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1. 发明授权

US09381082B2 Devices, systems and methods for accurate positioning of a prosthetic valve 有权
标题翻译：用于精确定位人造瓣膜的装置，系统和方法
公开(公告)号：US09381082B2
公开(公告)日：2016-07-05
申请号：US13432901
申请日：2012-03-28
申请人： Francis G. Duhay , David L. Zollinger
发明人： Francis G. Duhay , David L. Zollinger
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2433 , A61F2/2475 , A61F2230/0054
摘要： The invention is a system and method for accurately positioning a prosthetic valve such as a prosthetic heart valve at a desired position for deployment. The invention includes extendable positioning elements which provide tactile feedback to a user to confirm proper positioning of the catheter with respect to the native valve annulus. During delivery, the extendable positioning elements lie against the catheter, over the prosthetic valve and expandable balloon, providing a low profile for advancing the catheter to the desired treatment location via small passages such as body lumens. Prior to valve deployment, the positioning elements are extended and brought into contact with tissue of the native annulus to confirm the proper positioning of the delivery system and prosthetic valve.
摘要翻译：本发明是一种用于将假体瓣膜（例如假体心脏瓣膜）精确地定位在所需的展开位置的系统和方法。本发明包括可延伸的定位元件，其向使用者提供触觉反馈以确认导管相对于天然瓣膜环的正确定位。在分娩过程中，可延伸的定位元件靠在导管上，穿过人造瓣膜和可膨胀气囊，提供了一个低轮廓，用于通过诸如体腔的小通道将导管推进到期望的治疗位置。在阀部署之前，定位元件被延伸并与天然环的组织接触以确认输送系统和人工瓣膜的适当定位。

2. 发明申请

US20120271411A1 DEVICES, SYSTEMS AND METHODS FOR ACCURATE POSITIONING OF A PROSTHETIC VALVE 有权
标题翻译：用于精确定位预制阀的装置，系统和方法
公开(公告)号：US20120271411A1
公开(公告)日：2012-10-25
申请号：US13432901
申请日：2012-03-28
申请人： Francis G. Duhay , David L. Zollinger
发明人： Francis G. Duhay , David L. Zollinger
IPC分类号： A61F2/24
CPC分类号： A61F2/2436 , A61F2/2418 , A61F2/2433 , A61F2/2475 , A61F2230/0054
摘要： The invention is a system and method for accurately positioning a prosthetic valve such as a prosthetic heart valve at a desired position for deployment. The invention includes extendable positioning elements which provide tactile feedback to a user to confirm proper positioning of the catheter with respect to the native valve annulus. During delivery, the extendable positioning elements lie against the catheter, over the prosthetic valve and expandable balloon, providing a low profile for advancing the catheter to the desired treatment location via small passages such as body lumens. Prior to valve deployment, the positioning elements are extended and brought into contact with tissue of the native annulus to confirm the proper positioning of the delivery system and prosthetic valve.
摘要翻译：本发明是一种用于将假体瓣膜（例如假体心脏瓣膜）精确地定位在所需的展开位置的系统和方法。本发明包括可延伸的定位元件，其向使用者提供触觉反馈以确认导管相对于天然瓣膜环的正确定位。在分娩过程中，可延伸的定位元件靠在导管上，穿过人造瓣膜和可膨胀气囊，提供了一个低轮廓，用于通过诸如体腔的小通道将导管推进到期望的治疗位置。在阀部署之前，定位元件被延伸并与天然环的组织接触以确认输送系统和人工瓣膜的适当定位。

3. 发明授权

US08876712B2 Intracardiac sheath stabilizer 有权
标题翻译：心内鞘稳定剂
公开(公告)号：US08876712B2
公开(公告)日：2014-11-04
申请号：US12845584
申请日：2010-07-28
申请人： Kristopher Yee , Francis G. Duhay , Manouchehr Miraki
发明人： Kristopher Yee , Francis G. Duhay , Manouchehr Miraki
IPC分类号： A61B1/32 , A61B17/02 , A61B17/34
CPC分类号： A61B17/0206 , A61B17/0293 , A61B17/3423 , A61B90/11 , A61B90/50 , A61B2017/0237
摘要： A surgical stabilizer for use with a surgical site retractor has a base, a bendable arm, and a distal cuff adapted to resiliently hold a tube of an elongated port-access device. The cuff may have a body defining a partial enclosure within which is held a highly flexible gasket having a slit for resiliently receiving the tube. The surgical site retractor may have a collapsible ring and a flexible outer portion attached thereto, the ring being sized to pass through an intercostal incision and expand therein under adjacent ribs to prevent removal, and the flexible outer portion extending out of the incision and drawing over the stabilizer base to mutually secure the retractor and base. The port-access tube may be for a heart valve delivery system using an elongated port-access device for transapically delivering a prosthetic heart valve to the aortic valve annulus. A method involves partly installing the surgical site retractor, anchoring the base of the stabilizer with the flexible outer portion, deploying the port-access tube from outside the body through the incision and through a puncture in the heart wall, and resiliently capturing a tube of the port-access within the partial enclosure of the stabilizer cuff. A second bendable arm on the base having a clip may be used to hold still a proximal end of the port-access device.
摘要翻译：用于手术部位牵开器的手术稳定器具有底座，可弯曲臂和适于弹性地保持细长端口进入装置的管的远端箍。袖带可以具有限定部分外壳的主体，其中保持有高度柔性的垫圈，其具有用于弹性地接收管的狭缝。手术部位牵开器可具有可折叠的环和附接到其上的柔性外部部分，所述环的大小适于穿过肋间切口并在相邻的肋下方扩张，以防止移除，并且柔性外部部分延伸出切口并拉出稳定器基座以相互固定牵开器和底座。入口管可以用于心脏瓣膜输送系统，其使用细长的端口进入装置，用于将假体心脏瓣膜递送到主动脉瓣环。一种方法包括部分地安装手术部位牵开器，将稳定器的基部固定在柔性外部部分上，通过切口从身体的外部部署入口管，并穿过心脏壁中的穿刺，并弹性捕获管在稳定器袖口的部分外壳内的端口访问。具有夹子的基座上的第二可弯曲臂可以用于保持端口进入装置的近端。

4. 发明申请

US20110028797A1 INTRACARDIAC SHEATH STABILIZER 有权
标题翻译：肠内脂质量稳定剂
公开(公告)号：US20110028797A1
公开(公告)日：2011-02-03
申请号：US12845584
申请日：2010-07-28
申请人： Kristopher Yee , Francis G. Duhay
发明人： Kristopher Yee , Francis G. Duhay
IPC分类号： A61B1/32
CPC分类号： A61B17/0206 , A61B17/0293 , A61B17/3423 , A61B90/11 , A61B90/50 , A61B2017/0237
摘要： A surgical stabilizer for use with a surgical site retractor has a base, a bendable arm, and a distal cuff adapted to resiliently hold a tube of an elongated port-access device. The cuff may have a body defining a partial enclosure within which is held a highly flexible gasket having a slit for resiliently receiving the tube. The surgical site retractor may have a collapsible ring and a flexible outer portion attached thereto, the ring being sized to pass through an intercostal incision and expand therein under adjacent ribs to prevent removal, and the flexible outer portion extending out of the incision and drawing over the stabilizer base to mutually secure the retractor and base. The port-access tube may be for a heart valve delivery system using an elongated port-access device for transapically delivering a prosthetic heart valve to the aortic valve annulus. A method involves partly installing the surgical site retractor, anchoring the base of the stabilizer with the flexible outer portion, deploying the port-access tube from outside the body through the incision and through a puncture in the heart wall, and resiliently capturing a tube of the port-access within the partial enclosure of the stabilizer cuff. A second bendable arm on the base having a clip may be used to hold still a proximal end of the port-access device.
摘要翻译：用于手术部位牵开器的手术稳定器具有底座，可弯曲臂和适于弹性地保持细长端口进入装置的管的远端箍。袖带可以具有限定部分外壳的主体，其中保持有高度柔性的垫圈，其具有用于弹性地接收管的狭缝。手术部位牵开器可具有可折叠的环和附接到其上的柔性外部部分，所述环的大小适于穿过肋间切口并在相邻的肋下方扩张，以防止移除，并且柔性外部部分延伸出切口并拉出稳定器基座以相互固定牵开器和底座。入口管可以用于心脏瓣膜输送系统，其使用细长的端口进入装置，用于将假体心脏瓣膜递送到主动脉瓣环。一种方法包括部分地安装手术部位牵开器，将稳定器的基部固定在柔性外部部分上，通过切口从身体的外部部署入口管，并穿过心脏壁中的穿刺，并弹性捕获管在稳定器袖口的部分外壳内的端口访问。具有夹子的基座上的第二可弯曲臂可以用于保持端口进入装置的近端。

5. 发明申请

US20130245671A1 NOVEL APPROAHCES TO VENOUS OCCLUSION FOR EMBOLUS MANAGEMENT 审中-公开
标题翻译：对于EMBOLUS管理的民意调查的新想法
公开(公告)号：US20130245671A1
公开(公告)日：2013-09-19
申请号：US13872739
申请日：2013-04-29
申请人： Francis G. Duhay
发明人： Francis G. Duhay
IPC分类号： A61B17/12
CPC分类号： A61B17/1204 , A61B17/12022 , A61B17/12031 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/1322 , A61B2017/00199 , A61F2/01 , A61F2002/068 , A61F2230/0006
摘要： The invention provides a method and system for transiently occluding a vein that is downstream of an organ such as the brain, where the occlusion increases blood pressure within the vein, and where the increased pressure stimulates a reflex that reduces entry of emboli into that organ.
摘要翻译：本发明提供了一种用于瞬时闭塞在诸如脑的器官下游的静脉的方法和系统，其中闭塞增加了静脉内的血压，并且其中增加的压力刺激了减少栓塞进入该器官的反射。

6. 发明申请

US20100305432A1 System and Method for Locating Medical Devices in Vivo Using Ultrasound Doppler Mode 有权
标题翻译：使用超声多普勒模式定位医疗器械体内系统和方法
公开(公告)号：US20100305432A1
公开(公告)日：2010-12-02
申请号：US12789156
申请日：2010-05-27
申请人： Francis G. Duhay , David Zollinger
发明人： Francis G. Duhay , David Zollinger
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B8/0883 , A61B8/483 , A61B8/488
摘要： A system for locating a medical device in vivo includes an ultrasound scanner having a scan head and being capable of operating in a 3D Doppler mode, a medical device having a distal end configured to be inserted in vivo, and a vibratory element coupled to the medical device to induce vibrations in the first distal end. When the scan head is positioned over the distal end inserted in vivo to obtain scan data of the tissue volume, the ultrasound scanner is configured to generate 3D Doppler data in the form of a plurality of slices from the scan data and to identify a location of the distal end within the slices based upon localized data within one of the slices meeting predetermined criteria.
摘要翻译：用于在体内定位医疗装置的系统包括具有扫描头并且能够以3D多普勒模式操作的超声波扫描器，具有被配置为在体内插入的远端的医疗装置和耦合到医疗的振动元件在第一远端引起振动的装置。当扫描头位于插入体内的远端上以获得组织体积的扫描数据时，超声扫描器被配置为从扫描数据生成多个切片形式的3D多普勒数据，并且识别基于片段中的一个片段内的局部化数据满足预定标准的切片内的远端。

7. 发明授权

US08449466B2 System and method for locating medical devices in vivo using ultrasound Doppler mode 有权
标题翻译：使用超声多普勒模式在体内定位医疗器械的系统和方法
公开(公告)号：US08449466B2
公开(公告)日：2013-05-28
申请号：US12789156
申请日：2010-05-27
申请人： Francis G. Duhay , David Zollinger
发明人： Francis G. Duhay , David Zollinger
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B8/0883 , A61B8/483 , A61B8/488
摘要： A system for locating a medical device in vivo includes an ultrasound scanner having a scan head and being capable of operating in a 3D Doppler mode, a medical device having a distal end configured to be inserted in vivo, and a vibratory element coupled to the medical device to induce vibrations in the first distal end. When the scan head is positioned over the distal end inserted in vivo to obtain scan data of the tissue volume, the ultrasound scanner is configured to generate 3D Doppler data in the form of a plurality of slices from the scan data and to identify a location of the distal end within the slices based upon localized data within one of the slices meeting predetermined criteria.
摘要翻译：用于在体内定位医疗装置的系统包括具有扫描头并且能够以3D多普勒模式操作的超声波扫描器，具有被配置为在体内插入的远端的医疗装置和耦合到医疗的振动元件在第一远端引起振动的装置。当扫描头位于插入体内的远端上以获得组织体积的扫描数据时，超声扫描器被配置为从扫描数据生成多个切片形式的3D多普勒数据，并且识别基于片段中的一个片段内的局部化数据满足预定标准的切片内的远端。

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