which are prepared by aqueous emulsion polymerization of monomers containing ethylenic unsaturation with a "core/shell" structure comprising a hydrophobic core based on a polymer exhibiting a Tg (glass transition temperature) of between -30.degree. and +25.degree. C., preferably between -10.degree. and +20.degree. C., and a hydrophilic shell based on a polymer exhibiting a Tg higher than +55.degree. C., preferably higher than +90.degree. C., characterized in that the shell is bonded to the core by covalent bonds resulting from the reaction of an agent for grafting the shell onto the ethylenic unsaturations remaining in the core, and is substantially insoluble in an alkaline medium.
摘要翻译： PCT No.PCT / FR95 / 01699 Sec。 371日期：1997年9月8日 102（e）日期1997年9月8日PCT提交1995年12月20日PCT公布。公开号WO96 / 20963 日本1996年7月11日本发明涉及基于成膜聚合物的水分散性粉末，其基本上不溶于水，并且通过含有含有烯键式不饱和单体的单体的含水乳液聚合制备，所述“核/壳”结构包含基于显示Tg（玻璃化转变温度）为-30至+25℃，优选-10℃至+ 20℃之间的聚合物的疏水核心和基于显示Tg更高的聚合物的亲水性壳优选高于+90℃，其特征在于，通过由壳体接枝到残留在核心中的烯属不饱和基团的反应产生的共价键将壳结合到核心，以及基本上不溶于碱性介质。

7. 发明授权

US5753728A Polymer compositions comprising electroactive amphiphilic organic compounds and electroconductive shaped articles produced therefrom 失效
标题翻译：包含电活性两亲性有机化合物和由其制备的导电成型制品的聚合物组合物
公开(公告)号：US5753728A
公开(公告)日：1998-05-19
申请号：US465308
申请日：1995-06-05
申请人： Bernard Chauvel , Joel Richard
发明人： Bernard Chauvel , Joel Richard
IPC分类号： C08K5/00 , C08F8/30 , C08F8/34 , C08F8/42 , C08K5/45 , C08L33/02 , C08L35/06 , C08L47/00 , C08L101/00 , G06K9/48 , H01B1/12 , H01B1/20
CPC分类号： G06K9/48 , H01B1/121 , C08F2800/10
摘要： Polymeric compositions well suited for conversion into electroconductive shaped articles, e.g., films, comprise at least one convertible polymer (Pm) and at least one amphiphilic organic compound (B) which comprises a charge transfer complex or a radical ion salt having the formula (I): D.sub.d A.sub.a Z.sub.z, in which D is an electron donor; A is an electron acceptor; Z is a doping agent which itself can be a non-amphiphilic electron donor or electron acceptor, with the proviso that at least one of D and A is amphiphilic and contains at least one saturated or unsaturated hydrocarbon substituent having at least 10 carbon atoms; d is a number equal to or greater than 0; a is a number equal to or greater than 0; and z is a number equal to or greater than 0, with the further proviso that at least one of the symbols d and a is a number greater than 0.
摘要翻译：包含至少一种可转换聚合物（Pm）和至少一种两亲性有机化合物（B）的聚合物组合物，其包含电荷转移络合物或具有式（I）的自由基离子盐）：DdAaZz，其中D是电子给体; A是电子受体; Z是掺杂剂，其本身可以是非两亲电子给体或电子受体，条件是D和A中的至少一个是两亲性的并且含有至少一个具有至少10个碳原子的饱和或不饱和烃取代基; d是等于或大于0的数; a是等于或大于0的数; 并且z是等于或大于0的数，进一步的条件是符号d和a中的至少一个是大于0的数字。

8. 发明授权

US4925774A Microlithographic process for producing circuits using conductive organic films sensitive to electromagnetic radiation and to charged particles, as well as to the circuits and components obtained by this process 失效
标题翻译：使用对电磁辐射敏感的导电有机膜和带电粒子的电路的微光刻工艺，以及通过该方法获得的电路和部件
公开(公告)号：US4925774A
公开(公告)日：1990-05-15
申请号：US172597
申请日：1988-03-24
申请人： Andre Barraud , Joel Richard , Michel Vandevyver
发明人： Andre Barraud , Joel Richard , Michel Vandevyver
IPC分类号： H01B5/14 , H01B13/00 , H05K1/09 , H05K3/00 , H05K3/02 , H05K3/10
CPC分类号： H05K3/02 , H05K1/09 , H05K2201/0329 , H05K2203/107 , H05K2203/1142 , H05K3/027 , Y10S430/146 , Y10S430/168
摘要： The invention relates to a microlithographic process for producing circuits using organic, conductive films sensitive to electromagnetic radiation and to charged particles.This process for producing electricity conducting zones on a substrate consists of depositing on said substrate a coating of an electricity conducting, organic compound, such as alkyl pyridinium-tetracyanoquinodimethane and then irradiating certain locations (2,3) of the coating by means of charged particles and/or electromagnetic radiation, so that the irradiated locations become insulating and that on the organic compound coating the electricity conducting zones (1) are directly formed at the desired locations.
摘要翻译：本发明涉及使用对电磁辐射敏感的有机导电膜和带电粒子来制造电路的微光刻工艺。用于在衬底上产生导电区的该方法包括在所述衬底上沉积导电的有机化合物（例如烷基吡啶鎓 - 四氰基醌二甲烷）的涂层，然后通过带电粒子照射涂层的某些位置（2,3）和/或电磁辐射，使得照射的位置变得绝缘，并且涂覆导电区（1）的有机化合物在所需位置处直接形成。

9. 发明授权

US09272020B2 IFN-beta compositions, preparation methods and uses thereof 有权
标题翻译： IFN-β组合物，其制备方法和用途
公开(公告)号：US09272020B2
公开(公告)日：2016-03-01
申请号：US14118757
申请日：2012-05-16
申请人： Daniel Leblanc , Evert Nicolaas Lamme , Helen Gabriela Baldascini , Joel Richard , Frederic Checot , You-Ping Chan , Roger Kravtzoff , Gauthier Pouliquen
发明人： Daniel Leblanc , Evert Nicolaas Lamme , Helen Gabriela Baldascini , Joel Richard , Frederic Checot , You-Ping Chan , Roger Kravtzoff , Gauthier Pouliquen
IPC分类号： A61K38/21 , A61K9/00 , A61K47/34 , A61K47/36 , A61K9/20 , A61K9/19 , A61K47/42
CPC分类号： A61K38/215 , A61K9/0019 , A61K9/19 , A61K9/2018 , A61K47/34 , A61K47/42
摘要： The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.
摘要翻译：本发明涉及包含干扰素-β和平均分子量为26,000至40,000g / mol的接枝聚（谷氨酸）聚合物的干扰素-β（IFN-β）组合物，用α-生育酚取代基接枝，平均摩尔接枝率为4.5-5.5摩尔％，所述接枝的聚（谷氨酸）聚合物与IFN-β之间的重量/重量比为24至125.本发明还涉及这些组合物的制备方法及其应用以获得剂量单位的治疗组合物在长时间内形成IFN-β。

10. 发明授权

US6124416A Aqueous emulsion of (CO) polymer made from monomer containing isocyanate group and olefinic double bond 有权
标题翻译：由含有异氰酸酯基团和烯属双键的单体制备的（CO）聚合物的水乳液
公开(公告)号：US6124416A
公开(公告)日：2000-09-26
申请号：US251745
申请日：1999-02-18
申请人： Michel Desbois , Roland Reeb , Joel Richard , Fran.cedilla.oise Truchet
发明人： Michel Desbois , Roland Reeb , Joel Richard , Fran.cedilla.oise Truchet
IPC分类号： C07D521/00 , C07C275/62 , C08F2/22 , C08F12/00 , C08F16/36 , C08F20/34 , C08F20/36 , C08F20/52 , C08F20/60 , C08F26/00 , C08F212/00 , C08F214/06 , C08F214/08 , C08F218/02 , C08F218/04 , C08F220/10 , C08F220/36 , C08F220/42 , C08F220/44 , C08F220/54 , C08F222/22 , C08F226/00 , C08G18/46 , C08G18/67 , C08G18/72 , C08G18/80 , C08G18/81 , C08L31/02 , C08L31/04 , C08L33/04 , C08L33/18 , C08L33/24 , C08L39/00 , C08F26/02 , C08F26/06 , C08L39/04
CPC分类号： C08G18/4676 , C08F16/36 , C08F20/36 , C08F20/60 , C08G18/728 , C08G18/8077 , C08G18/8175
摘要： An aqueous emulsion comprising at least one (co)polymer is provided. The (co)polymer is derived from a monomer having formula (1):(R.sub.1 R.sub.2 C.dbd.CR.sub.3 --CO--L--).sub.q A(--NCOblock).sub.p(1)wherein R.sub.1, R.sub.2, and R.sub.3, which are the same or different, represent a hydrogen or a group selected from hydrocarbon chains comprising 1 to 12 carbon atoms, halogens, and electron-withdrawing functional groups; L, which is the same or different, represents a divalent hydrocarbon radical comprising 2 to 12 carbon atoms; A represents an organic backbone which has n free valencies, n is a number between 2 and 7, and is equal to p+q; NCOblock represents a protected isocyanate functional group; p is a number between 1 and 6; and q is a number between 1 and 6.
摘要翻译：提供包含至少一种（共）聚合物的水性乳液。（共）聚合物衍生自具有式（1）的单体:( R1R2C = CR3-CO-L-）qA（-NCOblock）p（1）其中R1，R2和R3相同或不同，表示氢或选自包含1至12个碳原子的烃链，卤素和吸电子官能团的基团; L相同或不同，表示包含2至12个碳原子的二价烃基; A表示具有n个自由价的有机骨架，n是2和7之间的数，并且等于p + q; NCOblock表示受保护的异氰酸酯官能团; p是1到6之间的数字; q是1到6之间的数字。

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