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1. 发明授权

US08886308B2 AV delay features 有权
标题翻译： AV延迟功能
公开(公告)号：US08886308B2
公开(公告)日：2014-11-11
申请号：US13401965
申请日：2012-02-22
申请人： David L. Perschbacher , Richard Milon Dujmovic, Jr. , Gary T. Seim
发明人： David L. Perschbacher , Richard Milon Dujmovic, Jr. , Gary T. Seim
IPC分类号： A61N1/00 , A61N1/39 , A61N1/368
CPC分类号： A61N1/3987 , A61N1/3682 , A61N1/3937 , A61N1/3962
摘要： An atrial event and a ventricular event can be received, and an atrioventricular (AV) delay can be provided using information about the atrial and ventricular events. The AV delay can be increased after a first condition is satisfied to allow a heart to regain intrinsic control of ventricular activation, and changed after a second condition is satisfied to allow the heart to remain in intrinsic control of ventricular activation.
摘要翻译：可以接收心房事件和心室事件，并且可以使用关于心房和心室事件的信息来提供房室（AV）延迟。在满足第一条件以允许心脏恢复心室激活的内在控制之后，AV延迟可以增加，并且在第二个条件被满足以允许心脏保持在心室激活的内在控制之后改变。

2. 发明授权

US08036744B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US08036744B2
公开(公告)日：2011-10-11
申请号：US12631944
申请日：2009-12-07
申请人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/08 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

3. 发明授权

US08391990B2 Modular antitachyarrhythmia therapy system 有权
标题翻译：模块化抗心律失常治疗系统
公开(公告)号：US08391990B2
公开(公告)日：2013-03-05
申请号：US11131583
申请日：2005-05-18
申请人： Joseph M. Smith , Richard Milon Dujmovic, Jr.
发明人： Joseph M. Smith , Richard Milon Dujmovic, Jr.
IPC分类号： A61N1/00
CPC分类号： A61N1/3962 , A61N1/3605 , A61N1/3621 , A61N1/3622 , A61N1/36514 , A61N1/36564 , A61N1/36585 , A61N1/372 , A61N1/37217 , A61N1/3756 , A61N1/3925 , A61N1/3956 , A61N1/3987
摘要： This document discusses, among other things, a modular antitachyarrhythmia therapy system. In an example, a modular antitachyarrhythmia system includes at least two separate modules that coordinate delivery an antitachyarrhythmia therapy, such as a defibrillation therapy. In another example, a modular antitachyarrhythmia therapy system includes a sensing module, an analysis module, and a therapy module.
摘要翻译：本文件尤其涉及模块化抗心律失常治疗系统。在一个示例中，模块化抗心律失常系统包括至少两个单独的模块，其协调递送抗心律不齐治疗，例如除颤疗法。在另一示例中，模块化抗心律不齐治疗系统包括感测模块，分析模块和治疗模块。

4. 发明授权

US07697993B2 Method and apparatus for question-based programming of cardiac rhythm management devices 失效
标题翻译：用于心律管理装置的基于问题的编程的方法和装置
公开(公告)号：US07697993B2
公开(公告)日：2010-04-13
申请号：US10844642
申请日：2004-05-13
申请人： James O. Gilkerson , Richard Milon Dujmovic, Jr.
发明人： James O. Gilkerson , Richard Milon Dujmovic, Jr.
IPC分类号： A61N1/00
CPC分类号： G06F19/3418 , A61N1/37247 , G06F19/00 , G16H10/20
摘要： A cardiac rhythm management (CRM) system includes a programming device that identifies the device type of an implantable medical device, selects a predetermined questioning sequence based on the device type, and interacts with a user through a user interface screen by conducting a question-and-answer session according to the predetermined questioning sequence. After displaying a question and receiving an answer to the question, the programming device sets one or more programmable parameter values and/or displays a follow-up question in response to the answer. The programming device also allows the user to enter one or more programmable parameter values directly during or after the question-and-answer session. The implantable medical device is programmed to operate in one or more operational modes based on at least the answers received from the user during the question-and-answer session and the parameter values entered by the user, if any.
摘要翻译：心律管理（CRM）系统包括识别植入式医疗装置的装置类型的编程装置，基于装置类型选择预定的询问序列，并通过用户界面屏幕通过进行问题与用户交互， - 根据预定的询问序列进行会话。在显示问题并接收到该问题的答案之后，程序设备响应于该答案设置一个或多个可编程参数值和/或显示后续问题。编程设备还允许用户在询问和答复会话期间或之后直接输入一个或多个可编程参数值。可植入医疗设备被编程为至少基于在问答环境期间从用户接收的答案以及由用户输入的参数值（如果有的话）以一种或多种操作模式操作。

5. 发明授权

US07386344B2 Pacer with combined defibrillator tailored for bradycardia patients 失效
标题翻译：步行者联合除颤器为心动过缓患者量身打造
公开(公告)号：US07386344B2
公开(公告)日：2008-06-10
申请号：US10921777
申请日：2004-08-18
申请人： Joseph M. Bocek , Richard Milon Dujmovic, Jr. , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard S. Sanders , Douglas R. Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
发明人： Joseph M. Bocek , Richard Milon Dujmovic, Jr. , Phil Foshee , Harley White , Jaeho Kim , Anthony Harrington , Richard S. Sanders , Douglas R. Daum , Paul De Coriolis , Joseph Smith , Richard Fogoros
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61N1/3962
摘要： A combination pacer/defibrillator is tailored for bradycardia patients. In one example, its shock-delivery specificity exceeds its sensitivity to shockable ventricular tachyarrhythmias. In another example, its specificity exceeds 95%, or 99%, or even 99.5%. Sensitivity is programmed to a high desired sensitivity value, but only if it can be done without decreasing the specificity below the desired specificity threshold value. This can be conceptualized as “avoiding at all costs” delivering false shocks, even at the expense of failing to deliver a shock to a treatable ventricular tachyarrhythmia. Specificity enhancements include, among other things, inhibiting shock delivery when the patient is breathing or not supine, using multiple channels or a high rate VT/VF detection threshold. The present pacer/defibrillator device could potentially save the lives of bradyarrhythmia patients who are not presently clinically indicated for a defibrillator/pacer, but who have an increased risk of sudden cardiac death due to one or more risk factors.
摘要翻译：组合起搏器/除颤器是为心动过缓患者量身打造的。在一个例子中，其冲击传递特异性超过其对可震荡室性快速性心律失常的敏感性。在另一个实例中，其特异性超过95％，或99％，甚至99.5％。灵敏度被编程为高期望的灵敏度值，但是只有在不降低低于所需特异性阈值的特异性的情况下才能进行。这可以被概念化为“不惜一切代价”，提供虚假的冲击，即使以不能对可治疗的室性快速性心律失常发生冲击为代价。特异性增强包括，当患者呼吸或不仰卧时，使用多个通道或高速率的VT / VF检测阈值来抑制冲击输送。本发明的起搏器/除颤器装置可能潜在地节省目前临床指示用于除颤器/止痛器但是由于一个或多个危险因素引起的心脏猝死风险增加的缓慢心律失常患者的生命。

6. 发明授权

US07228176B2 Systems, devices, and methods for tachyarrhythmia discrimination or therapy decisions 有权
标题翻译：用于快速心律失常辨别或治疗决定的系统，装置和方法
公开(公告)号：US07228176B2
公开(公告)日：2007-06-05
申请号：US10897365
申请日：2004-07-22
申请人： Valerie Smith , Richard Milon Dujmovic, Jr. , Julie Thompson
发明人： Valerie Smith , Richard Milon Dujmovic, Jr. , Julie Thompson
IPC分类号： A61N1/362
CPC分类号： A61B5/7264 , A61B5/0464 , A61N1/3622 , A61N1/3962
摘要： This document discusses, among other things, systems, devices, and methods for detecting or classifying tachyarrhythmias or making a therapy decision. In one example, a rate-dependent threshold is used for comparing atrial and ventricular rates for classifying a tachyarrhythmia as a ventricular tachyarrhythmia (VT) or a supraventricular tachyarrhythmia (SVT). In another example, the classification uses an atrial rate cutoff value, a ventricular rate cutoff value, or both. In another example, a tachyarrhythmia detection is tested over a time window with a duration that is automatically adjusted as a substantially continuously monotonically decreasing function of duration vs. rate. These techniques improve the specificity of arrhythmia detection or classification, allow anti-tachyarrhythmia therapy to be better tailored to the particular tachyarrhythmia, or provide more automatic operation making it easier for a physician to use an implantable device.
摘要翻译：本文件还讨论了用于检测或分类快速性心律失常或作出治疗决定的系统，设备和方法。在一个示例中，速率依赖阈值用于比较心房和心室率，用于将快速性心律失常分类为室性快速性心律失常（VT）或室上性快速性心律失常（SVT）。在另一个例子中，分类使用心房率截止值，心室率截止值或两者。在另一个示例中，在时间窗口上测试快速心律失常检测，其持续时间被自动调整为持续时间与速率的基本上连续单调递减的功能。这些技术改进了心律失常检测或分类的特异性，允许抗特发性心律失常治疗更适合特定的快速性心律失常，或提供更自动的操作，使得医生更容易使用可植入装置。

7. 发明授权

US08255053B2 Method and apparatus for question-based programming of cardiac rhythm management devices 有权
标题翻译：用于心律管理装置的基于问题的编程的方法和装置
公开(公告)号：US08255053B2
公开(公告)日：2012-08-28
申请号：US12724974
申请日：2010-03-16
申请人： James O. Gilkerson , Richard Milon Dujmovic, Jr.
发明人： James O. Gilkerson , Richard Milon Dujmovic, Jr.
IPC分类号： A61N1/00
CPC分类号： G06F19/3418 , A61N1/37247 , G06F19/00 , G16H10/20
摘要： A cardiac rhythm management (CRM) system includes a programming device that identifies the device type of an implantable medical device, selects a predetermined questioning sequence based on the device type, and interacts with a user through a user interface screen by conducting a question-and-answer session according to the predetermined questioning sequence. After displaying a question and receiving an answer to the question, the programming device sets one or more programmable parameter values and/or displays a follow-up question in response to the answer. The programming device also allows the user to enter one or more programmable parameter values directly during or after the question-and-answer session. The implantable medical device is programmed to operate in one or more operational modes based on at least the answers received from the user during the question-and-answer session and the parameter values entered by the user, if any.
摘要翻译：心律管理（CRM）系统包括识别植入式医疗装置的装置类型的编程装置，基于装置类型选择预定的询问序列，并通过用户界面屏幕通过进行问题与用户交互， - 根据预定的询问序列进行会话。在显示问题并接收到该问题的答案之后，程序设备响应于该答案设置一个或多个可编程参数值和/或显示后续问题。编程设备还允许用户在询问和答复会话期间或之后直接输入一个或多个可编程参数值。可植入医疗设备被编程为至少基于在问答环境期间从用户接收的答案以及由用户输入的参数值（如果有的话）以一种或多种操作模式操作。

8. 发明授权

US07643877B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US07643877B2
公开(公告)日：2010-01-05
申请号：US11061315
申请日：2005-02-18
申请人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/08 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

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