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1. 发明授权

US10407406B2 2-halo-5-alkynyl-pyridyl nicotinic ligands 有权
公开(公告)号：US10407406B2
公开(公告)日：2019-09-10
申请号：US15895252
申请日：2018-02-13
申请人： Georgetown University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu
IPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

2. 发明授权

US09303017B2 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof 有权
标题翻译： 2,5-二取代 - 吡啶基烟碱配体及其使用方法
公开(公告)号：US09303017B2
公开(公告)日：2016-04-05
申请号：US14357699
申请日：2012-11-09
申请人： Georgetown University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu , Edward D. Levin , Amir H. Rezvani
IPC分类号： A61K31/4427 , C07D401/12
CPC分类号： A61K31/4427 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K31/4439 , C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

3. 发明申请

US20180305335A1 2-HALO-5-ALKYNYL-PYRIDYL NICOTINIC LIGANDS 审中-公开
公开(公告)号：US20180305335A1
公开(公告)日：2018-10-25
申请号：US15895252
申请日：2018-02-13
申请人： Georgetown University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

4. 发明授权

US09890137B2 2-halo-5-alkynyl-pyridyl nicotinic ligands 有权
公开(公告)号：US09890137B2
公开(公告)日：2018-02-13
申请号：US14780788
申请日：2014-03-26
申请人： Georgetown University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

5. 发明申请

US20170035743A1 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof 有权
标题翻译： 2,5-二取代 - 吡啶基烟碱配体及其使用方法
公开(公告)号：US20170035743A1
公开(公告)日：2017-02-09
申请号：US15091128
申请日：2016-04-05
申请人： Georgetown University , Duke University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu , Edward D. Levin , Amir H. Rezvani
IPC分类号： A61K31/4427 , A61K31/4439 , A61K9/00
CPC分类号： A61K31/4427 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K31/4439 , C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

6. 发明授权

US09993465B2 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof 有权
公开(公告)号：US09993465B2
公开(公告)日：2018-06-12
申请号：US15091128
申请日：2016-04-05
申请人： Georgetown University , Duke University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu , Edward D. Levin , Amir H. Rezvani
IPC分类号： A61K31/4427 , C07D401/12 , A61K9/00 , A61K31/4439
CPC分类号： A61K31/4427 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K31/4439 , C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

7. 发明申请

US20160031853A1 2-Halo-5-Alkynyl-Pyridyl Nicotinic Ligands 有权
标题翻译： 2-卤代-5-炔基 - 吡啶基烟碱配体
公开(公告)号：US20160031853A1
公开(公告)日：2016-02-04
申请号：US14780788
申请日：2014-03-26
申请人： GEORGETOWN UNIVERSITY
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

8. 发明申请

US20140378428A1 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof 有权
标题翻译： 2,5-二取代 - 吡啶基烟碱配体及其使用方法
公开(公告)号：US20140378428A1
公开(公告)日：2014-12-25
申请号：US14357699
申请日：2012-11-09
申请人： Georgetown University , Duke University
发明人： Yingxian Xiao , Kenneth J. Kellar , Milton L. Brown , Mikell A. Paige , Yong Liu , Edward D. Levin , Amir H. Rezvani
IPC分类号： C07D401/12
CPC分类号： A61K31/4427 , A61K9/0019 , A61K9/0043 , A61K9/0053 , A61K9/006 , A61K31/4439 , C07D401/12
摘要： Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.
摘要翻译：公开了作为烟碱乙酰胆碱受体配体的杂环化合物。该化合物可用于治疗患有一系列治疗适应症，包括阿尔茨海默病，帕金森病，运动障碍，图雷特综合征，精神分裂症，注意力缺陷障碍，焦虑症，疼痛，抑郁症，强迫症，化学物质滥用酒精中毒，记忆缺陷，假性痴呆，甘ser综合征，偏头痛，贪食症，肥胖症，经前期综合征或晚期黄体期综合征，烟草滥用，创伤后综合征，社交恐惧症，慢性疲劳综合征，早泄，勃起障碍，神经性厌食症，睡眠障碍，孤独症，多发症，头发性短暂症和低体温。

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