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1. 发明授权

US10279097B2 Blood processing apparatus comprising a measurement device 有权
公开(公告)号：US10279097B2
公开(公告)日：2019-05-07
申请号：US15503124
申请日：2015-08-03
申请人： Fresenius Kabi Deutschland GmbH
发明人： Artur Meisberger , Melanie Fahrendorff , Ilka Sternheimer , Lars Michel , Frank Schmidt
IPC分类号： A61M1/36 , A61M1/02 , G01N33/49 , G01N29/02
摘要： A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

2. 发明授权

US10589008B2 Tubing set for use in a blood processing apparatus 有权
公开(公告)号：US10589008B2
公开(公告)日：2020-03-17
申请号：US15503136
申请日：2015-08-03
申请人： Fresenius Kabi Deutschland GmbH
发明人： Frank Schmidt , Artur Meisberger , Melanie Fahrendorff , Ilka Sternheimer , Lars Michel
IPC分类号： A61M1/02 , A61M1/36 , A61B5/145 , G01N33/49 , G01N29/024 , G01N29/22 , A61M39/00
摘要： A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.

3. 发明申请

US20170224893A1 TUBING SET FOR USE IN A BLOOD PROCESSING APPARATUS 审中-公开
公开(公告)号：US20170224893A1
公开(公告)日：2017-08-10
申请号：US15503136
申请日：2015-08-03
申请人： Fresenius Kabi Deutschland GmbH
发明人： Frank Schmidt , Artur Meisberger , Melanie Fahrendorff , Ilka Sternheimer , Lars Michel
IPC分类号： A61M1/02 , A61M39/00 , G01N29/22 , G01N33/49 , G01N29/024 , A61M1/36 , A61B5/145
CPC分类号： A61M1/0209 , A61B5/14535 , A61M1/0259 , A61M1/0281 , A61M1/36 , A61M1/3609 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M39/00 , A61M2205/12 , A61M2205/121 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , G01N29/024 , G01N29/222 , G01N33/49 , G01N33/4915 , G01N2291/02466
摘要： A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.

4. 发明申请

US20160339451A1 DEVICE FOR PROCESSING A LIQUID MEDIUM COMPRISING CELLS 有权
标题翻译：用于处理包含细胞的液体介质的装置
公开(公告)号：US20160339451A1
公开(公告)日：2016-11-24
申请号：US15035711
申请日：2014-12-17
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Artur Meisberger , Melanie Fahrendorff , Michael Brinkmann , Martin Biehl
IPC分类号： B04B11/02 , B04B9/10 , B04B5/04 , A61M1/02 , A61M1/36
CPC分类号： B04B11/02 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.
摘要翻译：本发明涉及一种用于处理初始液体介质（4）的装置，其中初始液体介质（4）包含初始浓度的单元，以便获得包含产品浓度的单元的产品液体介质（4'），该装置（2）包括分离器）适于将初始液体介质（4）分离成各种组分，用于将初始液体介质（4）供应到分离器（6）的第一供应系统（8），用于提取产物液体的第一出口系统（12）来自分离器（6）的介质（4'），适于测量与初始或产品液体介质（4,4'）中的细胞浓度相关的物理参数的传感器（22,22'），以及控制单元（24），其耦合到所述传感器（22,22'），并且适于根据由所述传感器（22,22'）测量的物理参数来控制所述设备（2）的至少一个过程。该装置的特征在于用于以给定的流量将溶液（18）供应到分离器（6）的第二供应系统（10）。基于至少一个工艺参数来确定第二供应系统（10）在供应到分离器（6）期间的溶液（18）的流量。

5. 发明授权

US10632476B2 Method for processing a liquid medium comprising cells 有权
公开(公告)号：US10632476B2
公开(公告)日：2020-04-28
申请号：US16028636
申请日：2018-07-06
申请人： Fresenius Kabi Deutschland GmbH
发明人： Artur Meisberger , Melanie Fahrendorff , Michael Brinkmann , Martin Biehl
IPC分类号： B04B9/10 , A61M1/02 , A61M1/36 , B04B5/04 , B04B11/02
CPC分类号： B04B9/10 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B11/02
摘要： A method for processing an initial liquid medium including cells in an initial concentration to obtain a product liquid medium including cells in a product concentration includes supplying the initial medium to a separator via a first supply system, separating the initial medium into various constituents including the product medium, extracting the product medium from the separator via a first outlet system, measuring a physical parameter related to the concentration of the cells in the initial medium using a sensor, and controlling at least one process parameter as a function of the physical parameter. During the step of separating the initial medium, a solution is supplied to the separator at a flow rate via a second supply system. The flow rate of the solution is determined based on the at least one process parameter, and is reduced when the concentration of the cells measured in the initial medium increases.

6. 发明授权

US10111992B2 Apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir of an autologous blood transfusion system 有权
公开(公告)号：US10111992B2
公开(公告)日：2018-10-30
申请号：US15112926
申请日：2014-12-17
申请人： Fresenius Kabi Deutschland GmbH
发明人： Artur Meisberger , Melanie Fahrendorff , Manfred Eirich
IPC分类号： A61M1/02 , A61M1/36 , G01F23/292
摘要： Disclosed is an apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir (11) of an autologous blood transfusion system (20), comprising sensing means (10, 12) for periodically sensing the liquid level of the salvaged blood in said blood collection reservoir (11) and outputting corresponding signals, and determining means (2) for determining the liquid level of the salvaged blood in said blood collection reservoir (11) based on said output signal of said sensing means. The sensing means comprises a plurality of light emitters (12) disposed on a first side of said blood collection reservoir (11) at different height levels (L1-L9) for emitting light and a plurality of light receivers (10) disposed at said different height levels (L1-L9) on a second side of said blood collection reservoir (11) opposite to said first side for sensing light emitted by said light emitters (12) and transmitted through said blood collection reservoir (11). Parameters of the optical set-up used for detection and signal analysis may be adjusted individually and dynamically so that disturbing effects caused e.g. by absorptive films on the inner surface of the blood collection reservoir (11) may be identified and prevented to thereby enhance the reliability of signal detection and analysis.

7. 发明授权

US10022732B2 Device for processing a liquid medium comprising cells 有权
公开(公告)号：US10022732B2
公开(公告)日：2018-07-17
申请号：US15035711
申请日：2014-12-17
申请人： Fresenius Kabi Deutschland GMBH
发明人： Artur Meisberger , Melanie Fahrendorff , Michael Brinkmann , Martin Biehl
IPC分类号： B04B11/02 , A61M1/02 , A61M1/36 , B04B5/04 , B04B9/10
摘要： The invention relates to a device for processing an initial liquid medium (4) comprising cells in an initial concentration in order to obtain a product liquid medium (4′) comprising cells in a product concentration, the device (2) comprising a separator (6) adapted to separate the initial liquid medium (4) into various constituents, a first supply system (8) for supplying the initial liquid medium (4) to the separator (6), a first outlet system (12) for extracting the product liquid medium (4′) from the separator (6), a sensor (22, 22′) adapted to measure a physical parameter related to the concentration of the cells in the initial or product liquid medium (4, 4′), and a control unit (24) coupled to the sensor (22, 22′) and adapted to control at least one process of the device (2) as a function of the physical parameter measured by the sensor (22, 22′). The device is characterized by a second supply system (10) for supplying a solution (18) to the separator (6) with a given flow rate. The flow rate of the solution (18) in the second supply system (10) during its supply to the separator (6) is determined based on the at least one process parameter.

8. 发明申请

US20180333419A1 METHOD FOR PROCESSING A LIQUID MEDIUM COMPRISING CELLS 审中-公开
公开(公告)号：US20180333419A1
公开(公告)日：2018-11-22
申请号：US16028636
申请日：2018-07-06
申请人： Fresenius Kabi Deutschland GmbH
发明人： Artur Meisberger , Melanie Fahrendorff , Michael Brinkmann , Martin Biehl
IPC分类号： A61K31/53 , C07D413/10 , A61K45/06 , C07D403/04 , C07D417/04 , C07D253/075 , C07D405/10 , C07D403/10 , C07D413/04
CPC分类号： A61K31/53 , A61K45/06 , A61M1/0272 , A61M1/3692 , A61M1/3696 , B04B5/0442 , B04B9/10 , B04B11/02 , C07D253/075 , C07D403/04 , C07D403/10 , C07D405/10 , C07D413/04 , C07D413/10 , C07D417/04
摘要： A method for processing an initial liquid medium including cells in an initial concentration to obtain a product liquid medium including cells in a product concentration includes supplying the initial medium to a separator via a first supply system, separating the initial medium into various constituents including the product medium, extracting the product medium from the separator via a first outlet system, measuring a physical parameter related to the concentration of the cells in the initial medium using a sensor, and controlling at least one process parameter as a function of the physical parameter. During the step of separating the initial medium, a solution is supplied to the separator at a flow rate via a second supply system. The flow rate of the solution is determined based on the at least one process parameter, and is reduced when the concentration of the cells measured in the initial medium increases.

9. 发明申请

US20170232178A1 A BLOOD PROCESSING APPARATUS COMPRISING A MEASUREMENT DEVICE 审中-公开
公开(公告)号：US20170232178A1
公开(公告)日：2017-08-17
申请号：US15503124
申请日：2015-08-03
申请人： Fresenius Kabi Deutschland GmbH
发明人： Artur Meisberger , Melanie Fahrendorff , Ilka Sternheimer , Lars Michel , Frank Schmidt
IPC分类号： A61M1/36 , G01N21/85 , G01N33/49 , A61M1/02
CPC分类号： A61M1/3609 , A61M1/0209 , A61M1/0259 , A61M1/0281 , A61M1/36 , A61M1/361 , A61M1/3612 , A61M1/3632 , A61M1/3692 , A61M1/3693 , A61M2205/12 , A61M2205/121 , A61M2205/3375 , A61M2209/086 , A61M2230/207 , G01N29/02 , G01N33/49 , G01N33/4915 , G01N2291/02466
摘要： A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

10. 发明申请

US20160375185A1 APPARATUS AND METHOD FOR DETERMINING THE LIQUID LEVEL OF SALVAGED BLOOD IN A BLOOD COLLECTION RESERVOIR OF AN AUTOLOGOUS BLOOD TRANSFUSION SYSTEM 审中-公开
标题翻译：用于确定自动血液透析系统血液收集储存器中血液中液体液位的装置和方法
公开(公告)号：US20160375185A1
公开(公告)日：2016-12-29
申请号：US15112926
申请日：2014-12-17
申请人： FRESENIUS KABI DEUTSCHLAND GMBH
发明人： Artur Meisberger , Melanie Fahrendorff , Manfred Eirich
IPC分类号： A61M1/02 , G01F23/292
CPC分类号： A61M1/0259 , A61M1/3627 , A61M2205/18 , A61M2205/3306 , A61M2205/3313 , A61M2205/3389 , A61M2205/52 , G01F23/2924
摘要： Disclosed is an apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir (11) of an autologous blood transfusion system (20), comprising sensing means (10, 12) for periodically sensing the liquid level of the salvaged blood in said blood collection reservoir (11) and outputting corresponding signals, and determining means (2) for determining the liquid level of the salvaged blood in said blood collection reservoir (11) based on said output signal of said sensing means. The sensing means comprises a plurality of light emitters (12) disposed on a first side of said blood collection reservoir (11) at different height levels (L1-L9) for emitting light and a plurality of light receivers (10) disposed at said different height levels (L1-L9) on a second side of said blood collection reservoir (11) opposite to said first side for sensing light emitted by said light emitters (12) and transmitted through said blood collection reservoir (11). Parameters of the optical set-up used for detection and signal analysis may be adjusted individually and dynamically so that disturbing effects caused e.g. by absorptive films on the inner surface of the blood collection reservoir (11) may be identified and prevented to thereby enhance the reliability of signal detection and analysis.
摘要翻译：公开了一种用于确定自体输血系统（20）的采集血液储存器（11）中的回收血液的液位的装置和方法，包括用于周期性地感测被打捞血液的液位的感测装置（10,12）在所述血液采集储存器（11）中输出相应的信号;以及确定装置（2），用于基于所述感测装置的所述输出信号来确定所述采血储存器（11）中的所述经消化的血液的液位。感测装置包括多个发光器（12），其设置在用于发射光的不同高度级别（L1-L9）处的所述采集容器（11）的第一侧上，以及设置在所述不同的位置处的多个光接收器（10）在与所述第一侧相对的所述采血池（11）的第二侧上的高度水平（L1-L9）用于感测由所述光发射器（12）发射并透过所述采血池（11）的光。可以单独和动态地调整用于检测和信号分析的光学设置的参数，可以识别和防止在采集池（11）的内表面上的吸收膜，从而增强信号检测和分析的可靠性。

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