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1. 发明授权

US09956106B2 Gastrointestinal device with associated commensal microbes 有权
公开(公告)号：US09956106B2
公开(公告)日：2018-05-01
申请号：US14471200
申请日：2014-08-28
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , William David Duncan , Roderick A. Hyde , Wayne R. Kindsvogel , Elizabeth A. Sweeney
IPC分类号： A61M5/00 , A61F5/00 , A61F2/04 , A61L27/54 , A61L29/14 , A61L29/16 , A61K35/741 , A61L29/08 , A61L31/00 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61K38/16 , A61K35/745 , A61K35/747 , A61K35/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F2002/045 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K35/74 , A61K35/741 , A61K35/745 , A61K35/747 , A61K38/168 , A61K2035/115 , A61L27/54 , A61L29/08 , A61L29/148 , A61L29/16 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/604 , A61L2300/62 , A61L2420/02 , A61L2420/06
摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including a layered wall, the flexible tubular structure including a plurality of at least one type of commensal microbe encased in the layered wall, the layered wall configured to allow an interaction between the plurality of the at least one type of commensal microbe and an ingested product within the flexible tubular structure, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

2. 发明申请

US20170238488A1 RAPID BREEDING OF PLANTS 审中-公开
公开(公告)号：US20170238488A1
公开(公告)日：2017-08-24
申请号：US15590259
申请日：2017-05-09
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , Philip A. Eckhoff , Roderick A. Hyde , Edward K. Y. Jung , Wayne R. Kindsvogel , Lowell L. Wood, JR.
IPC分类号： A01H4/00 , C12Q1/68 , A01H1/02 , C12N5/00 , A01H5/10
CPC分类号： A01H4/001 , A01H1/02 , A01H1/025 , A01H1/04 , A01H1/08 , A01H4/00 , A01H5/10 , C12N5/0025 , C12Q1/6895 , G16C99/00
摘要： Various embodiments disclosed herein include systems, methods, compositions, and products by process for Rapid-breeding of plants. In certain embodiments, the systems and/or methods are at least partially automated.

3. 发明授权

US09717618B2 Gastrointestinal device with associated commensal microbes 有权
公开(公告)号：US09717618B2
公开(公告)日：2017-08-01
申请号：US14471169
申请日：2014-08-28
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , William David Duncan , Roderick A. Hyde , Wayne R. Kindsvogel , Elizabeth A. Sweeney
IPC分类号： A61B19/00 , A61F5/00 , A61F2/04 , A61L27/54 , A61L29/14 , A61L29/16 , A61K35/741 , A61L29/08 , A61L31/00 , A61L31/04 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/16 , A61K38/16 , A61K35/745 , A61K35/747 , A61K35/00
CPC分类号： A61F5/0076 , A61F2/04 , A61F2002/045 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K35/74 , A61K35/741 , A61K35/745 , A61K35/747 , A61K38/168 , A61K2035/115 , A61L27/54 , A61L29/08 , A61L29/148 , A61L29/16 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/604 , A61L2300/62 , A61L2420/02 , A61L2420/06
摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.

4. 发明授权

US09662354B2 Compositions, methods, and computer systems related to making and administering modified T cells 有权
公开(公告)号：US09662354B2
公开(公告)日：2017-05-30
申请号：US15290043
申请日：2016-10-11
申请人： Elwha LLC
发明人： Roderick A. Hyde , Wayne R. Kindsvogel , Gary L. McKnight
IPC分类号： A61K35/26 , C12N5/22 , A61K35/17 , C12Q1/68 , C12N5/0783 , A61K35/12
CPC分类号： A61K35/17 , A61K2035/124 , C12N5/0636 , C12N2510/00 , C12Q1/68 , C12Q1/6883 , C12Q2600/158
摘要： Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.

5. 发明授权

US09649185B2 Adjuncts for gastrointestinal devices 有权
公开(公告)号：US09649185B2
公开(公告)日：2017-05-16
申请号：US14533400
申请日：2014-11-05
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , William David Duncan , Roderick A. Hyde , Wayne R. Kindsvogel , Elizabeth A. Sweeney
IPC分类号： A61M5/00 , A61F2/04 , A61L29/16 , A61L29/14 , A61K45/06 , A61K9/00 , A61F5/00 , A61K9/70 , A61K35/74 , A61K47/34 , A61F2/82
CPC分类号： A61F2/04 , A61F2/82 , A61F5/0036 , A61F5/0076 , A61F2002/045 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K9/0092 , A61K9/7023 , A61K35/74 , A61K45/06 , A61K47/34 , A61L29/148 , A61L29/16 , A61L2300/30 , A61L2300/64
摘要： An adjunct for a gastrointestinal device and a system including said adjunct are described herein and include a substrate configured to attach to a gastrointestinal device, the substrate including a first surface and a second surface, and a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the first surface and the second surface of the substrate.

6. 发明授权

US09512213B2 Compositions and methods including recombinant B lymphocyte cell line including an exogenously incorporated nucleic acid expressing an exogenous membrane immunoglobulin reactive to a first antigen and including an endogenous gene expressing an endogenous secreted immunoglobulin reactive to a second antigen 有权
公开(公告)号：US09512213B2
公开(公告)日：2016-12-06
申请号：US14549685
申请日：2014-11-21
申请人： Elwha LLC
发明人： Roderick A. Hyde , Wayne R. Kindsvogel
IPC分类号： A61K35/12 , A01N63/00 , C07K16/18 , A61K39/00 , C12N5/0781 , C07K16/00 , C07K16/10 , C07K16/12 , C07K16/30 , C07K16/44 , G01N33/68
CPC分类号： C07K16/18 , A61K39/00 , A61K2039/505 , A61K2039/5156 , C07K16/00 , C07K16/1018 , C07K16/109 , C07K16/1271 , C07K16/3069 , C07K16/44 , C07K2317/14 , C07K2317/76 , C12N5/0635 , C12N2510/00 , G01N33/6854
摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen.

7. 发明申请

US20160058803A1 ADJUNCTS FOR GASTROINTESTINAL DEVICES 审中-公开
标题翻译：胃肠外科手术
公开(公告)号：US20160058803A1
公开(公告)日：2016-03-03
申请号：US14533425
申请日：2014-11-05
申请人： Elwha LLC
发明人： Mahalaxmi Gita Bangera , William David Duncan , Roderick A. Hyde , Wayne R. Kindsvogel , Elizabeth A. Sweeney
IPC分类号： A61K35/74 , A61K9/00 , A61F5/00 , A61K45/06
CPC分类号： A61F2/04 , A61F2/82 , A61F5/0036 , A61F5/0076 , A61F2002/045 , A61F2210/0004 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K9/0092 , A61K9/7023 , A61K35/74 , A61K45/06 , A61K47/34 , A61L29/148 , A61L29/16 , A61L2300/30 , A61L2300/64
摘要： An adjunct for a gastrointestinal device and a system including said adjunct are described herein and include a substrate configured to attach to a gastrointestinal device, the substrate including a first surface and a second surface, and at least one microbe-promoting agent associated with at least one of the first surface and the second surface of the substrate, the at least one microbe-promoting agent configured to promote at least one of attraction, colonization, and growth of at least one type of commensal microbe.
摘要翻译：本文描述了用于胃肠装置的辅助装置和包括所述辅助装置的系统，并且包括构造成附接到胃肠装置的基底，所述基底包括第一表面和第二表面，以及至少一种与至少相关联的微生物促进剂所述至少一种微生物促进剂被配置为促进至少一种类型的共生微生物的吸引，定殖和生长中的至少一种。

8. 发明申请

US20150294086A1 DEVICES, SYSTEMS, AND METHODS FOR AUTOMATED ENHANCED CARE ROOMS 审中-公开
公开(公告)号：US20150294086A1
公开(公告)日：2015-10-15
申请号：US14252158
申请日：2014-04-14
申请人： Elwha LLC
发明人： Jordin T. Kare , Wayne R. Kindsvogel , Elizabeth A. Sweeney
IPC分类号： G06F19/00
CPC分类号： G06F19/3481 , G16H10/60 , G16H40/20
摘要： Disclosed are various embodiments of systems and methods related to determining beneficial and customized surroundings for a subject in a healthcare setting or related type setting, based at least in part on the subject's personal profile including one or more of personal health information, detected biological data, input from the subject itself, or input from a healthcare worker.

9. 发明申请

US20140271579A1 Compositions, Methods, and Computer Systems Related to Making and Administering Modified T Cells 有权
标题翻译：与制备和管理修饰的T细胞相关的组合物，方法和计算机系统
公开(公告)号：US20140271579A1
公开(公告)日：2014-09-18
申请号：US13804224
申请日：2013-03-14
申请人： ELWHA LLC
发明人： Roderick A. Hyde , Wayne R. Kindsvogel , Gary L. McKnight
IPC分类号： C12N15/10
CPC分类号： C12N15/1037 , C12N15/1093
摘要： Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subject's own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
摘要翻译：本文描述的实施例涉及用于推导T CAR图书馆（通用主题或个人主题）的方法，装置和计算机系统，用于个体化治疗受试者的疾病。在某些实施方案中，利用正常和患病组织表达数据的差异筛选来确定疾病特异性抗原，从而产生对这种抗原反应的T CAR细胞以形成疾病特异性文库。在某些实施方案中，来自疾病特异性文库的最有效的T CAR克隆的测定是基于受试者自己的疾病特异性抗原。在某些实施方案中，用治疗有效量的T CAR克隆治疗受试者。

10. 发明申请

US20190352385A1 Compositions and Methods for Modified B Cells Expressing Reassigned Biological Agents 审中-公开
公开(公告)号：US20190352385A1
公开(公告)日：2019-11-21
申请号：US16523664
申请日：2019-07-26
申请人： Elwha LLC
发明人： Roderick A. Hyde , Wayne R. Kindsvogel , Gary L. McKnight
IPC分类号： C07K16/18 , C07K16/00 , C07K16/10 , G01N33/68 , A61K39/00 , C12N5/0781 , C07K16/44 , C07K16/30 , C07K16/12
摘要： Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin capable of binding to a first antigen and at least one endogenous secreted immunoglobulin capable of binding to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.

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