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1. 发明授权

US09358108B2 Transcatheter valve prosthesis 有权
标题翻译：经导管瓣膜假体
公开(公告)号：US09358108B2
公开(公告)日：2016-06-07
申请号：US14204171
申请日：2014-03-11
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/0003 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/007
摘要： A system for implanting a heart valve includes a radially self-expandable tubular body having a preformed groove disposed at an outer surface of the tubular body, and a valve disposed within the tubular body. The preformed groove extends at least partially around the tubular body, and has a circumferential opening facing radially outward. A trapping member is configured to be disposed within the preformed groove on the outer surface of the tubular body and form at least a partial loop around the tubular body. The circumferential opening of the preformed groove is relatively larger when an outflow end of the tubular body has been deployed from a catheter and an inflow end of the tubular body is disposed within the catheter, and the circumferential opening of the preformed groove is relatively smaller when both the outflow end and the inflow end are fully deployed from the catheter.
摘要翻译：用于植入心脏瓣膜的系统包括径向自扩张的管状体，其具有设置在管状体的外表面处的预成形凹槽和设置在管状体内的阀。预制凹槽至少部分地围绕管状体延伸，并且具有面向径向向外的周向开口。捕获构件被配置为设置在管状体的外表面上的预成型凹槽内，并且形成围绕管体的至少一部分环。当管状体的流出端已经从导管展开并且管状体的流入端设置在导管内时，预成型的凹槽的圆周开口相对较大，并且预成型的凹槽的周向开口相对较小，当流出端和流入端都从导管完全展开。

2. 发明申请

US20140277409A1 TRANSCATHETER VALVE PROSTHESIS 有权
公开(公告)号：US20140277409A1
公开(公告)日：2014-09-18
申请号：US14204171
申请日：2014-03-11
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek NASR
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/0003 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/007
摘要： A system for implanting a heart valve includes a radially self-expandable tubular body having a preformed groove disposed at an outer surface of the tubular body, and a valve disposed within the tubular body. The preformed groove extends at least partially around the tubular body, and has a circumferential opening facing radially outward. A trapping member is configured to be disposed within the preformed groove on the outer surface of the tubular body and form at least a partial loop around the tubular body. The circumferential opening of the preformed groove is relatively larger when an outflow end of the tubular body has been deployed from a catheter and an inflow end of the tubular body is disposed within the catheter, and the circumferential opening of the preformed groove is relatively smaller when both the outflow end and the inflow end are fully deployed from the catheter.
摘要翻译：用于植入心脏瓣膜的系统包括径向自扩张的管状体，其具有设置在管状体的外表面处的预成形凹槽和设置在管状体内的阀。预制凹槽至少部分地围绕管状体延伸，并且具有面向径向向外的周向开口。捕获构件被配置为设置在管状体的外表面上的预成型凹槽内，并且形成围绕管体的至少一部分环。当管状体的流出端已经从导管展开并且管状体的流入端设置在导管内时，预成型的凹槽的圆周开口相对较大，并且预成型的凹槽的周向开口相对较小，当流出端和流入端都从导管完全展开。

3. 发明授权

US11642220B2 Transcatheter valve prosthesis 有权
公开(公告)号：US11642220B2
公开(公告)日：2023-05-09
申请号：US17061052
申请日：2020-10-01
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24 , A61F2/82 , A61F2/86 , A61F2/848
CPC分类号： A61F2/243 , A61F2/2418 , A61F2/2427 , A61F2/848 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/008 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2250/006 , A61F2250/007 , A61F2250/0063 , A61F2250/0069
摘要： A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular heart valve in a connection channel, the prosthesis comprising a radially expandable tubular body extending along an axis, and a valve arranged within and attached to the tubular body. The tubular body is provided with an outer circumferential groove which is open to the radial outside of the tubular body, whereby the tubular body is separated by the outer circumferential groove into first and second body sections. The tubular body is provided with a first plurality of projections which extend from the first or second body section in an axial direction of the tubular body and each of which has a free end arranged to overlap the outer circumferential groove. An elongate outer member may be disposed at the exterior of the connection channel wall structure at a level of the circumferential groove.

4. 发明授权

US10828157B2 Transcatheter valve prosthesis 有权
公开(公告)号：US10828157B2
公开(公告)日：2020-11-10
申请号：US15448071
申请日：2017-03-02
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24 , A61F2/848
摘要： A transcatheter atrio-ventricular valve prosthesis for functional replacement of an atrio-ventricular heart valve in a connection channel, the prosthesis comprising a radially expandable tubular body extending along an axis, and a valve arranged within and attached to the tubular body. The tubular body is provided with an outer circumferential groove which is open to the radial outside of the tubular body, whereby the tubular body is separated by the outer circumferential groove into first and second body sections. The tubular body is provided with a first plurality of projections which extend from the first or second body section in an axial direction of the tubular body and each of which has a free end arranged to overlap the outer circumferential groove. An elongate outer member may be disposed at the exterior of the connection channel wall structure at a level of the circumferential groove.

5. 发明授权

US08956404B2 Transcatheter valve prosthesis 有权
标题翻译：经导管瓣膜假体
公开(公告)号：US08956404B2
公开(公告)日：2015-02-17
申请号：US14204518
申请日：2014-03-11
申请人： Highlife SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/0003 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/007
摘要： A system for implanting a heart valve that includes a radially self-expandable tubular body having an inflow end and an outflow end, and a valve disposed within and attached to the tubular body. A first end of a projection is located at a side surface of the tubular body, and a second free end of the projection defines a groove between the projection and the tubular body. The groove has an opening between the tubular body and the second free end of the projection. Additionally, an elongate outer member is configured to move into the groove and to move heart tissue into the groove, such that the heart tissue is disposed between the tubular body and the projection.
摘要翻译：一种用于植入心脏瓣膜的系统，其包括具有流入端和流出端的径向自扩张管状体，以及设置在管状体内并连接到管状体的阀。突起的第一端位于管状体的侧表面处，并且突出部的第二自由端在突起和管状体之间限定凹槽。凹槽在管状体和突起的第二自由端之间具有开口。此外，细长的外部构件构造成移动到凹槽中并将心脏组织移动到凹槽中，使得心脏组织设置在管状体和突起之间。

6. 发明授权

US10080651B2 Transcatheter valve prosthesis 有权
公开(公告)号：US10080651B2
公开(公告)日：2018-09-25
申请号：US14204293
申请日：2014-03-11
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2427 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2230/0013 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/0003 , A61F2250/0039 , A61F2250/006 , A61F2250/0069 , A61F2250/007
摘要： A system for implanting a heart valve includes a radially self-expandable tubular body having an inflow end and an outflow end and a preformed groove disposed at an outer surface of the tubular body between the inflow end and the outflow end. The preformed groove extends at least partially around the tubular body and has a circumferential opening facing radially outward of the tubular body. A valve is disposed within and is attached to the tubular body, and an elongate outer member is configured to form a loop encircling the preformed groove so as to guide portions of native valve leaflets and/or chords into the preformed groove. The outflow end of the tubular body includes a frustoconical shape that slopes radially outward from the preformed groove toward the outflow end when the outflow end but not the inflow end has been released from a delivery catheter.

7. 发明授权

US09387075B2 Transcatheter valve prosthesis 有权
标题翻译：经导管瓣膜假体
公开(公告)号：US09387075B2
公开(公告)日：2016-07-12
申请号：US14204517
申请日：2014-03-11
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/06 , A61F2/24 , A61F2/848
CPC分类号： A61F2/243 , A61F2/24 , A61F2/2418 , A61F2/2427 , A61F2/848 , A61F2002/8483 , A61F2220/0008 , A61F2220/0016 , A61F2230/0054 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/006 , A61F2250/0063 , A61F2250/0069 , A61F2250/007
摘要： A method for implanting a heart valve includes advancing an elongate outer member from a first delivery catheter to form a loop around native valve leaflets and/or chords of a native valve without substantially occluding the native valve. The method further includes partially deploying from a second delivery catheter a radially self-expandable tubular body having a valve disposed within a lumen of the tubular body, and a preformed groove disposed at an outer surface of the tubular body. The preformed groove extends at least partially around the tubular body, and has a circumferential opening facing radially outward of the tubular body. When the tubular body is partially deployed, the native valve is substantially occluded. Additionally, the method includes moving the loop into the preformed groove after partially deploying the tubular body. The native valve is no longer substantially occluded after fully deploying the tubular body from the second delivery catheter.
摘要翻译：用于植入心脏瓣膜的方法包括使细长的外部构件从第一输送导管前进，以在基本上闭塞所述天然瓣膜的情况下形成围绕天然瓣膜和/或天然瓣膜的和弦的环。该方法还包括从第二递送导管部分展开具有设置在管状体的管腔内的阀的径向自扩张管状体，以及设置在管状体的外表面处的预成形槽。预制凹槽至少部分地围绕管状体延伸，并且具有面向管状体径向向外的周向开口。当管状体部分展开时，本体阀基本上封闭。此外，该方法包括在部分地展开管状体之后将环移动到预成型的凹槽中。在从第二输送导管完全展开管状体后，天然瓣膜不再基本上闭塞。

8. 发明授权

US11938022B2 Transcatheter valve prosthesis and method for implanting the same 有权
公开(公告)号：US11938022B2
公开(公告)日：2024-03-26
申请号：US17329724
申请日：2021-05-25
申请人： HIGHLIFE SAS
发明人： Malek Nasr , Georg Börtlein
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2220/0016 , A61F2220/0083
摘要： A transcatheter valve prosthesis and a method for implanting the prosthesis in a heart are disclosed. The prosthesis includes a tubular body a coupled to a prosthetic valve. A fabric may be disposed on an outer surface of the tubular body. The method includes partially deploying the tubular body from a catheter to at position distal of a distal edge of a native valve leaflet, and moving the catheter such that the deployed outflow end portion of the tubular body engages the distal edge of the native valve leaflet and lifts the native valve leaflet in the proximal direction towards an atrial chamber of the heart. Then, the tubular body can be fully deployed such that the native valve leaflet is captured between the outflow end portion and the inflow end portion.

9. 发明授权

US09889003B2 Transcatheter valve prosthesis 有权
公开(公告)号：US09889003B2
公开(公告)日：2018-02-13
申请号：US14204394
申请日：2014-03-11
申请人： HIGHLIFE SAS
发明人： Georg Börtlein , Malek Nasr
IPC分类号： A61F2/24 , A61F2/848
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2002/8483 , A61F2220/0016 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/006
摘要： A system for implanting a heart valve that includes a radially self-expandable tubular body having an inflow end and a preformed groove disposed at an outer surface of the tubular body between the inflow end and the outflow end, wherein the preformed groove extends at least partially around the tubular body and having a circumferential opening facing radially outward of the tubular body. A valve may be disposed within and attached to the tubular body. Additionally, a trapping member may be configured to form at least a partial loop encircling the preformed groove so as to trap portions of native valve leaflets and/or chords in the preformed groove, the trapping member including one or more barbs.

10. 发明授权

US11484407B2 Transcatheter valve prosthesis 有权
公开(公告)号：US11484407B2
公开(公告)日：2022-11-01
申请号：US16736116
申请日：2020-01-07
申请人： HIGHLIFE SAS
发明人： Will Wang , Malek Nasr , Georg Börtlein , Garrett Offerman , Gilbert Madrid , Martin Rothman , Glenn Balke , Eric Diep
IPC分类号： A61F2/24
摘要： A replacement heart valve system and a method of implanting a replacement heart valve in a patient. The replacement heart valve system includes a radially self-expandable tubular body and a valve including a plurality of leaflets coupled to the tubular body. The tubular body includes interconnected struts defining circumferential rows of cells, and has an outflow end and an inflow end that flares radially outward so as to have a larger outer diameter than that of the outflow end. A first row of proximal-most cells formed at the inflow end includes circumferentially adjacent cells that are disconnected from each other so as to be spaced from each other in the circumferential direction. A method of implanting the replacement heart valve includes delivering from a delivery catheter the tubular body, and expanding the tubular body such that the proximal-most cells are disposed against the native heart valve annulus.

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