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1. 发明申请

US20050043272A1 Compositions and methods for hydrophobic drug delivery 审中-公开
标题翻译：疏水药物递送的组合物和方法
公开(公告)号：US20050043272A1
公开(公告)日：2005-02-24
申请号：US10889555
申请日：2004-07-12
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K20060101 , A61K9/00 , A61K31/715
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/1075
摘要： Disclosed herein are compositions and methods for the delivery and targeting of therapeutics using nanometer sized polysaccharide structures. The methods and compositions described herein afford improved efficacy for pharmaceuticals such as anti-tumor drugs on metastatic tumor. The methods described herein are applicable to all chemotherapeutic agents and are especially useful for poorly soluble (hydrophobic) drugs which when formulated with the present compositions render them deliverable in physiological fluids. The methods and compositions described herein also improve the efficacy of pharmaceutical agents by targeting carbohydrate receptors specific to tumors that mediate endocytosis or enhance delivery of the drug to the ultimate site of action.
摘要翻译：本文公开了使用纳米尺寸多糖结构递送和靶向治疗剂的组合物和方法。本文所述的方法和组合物提供药物（例如抗肿瘤药物）对转移性肿瘤的功效。本文描述的方法适用于所有化学治疗剂，并且特别适用于当与本发明组合物配制使其能够在生理流体中递送时的难溶性（疏水性）药物。本文所述的方法和组合物还通过靶向调节内吞作用的肿瘤特异性的碳水化合物受体或增强药物到最终作用位点而提高药剂的功效。

2. 发明申请

US20080107622A1 GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES 有权
标题翻译：胶体聚合多糖在抗菌药物治疗中的应用
公开(公告)号：US20080107622A1
公开(公告)日：2008-05-08
申请号：US11749728
申请日：2007-11-13
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/715 , A61K38/20 , A61K38/21 , A61K31/727 , A61P17/00 , A61K31/716 , A61K39/395
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.
摘要翻译：提供了用于减少纤维化和肝硬化的方法和组合物，其中有效剂量的多糖化合物和例如选自细胞内或细胞表面特异性抗体的化合物的混合物：（i）β-PDGF 受体; （ii）突触素; （iii）zvegf3; （iv）CCR1受体; （v）结缔组织生长因子; （vi）α1-平滑肌肌动蛋白; （vii）基质金属蛋白酶MMP2和MMP9; （viii）基质金属蛋白酶抑制剂TIMP1和TMP2; （ix）整合素; （x）TFG-β1; （xi）内皮素受体拮抗剂; 和（xii）胶原合成和降解调节化合物; （xiii）肌动蛋白合成和降解调节化合物; 并且（xiv）酪氨酸激酶被施用于动物以便治疗纤维化。

3. 发明申请

US20120157407A1 GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES 有权
公开(公告)号：US20120157407A1
公开(公告)日：2012-06-21
申请号：US13333497
申请日：2011-12-21
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/736 , A61P9/12 , A61P25/00 , A61P1/16
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.

4. 发明申请

US20080207516A1 CO-ADMINISTRATION OF A POLYSACCHARIDE WITH A CHEMOTHERAPEUTIC AGENT FOR THE TREATMENT OF CANCER 有权
标题翻译：多氯联苯与治疗癌症治疗药物的联合给药
公开(公告)号：US20080207516A1
公开(公告)日：2008-08-28
申请号：US12036608
申请日：2008-02-25
申请人： David Platt , Anatole Klyosov , Eliezer Zomer
发明人： David Platt , Anatole Klyosov , Eliezer Zomer
IPC分类号： A61K38/19 , A61K31/513 , A61P35/04 , A61K31/519
CPC分类号： A61K9/0019 , A61K31/4965 , A61K31/519 , A61K33/24 , A61K38/2013 , A61K38/208 , A61K38/212 , A61K45/06 , A61K47/36 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating diseases such as cancer. The compositions comprise one or more polysaccharides in an admixture with one or more therapeutic agents. This admixture can be administered to a subject in need thereof using any known method of administration. The therapeutic agent, if administered alone, can cause undesirable side-effects in the subject. The polysaccharide component minimizes or eliminates these side effects. The compositions described herein effectuate an enhanced therapeutic effect along with reduced toxicity.
摘要翻译：本文公开了用于治疗诸如癌症的疾病的组合物和方法。组合物包含与一种或多种治疗剂混合的一种或多种多糖。可以使用任何已知的施用方法将该混合物施用于有需要的受试者。治疗剂，如果单独施用，可能在受试者中引起不期望的副作用。多糖组分最小化或消除了这些副作用。本文所述的组合物实现了增强的治疗效果以及毒性的降低。

5. 发明申请

US20050239743A1 Compositions and methods to inhibit restenosis 审中-公开
标题翻译：抑制再狭窄的组合物和方法
公开(公告)号：US20050239743A1
公开(公告)日：2005-10-27
申请号：US11103310
申请日：2005-04-11
申请人： Eliezer Zomer , David Platt , Anatole Klyosov
发明人： Eliezer Zomer , David Platt , Anatole Klyosov
IPC分类号： A61K31/4745 , A61K31/7072 , A61K31/7076 , A61K31/736 , A61K38/09 , A61K38/16 , A61K38/21
CPC分类号： A61K31/736 , A61K31/4745 , A61K31/7072 , A61K31/7076 , A61K38/09 , A61K38/212 , A61K2300/00
摘要： Disclosed herein are compositions and methods comprising a polysaccharide in combination with a pharmaceutical agent wherein the composition can be used to prevent restenosis.
摘要翻译：本文公开了包含与药物组合的多糖的组合物和方法，其中该组合物可用于预防再狭窄。

6. 发明申请

US20070258969A1 Compositions and methods for targeting metastatic tumors using multivalent ligand-linked carbohydrate polymers 审中-公开
标题翻译：使用多价配体连接的碳水化合物聚合物靶向转移性肿瘤的组合物和方法
公开(公告)号：US20070258969A1
公开(公告)日：2007-11-08
申请号：US10557120
申请日：2005-03-18
申请人： Eliezer Zomer , Anatole Klyosov , David Platt
发明人： Eliezer Zomer , Anatole Klyosov , David Platt
IPC分类号： A61K38/46 , A61K31/7072 , A61K31/704 , A61K31/7056 , A61K31/7048 , A61K31/737
CPC分类号： A61K38/21 , A61K31/70 , A61K38/09 , A61K38/191 , A61K47/61
摘要： Disclosed herein are compositions comprising a drug linked to a multivalent ligand polysaccharide and the use of this composition in the prevention and treatment of cancer. In one aspect, the polysaccharide is obtained by physical and chemical treatment of naturally occurring polymers or semi synthetic polymers which are bridged specifically with one or more anti-cancer chemotherapeutic agents. Another aspect is directed to the effective delivery of the polysaccharide together with the chemotherapeutic agent to diseased tissue including cancerous tissue.
摘要翻译：本文公开了包含与多价配体多糖连接的药物的组合物，以及该组合物在预防和治疗癌症中的用途。一方面，多糖通过物理和化学处理与一种或多种抗癌化学治疗剂特异性桥接的天然存在的聚合物或半合成聚合物获得。另一方面涉及将多糖与化学治疗剂一起有效递送到包括癌组织在内的病变组织。

7. 发明授权

US08722645B2 Galactose-pronged polysaccharides in a formulation for antifibrotic therapies 有权
标题翻译：用于抗纤维化治疗的制剂中的半乳糖多糖
公开(公告)号：US08722645B2
公开(公告)日：2014-05-13
申请号：US13550962
申请日：2012-07-17
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： C08B37/06 , A61K31/732 , C08B37/00
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.
摘要翻译：提供了用于减少纤维化和肝硬化的方法和组合物，其中有效剂量的多糖化合物和例如选自细胞内或细胞表面特异性抗体的化合物的混合物：（i）β-PDGF 受体; （ii）突触素; （iii）zvegf3; （iv）CCR1受体; （v）结缔组织生长因子; （vi）α1-平滑肌肌动蛋白; （vii）基质金属蛋白酶MMP2和MMP9; （viii）基质金属蛋白酶抑制剂TIMP1和TMP2; （ix）整合素; （x）TFG-＆bgr; 1; （xi）内皮素受体拮抗剂; 和（xii）胶原合成和降解调节化合物; （xiii）肌动蛋白合成和降解调节化合物; 并且（xiv）酪氨酸激酶被施用于动物以便治疗纤维化。

8. 发明授权

US08367638B2 Galactose-pronged polysaccharides in a formulation for antifibrotic therapies 有权
公开(公告)号：US08367638B2
公开(公告)日：2013-02-05
申请号：US13333497
申请日：2011-12-21
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/736 , C08B37/00
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.

9. 发明申请

US20120282220A1 GALACTOSE-PRONGED POLYSACCHARIDES IN A FORMULATION FOR ANTIFIBROTIC THERAPIES 有权
标题翻译：胶体聚合多糖在抗菌药物治疗中的应用
公开(公告)号：US20120282220A1
公开(公告)日：2012-11-08
申请号：US13550962
申请日：2012-07-17
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/715 , A61K31/737 , A61K38/21 , A61P1/16 , A61K39/395 , A61K38/20
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-β1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.
摘要翻译：提供了用于减少纤维化和肝硬化的方法和组合物，其中有效剂量的多糖化合物和例如选自细胞内或细胞表面特异性抗体的化合物的混合物：（i）β-PDGF 受体; （ii）突触素; （iii）zvegf3; （iv）CCR1受体; （v）结缔组织生长因子; （vi）α1-平滑肌肌动蛋白; （vii）基质金属蛋白酶MMP2和MMP9; （viii）基质金属蛋白酶抑制剂TIMP1和TMP2; （ix）整合素; （x）TFG-＆bgr; 1; （xi）内皮素受体拮抗剂; 和（xii）胶原合成和降解调节化合物; （xiii）肌动蛋白合成和降解调节化合物; 并且（xiv）酪氨酸激酶被施用于动物以便治疗纤维化。

10. 发明授权

US08236780B2 Galactose—pronged polysaccharides in a formulation for antifibrotic therapies 有权
标题翻译：用于抗纤维化治疗的制剂中的半乳糖多糖
公开(公告)号：US08236780B2
公开(公告)日：2012-08-07
申请号：US11749728
申请日：2007-05-16
申请人： David Platt , Eliezer Zomer , Anatole Klyosov
发明人： David Platt , Eliezer Zomer , Anatole Klyosov
IPC分类号： A61K31/732 , C08B37/06 , C12P19/04
CPC分类号： A61K31/732 , A61K31/715 , A61K39/395 , A61K45/06 , C08B37/0045 , C08B37/006 , A61K2300/00
摘要： Methods and compositions for reducing fibrosis are provided, wherein an admixture of at least a galactose-pronged polymer and a pharmaceutically acceptable carrier is obtained and administered, wherein the administration of a sufficient amount of the admixture is measured by a quantitative change in a fibrosis tissue marker.
摘要翻译：提供了用于减少纤维化的方法和组合物，其中获得并施用至少半乳糖注射的聚合物和药学上可接受的载体的混合物，其中通过纤维化组织的定量变化来测量足量的混合物的施用标记。

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