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1. 发明申请

US20120035094A1 F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS 有权
标题翻译： F11受体（F11R）作为治疗药物的拮抗剂
公开(公告)号：US20120035094A1
公开(公告)日：2012-02-09
申请号：US13156883
申请日：2011-06-09
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： A61K38/17 , C07K7/06 , A61P25/00 , A61P7/02 , A61P9/10 , A61P9/04 , C07K7/08 , C07K14/435
CPC分类号： C07K14/00 , A61K38/00 , C07K5/10 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/70503
摘要： The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.
摘要翻译：本发明提供了一种化合物，其包括与F11R分子的结合位点空间相互作用的拟肽，所述拟肽包括具有SEQ ID NO：4D的拟肽。本发明还提供了治疗病症的方法，包括向哺乳动物施用肽4D。

2. 发明授权

US09556235B2 F11 receptor (F11R) antagonists as therapeutic agents 有权
标题翻译： F11受体（F11R）拮抗剂作为治疗剂
公开(公告)号：US09556235B2
公开(公告)日：2017-01-31
申请号：US14052147
申请日：2013-10-11
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich , Moro Salifu
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich , Moro Salifu
IPC分类号： C07K14/00 , C07K14/705 , C07K7/06 , C07K7/08 , C07K7/02 , C07K5/10 , A61K38/00
CPC分类号： C07K14/00 , A61K38/00 , C07K5/10 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/70503
摘要： The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.
摘要翻译：本发明提供了一种化合物，其包括与F11R分子的结合位点空间相互作用的拟肽，所述拟肽包括具有SEQ ID NO：4D的拟肽。本发明还提供了治疗病症的方法，包括向哺乳动物施用肽4D。

3. 发明授权

US10537610B1 Peptide for inhibition of cancer 有权
公开(公告)号：US10537610B1
公开(公告)日：2020-01-21
申请号：US16169118
申请日：2018-10-24
申请人： Anna Babinska , Radoslaw Bednarek , Elizabeth Kornecki , Moro O. Salifu , Yigal H. Ehrlich , Maria Swiatkowska , Cristina C. Clement
发明人： Anna Babinska , Radoslaw Bednarek , Elizabeth Kornecki , Moro O. Salifu , Yigal H. Ehrlich , Maria Swiatkowska , Cristina C. Clement
IPC分类号： A61K38/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K14/00 , C07K5/10 , C07K7/02 , C07K7/06 , C07K7/08 , A61K38/17 , A61P35/00
摘要： Methods for treating breast cancer, the methods can include administering to a subject an effective amount of a cell adhesion molecule Receptor (F11R peptide).

4. 发明申请

US20090170779A1 F11 Receptor (F11R) Antagonists as Therapeutic Agents 有权
标题翻译： F11受体（F11R）拮抗剂作为治疗剂
公开(公告)号：US20090170779A1
公开(公告)日：2009-07-02
申请号：US12141635
申请日：2008-06-18
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： A61K38/16 , C07K14/435 , C07K7/08 , A61K38/10
CPC分类号： C07K14/705 , A61K38/1709 , C07K14/70503
摘要： The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.
摘要翻译：本发明提供了称为F11受体（F11R）的细胞粘附分子（CAM），其是位于人血小板表面上的免疫球蛋白超家族的成员，并且被确定为影响血小板聚集，分泌，血小板扩散和细胞粘附。提供克隆的F11R cDNA和全长F11R cDNA和氨基酸序列。还提供了用于预防和治疗血栓形成，动脉粥样硬化，心脏病发作，中风和涉及血栓形成的其他临床病症的F11R-拮抗剂和方法。

5. 发明授权

US07829663B2 F11 receptor (F11R) antagonists as therapeutic agents 有权
标题翻译： F11受体（F11R）拮抗剂作为治疗剂
公开(公告)号：US07829663B2
公开(公告)日：2010-11-09
申请号：US12141635
申请日：2008-06-18
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： A61K38/00 , A61K38/16 , A61K38/10 , A61K39/00
CPC分类号： C07K14/705 , A61K38/1709 , C07K14/70503
摘要： The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.
摘要翻译：本发明提供了称为F11受体（F11R）的细胞粘附分子（CAM），其是位于人血小板表面上的免疫球蛋白超家族的成员，并且被确定为影响血小板聚集，分泌，血小板扩散和细胞粘附。提供克隆的F11R cDNA和全长F11R cDNA和氨基酸序列。还提供了用于预防和治疗血栓形成，动脉粥样硬化，心脏病发作，中风和涉及血栓形成的其他临床病症的F11R-拮抗剂和方法。

6. 发明申请

US20140155576A1 F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS 审中-公开
标题翻译： F11受体（F11R）作为治疗药物的拮抗剂
公开(公告)号：US20140155576A1
公开(公告)日：2014-06-05
申请号：US14052147
申请日：2013-10-11
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： C07K14/00 , C07K7/06 , C07K5/10 , C07K7/08
CPC分类号： C07K14/00 , A61K38/00 , C07K5/10 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/70503
摘要： The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.
摘要翻译：本发明提供了一种化合物，其包括与F11R分子的结合位点空间相互作用的拟肽，所述拟肽包括具有SEQ ID NO：4D的拟肽。本发明还提供了治疗病症的方法，包括向哺乳动物施用肽4D。

7. 发明授权

US08557957B2 Methods of treating disorders by administration of F11 receptor antagonists 有权
标题翻译：通过施用F11受体拮抗剂治疗病症的方法
公开(公告)号：US08557957B2
公开(公告)日：2013-10-15
申请号：US13156883
申请日：2011-06-09
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： A61K38/04 , A61K39/00 , C07K7/08
CPC分类号： C07K14/00 , A61K38/00 , C07K5/10 , C07K7/02 , C07K7/06 , C07K7/08 , C07K14/70503
摘要： The present invention provides a compound including a peptidomimetic which interacts sterically with the binding site of a F11R molecule, the peptidomimetic including a peptidomimetic having the SEQ ID NO: 4D. The present invention also provides a method for treating a disorder comprising administering peptide 4D to a mammal.
摘要翻译：本发明提供了一种化合物，其包括与F11R分子的结合位点空间相互作用的拟肽，所述拟肽包括具有SEQ ID NO：4D的拟肽。本发明还提供了治疗病症的方法，其包括向哺乳动物施用肽4D。

8. 发明申请

US20090202538A1 F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS 审中-公开
标题翻译： F11受体（F11R）作为治疗药物的拮抗剂
公开(公告)号：US20090202538A1
公开(公告)日：2009-08-13
申请号：US12358352
申请日：2009-01-23
申请人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal H. Ehrlich
IPC分类号： A61K39/395 , C07K14/00 , C07K16/18 , A61K38/16 , A61P7/04
CPC分类号： C07K14/70503 , A61K38/00 , C07K16/2803 , C07K2317/76
摘要： The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R) and its use to inhibit platelet aggregation and platelet adhesion for the treatment and prevention of cardiovascular disorders. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided. There are at least two kinds of antagonists that may be employed together. Peptides derived from the extracellular domain of F11R and small molecules and peptidomimetics based on the structure of these peptides, as well as inhibitory antibodies and functional fragments thereof, are shown to inhibit human platelet aggregation and platelet adhesion to endothelial cells, and therefore, inhibit the formation of atherosclerotic plaques.
摘要翻译：本发明提供了称为F11受体（F11R）的细胞粘附分子（CAM）及其用于抑制血小板聚集和血小板粘附用于治疗和预防心血管疾病的用途。提供克隆的F11R cDNA和全长F11R cDNA和氨基酸序列。还提供了用于预防和治疗血栓形成，动脉粥样硬化，心脏病发作，中风和涉及血栓形成的其他临床病症的F11R-拮抗剂和方法。至少有两种可以一起使用的拮抗剂。来自F11R的细胞外结构域的肽和基于这些肽的结构的小分子和肽模拟物以及抑制性抗体及其功能片段显示出抑制人血小板聚集和血小板粘附于内皮细胞，因此抑制形成动脉粥样硬化斑块。

9. 发明申请

US20050265992A1 F11 receptor (F11R) antagonists as therapeutic agents 审中-公开
标题翻译： F11受体（F11R）拮抗剂作为治疗剂
公开(公告)号：US20050265992A1
公开(公告)日：2005-12-01
申请号：US11173037
申请日：2005-07-01
申请人： Elizabeth Kornecki , Anna Babinska , Yigal Ehrlich
发明人： Elizabeth Kornecki , Anna Babinska , Yigal Ehrlich
IPC分类号： A61K38/17 , A61K39/395 , C07K14/705
CPC分类号： C07K14/705 , A61K38/1709 , C07K14/70503
摘要： The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.
摘要翻译：本发明提供了称为F11受体（F11R）的细胞粘附分子（CAM），其是位于人血小板表面上的免疫球蛋白超家族的成员，并且被确定为影响血小板聚集，分泌，血小板扩散和细胞粘附。还提供了用于预防和治疗血栓形成，动脉粥样硬化，心脏病发作，中风和涉及血栓形成的其他临床病症的F11R-拮抗剂和方法。

10. 发明授权

US06699688B1 Human platelet F11 receptor 失效
标题翻译：人血小板F11受体
公开(公告)号：US06699688B1
公开(公告)日：2004-03-02
申请号：US09397243
申请日：1999-09-16
申请人： Elizabeth Kornecki , Malgorzata B. Sobocka
发明人： Elizabeth Kornecki , Malgorzata B. Sobocka
IPC分类号： C07K100
CPC分类号： G01N33/566 , C07H21/04 , C07K14/705 , G01N2500/00
摘要： The present invention is directed to isolated nucleic acid molecules encoding human platelet F11 receptors. Expression vectors and host cells comprising the nucleic acid molecules are also provided, as well as methods for increasing or decreasing the expression of the human platelet F11 receptor in host cells. The invention further provides a method of screening a substance for the ability of the substance to modify human platelet F11 receptor function, and a method for isolating other human platelet F11 receptor molecules. DNA oligomers capable of hybridizing to the nucleic acid molecule encoding the human platelet F11 receptor are provided, which can be used to detect human platelet F11 receptor in a sample.
摘要翻译：本发明涉及编码人血小板F11受体的分离的核酸分子。还提供了包含核酸分子的表达载体和宿主细胞，以及用于增加或降低宿主细胞中人血小板F11受体表达的方法。本发明还提供了筛选物质改变人血小板F11受体功能的能力的方法，以及分离其他人血小板F11受体分子的方法。提供能够与编码人血小板F11受体的核酸分子杂交的DNA寡聚体，其可用于检测样品中的人血小板F11受体。

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