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1. 发明授权

US10973662B2 Methods and devices for heart valve repair 有权
公开(公告)号：US10973662B2
公开(公告)日：2021-04-13
申请号：US17073052
申请日：2020-10-16
申请人： Elixir Medical Corporation
发明人： Motasim Sirhan , Vinayak Bhat , Joseph Paraschac , Benjamyn Serna , John Yan
IPC分类号： A61F2/24 , A61F2/89 , A61F2/90 , A61F2/915 , A61F2/07 , A61F2/82
摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

2. 发明申请

US20200146854A1 METHODS AND DEVICES FOR HEART VALVE REPAIR 审中-公开
公开(公告)号：US20200146854A1
公开(公告)日：2020-05-14
申请号：US16740172
申请日：2020-01-10
申请人： Elixir Medical Corporation
发明人： Motasim Sirhan , Vinayak Bhat , Joseph Paraschac , Benjamyn Serna , John Yan , Brett Cryer
IPC分类号： A61F2/89 , A61F2/90 , A61F2/915
摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

3. 发明授权

US10383750B1 Uncaging stent 有权
公开(公告)号：US10383750B1
公开(公告)日：2019-08-20
申请号：US16356933
申请日：2019-03-18
申请人： Elixir Medical Corporation
发明人： Motasim Sirhan , John Yan , Vinayak Bhat , Joseph Paraschac , Brett Cryer , Benjamyn Serna
IPC分类号： A61F2/89 , A61F2/915 , A61F2/90 , A61F2/07 , A61F2/24 , A61F2/82
摘要： A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

4. 发明授权

US10350093B2 Degradable implantable medical devices 有权
公开(公告)号：US10350093B2
公开(公告)日：2019-07-16
申请号：US14998288
申请日：2015-12-23
申请人： Elixir Medical Corporation
发明人： John Yan , Motasim Sirhan , Brett Cryer , Vinayak Bhat
IPC分类号： A61F2/82 , A61F2/02 , A61F2/06 , A61F2/07 , B23K26/00 , B23K26/40 , B23K26/0622 , B23K26/382 , B23K26/352 , A61F2/90 , B23K101/06 , B23K103/02 , B23K103/12 , B23K103/00
摘要： Devices and methods are provided for an implantable medical device which is degradable over a clinically relevant period of time. The medical devices may have the form of implants, graft implants, vascular implants, non vascular implants, wound closure implants, sutures, drug delivery implants, biologic delivery implants, urinary tract implants, inter-uterine implants, organ implants, bone implants including bone plates, bone screws, dental implants, spinal disks, or the like. In preferred embodiments, the implantable medical device comprises an implantable luminal prosthesis, such as vascular and non-vascular stents and stents grafts.

5. 发明申请

US20190070334A1 LUMINAL PROSTHESES AND METHODS FOR COATING THEREOF 审中-公开
公开(公告)号：US20190070334A1
公开(公告)日：2019-03-07
申请号：US15910779
申请日：2018-03-02
申请人： Elixir Medical Corporation
发明人： John Yan , Howard Huang , Vinayak D. Bhat
IPC分类号： A61L27/34 , A61L29/16 , A61L29/08
摘要： Luminal prostheses comprise scaffolds having coatings adhered to at least a portion of their outer surfaces. The surfaces are modified to enhance binding of the coatings. For example, the surfaces may be microblasted, laser treated, chemically etched, exposed to plasma, or exposed to a corona discharge, allowing a polymeric coating to adhere to the scaffold more tightly than in the absence of the surface modification. The coatings can be used to deliver therapeutic or other agents dispersed therein.

6. 发明申请

US20170156899A1 BIODEGRADABLE ENDOPROSTHESES AND METHODS FOR THEIR FABRICATION 审中-公开
公开(公告)号：US20170156899A1
公开(公告)日：2017-06-08
申请号：US15420615
申请日：2017-01-31
申请人： Elixir Medical Corporation
发明人： Xiaoxia Zheng , John Yan , Vinayak Bhat
IPC分类号： A61F2/915 , A61L31/06 , A61L31/14
CPC分类号： A61F2/915 , A61F2/82 , A61F2/90 , A61F2/91 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2230/0013 , A61F2230/0069 , A61F2240/001 , A61F2250/0073 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , B33Y80/00 , C08L67/04
摘要： The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.

7. 发明申请

US20160045344A1 BIODEGRADABLE ENDOPROSTHESES AND METHODS OF THEIR FABRICATION 有权
公开(公告)号：US20160045344A1
公开(公告)日：2016-02-18
申请号：US14800536
申请日：2015-07-15
申请人： Elixir Medical Corporation
发明人： John Yan , Vinayak Bhat
IPC分类号： A61F2/915 , A61F2/89 , A61F2/844
CPC分类号： A61F2/915 , A61F2/89 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2210/0014 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/0069 , A61F2250/0036 , A61F2250/0067
摘要： A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

8. 发明申请

US20150352089A1 MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE 审中-公开
标题翻译： MACROCYCLIC LACTONE化合物及其使用方法
公开(公告)号：US20150352089A1
公开(公告)日：2015-12-10
申请号：US14831747
申请日：2015-08-20
申请人： Elixir Medical Corporation
发明人： John Yan , Xiaoxia Zheng , Vinayak D. Bhat
IPC分类号： A61K31/439 , A61K45/06 , A61K9/00
CPC分类号： A61K31/436 , A61K9/0004 , A61K31/439 , A61K31/4525 , A61K45/06
摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites N-oxides and prodrugs thereof.
摘要翻译：本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R1，R2，R3，R5，R6，R8，M1，M2，M3，M4，M5，M6和M7各自独立地为成员选自H，C 1-6烷基，OH和C 1-6羟基烷基; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中下标n和m各自独立地为2至8，下标o为1至6; L1和L4各自独立地选自：其中每个M8独立地是选自C 1-6烷基，OH和C 1-6羟基烷基的成员; L2和L3中的每一个独立地选自：盐，水合物，异构体，代谢物N-氧化物和前药。

9. 发明授权

US08814930B2 Biodegradable endoprosthesis and methods for their fabrication 有权
标题翻译：可生物降解内置假体及其制造方法
公开(公告)号：US08814930B2
公开(公告)日：2014-08-26
申请号：US13897302
申请日：2013-05-17
申请人： Elixir Medical Corporation
发明人： Xiaoxia Zheng , John Yan , Vinayak Bhat
IPC分类号： A61F2/06 , A61F2/91 , A61F2/82
CPC分类号： A61F2/915 , A61F2/82 , A61F2/90 , A61F2/91 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2230/0013 , A61F2230/0069 , A61F2240/001 , A61F2250/0073 , A61L31/048 , A61L31/06 , A61L31/14 , A61L31/148 , B33Y80/00 , C08L67/04
摘要： The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.
摘要翻译：本公开提供了可生物降解的可植入装置，例如包括可生物降解聚合物的支架，其中处理聚合物材料以控制结晶度和/或Tg。支架能够在体腔中的体温从卷曲构型扩展到展开的直径，并且具有足够的强度来支撑体腔。

10. 发明申请

US20210186722A1 METHODS AND DEVICES FOR HEART VALVE REPAIR 有权
公开(公告)号：US20210186722A1
公开(公告)日：2021-06-24
申请号：US17195478
申请日：2021-03-08
申请人： Elixir Medical Corporation
发明人： Motasim Sirhan , Vinayak Bhat , Joseph Paraschac , Benjamyn Serna , John Yan
IPC分类号： A61F2/89 , A61F2/915 , A61F2/90 , A61F2/24
摘要： A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.

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