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1. 发明授权

US07205290B2 Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效
标题翻译：具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途
公开(公告)号：US07205290B2
公开(公告)日：2007-04-17
申请号：US10813954
申请日：2004-03-31
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： C07D205/08 , A61K31/397 , A61P9/10 , A61P3/06 , C07C229/22
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译：本发明涉及式1的化合物

2. 发明授权

US07772429B2 Diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效
标题翻译：具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途
公开(公告)号：US07772429B2
公开(公告)日：2010-08-10
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： C07C229/08 , C07C229/12
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译：本发明涉及式1的化合物及其生理上可接受的盐。该化合物例如可用作降血脂药物。

3. 发明申请

US20050020563A1 Nover diphenylazetidinone with improved physiological properties, process for its preparation, medicaments comprising this compound, and its use 失效
标题翻译：具有改善的生理特性的二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途
公开(公告)号：US20050020563A1
公开(公告)日：2005-01-27
申请号：US10813954
申请日：2004-03-31
申请人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard Jaehne , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： A61P3/06 , C07C233/18 , C07D205/08 , A61K31/397
CPC分类号： C07C233/18 , C07D205/08
摘要： The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译：本发明涉及式1的化合物及其生理上可接受的盐。该化合物例如可用作降血脂药物。

4. 发明申请

US20070197498A1 NOVEL DIPHENYLAZETIDINONE WITH IMPROVED PHYSIOLOGICAL PROPERTIES, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND ITS USE 失效
标题翻译：具有改善的生理特性的新型二氢噻吩酮，其制备方法，包含该化合物的药物及其用途
公开(公告)号：US20070197498A1
公开(公告)日：2007-08-23
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： A61K31/397 , C07D205/02
CPC分类号： C07C233/18 , C07D205/08
摘要： Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译：新型二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途本发明涉及式1的化合物及其生理上可接受的盐。该化合物例如可用作降血脂药物。

5. 发明申请

US20110038930A1 HOT-MELT EXTRUDED PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：热熔制品药物剂型
公开(公告)号：US20110038930A1
公开(公告)日：2011-02-17
申请号：US12840439
申请日：2010-07-21
申请人： Lutz BARNSCHEID , Eric Galia
发明人： Lutz BARNSCHEID , Eric Galia
IPC分类号： A61K9/20 , A61K9/28 , A61K31/133 , A61P25/04 , B29C69/02
CPC分类号： A61K9/2072 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K31/137
摘要： The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side;wherein the core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form; and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.
摘要翻译：本发明涉及一种具有控制释放包含聚合物（C）的基质中的药理学活性成分（A）的热熔挤出药物剂型，所述剂型具有至少300N的断裂强度并且具有长方形形状，其包括纵向延伸方向，垂直于所述纵向延伸方向的横向方向，所述前侧和后侧之间的前侧，相对的后侧和周向边缘; 其中所述药物剂型的核心具有由与所述剂型的延伸长度方向基本正交的热熔融挤出引起的形态取向; 和/或通过前侧和相对背侧的药理活性成分（A）的每个面积的释放比通过周缘的释放快。

6. 发明授权

US10363228B2 Transdermal administration of memantine 有权
公开(公告)号：US10363228B2
公开(公告)日：2019-07-30
申请号：US13162604
申请日：2011-06-17
申请人： René Eifler , Michael Horstmann , Regine Kaufmann , Patrick Mohr , Eric Galia , Wolfgang Prange , Stefan Buller , Klaus Pusecker , Jan Stampfuss , Susanne Stoelben
发明人： René Eifler , Michael Horstmann , Regine Kaufmann , Patrick Mohr , Eric Galia , Wolfgang Prange , Stefan Buller , Klaus Pusecker , Jan Stampfuss , Susanne Stoelben
IPC分类号： A61F13/00 , A61M35/00 , A61N1/30 , A61K9/70 , A61K31/13
摘要： The invention relates to transdermal therapeutic systems (TTS) which include, as active ingredient, the NMDA receptor antagonist memantine or one of its physiologically compatible salts. The TTSs can be produced and used for treating diseases of the central nervous system.

7. 发明授权

US10080721B2 Hot-melt extruded pharmaceutical dosage form 有权
公开(公告)号：US10080721B2
公开(公告)日：2018-09-25
申请号：US12840439
申请日：2010-07-21
申请人： Lutz Barnscheid , Eric Galia
发明人： Lutz Barnscheid , Eric Galia
IPC分类号： A61K9/22 , A61K9/20 , A61K31/137
CPC分类号： A61K9/2072 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K31/137
摘要： The invention relates to a hot-melt extruded pharmaceutical dosage form with controlled release of a pharmacologically active ingredient (A) embedded in a matrix comprising a polymer (C), the dosage form exhibiting a breaking strength of at least 300 N and having an oblong shape comprising a longitudinal direction of extension, a transversal direction of extension orthogonal to the longitudinal direction of extension, a front side, an opposite back side and a circumferential rim between said front and back side;wherein the core of the pharmaceutical dosage form has a morphological orientation caused by hot-melt extrusion that is substantially orthogonal to the longitudinal direction of extension of the dosage form; and/or the release per area of the pharmacologically active ingredient (A) through the front side and the opposite back side is faster than the release through the circumferential rim.

8. 发明授权

US08383152B2 Pharmaceutical dosage form 有权
标题翻译：药物剂型
公开(公告)号：US08383152B2
公开(公告)日：2013-02-26
申请号：US12358415
申请日：2009-01-23
申请人： Eugeen Marie Jozef Jans , Filip René Irena Kiekens , Jody Firmin Marceline Voorspoels , Anne Faure , Elisabeth Arkenau-Maric , Lutz Barnscheid , Johannes Bartholomäus , Marc Frevel , Eric Galia , Iris Ziegler , Andrea Schüssele
发明人： Eugeen Marie Jozef Jans , Filip René Irena Kiekens , Jody Firmin Marceline Voorspoels , Anne Faure , Elisabeth Arkenau-Maric , Lutz Barnscheid , Johannes Bartholomäus , Marc Frevel , Eric Galia , Iris Ziegler , Andrea Schüssele
IPC分类号： A61K9/22 , A61K9/20 , A61K9/28 , A61K31/135
CPC分类号： A61K9/2072 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K31/135 , A61K31/137 , Y10T428/24479
摘要： The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
摘要翻译：本发明涉及药物剂型，优选具有其中所含的药理活性化合物（A）的受控释放，所述药物剂型非常优选是防篡改的，最优选地具有至少500N的断裂强度B1，方向为并且在延伸方向E2具有小于500N的断裂强度B2。

9. 发明申请

US20120136021A1 OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM 审中-公开
标题翻译：氧化稳定的耐篡改剂型
公开(公告)号：US20120136021A1
公开(公告)日：2012-05-31
申请号：US13343846
申请日：2012-01-05
申请人： Lutz Barnscheid , Eric Galia , Sebastian Schwier , Ulrike Bertram , Anja Geissler , Kornelia Griessmann , Johannes Bartholomäus
发明人： Lutz Barnscheid , Eric Galia , Sebastian Schwier , Ulrike Bertram , Anja Geissler , Kornelia Griessmann , Johannes Bartholomäus
IPC分类号： A61K31/485 , A61P25/04 , A61K47/34
CPC分类号： A61K9/2013 , A61K9/20 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K9/284 , A61K31/485
摘要： A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
摘要翻译：一种具有至少300N断裂强度的热成型药物剂型，所述剂型包含药理学活性成分（A），游离生理上可接受的酸（B），其量为0.001重量％至5.0重量％％，基于药物剂型的总重量，以及重均分子量Mw至少为200,000g / mol的聚环氧烷（C）。

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