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1. 发明申请

US20080193431A1 ACTIVATABLE PHOTODYNAMIC THERAPY AGENTS 有权
标题翻译：可激活的光电治疗剂
公开(公告)号：US20080193431A1
公开(公告)日：2008-08-14
申请号：US11383487
申请日：2006-05-15
申请人： Gang Zheng , Jerry D. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
发明人： Gang Zheng , Jerry D. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
IPC分类号： A61K38/43 , C12N9/00
CPC分类号： A61K41/0071 , A61K38/00 , A61K41/0057 , A61K41/0076 , A61K47/544 , A61K47/549 , A61K47/64 , A61K47/65 , C07K5/1008 , C07K5/101 , C07K5/1021 , C07K5/1024 , C07K7/06
摘要： The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodynamic therapy agents. The invention further relates to methods for decontaminating blood and methods for treating cancer or viral infection in a subject using the conjugates of the present invention.
摘要翻译：本发明涉及包含与至少一种可光活化杀伤剂和至少一种第一猝灭剂连接的底物的缀合物领域及其使用方法。更具体地说，本发明涉及光动力治疗剂。本发明还涉及使用本发明的缀合物来净化血液的方法和用于治疗受试者的癌症或病毒感染的方法。

2. 发明授权

US08133482B2 Activatable photodynamic therapy agents 有权
标题翻译：可活化的光动力治疗剂
公开(公告)号：US08133482B2
公开(公告)日：2012-03-13
申请号：US11383487
申请日：2006-05-15
申请人： Gang Zheng , Jerry P. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
发明人： Gang Zheng , Jerry P. Glickson , Britton Chance , Edward James Delikatny , Klara Stefflova , Juan Chen
IPC分类号： A61K38/43 , A61K38/46 , A61K38/47 , A61K38/48 , C12N9/00
CPC分类号： A61K41/0071 , A61K38/00 , A61K41/0057 , A61K41/0076 , A61K47/544 , A61K47/549 , A61K47/64 , A61K47/65 , C07K5/1008 , C07K5/101 , C07K5/1021 , C07K5/1024 , C07K7/06
摘要： The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodynamic therapy agents. The invention further relates to methods for decontaminating blood and methods for treating cancer or viral infection in a subject using the conjugates of the present invention.
摘要翻译：本发明涉及包含与至少一种可光活化杀伤剂和至少一种第一猝灭剂连接的底物的缀合物领域及其使用方法。更具体地说，本发明涉及光动力治疗剂。本发明还涉及使用本发明的缀合物来净化血液的方法和用于治疗受试者的癌症或病毒感染的方法。

3. 发明申请

US20080269112A1 Antineoplastic Agents Targeted via Glut Transporters 审中-公开
标题翻译：通过谷物转运蛋白靶向的抗肿瘤药物
公开(公告)号：US20080269112A1
公开(公告)日：2008-10-30
申请号：US12027014
申请日：2008-02-06
申请人： Gang Zheng , Jerry D. Glickson , Britton Chance
发明人： Gang Zheng , Jerry D. Glickson , Britton Chance
IPC分类号： A61K38/16
CPC分类号： A61K41/0071 , A61K41/0057 , A61K47/549 , A61K49/0036 , A61K49/0052 , C07H17/04
摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neoplastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The inventions also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
摘要翻译：本发明涉及通过GLUT运输系统特异性靶向肿瘤细胞的新型抗肿瘤剂和癌症诊断剂。更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

4. 发明授权

US07943586B2 Antineoplastic agents targeted via glut transporters 有权
标题翻译：通过谷氨酸转运蛋白靶向的抗肿瘤剂
公开(公告)号：US07943586B2
公开(公告)日：2011-05-17
申请号：US10560075
申请日：2004-06-09
申请人： Gang Zheng , Jerry D. Glickson , Britton Chance
发明人： Gang Zheng , Jerry D. Glickson , Britton Chance
IPC分类号： C07G3/00 , C07G11/00 , C07H15/00 , C07H17/00 , C07H5/06 , A01N43/04 , A61K31/70
CPC分类号： A61K41/0071 , A61K41/0057 , A61K47/549 , A61K49/0036 , A61K49/0052 , C07H17/04
摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
摘要翻译：本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

5. 发明申请

US20100075899A1 TARGETED PHOTODYNAMIC THERAPY AGENT 审中-公开
标题翻译：目标光电治疗剂
公开(公告)号：US20100075899A1
公开(公告)日：2010-03-25
申请号：US12443019
申请日：2007-09-28
申请人： Gang Zheng , Klara Stefflova
发明人： Gang Zheng , Klara Stefflova
IPC分类号： A61K38/16 , C07K5/113 , C07K5/10 , C07K7/06 , C07K7/08 , C07K14/00 , C12N5/09 , A61K38/07 , A61K38/08 , A61K38/10 , A61P35/00
CPC分类号： C07K5/1021 , A61K38/00 , A61K41/0057 , A61K41/0066 , A61K41/0071 , A61K47/64 , A61K47/65 , A61K49/0036 , A61K49/0052 , A61K49/0056 , C07K5/101 , C07K5/1016 , C07K7/06
摘要： The present invention relates to the field of conjugates comprising a substrate, a photosensitizer, and a targeting ligand, and methods for their use. More particularly, the invention further relates to methods for treating cancer in a subject using the conjugates of the present invention.
摘要翻译：本发明涉及包含底物，光敏剂和靶向配体的缀合物领域及其使用方法。更具体地，本发明还涉及使用本发明的缀合物治疗受试者的癌症的方法。

6. 发明申请

US20080253960A1 Lipoprotein-Based Nanoplatforms 审中-公开
标题翻译：基于脂蛋白的纳米平台
公开(公告)号：US20080253960A1
公开(公告)日：2008-10-16
申请号：US11547015
申请日：2005-04-01
申请人： Gang Zheng , Jerry D. Glickson
发明人： Gang Zheng , Jerry D. Glickson
IPC分类号： A61K51/00 , A61K47/42 , A61K49/06 , A61K49/22 , A61K31/337 , A61K31/704 , A61K31/164 , A61K31/433 , A61K31/137 , A61K31/138 , A61K31/675 , A61K49/00 , A61K49/04 , A61K38/02
CPC分类号： A61K49/0052 , A61K41/0071 , A61K47/6917 , A61K47/6929 , A61K49/008 , A61K49/14 , A61K49/1806 , B82Y5/00
摘要： The present invention provides a non-naturally occurring lipoprotein nanoplatform (“LBNP”) comprising at least one cell surface receptor ligand; at least one lipoprotein; and at least one diagnostic agent and/or at least one therapeutic agent. In embodiments of the present invention, the cell surface receptor ligand is not a low-density lipoprotein receptor ligand and the cell surface receptor ligand is covalently bonded to the apoprotein. The present invention also provides pharmaceutical formulations comprising LBNPs and methods of making the LBNPs.
摘要翻译：本发明提供了包含至少一种细胞表面受体配体的非天然存在的脂蛋白纳米平板（“LBNP”）; 至少一种脂蛋白; 和至少一种诊断剂和/或至少一种治疗剂。在本发明的实施方案中，细胞表面受体配体不是低密度脂蛋白受体配体，并且细胞表面受体配体与载脂蛋白共价结合。本发明还提供了包含LBNP的药物制剂和制备LBNP的方法。

7. 发明申请

US20060171893A1 Antineoplastic agents targeted via glut transporters 有权
标题翻译：通过谷氨酸转运蛋白靶向的抗肿瘤剂
公开(公告)号：US20060171893A1
公开(公告)日：2006-08-03
申请号：US10560075
申请日：2004-06-09
申请人： Gang Zheng , Jerry Glickson , Britton Chance
发明人： Gang Zheng , Jerry Glickson , Britton Chance
IPC分类号： A61K49/00 , C07H17/04 , A61K31/7052 , A61K31/704 , A61K31/337
CPC分类号： A61K41/0071 , A61K41/0057 , A61K47/549 , A61K49/0036 , A61K49/0052 , C07H17/04
摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.
摘要翻译：本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

8. 发明申请

US20110020242A1 HIGH-DENSITY LIPOPROTEIN-LIKE PEPTIDE-PHOSPHOLIPID SCAFFOLD ("HPPS") NANOPARTICLES 审中-公开
标题翻译：高密度脂蛋白样肽 - 磷脂酰胆碱（“HPPS”）纳米颗粒
公开(公告)号：US20110020242A1
公开(公告)日：2011-01-27
申请号：US12747815
申请日：2008-12-12
申请人： Gang Zheng , Zhihong Zhang , Ian Corbin , Juan Chen
发明人： Gang Zheng , Zhihong Zhang , Ian Corbin , Juan Chen
IPC分类号： A61K49/14 , C07K17/02 , A61K49/00 , A61K9/14 , A61P35/00
CPC分类号： A61K49/0082 , A61K47/6917 , A61K47/6919 , A61K49/0002 , A61K49/0032 , A61K49/0056 , B82Y5/00 , G01N33/54346 , G01N33/587 , G01N2800/00
摘要： The present invention provides a non-naturally occurring High-Density Lipoprotein-like peptide-phospholipid scaffold (“HPPS”) nanoparticle. More particularly, the invention provides a non-naturally occurring peptide-lipid nanoscaffold comprising: (a) at least one phospholipid; (b) at least one unsaturated lipid, preferably an unsaturated sterol ester, further preferably an unsaturated cholesterol ester, further preferably cholsteryl oleate; and (c) at least one peptide, the peptide comprising an amino acid sequence capable of forming at least one amphipathic a-helix; wherein the components a), b) and c) associate to form the peptide-phospholipid nanoscaffold. In embodiments of the present invention, a cell surface receptor ligand is incorporated into the HPPS. In one embodiment, the cell surface receptor ligand is covalently bonded to the peptide scaffold of the HPPS nanoparticles. In other embodiments, a cell surface receptor ligand is coupled to a lipid anchor and is displayed on the surface of the HPPS nanoparticles by incorporation of the lipid anchor into the phospholipids monolayer of the HPPS nanoparticle. The present invention also provides pharmaceutical formulations comprising HPPS nanoparticles and methods of making the HPPS nanoparticles.
摘要翻译：本发明提供非天然存在的高密度脂蛋白样肽 - 磷脂支架（“HPPS”）纳米颗粒。更具体地，本发明提供非天然存在的肽 - 脂质纳米支架，其包含：（a）至少一种磷脂; （b）至少一种不饱和脂质，优选不饱和甾醇酯，更优选不饱和胆固醇酯，更优选油酸胆甾醇酯; 和（c）至少一种肽，所述肽包含能够形成至少一种两亲性α-螺旋的氨基酸序列; 其中组分a），b）和c）缔合形成肽 - 磷脂纳米支架。在本发明的实施方案中，将细胞表面受体配体掺入HPPS中。在一个实施方案中，细胞表面受体配体共价键合到HPPS纳米颗粒的肽支架上。在其它实施方案中，将细胞表面受体配体偶联到脂质锚定物上，并通过将脂质锚点掺入HPPS纳米颗粒的磷脂单层中而显示在HPPS纳米颗粒的表面上。本发明还提供了包含HPPS纳米颗粒的药物制剂和制备HPPS纳米颗粒的方法。

9. 发明申请

US20070217788A1 Passive Optical Network System and Method for Protecting the Services of the Same 有权
标题翻译：被动光网络系统及其保护方法
公开(公告)号：US20070217788A1
公开(公告)日：2007-09-20
申请号：US11611382
申请日：2006-12-15
申请人： Hai Gao , Gang Zheng
发明人： Hai Gao , Gang Zheng
IPC分类号： H04B10/00
CPC分类号： H04Q11/0067 , H04J3/14 , H04J3/1694 , H04Q2011/0081
摘要： The present disclosure provides a passive optical network (PON) system and a method for protecting the service of the system for service recovery and fault locating in case of a failure of the network, wherein the PON system comprises an optical line terminal (OLT), an optical distribution network (ODN) and an optical network terminal (ONT) equipment protection group comprising a plurality of ONT equipment groups, each of which is connected to at least one of other ONT equipment groups within the ONT equipment protection group for the mutual protection relationship. The PON system of the present disclosure does not require equipment and link redundancy for backup, contributes to reduced cost and improved utilization of resources, and provides a means for diagnosing any faults of the links and equipment in the network.
摘要翻译：本公开提供了一种无源光网络（PON）系统和一种在网络故障的情况下保护用于服务恢复和故障定位的系统的服务的方法，其中PON系统包括光线路终端（OLT），光分配网络（ODN）和包括多个ONT设备组的光网络终端（ONT）设备保护组，每个ONT设备组连接到ONT设备保护组内的其他ONT设备组中的至少一个，用于相互保护关系。本公开的PON系统不需要用于备份的设备和链路冗余，有助于降低成本并提高资源的利用率，并且提供用于诊断网络中的链路和设备的任何故障的手段。

10. 发明授权

US09017974B2 Method for the synthesis of porphyrin-phospholipid conjugates 有权
标题翻译：卟啉 - 磷脂共轭物的合成方法
公开(公告)号：US09017974B2
公开(公告)日：2015-04-28
申请号：US14125035
申请日：2012-05-25
申请人： Gang Zheng , Jonathan Lovell
发明人： Gang Zheng , Jonathan Lovell
IPC分类号： C12P17/18 , B01J13/02 , A61K31/704 , C07F9/6561 , C07F9/10 , C09B67/02 , A61K41/00 , A61K47/48 , A61K8/55 , A61Q19/00 , A61K8/14 , C09B69/10
CPC分类号： C12P17/182 , A61K8/14 , A61K8/553 , A61K31/704 , A61K41/0071 , A61K47/544 , A61K2800/10 , A61Q19/00 , B01J13/02 , C07F9/106 , C07F9/6561 , C09B67/0097 , C09B69/108
摘要： There is herein described a nanovesicle comprising a bilayer of porphyrin-phospholipid conjugates. Each porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain at one of the sn-1 or the sn-2 positions of one phospholipid. Further, the nanovesicle has a defined regioisomeric ratio of sn-1:sn-2 porphyrin-phospholipid conjugates.
摘要翻译：本文描述了包含卟啉 - 磷脂共轭物双层的纳米囊。每个卟啉 - 磷脂缀合物包含一个卟啉，卟啉衍生物或卟啉类似物，其共价连接到一个磷脂的sn-1或sn-2位置之一的脂质侧链。此外，纳米囊具有定义的sn-1：sn-2卟啉 - 磷脂缀合物的区域异构体比例。

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