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1. 发明授权

US08546442B2 Pyrazolopiperidine compounds as CCR1 receptor antagonists 有权
标题翻译：吡唑并哌啶化合物作为CCR1受体拮抗剂
公开(公告)号：US08546442B2
公开(公告)日：2013-10-01
申请号：US13328199
申请日：2011-12-16
申请人： Rajashekhar Betageri , Brian Nicholas Cook , Darren DiSalvo , Christian Harcken , Daniel Kuzmich , Pingrong Liu , John Lord , Can Mao , Hossein Razavi
发明人： Rajashekhar Betageri , Brian Nicholas Cook , Darren DiSalvo , Christian Harcken , Daniel Kuzmich , Pingrong Liu , John Lord , Can Mao , Hossein Razavi
IPC分类号： A01N43/56 , A01N43/42 , A61K31/415 , A61K31/44 , C07D231/54 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译：公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。还公开了制备方法和使用方法。

2. 发明授权

US07879873B2 Azaindazole compounds as CCR1 receptor antagonists 有权
公开(公告)号：US07879873B2
公开(公告)日：2011-02-01
申请号：US12564129
申请日：2009-09-22
申请人： Brian Nicholas Cook , Darren DiSalvo , Daniel Robert Fandrick , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Jonathan Timothy Reeves , Jinhua J. Song , Alan David Swinamer , Zhulin Tan
发明人： Brian Nicholas Cook , Darren DiSalvo , Daniel Robert Fandrick , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Jonathan Timothy Reeves , Jinhua J. Song , Alan David Swinamer , Zhulin Tan
IPC分类号： A61K31/437 , C07D515/04
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

3. 发明授权

US08163918B2 Azaindazole compounds as CCR1 receptor antagonists 有权
标题翻译：阿扎唑类化合物作为CCR1受体拮抗剂
公开(公告)号：US08163918B2
公开(公告)日：2012-04-24
申请号：US13273509
申请日：2011-10-14
申请人： Daniel Kuzmich , John Lord , Can Mao
发明人： Daniel Kuzmich , John Lord , Can Mao
IPC分类号： C07D515/04
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are intermediates thereof, and methods of making and methods of using same.
摘要翻译：公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。还公开了其中间体及其制备方法及其使用方法。

4. 发明授权

US08063065B2 Azaindazole compounds as CCR1 receptor antagonists 有权
标题翻译：阿扎唑类化合物作为CCR1受体拮抗剂
公开(公告)号：US08063065B2
公开(公告)日：2011-11-22
申请号：US12969753
申请日：2010-12-16
申请人： Brian Nicholas Cook , Darren Di Salvo , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Alan David Swinamer
发明人： Brian Nicholas Cook , Darren Di Salvo , Christian Harcken , Daniel Kuzmich , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , Can Mao , Jochen Neu , Brian Christopher Raudenbush , Hossein Razavi , Alan David Swinamer
IPC分类号： A61K31/437 , C07D515/04
CPC分类号： C07D471/04
摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
摘要翻译：公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。还公开了制备方法和使用方法。

5. 发明授权

US08268859B2 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：US08268859B2
公开(公告)日：2012-09-18
申请号：US12477586
申请日：2009-06-03
申请人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , David Thomson
发明人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , David Thomson
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R1，R2，X和Y如本文所定义的式（I）化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

6. 发明申请

US20090325988A1 Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof 有权
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：US20090325988A1
公开(公告)日：2009-12-31
申请号：US12477586
申请日：2009-06-03
申请人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-Ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , Daivd Thomson
发明人： Christian Harcken , Rajashekhar Betageri , Todd Bosanac , Michael Jason Burke , Soojin Kim , Daniel Kuzmich , Thomas Wai-Ho Lee , Zhibin Li , Pingrong Liu , John Lord , Hossein Razavi , Jonathan Timothy Reeves , Daivd Thomson
IPC分类号： A61K31/437 , C07D471/04 , C07D211/72 , C07D239/46 , A61K31/44 , A61K31/505 , A61P9/00 , A61P37/08 , A61P17/00 , A61P1/00 , A61P25/00 , A61P35/00 , A61P7/00
CPC分类号： C07D471/04
摘要： Compounds of Formula (I) wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R1，R2，X和Y如本文所定义的式（I）化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

7. 发明申请

US20110230521A1 Pyrazole Compounds As CCR1 Antagonists 有权
标题翻译：吡唑化合物作为CCR1拮抗剂
公开(公告)号：US20110230521A1
公开(公告)日：2011-09-22
申请号：US12990248
申请日：2009-05-01
申请人： Brian Nicholas Cook , Christian Harcken , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , CAN Mao , Wang Mao , Brain Christopher Raudenbush , Hossein Razavi , Christopher Ronald Sarko , Alan David Swinamer
发明人： Brian Nicholas Cook , Christian Harcken , Thomas Wai-Ho Lee , Pingrong Liu , John Lord , CAN Mao , Wang Mao , Brain Christopher Raudenbush , Hossein Razavi , Christopher Ronald Sarko , Alan David Swinamer
IPC分类号： A61K31/454 , C07D231/14 , C07D401/12 , C07D401/04 , C07D405/14 , C07D417/12 , A61K31/415 , A61K31/4439 , A61K31/427 , A61P3/10 , A61P25/00 , A61P29/00 , A61P7/00 , A61P13/12 , A61P25/28 , A61P11/06 , A61P19/02 , A61P17/06 , A61P37/08
CPC分类号： C07D401/12 , C07D231/14 , C07D405/14 , C07D417/12
摘要： Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译：公开了式（I）的化合物，其阻断CCR1及其配体的相互作用，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫疾病，例如类风湿性关节炎和多发性硬化。还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

8. 发明申请

US20070042729A1 Inductive power supply, remote device powered by inductive power supply and method for operating same 审中-公开
标题翻译：感应电源，由感应电源供电的远程设备及其操作方法
公开(公告)号：US20070042729A1
公开(公告)日：2007-02-22
申请号：US11204820
申请日：2005-08-16
申请人： David Baaman , Nathan Stien , Wesley Bachman , John Lord
发明人： David Baaman , Nathan Stien , Wesley Bachman , John Lord
IPC分类号： H04B1/04
CPC分类号： H02J50/12 , H02J5/005
摘要： An inductive power supply includes a transceiver for sending information between the remote device and the inductive power supply. The remote device determines the actual voltage and then sends a command to the inductive power supply to change the operating frequency if the actual voltage is different from the desired voltage. In order to determine the actual voltage, the remote device determines a peak voltage and then applies a correction factor.
摘要翻译：感应电源包括用于在远程设备和感应电源之间发送信息的收发器。远程设备确定实际电压，然后如果实际电压与期望电压不同，则向感应电源发送命令以改变工作频率。为了确定实际电压，远程设备确定峰值电压，然后应用校正因子。

9. 发明授权

US4280908A Injection molding filter assembly 失效
标题翻译：注塑过滤器总成
公开(公告)号：US4280908A
公开(公告)日：1981-07-28
申请号：US162809
申请日：1980-06-24
申请人： John Lord , Jobst U. Gellert
发明人： John Lord , Jobst U. Gellert
IPC分类号： B29C45/00 , B01D29/44 , B29B7/00 , B29C37/00 , B29C45/20 , B29C45/24 , B29C45/26 , B29C45/62 , B29C47/00 , B29C47/68 , B01D35/02
CPC分类号： B29C45/24 , B01D29/44
摘要： This invention relates to an improved injection molding filter assembly to be located between the molding machine and the mold. The assembly has an elongated inner torpedo member with a generally cylindrical outer surface which is centrally located in a passage through a hollow outer member. The passage is defined by a generally cylindrical inner wall which is interrupted by an even number of inwardly opening longitudinally extending channels. Inlet channels extending from the inlet of the assembly and dead ending adjacent the outlet alternate with outlet channels extending from the outlet of the assembly and dead ending adjacent the inlet. Filtering apertures are formed between the outer surface of the torpedo member and the lands between the inlet and outlet channels through which the melt flows from the inlet channels to the outlet channels. A single elongated aperture may be formed at each land or a plurality of smaller apertures may be formed by providing alternating laterally extending ridges and grooves on the inner surfaces of the lands and/or on the outer surface of the torpedo member. Contaminants which are too large to pass through the filtering apertures accumulate adjacent the dead ends of the inlet channels. The outer member has a collar portion which may be detached to take out the torpedo member for periodic removal of accumulated contaminants. The location of the channels in the outer member provides improved heat flow characteristics and allows the width of the filtering slits to be quickly and easily changed by substituting a relatively inexpensive torpedo member having a different diameter.
摘要翻译：本发明涉及一种位于成型机和模具之间的改进的注塑过滤器组件。组件具有细长的内部鱼雷构件，其具有大致圆柱形的外表面，其中心位于穿过中空外部构件的通道中。该通道由通常为圆柱形的内壁限定，其被偶数数量的向内开口的纵向延伸的通道中断。从组件的入口延伸出来的入口通道和与出口相邻的死点与从组件的出口延伸出来的出口通道相邻，并且与入口相邻的死点。在鱼雷构件的外表面和入口通道和出口通道之间形成过滤孔，熔体通过入口通道流到出口通道。单个细长孔可以形成在每个陆地处，或者可以通过在鱼雷的内表面上和/或在鱼雷构件的外表面上提供交替的横向延伸的脊和凹槽来形成多个较小的孔。太大而不能通过过滤孔的污染物在入口通道的死端附近聚集。外部构件具有套环部分，其可以被拆卸以取出鱼雷构件以周期性地去除积聚的污染物。通道在外部构件中的位置提供了改进的热流特性，并且通过替代具有不同直径的相对便宜的鱼雷构件，可以快速容易地改变过滤狭缝的宽度。

10. 发明授权

US10607587B1 Electrical hum eliminator 有权
公开(公告)号：US10607587B1
公开(公告)日：2020-03-31
申请号：US16014405
申请日：2018-06-21
申请人： John Lord
发明人： John Lord
IPC分类号： G10H3/18 , G10H1/32 , G10D1/08
摘要： A noise eliminator to eliminate electrical hum from an amplified musical instrument is provided. An aspect provides a method of playing an electrically amplified musical instrument having a sound pickup system that is electrically grounded, including, but not limited to, the steps of: disposing a first connector to the skin of a player of the amplified musical instrument, wherein the connector has least two oppositely disposed sides, and wherein the first disposed side removably adheres to the skin of the player and the second disposed side permits an electrical connection to be made with the player's skin; disposing a second connector that is electrically connected to the electrical ground of the sound pickup system; and establishing an electrical connection between the first connector and the second connector. Other aspects are described and claimed.

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