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1. 发明授权

US10697019B2 Method of diagnosis and prognosis 有权
公开(公告)号：US10697019B2
公开(公告)日：2020-06-30
申请号：US14113518
申请日：2012-04-27
申请人： Guido Franzoso , Laura Tornatore , Menotti Ruvo , Alberto Rocci , Antonio Palumbo
发明人： Guido Franzoso , Laura Tornatore , Menotti Ruvo , Alberto Rocci , Antonio Palumbo
IPC分类号： C12Q1/68 , C12Q1/6886
摘要： A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

2. 发明申请

US20140128330A1 METHOD OF DIAGNOSIS AND PROGNOSIS 审中-公开
标题翻译：诊断和预防方法
公开(公告)号：US20140128330A1
公开(公告)日：2014-05-08
申请号：US14113518
申请日：2012-04-27
申请人： Guido Franzoso , Laura Tornatore , Menotti Ruvo , Alberto Rocci , Antonio Palumbo
发明人： Guido Franzoso , Laura Tornatore , Menotti Ruvo , Alberto Rocci , Antonio Palumbo
IPC分类号： C12Q1/68
摘要： A method of measuring Gadd45β expression comprising the step of measuring Gadd45β expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45β and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.
摘要翻译：测量Gadd45＆bgr的方法包括测量Gadd45＆bgr的步骤; 从已知具有或怀疑具有血液恶性肿瘤的受试者获得的细胞样品中的表达水平，例如CD138表达细胞。表达水平可以用于例如多发性骨髓瘤的诊断中，例如在具有多发性骨髓瘤的患者中或在指导选择适当的治疗剂，特别是包含Gadd45和bgr的治疗剂时提供预后。和/或MKK7抑制剂。还包括来自多个受试者的测量表达水平的数据集。

3. 发明授权

US09623346B2 Compositions and methods for separating emulsions using the same 有权
公开(公告)号：US09623346B2
公开(公告)日：2017-04-18
申请号：US12848514
申请日：2010-08-02
申请人： Kalman Koczo , Benjamin Falk , Antonio Palumbo
发明人： Kalman Koczo , Benjamin Falk , Antonio Palumbo
IPC分类号： B01D17/05 , B01D17/04 , C10G33/04 , C08L83/04 , C08L83/12 , C08G77/14 , C08G77/46
CPC分类号： B01D17/047 , C08G77/14 , C08G77/46 , C08L83/04 , C08L83/12 , C10G33/04
摘要： The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a silicon containing co-polymer. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.

4. 发明申请

US20120220791A1 COPOLYMERS OF EPOXY COMPOUNDS AND AMINO SILANES 审中-公开
标题翻译：环氧化合物和氨基硅烷的共聚物
公开(公告)号：US20120220791A1
公开(公告)日：2012-08-30
申请号：US13465427
申请日：2012-05-07
申请人： Kalman Koczo , Benjamin Falk , Antonio Palumbo , Monjit Phukan
发明人： Kalman Koczo , Benjamin Falk , Antonio Palumbo , Monjit Phukan
IPC分类号： C07F7/10
CPC分类号： C08G77/54 , C07F7/1804 , C08C19/40 , C08F8/32 , C08F8/42 , C08G59/1477 , C08G59/4085 , C08G77/12 , C08G77/14 , C08G77/20 , C08G77/26 , C08G77/388 , C08G77/46 , C08G77/50 , C08G77/80 , C08L63/00 , C08L83/04 , C09D183/08 , D06M15/6436 , D06M15/65
摘要： A composition includes a non-crosslinked reaction product of an oxirane or oxetane compound (I) comprising at least two oxirane or oxetane groups; a compound (II) comprising silicon and one or more amino groups; and optionally a polyamine (III); and a secondary amine (IV).
摘要翻译：组合物包括环氧乙烷或氧杂环丁烷化合物（I）的非交联反应产物，其包含至少两个环氧乙烷或氧杂环丁烷基团; 包含硅和一个或多个氨基的化合物（II）; 和任选的多胺（III）; 和仲胺（IV）。

5. 发明申请

US20120329887A1 BIODEGRADABLE POLYORGANOSILOXANE DEMULSIFIER COMPOSITION AND METHOD FOR MAKING THE SAME 有权
标题翻译：可生物降解的聚羟基烷氧基化合物组合物及其制备方法
公开(公告)号：US20120329887A1
公开(公告)日：2012-12-27
申请号：US13165085
申请日：2011-06-21
申请人： Monjit PHUKAN , Anubhav Saxena , Mayank Kumar Dubey , Antonio Palumbo , Kalman Koczo
发明人： Monjit PHUKAN , Anubhav Saxena , Mayank Kumar Dubey , Antonio Palumbo , Kalman Koczo
IPC分类号： B01D17/00
CPC分类号： C08L83/12 , B01D17/047 , C08G77/46 , C10G33/04
摘要： There is provided herein a demulsifying composition comprising at least one polyorganosiloxane compound having the general formula (I): M1aM2bD1cD2dT1eT2fQg (I) wherein: M1=R1R2R3SiO1/2, M2=R4R5RLSiO1/2, D1=R6R7SiO2/2, D2=R8RLSiO2/2, T1=R9SiO3/2, T2=RLSiO3/2, Q=SiO4/2, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently chosen from monovalent alkyl, aryl or aralkyl hydrocarbon radicals, or chosen from RP; RP is a monovalent polyether radical independently of the general formula (II): —(CnH2n)—O—(C2H4O)o—(C3H6O)p—(C4H8O)q—R10 (II) RL is a monovalent radical independently chosen from the general formula (III): —X—O—(C2H4O)r—(C3H6O)s—(C4H8O)t—{C(O)CuH2uO}v—R11 (III). There is also provided herein a method for separating emulsions comprising combining the components of the demulsification composition into a mixture; allowing the mixture to separate into at least two phases and separating said at least two phases from each other.
摘要翻译：本文提供了包含至少一种具有通式（I）的聚有机硅氧烷化合物的破乳组合物：M1aM2bD1cD2dT1eT2fQg（I）其中：M1 = R1R2R3SiO1 / 2，M2 = R4R5RLSiO1 / 2，D1 = R6R7SiO2 / 2，D2 = R8RLSiO2 / 2 ，T1 = R9SiO3 / 2，T2 = RLSiO3 / 2，Q = SiO4 / 2，其中R1，R2，R3，R4，R5，R6，R7，R8和R9各自独立地选自一价烷基，芳基或芳烷基烃基，或从RP中选择; RP是独立于通式（II）的单价聚醚基： - （C n H 2n）-O-（C 2 H 4 O）O-（C 3 H 6 O）p - （C 4 H 8 O）q -R 10（II）RL是独立地选自通式（III）：-X-O-（C 2 H 4 O）r - （C 3 H 6 O）s - （C 4 H 8 O）t - {C（O）Cu H 2uO} v -R 11（III）。本文还提供了用于分离乳液的方法，其包括将破乳组合物的组分混合成混合物; 允许混合物分离成至少两相，并将所述至少两相彼此分离。

6. 发明授权

US08198361B2 Silicon polyethers and a method of producing the same 有权
标题翻译：硅聚醚及其制备方法
公开(公告)号：US08198361B2
公开(公告)日：2012-06-12
申请号：US12694636
申请日：2010-01-27
申请人： Benjamin Falk , Kalman Koczo , Antonio Palumbo
发明人： Benjamin Falk , Kalman Koczo , Antonio Palumbo
IPC分类号： C08L83/00 , C08L83/04 , C07F7/02
CPC分类号： C08G65/336 , C07F7/081 , C07F7/0838
摘要： The present invention provides a non-crosslinked silicon polyether composition comprising at least one compound with the following formula; [(R1O)(C2H4O)a(C3H6O)b(C4H8O)c]dR2(R3)e wherein R1 is a monovalent radical defined as MgMAhMBiMHjMEkDlDHmDEnToTHpTEqQr M=R4R5R6SiO1/2; MA=R7R8R9SiR10; MB=[(R11R12R13Si)sR14]tSi(R15)u(R16)vR17 MH=R18Si(R19)(R20)O1/2; ME=R21R22RESiO1/2; D=R23R24SiO2/2; DH=R25Si(R26)O2/2; DE=R27RESiO2/2; T=R28SiO3/2; TH=R29SiO3/2; TE=RESiO2/2; and Q=SiO4/2; R2 and R14 are polyvalent linear or branched; R3 is —(C2H4O)(C3H6O)b(C4H8O)c—R30 or R1; R30 is a monovalent saturated; R4, R5, R6, R7, R8, R9, R11, R12, R13, R15, R16, R19, R20, R21, R22, R23, R24, R26, R27, and, R28 are monovalent hydrocarbon radicals having from 1 to about 10 carbons; R10, R17, R18, R25 and R29 are divalent hydrocarbon radicals having 1 to about 25 carbons; RE is —R32—(C2H4O)a(C3H6O)b(C4H8O)c—R33; R32 is a divalent hydrocarbon radical having 1 to about 60 carbons; R33 is a monovalent hydrocarbon radical having 1 to about 20 carbons; h is 0 or 1 subject to the limitation if h is 1 then g+i+j+k+l+m+n+o+p+q+r=0; subscript d is 1
摘要翻译：本发明提供一种非交联硅聚醚组合物，其包含至少一种具有下式的化合物： [（R1O）（C2H4O）a（C3H6O）b（C4H8O）c] dR2（R3）e其中R1是定义为MgMAhMBiMHjMEkD1DHmDEnToTHpTEqQrM = R4R5R6SiO1 / 2的一价基团; MA = R7R8R9SiR10; MB = [（R11R12R13Si）sR14] tSi（R15）u（R16）vR17 MH = R18Si（R19）（R20）O1 / 2; ME = R21R22RESiO1 / 2; D = R23R24SiO2 / 2; DH = R25Si（R26）O2 / 2; DE = R27RESiO2 / 2; T = R28SiO3 / 2; TH = R29SiO3 / 2; TE = RESiO2 / 2; 和Q = SiO4 / 2; R2和R14是多价直链或支链的; R3是 - （C2H4O）（C3H6O）b（C4H8O）c-R30或R1; R30是一价饱和的; R4，R5，R6，R7，R8，R9，R11，R12，R13，R15，R16，R19，R20，R21，R22，R23，R24，R26，R27和R28均为1〜 10个碳; R 10，R 17，R 18，R 25和R 29是具有1至约25个碳的二价烃基; RE为-R32-（C2H4O）a（C3H6O）b（C4H8O）c-R33; R32是具有1至约60个碳的二价烃基; R33是具有1至约20个碳的一价烃基; h为0或1，如果h为1，则g + i + j + k + l + m + n + o + p + q + r = 0; 下标d是1

7. 发明授权

US08198337B2 Demulsifier compositions and methods for separating emulsions using the same 失效
标题翻译：破乳剂组合物和使用其的乳液分离方法
公开(公告)号：US08198337B2
公开(公告)日：2012-06-12
申请号：US12694676
申请日：2010-01-27
申请人： Benjamin Falk , Kalman Koczo , Monjit Phukan , Antonio Palumbo , Anubhav Saxena
发明人： Benjamin Falk , Kalman Koczo , Monjit Phukan , Antonio Palumbo , Anubhav Saxena
IPC分类号： B01F3/00 , C07F7/00 , C07F7/02
CPC分类号： C08G77/46 , C08L83/12 , C10G33/04
摘要： The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a non-crosslinked silicon polyether. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.
摘要翻译：本发明提供了一种破乳组合物，其包含a）乳液的共混物; 和b）破乳有效量的非交联硅聚醚。本发明还提供了使用所讨论的破乳组合物分离乳液的方法。

8. 发明申请

US20210337754A1 PLANT CUTTING AND CLONE-GROWTH DEVICE AND RELATED METHODS 有权
公开(公告)号：US20210337754A1
公开(公告)日：2021-11-04
申请号：US17244297
申请日：2021-04-29
申请人： Antonio Palumbo
发明人： Antonio Palumbo
IPC分类号： A01H4/00 , A01G2/10
摘要： The present description relates to a plant cutting device for cutting or cloning a plant, and housing the plant for growth. The plant cutting device generally comprises two compartments that are operatively connected together and displaceable from an open position to a closed position defining an enclosure, a cutter mounted within at least one of the compartments and configured to cut a plant part when the first and second compartments are displaced to the closed position, a cut end of the plant part being accommodated within the enclosure; and a growth medium disposed in the first compartment and/or the second compartment for contacting the cut end of the plant part allowing for the growth of the plant.

9. 发明授权

US08779012B2 Biodegradable polyorganosiloxane demulsifier composition and method for making the same 有权
标题翻译：可生物降解聚有机硅氧烷破乳剂组合物及其制备方法
公开(公告)号：US08779012B2
公开(公告)日：2014-07-15
申请号：US13165085
申请日：2011-06-21
申请人： Monjit Phukan , Anubhav Saxena , Mayank Kumar Dubey , Antonio Palumbo , Kalman Koczo
发明人： Monjit Phukan , Anubhav Saxena , Mayank Kumar Dubey , Antonio Palumbo , Kalman Koczo
IPC分类号： B01D17/00
CPC分类号： C08L83/12 , B01D17/047 , C08G77/46 , C10G33/04
摘要： There is provided herein a demulsifying composition comprising at least one polyorganosiloxane compound having the general formula (I): M1aM2bD1cD2dT1eT2fQg (I) wherein: M1=R1R2R3SiO1/2, M2=R4R5RLSiO1/2, D1=R6R7SiO2/2, D2=R8RLSiO2/2, T1=R9SiO3/2, T2=RLSiO3/2, Q=SiO4/2, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 are each independently chosen from monovalent alkyl, aryl or aralkyl hydrocarbon radicals, or chosen from RP; RP is a monovalent polyether radical independently of the general formula (II): —(CnH2n)—O—(C2H4O)o—(C3H6O)p—(C4H8O)q—R10 (II) RL is a monovalent radical independently chosen from the general formula (III): —X—O—(C2H4O)r—(C3H6O)s—(C4H8O)t—{C(O)CuH2uO}v—R11 (III) There is also provided herein a method for separating emulsions comprising combining the components of the demulsification composition into a mixture; allowing the mixture to separate into at least two phases and separating said at least two phases from each other.
摘要翻译：本文提供了包含至少一种具有通式（I）的聚有机硅氧烷化合物的破乳组合物：M1aM2bD1cD2dT1eT2fQg（I）其中：M1 = R1R2R3SiO1 / 2，M2 = R4R5RLSiO1 / 2，D1 = R6R7SiO2 / 2，D2 = R8RLSiO2 / 2 ，T1 = R9SiO3 / 2，T2 = RLSiO3 / 2，Q = SiO4 / 2，其中R1，R2，R3，R4，R5，R6，R7，R8和R9各自独立地选自一价烷基，芳基或芳烷基烃基，或从RP中选择; RP是独立于通式（II）的单价聚醚基： - （C n H 2n）-O-（C 2 H 4 O）O-（C 3 H 6 O）p - （C 4 H 8 O）q -R 10（II）RL是独立地选自通式（III）：-X-O-（C 2 H 4 O）r - （C 3 H 6 O）s - （C 4 H 8 O）t- {C（O）Cu H 2u O} v-R 11（III）本文还提供了分离乳液的方法，将破乳组合物的组分混合成混合物; 允许混合物分离成至少两相，并将所述至少两相彼此分离。

10. 发明申请

US20110184075A1 DEMULSIFIER COMPOSITIONS AND METHODS FOR SEPARATING EMULSIONS USING THE SAME 失效
标题翻译：分解组合物和使用其分离乳液的方法
公开(公告)号：US20110184075A1
公开(公告)日：2011-07-28
申请号：US12694676
申请日：2010-01-27
申请人： Benjamin Falk , Kalman Koczo , Monjit Phukan , Antonio Palumbo , Anubhav Saxena
发明人： Benjamin Falk , Kalman Koczo , Monjit Phukan , Antonio Palumbo , Anubhav Saxena
IPC分类号： B01D17/05
CPC分类号： C08G77/46 , C08L83/12 , C10G33/04
摘要： The present invention provides for a demulsifying composition comprising a blend of a) an emulsion; and b) a demulsifying-effective amount of a non-crosslinked silicon polyether. The present invention also provides for a method for separating emulsions using the demulsifying composition discussed.
摘要翻译：本发明提供了一种破乳组合物，其包含a）乳液的共混物; 和b）破乳有效量的非交联硅聚醚。本发明还提供了使用所讨论的破乳组合物分离乳液的方法。

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