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1. 发明申请

US20150046191A1 SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开
公开(公告)号：US20150046191A1
公开(公告)日：2015-02-12
申请号：US14463073
申请日：2014-08-19
申请人： FOUNDATION MEDICINE, INC.
发明人： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann , Jeffrey B. Collemer
IPC分类号： G06F19/00
CPC分类号： G16H10/60 , G06F19/3456 , G06Q50/24 , G16C99/00 , G16H15/00
摘要： Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

2. 发明申请

US20150046180A1 SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开
标题翻译：用于管理基因信息的系统和方法
公开(公告)号：US20150046180A1
公开(公告)日：2015-02-12
申请号：US14463068
申请日：2014-08-19
申请人： FOUNDATION MEDICINE, INC.
发明人： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann
IPC分类号： G06F19/00
CPC分类号： G16H50/20 , G06Q50/24 , G16C99/00 , G16H10/60 , G16H15/00
摘要： Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.
摘要翻译：各种实施方案提供了接口以访问基因组测试信息并将其并入日常医师实践中。根据一个方面，使用可用于组织和修改精密医学知识的基于图的数据模型。在一个示例结构中，基因状态被抽象为变更组，其中使用反向工程可操作信息构建变更组，并将该信息存储在基于图的数据结构内。将基因组变化和相关信息（例如，期刊文章，临床试验信息，治疗等）的卷分析并合成为以基于图表的数据格式在变更系统上可见的可操作的信息项。根据一个实施例，系统可以被配置为将从业者聚焦在它们可以作用于其上的变更信息的离散部分上。根据其他方面，在系统上提供了策划的信息，以使从业者就具体基因组改变的存在的含义做出明智的决定。

3. 发明授权

US11450438B2 System and method for outcome tracking and analysis 有权
公开(公告)号：US11450438B2
公开(公告)日：2022-09-20
申请号：US16579496
申请日：2019-09-23
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC分类号： G16H70/60 , G16B30/00 , G16H15/00 , G16H10/60 , G16H10/20 , G16H50/20 , G16H20/10
摘要： A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.

4. 发明申请

US20140337052A1 SYSTEM AND METHOD FOR OUTCOME TRACKING AND ANALYSIS 审中-公开
标题翻译：用于观察跟踪和分析的系统和方法
公开(公告)号：US20140337052A1
公开(公告)日：2014-11-13
申请号：US14146742
申请日：2014-01-03
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC分类号： G06F19/00
CPC分类号： G06F19/3456 , G06F19/32 , G06Q50/24 , G16B30/00 , G16H10/60 , G16H15/00
摘要： Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.
摘要翻译：提供了用于捕获与各种癌症治疗相关的结果信息的系统和方法。该系统有助于捕获和分析癌症治疗信息和相关的结果信息。治疗和结果信息可以包括基因组分析和治疗不同癌症的信息。该系统可以存储和分析以下中的一种或多种：肿瘤类型，基因组改变（例如，基因和相关的改变，基因序列突变，改变，扩增，缺失等）和治疗数据（包括例如靶向治疗到特定基因和/或基因组改变）。结果系统的用户可以提供和使用治疗和结果信息来促进诊断和治疗决策。可以将系统内的用户界面配置为允许用户轻松定位与具有某些基因组改变的肿瘤的特定治疗相关联的结果信息。

5. 发明申请

US20200294668A1 SYSTEM AND METHOD FOR MANAGING GENOMIC TESTING RESULTS 审中-公开
公开(公告)号：US20200294668A1
公开(公告)日：2020-09-17
申请号：US16793405
申请日：2020-02-18
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Philip James Stephens
IPC分类号： G16H50/20 , G16H10/60 , G16B30/00 , G16H15/00
摘要： Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

6. 发明申请

US20200211679A1 SYSTEM AND METHOD FOR OUTCOME TRACKING AND ANALYSIS 审中-公开
公开(公告)号：US20200211679A1
公开(公告)日：2020-07-02
申请号：US16579496
申请日：2019-09-23
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Vincent A. Miller
IPC分类号： G16H10/20 , G16B30/00 , G16H10/60 , G16H15/00
摘要： A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.

7. 发明授权

US11158425B2 System and method for managing genomic information 有权
公开(公告)号：US11158425B2
公开(公告)日：2021-10-26
申请号：US14463068
申请日：2014-08-19
申请人： FOUNDATION MEDICINE, INC.
发明人： Helena Futscher de Deus , Rachel Lauren Erbach , Ronald David Collette , Alexander N. Parker , Michael Pellini , Gary Palmer , Mary Pat Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann
IPC分类号： G16H50/20 , G16H10/60 , G16C99/00 , G16H10/20 , G16H10/40 , G16H70/60 , G16H15/00
摘要： Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge. In one example structure, gene states are abstracted into alteration groups, where alteration groups are built using reverse engineering actionable information and storing that information within the graph-based data structure. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system in a graph-based data format. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.

8. 发明申请

US20200020430A1 SYSTEM AND METHOD FOR MANAGING GENOMIC INFORMATION 审中-公开
公开(公告)号：US20200020430A1
公开(公告)日：2020-01-16
申请号：US16579500
申请日：2019-09-23
申请人： FOUNDATION MEDICINE, INC.
发明人： Helena Futscher de Deus , Rachel Lauren Erlich , Ronald David Collette , Alexander Nevin Parker , Michael Pellini , Gary Palmer , Mary Patricia Lancelotta , Matthew J. Hawryluk , Philip James Stephens , Eric Karl Neumann
IPC分类号： G16H10/60
摘要： A system for managing genomic information includes a processor to collect and store biomarker data, receive and store patient-specific pathology information, generate a graph-based data structure of complex data elements arranged into a walkable graph representation that includes at least one of a disease alteration group association (DAGA) element representing a relationship between a disease and an alteration group (AG), at least one of a disease therapy association (DTA) element representing a relationship between a disease and a therapy for treating the disease, and a therapy genomic effect (TGE) element representing a relationship between a gene and a known effect of a therapy on the gene. The processor follows links in the walkable graph representation to determine at least one inferred path, generates inferential matches to actionable items based on an accumulated trust score of the at least one inferred path, and determines a treatment decision for a cancer patient.

9. 发明申请

US20140336943A1 SYSTEM AND METHOD FOR MANAGING GENOMIC TESTING RESULTS 审中-公开
标题翻译：用于管理基因测试结果的系统和方法
公开(公告)号：US20140336943A1
公开(公告)日：2014-11-13
申请号：US14146743
申请日：2014-01-03
申请人： FOUNDATION MEDICINE, INC.
发明人： Michael Pellini , Gary Palmer , Mary P. Lancelotta , Matthew J. Hawryluk , Philip J. Stephens
IPC分类号： G06F19/00 , G06F19/22
CPC分类号： G06F19/3456 , G06F19/32 , G06Q50/24 , G16B30/00 , G16H10/60 , G16H15/00
摘要： Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications. Volumes of genomic alterations and associated information (e.g., journal articles, clinical trial information, therapies, etc.) are analyzed and synthesized into actionable information items viewable on an alteration system. According to one embodiment, the system can be configured to focus practitioners on discrete portions of the alteration information on which they can act. According to other aspects, curated information is provided on the system to enable practitioners to make informed decisions regarding the implications of the presence of specific genomic alterations.
摘要翻译：各种实施方案提供了接口以访问基因组测试信息并将其并入日常医师实践中。在一些实施方案中，基因组改变数据的呈现被简化和/或与上下文应用相结合。将基因组变化和相关信息（例如，期刊文章，临床试验信息，治疗等）的卷分析并合成为可变更的信息项目。根据一个实施例，系统可以被配置为将从业者聚焦在它们可以作用于其上的变更信息的离散部分上。根据其他方面，在系统上提供了策划的信息，以使从业者就具体基因组改变的存在的含义做出明智的决定。

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