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    • 8. 发明申请
    • Regulation of Autophagy and Cell Survival
    • 自噬和细胞存活的调控
    • US20080269259A1
    • 2008-10-30
    • US11814365
    • 2006-01-19
    • Craig B. ThompsonJulian LumDaniel Bauer
    • Craig B. ThompsonJulian LumDaniel Bauer
    • A61K31/52A61K31/47C12Q1/02A61P35/00
    • C12Q1/26A61K31/00A61K31/4706A61K31/675A61K45/06G01N33/574G01N2500/00A61K2300/00
    • Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to such an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that renders the cancer incapable of glycolysis and an autophagy inhibit are also disclosed. Methods of treating an individual who has a disease characterized b cell degeneration and cell death due to autophagy are disclosed. The methods comprise administering to the individual a permeable form of a metabolic substrate that can be oxidized in the tricarboxylic acid cycle to produce NADH. Methods for identifying an autophagy inhibitor comprising performing a test assay using an apopto sis-resistant cell are disclosed.
    • 公开了已经鉴定为具有糖酵解依赖性癌症的个体的治疗方法。 所述方法包括以下步骤:向这样的个体施用使癌症不能糖酵解的抗癌组合物与自噬抑制剂的组合。 还公开了包含其的药物组合物和试剂盒,使癌症不能进行糖酵解和自噬抑制。 公开了治疗患有由于自噬引起的b细胞变性和细胞死亡的疾病的个体的方法。 所述方法包括向个体施用可在三羧酸循环中被氧化以产生NADH的代谢底物的可渗透形式。 公开了用于鉴定自噬抑制剂的方法,包括使用抗凋亡细胞进行测试测定。
    • 9. 发明申请
    • Compositions and methods for treating cancer
    • 用于治疗癌症的组合物和方法
    • US20070259956A1
    • 2007-11-08
    • US10556220
    • 2004-05-07
    • Craig ThompsonDaniel BauerGeorgia Hatzivassiliou
    • Craig ThompsonDaniel BauerGeorgia Hatzivassiliou
    • A61K31/215A61K31/21
    • A61K31/34A61K51/0491
    • Methods of treating individuals identified as having cancer using ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of inducing apoptosis in cancer cells using an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating an individual who has cancer comprising the steps of identifying the cancer as having a high rate of aerobic glycolysis, and administering an ATP citrate lyase inhibitor and/or tricarboxylate transporter inhibitor are disclosed. Methods of treating individuals who have cancer using compounds that inhibit the expression of ATP citrate lyase or tricarboxylate transporter are disclosed. Methods of identifying a compound with anticancer activity are disclosed.
    • 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂治疗被鉴定为具有癌症的个体的方法。 公开了使用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂诱导癌细胞凋亡的方法。 公开了治疗患有癌症的个体的方法,包括将癌症鉴定为具有高比例的有氧糖酵解的步骤,以及施用ATP柠檬酸裂解酶抑制剂和/或三羧酸转运蛋白抑制剂。 公开了使用抑制ATP柠檬酸裂合酶或三羧酸转运蛋白的表达的化合物治疗患有癌症的个体的方法。 公开了鉴定具有抗癌活性的化合物的方法。