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1. 发明授权

US07693320B2 Three time point lung cancer detection, diagnosis and assessment of prognosis 有权
标题翻译：三个时间点肺癌检测，诊断和评估预后
公开(公告)号：US07693320B2
公开(公告)日：2010-04-06
申请号：US10593887
申请日：2005-04-08
申请人： Hadassa Degani , Daphna Weinstein
发明人： Hadassa Degani , Daphna Weinstein
IPC分类号： G06K9/00 , A61B6/00
CPC分类号： A61B6/481 , G06K9/00127 , G06K2209/05 , G06T7/0012 , G06T2207/30061 , G06T2207/30096
摘要： A malignancy classification method and medium for classifying a region of lung tissue are disclosed. The classifying includes: setting time points T1 and T2 measured from injection of a contrast agent. TI represents a wash-in time point for malignant lung tissue at which a first concentration value of the injected contrast agent is substantially equal to or near a peak for injected contrast agent concentration in the region of lung tissue. Patient concentration values of the contrast agent for the area of lung tissue at time points T1 and T2 are obtained, and a malignancy classification for the region of lung tissue is provided by comparing the obtained sample concentration values with a predetermined malignancy profile. A visual representation of the malignancy classification of the region of lung tissue is outputted.
摘要翻译：公开了用于分类肺组织区域的恶性分类方法和培养基。分类包括：设定从注射造影剂测量的时间点T1和T2。 TI表示对于恶性肺组织的洗涤时间点，其中注射的造影剂的第一浓度值基本上等于或接近肺组织区域中注射造影剂浓度的峰值。获得在时间点T1和T2的肺组织区域的造影剂的患者浓度值，并通过将获得的样品浓度值与预定的恶性肿瘤特征进行比较来提供肺组织区域的恶性分类。输出肺组织区域的恶性分类的视觉表示。

2. 发明申请

US20090264734A1 APPARATUS FOR MONITORING A SYSTEM PRESSURE IN SPACE WITH TIME AND METHOD FOR ASSESSING DRUG DELIVERY AND RESISTANCE TO THERAPY AND PRODUCT 失效
标题翻译：用于监测空间中的系统压力的装置和用于评估药物递送和抵抗治疗和产品的方法
公开(公告)号：US20090264734A1
公开(公告)日：2009-10-22
申请号：US12440066
申请日：2007-09-06
申请人： Hadassa Degani , Yaron Hassid
发明人： Hadassa Degani , Yaron Hassid
IPC分类号： A61B5/055
CPC分类号： A61B5/03 , A61B5/055 , A61B5/415 , A61B5/418 , A61B5/42 , A61B5/4839
摘要： A method, apparatus and a computer readable medium containing executable instructions for monitoring a system pressure within a mammal, human or animal, via a tracer/contrast agent, in space in time for determining non-invasively actual interstitial fluid pressure and/or concentration of the tracer/contrast agent. Further, an imaging method, an apparatus and a product for non-invasive mapping of actual interstitial fluid pressure and/or a tracer/contrast agent concentration for assessing drug delivery and resistance to therapy of a tumor or organ within a mammal, to suppress or reduce pressure in a tumor or organ and to control the delivery of drugs to a tumor or organ.
摘要翻译：一种包含可执行指令的方法，装置和计算机可读介质，用于通过示踪剂/造影剂在时间上监测哺乳动物，人或动物内的系统压力，用于确定非侵入式实际的间质液压和/或浓度示踪剂/造影剂。此外，用于评估药物递送和对哺乳动物内的肿瘤或器官的治疗的抵抗力的实际间质液压力和/或示踪剂/造影剂浓度的非侵入性映射的成像方法，装置和产品抑制或降低肿瘤或器官的压力，并控制向肿瘤或器官递送药物。

3. 发明申请

US20080187200A1 Lung Cancer Diagnosis Using Magnetic Resonance Imaging Data Obtained at Three Time Points 有权
标题翻译：使用三个时间点获得的磁共振成像数据进行肺癌诊断
公开(公告)号：US20080187200A1
公开(公告)日：2008-08-07
申请号：US11912554
申请日：2005-04-28
申请人： Hadassa Degani , Edna Haran
发明人： Hadassa Degani , Edna Haran
IPC分类号： G06K9/00
CPC分类号： G06T7/0016 , G06K2209/053 , G06T2207/10088 , G06T2207/30061
摘要： A malignancy classification method and medium for diagnosing a region of lung tissue based on MRI data are disclosed. The classifying includes: setting time points T1 and T2 measured from injection of a contrast agent. T1 represents a wash-in time point for malignant lung tissue at which a first concentration value of the injected contrast agent is substantially equal to or near a peak for injected contrast agent concentration in the region of lung tissue. Patient concentration values of the contrast agent for the area of lung tissue at time points T1 and T2 are obtained, and a malignancy classification for the region of lung tissue is provided by comparing the obtained sample concentration values with a predetermined malignancy profile. A visual representation of the malignancy classification of the region of lung tissue is outputted.
摘要翻译：公开了一种基于MRI数据诊断肺组织区域的恶性分类方法和介质。分类包括：从注射造影剂测量的时间点T 1> 1和T 2> 。 T 1表示恶性肺组织的洗涤时间点，其中注射的造影剂的第一浓度值基本上等于或接近于在肺组织区域中注射的造影剂浓度的峰值。获得在时间点T 1和T 2 2处的肺组织区域的造影剂的患者浓度值，并且提供肺组织区域的恶性分类通过将获得的样品浓度值与预定的恶性曲线进行比较。输出肺组织区域的恶性分类的视觉表示。

4. 发明授权

US07110903B2 Apparatus for monitoring a system with time in space and method therefor 有权
公开(公告)号：US07110903B2
公开(公告)日：2006-09-19
申请号：US10342509
申请日：2003-01-15
申请人： Hadassa Degani
发明人： Hadassa Degani
IPC分类号： G01F1/12
CPC分类号： G06T13/00 , A61B5/0263 , A61B5/0275 , A61B5/055 , G01R33/281 , G01R33/5601 , G01R33/56366 , G06T7/0004 , G06T7/0012 , G06T7/90 , G06T11/206 , G06T13/20 , G06T2207/10088 , G06T2207/10096 , G06T2207/10116 , G06T2207/30068 , G06T2207/30108 , G06T2210/24
摘要： Apparatus and method for monitoring a system in which a fluid flows and which is characterized by a change in the system with time in space. A preselected place in the system is monitored to collect data at two or more time points correlated to a system event. The data is indicative of a system parameter that varies with time as a function of at least two variables related to system wash-in and wash-out behavior. A calibration map is made on a calculated basis with each pixel or voxel representative of a color hue indicative of wash-out behavior and a color intensity indicative of wash-in behavior. When a satisfactory map is obtained, the collected data is processed on the basis of the map to obtain an image of the preselected place with each spatial unit thereof correlated with a color hue and a color intensity. Software and a data processing system are provided to develop the calibration map. The calibration map and image of the preselected place are also novel implementations. Two sets of maps and images can be acquired using different sets of time points.

5. 发明授权

US08175366B2 Method for obtaining spatial images through MRI and processing the resulting spatial images and product 失效
标题翻译：通过MRI获取空间图像并处理所得到的空间图像和产品的方法
公开(公告)号：US08175366B2
公开(公告)日：2012-05-08
申请号：US12443943
申请日：2007-10-17
申请人： Hadassa Degani , Erez Eyal
发明人： Hadassa Degani , Erez Eyal
IPC分类号： G06K9/00
CPC分类号： G01R33/56366 , G01R33/5601 , G01R33/5608 , G06T7/11 , G06T7/187 , G06T2207/10016 , G06T2207/10088
摘要： A method for recording a set of MRI images of a tissue pixel by pixel that evolve with time in a specific manner described by a function; processing the recorded MRI images by aggregating the pixels thereof according to a preselected aspect of time behavior; best fitting the aggregated pixels to a predetermined pixel function to obtain the parameters of the function; and presenting the parameters visually. A computer readable medium containing executable program instructions for carrying out the method.
摘要翻译：一种用于以由功能描述的特定方式随时间演化的用于记录一组组织的一组MRI图像的方法; 通过根据时间行为的预选方面聚集其像素来处理记录的MRI图像; 将聚合像素最佳拟合到预定像素函数以获得该函数的参数; 并直观呈现参数。一种包含用于执行该方法的可执行程序指令的计算机可读介质。

6. 发明申请

US20080305049A1 Mri Contrast Agents for Diagnosis and Prognosis of Tumors 审中-公开
标题翻译： Mri对比剂用于诊断和预后肿瘤
公开(公告)号：US20080305049A1
公开(公告)日：2008-12-11
申请号：US11815072
申请日：2006-01-31
申请人： Hadassa Degani , David Stein
发明人： Hadassa Degani , David Stein
IPC分类号： A61K49/10 , C07J43/00 , C07F19/00 , C07D213/72 , C07D471/04
CPC分类号： A61K49/085 , A61K49/10
摘要： The invention relates to bifunctional conjugates comprising a receptor ligand moiety and a metal binding moiety and complexes thereof with paramagnetic lanthanide or transition metals, and to the use of the metal complexes as contrast agents in magnetic resonance imaging (MRI) of tumors and other abnormalities.
摘要翻译：本发明涉及包含受体配体部分和金属结合部分及其与顺磁镧系元素或过渡金属的复合物的双功能缀合物，以及在肿瘤和其他异常的磁共振成像（MRI）中使用金属络合物作为造影剂。

7. 发明授权

US06611778B2 Apparatus for monitoring a system in which a fluid flows 有权
标题翻译：用于监测流体流动的系统的装置
公开(公告)号：US06611778B2
公开(公告)日：2003-08-26
申请号：US09993190
申请日：2001-11-16
申请人： Hadassa Degani
发明人： Hadassa Degani
IPC分类号： A61B800
CPC分类号： G06T13/00 , G06T7/0012 , G06T11/206 , G06T2207/10096 , G06T2207/30068 , G06T2210/24
摘要： Apparatus and method for monitoring a system in which a fluid flows and which is characterized by a change in the system with time in space. A preselected place in the system is monitored to collect data at two or more time points correlated to a system event. The data is indicative of a system parameter that varies with time as a function of at least two variables related to system wash-in and wash-out behavior. A calibration map is made on a calculated basis with each pixel or voxel representative of a color hue indicative of wash-out behavior and a color intensity indicative of wash-in behavior. When a sastisfactory map is obtained, the collected data is processed on the basis of the map to obtain an image of the preselected place with each spatial unit thereof correlated with a color hue and a color intensity. Software and a data processing system are provided to develop the calibration map. The calibration map and image of the preselected place are also novel implementations.
摘要翻译：用于监测流体流动的系统的装置和方法，其特征在于系统随时间的变化。监视系统中的预选位置以在与系统事件相关的两个或更多个时间点收集数据。该数据表示系统参数随着时间而变化，其与至少两个与系统洗涤和洗出行为相关的变量的函数变化。校准图是在计算的基础上进行的，每个像素或体素代表指示洗出行为的色调和指示洗涤行为的颜色强度。当获得了一个满意的地图时，根据地图对收集的数据进行处理，以获得每个空间单元与色调和颜色强度相关的预选地点的图像。提供软件和数据处理系统来开发校准图。校准图和预选地点的图像也是新颖的实现。

8. 发明授权

US09922421B1 Diffusion ellipsoid mapping of tissue 有权
公开(公告)号：US09922421B1
公开(公告)日：2018-03-20
申请号：US15344518
申请日：2016-11-06
申请人： Hadassa Degani
发明人： Hadassa Degani
IPC分类号： G06K9/00 , G06T7/00 , G06T11/00 , G06T11/60 , G06K9/46
CPC分类号： G06T7/0012 , G06K9/4604 , G06K9/4642 , G06T7/11 , G06T11/001 , G06T11/60 , G06T2207/10092 , G06T2207/30068
摘要： Disclosed herein are methods and devices for generating novel diffusion ellipsoid maps from diffusion tensor imaging (DTI) scan data. One example method includes: (i) generating, from DTI scan data, for each voxel in a plurality of voxels in one or more slabs of a target tissue, a respective diffusion tensor; (ii) generating, for each voxel, eigenvalues and eigenvectors of the respective diffusion tensor and a respective set of diffusion parameters; (iii) partitioning the voxels into two groups, wherein voxels, whose respective set of diffusion parameters is such that each element in the set is smaller than a corresponding element in a set of thresholds, are substantially all in a first group of the two groups; and (iv) providing a graphical representation of a diffusion ellipsoid map of at least one of the one or more slabs, wherein ellipsoids, associated with voxels in the first group, are displayed differently to the other ellipsoids. The utility of the disclosed methods and devices in breast cancer detection is demonstrated.

9. 发明授权

US08069002B2 Apparatus for monitoring a system with time in space and method therefor 有权
公开(公告)号：US08069002B2
公开(公告)日：2011-11-29
申请号：US12971991
申请日：2010-12-17
申请人： Hadassa Degani
发明人： Hadassa Degani
IPC分类号： G01F1/12
CPC分类号： G06T13/00 , A61B5/0263 , A61B5/0275 , A61B5/055 , G01R33/281 , G01R33/5601 , G01R33/56366 , G06T7/0004 , G06T7/0012 , G06T7/90 , G06T11/206 , G06T13/20 , G06T2207/10088 , G06T2207/10096 , G06T2207/10116 , G06T2207/30068 , G06T2207/30108 , G06T2210/24
摘要： Apparatus and method for monitoring a system in which a fluid flows and which is characterized by a change in the system with time in space. A preselected place in the system is monitored to collect data at two or more time points correlated to a system event. The data is indicative of a system parameter that varies with time as a function of at least two variables related to system wash-in and wash-out behavior. A calibration map is made on a calculated basis with each pixel or voxel representative of a color hue indicative of wash-out behavior and a color intensity indicative of wash-in behavior. The calibration map serves as a criteria for selecting the time points. Software and a data processing system are provided to develop a color coded output map. The calibration map, the color coded output map and image of the preselected place are also novel implementations.

10. 发明申请

US20100142786A1 METHOD AND APPARATUS FOR COMPUTER-AIDED DIAGNOSIS OF CANCER AND PRODUCT 失效
标题翻译：用于计算机辅助诊断癌症和产品的方法和装置
公开(公告)号：US20100142786A1
公开(公告)日：2010-06-10
申请号：US12598801
申请日：2008-05-16
申请人： Hadassa Degani , Erez Eyal
发明人： Hadassa Degani , Erez Eyal
IPC分类号： G06K9/00
CPC分类号： G06K9/00214 , A61B5/055 , A61B5/7267 , G06K2209/051 , G06T7/0012 , G06T2207/10096 , G06T2207/20081 , G06T2207/30068 , G06T2207/30096 , G06T2207/30104
摘要： Method and apparatus performing dynamic contrast-enhanced-magnetic resonance imaging on tissue to obtain a plurality of datasets of images. Principal component analysis is performed on each dataset to obtain a covariance matrix and its corresponding eigenvalues and eigenvectors and produce a common base of eigenvectors. The dominant eigenvectors that are not associated with instrumental and random noise, commonly the 2nd eigen-state and the 3rd eigenvectors, or the 1st and 2nd eigen vectors, are correlated with the physiological relevant parameters of the 3TP method to obtain a hybrid method. The fusion of the eigenvectors with the 3TP parameters is dictating a rotation of the two relevant eigenvectors to obtain new rotated eigenvectors that serve to calculate new projection coefficient maps of the rotated eigenvectors for the imaged tissue indicative of physiological relevant parameters reflecting wash-out and wash-in patterns that detect abnormal tissue and distinguishes between cancerous and benign tumors. Computer-readable medium containing program instructions for carrying out the above.
摘要翻译：在组织上进行动态对比增强磁共振成像以获得多个图像数据的方法和装置。在每个数据集上执行主成分分析，以获得协方差矩阵及其对应的特征值和特征向量，并产生特征向量的公共基础。与工具和随机噪声无关的主要特征向量与通常的第二特征状态和第三特征向量或第一和第二特征向量相关联，与3TP方法的生理相关参数相关，以获得混合方法。特征向量与3TP参数的融合决定了两个相关特征向量的旋转，以获得新的旋转特征向量，其用于计算针对成像组织的旋转特征向量的新投影系数图，其指示反映洗出和洗涤的生理相关参数 - 检测异常组织并区分癌性和良性肿瘤的模式。包含用于执行上述的程序指令的计算机可读介质。

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