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1. 发明授权

US08354382B2 Hemifumarate of a pyrazole derivative 有权
标题翻译：吡唑衍生物的半富马酸盐
公开(公告)号：US08354382B2
公开(公告)日：2013-01-15
申请号：US12988273
申请日：2009-04-13
申请人： Hideki Takeuchi , Eiji Tsuru
发明人： Hideki Takeuchi , Eiji Tsuru
IPC分类号： A01N43/04 , A61K31/70 , C07G3/00 , C07H15/00 , C07H17/00 , C07H17/02 , C07H23/00
CPC分类号： C07H17/02
摘要： The present invention provides a novel form of 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}-propylamino)-2,2-dimethylpropionamide hemifumarate dihydrate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
摘要翻译：本发明提供3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）具有改善的储存稳定性的2-二甲基丙酰胺。由于3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基} - 丙基氨基）-2,2-二甲基丙酰胺半富马酸盐二水合物具有极好的储存稳定性，作为药物有用。此外，其显示出非常好的结晶性，并且可以通过方便的方法进行纯化，因此适用于工业制备。

2. 发明授权

US08399418B2 Monosebacate of pyrazole derivative 有权
标题翻译：吡唑衍生物单癸二酸酯
公开(公告)号：US08399418B2
公开(公告)日：2013-03-19
申请号：US12810476
申请日：2008-12-24
申请人： Hideki Takeuchi , Eiji Tsuru
发明人： Hideki Takeuchi , Eiji Tsuru
IPC分类号： C07H17/02 , A61K31/7056 , A61P3/10
CPC分类号： C07H17/02
摘要： The present invention provides a novel form of 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since bis[3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide]monosebacate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
摘要翻译：本发明提供3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）具有改进的储存稳定性的2-二甲基丙酰胺。由于双[3-（3- {4- [3-（＆bgr-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）-2,2-二甲基丙酰胺] 具有非常优异的储存稳定性，作为药物有用。此外，其显示出非常好的结晶性，并且可以通过方便的方法进行纯化，因此适用于工业制备。

3. 发明申请

US20100279962A1 MONOSEBACATE OF PYRAZOLE DERIVATIVE 有权
标题翻译：吡唑衍生物的单体
公开(公告)号：US20100279962A1
公开(公告)日：2010-11-04
申请号：US12810476
申请日：2008-12-24
申请人： Hideki Takeuchi , Eiji Tsuru
发明人： Hideki Takeuchi , Eiji Tsuru
IPC分类号： A61K31/7056 , C07H17/02 , A61P3/10
CPC分类号： C07H17/02
摘要： The present invention provides a novel form of 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since bis[3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide] monosebacate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
摘要翻译：本发明提供3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）具有改善的储存稳定性的2-二甲基丙酰胺。由于双[3-（3- {4- [3-（＆bgr-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）-2,2-二甲基丙酰胺] 具有非常优异的储存稳定性，作为药物有用。此外，其显示出非常好的结晶性，并且可以通过方便的方法进行纯化，因此适用于工业制备。

4. 发明申请

US20110034679A1 HEMIFUMARATE OF A PYRAZOLE DERIVATIVE 有权
标题翻译：吡唑衍生物的高密度脂蛋白
公开(公告)号：US20110034679A1
公开(公告)日：2011-02-10
申请号：US12988273
申请日：2009-04-13
申请人： Hideki Takeuchi , Eiji Tsuru
发明人： Hideki Takeuchi , Eiji Tsuru
IPC分类号： C07H17/02
CPC分类号： C07H17/02
摘要： The present invention provides a novel form of 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide with improved storage stability. Since 3-(3-{4-[3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}-propylamino)-2,2-dimethylpropionamide hemifumarate dihydrate has extremely excellent storage stability, it is useful as a drug substance. Furthermore, it shows an extremely good crystalline property and can be purified by a convenient method, and therefore is suitable for the industrial preparation.
摘要翻译：本发明提供3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基}丙基氨基）具有改善的储存稳定性的2-二甲基丙酰胺。由于3-（3- {4- [3-（＆bgr。-D-吡喃葡萄糖氧基）-5-异丙基-1H-吡唑-4-基甲基] -3-甲基苯氧基} - 丙基氨基）-2,2-二甲基丙酰胺半富马酸盐二水合物极好的储存稳定性，作为药物有用。此外，其显示出非常好的结晶性，并且可以通过方便的方法进行纯化，因此适用于工业制备。

5. 发明授权

US07892368B2 UOE steel pipe excellent in collapse strength and method of production thereof 有权
公开(公告)号：US07892368B2
公开(公告)日：2011-02-22
申请号：US10515543
申请日：2003-05-23
申请人： Eiji Tsuru , Hitoshi Asahi
发明人： Eiji Tsuru , Hitoshi Asahi
IPC分类号： C21D9/08 , F16L9/00
CPC分类号： C22C38/02 , B21C37/065 , B21C37/08 , B21C37/0822 , B21C37/0826 , C21D9/08 , C21D9/50 , C22C38/04 , C22C38/12 , C22C38/14 , Y10T29/18
摘要： The present invention relates to UOE steel pipe excellent in collapse characteristics formed by the UOE production method and a method for forming this UOE steel pipe, said UOE steel pipe characterized in that a ratio between compression and tension of yield strength in the circumferential direction is at least 1.05 near the inside surface and is at least 0.9 to not more to 1.0 from the center of plate thickness to the outside surface.

6. 发明授权

US5919577A Fe-based alloy foil for liquid-phase diffusion bonding of Fe-based materials by enabling bonding in oxidizing atmospheres 失效
标题翻译： Fe基合金箔，用于通过在氧化气氛中接合而使Fe基材料进行液相扩散接合
公开(公告)号：US5919577A
公开(公告)日：1999-07-06
申请号：US11583
申请日：1998-01-30
申请人： Yasushi Hasegawa , Eiji Tsuru , Yuichi Sato , Shigekatsu Ozaki
发明人： Yasushi Hasegawa , Eiji Tsuru , Yuichi Sato , Shigekatsu Ozaki
IPC分类号： B23K20/02 , B23K20/227 , B23K35/02 , B23K35/30 , C22C38/02 , C22C38/32 , C22C38/54
CPC分类号： C22C38/002 , B23K20/023 , B23K20/227 , B23K35/0233 , B23K35/308 , B23K35/3093 , C22C38/02 , C22C38/08 , C22C38/10 , C22C38/105 , C22C38/12 , C22C38/14 , C22C38/22 , C22C38/24 , C22C38/26 , C22C38/28 , C22C38/44 , C22C38/46 , C22C38/48 , C22C38/50 , B23K2201/06 , B23K2203/02 , Y10T428/12431
摘要： The present invention provides an Fe-based alloy foil for liquid phase diffusion bonding of Fe-based material by enabling bonding in oxidizing atmospheres at relatively high bonding temperatures to minimize thermal influence on the base material (the material to be bonded) and, thereby, ensures production of a bonded joint having a uniform microstructure and a good bonded joint strength and enables reduction in the bonding time. The Fe-based alloy foil contains, as essential elements, one of 1.0 to 20.0% P and 1.0 to 20.0% B, 1.0 to 20.0% Si, and 0.1 to 20.0% V, in terms of atomic percentage, the balance substantially of Fe and unavoidable impurities, and has a thickness of 3.0 to 100 .mu.m. Alternatively, the Fe-based alloy foil contains, as essential elements, 1.0 to 20.0% P, 1.0 to 20.0% Si, and 0.1 to 20.0% V, and 1.0 to 20.0% B, in terms of atomic percentage, the balance substantially of Fe and unavoidable impurities, and has a thickness of 3.0 to 200 .mu.m. In accordance with need, one or more of Cr, Ni and Co and/or one or more of W, Nb and Ti are also contained in suitable amounts. The foil advantageously has a substantially amorphous crystallographic structure.
摘要翻译： PCT No.PCT / JP97 / 01900 Sec。 371日期1998年1月30日 102（e）1998年1月30日PCT PCT 1997年6月4日PCT公布。公开号WO97 / 46347 日期1997年12月11日本发明提供了一种Fe基合金箔，其用于通过在相对高的接合温度下在氧化气氛中进行接合而使Fe基材料的液相扩散接合，以最小化对基材（待结合的材料）的热影响），从而确保具有均匀的微结构和良好的接合接合强度的接合接头的制造，并且能够缩短接合时间。 Fe基合金箔作为必要元素含有以原子百分比计的1.0至20.0％的P和1.0至20.0％的B，1.0至20.0％的Si和0.1至20.0％的V中的一种，其余基本上为Fe 和不可避免的杂质，其厚度为3.0〜100μm。或者，Fe基合金箔作为必要元素含有1.0〜20.0％的P，1.0〜20.0％的Si和0.1〜20.0％的V，以原子百分比计含有1.0〜20.0％的B，其余量基本上为 Fe和不可避免的杂质，其厚度为3.0〜200μm。根据需要，还可以以合适的量含有Cr，Ni和Co中的一种或多种和/或W，Nb和Ti中的一种或多种。箔有利地具有基本上非晶的晶体结构。

7. 发明授权

US07438778B2 Elastic endless crawler and method of manufacturing the same 有权
标题翻译：弹性爬行器及其制造方法相同
公开(公告)号：US07438778B2
公开(公告)日：2008-10-21
申请号：US10866730
申请日：2004-06-15
申请人： Eiji Tsuru
发明人： Eiji Tsuru
IPC分类号： G03D15/04
CPC分类号： B62D55/244 , Y10T428/192
摘要： An elastic endless includes an annular belt-shaped elastic crawler body and a plurality of cords with ends, the cords being disposed substantially parallel with one another at predetermined intervals and embedded in the crawler body, wherein one end and the other end of each cord are overlapped, as seen from the belt side.
摘要翻译：弹性环形件包括环形带状弹性履带体和多个具有端部的绳索，绳索以预定的间隔彼此大致平行地设置并且嵌入履带主体中，每个帘线的一端和另一端为重叠，从皮带侧看。

8. 发明授权

US07077485B2 Rubber crawler 有权
标题翻译：橡胶履带
公开(公告)号：US07077485B2
公开(公告)日：2006-07-18
申请号：US10433774
申请日：2001-12-04
申请人： Hitoshi Akiyama , Eiji Tsuru
发明人： Hitoshi Akiyama , Eiji Tsuru
IPC分类号： B62D55/26
CPC分类号： B62D55/24 , B62D55/244
摘要： A core-less rubber crawler has a guide protrusion protruding from an internal surface of a rubber main body in the shape of an endless belt, and the protrusion extends in the lengthwise direction of the rubber main body at the center with respect to the widthwise direction thereof, and ground contacting lugs are provided on the rubber main body characterized in that non-ground contacting areas are formed on the ground contacting lugs correspondingly to a region where the guide protrusion is provided. By the existence of the non-ground contacting area of the ground contacting lugs correspondingly to the place where the guide protrusion is provided, no ground contacting repulsive force is received in the non-ground contacting area. Therefore, it is possible to restrict the shearing force in the vicinity of the basal part of the guide protrusion.
摘要翻译：无芯橡胶履带具有从环形带的橡胶主体的内表面突出的引导突起，并且突起在橡胶主体的长度方向上相对于宽度方向的中心延伸并且在橡胶主体上设置接地接触凸耳，其特征在于，非接地区域对应于设置有引导突起的区域形成在接地凸耳上。通过存在与接地凸耳相对应的地面接触凸耳的非接地区域，在非接地区域内不接收接地排斥力。因此，可以限制引导突起的基部附近的剪切力。

9. 发明授权

US06376707B1 Crystal polymorphism of aminoethylphenoxyacetic acid derivative 失效
标题翻译：氨基乙基苯氧基乙酸衍生物的晶体多晶型
公开(公告)号：US06376707B1
公开(公告)日：2002-04-23
申请号：US09889857
申请日：2001-07-23
申请人： Michio Toda , Tetsuro Tamai , Nobuyuki Tanaka , Kiyoshi Kasai , Junichi Sonehara , Eiji Tsuru
发明人： Michio Toda , Tetsuro Tamai , Nobuyuki Tanaka , Kiyoshi Kasai , Junichi Sonehara , Eiji Tsuru
IPC分类号： C07C22900
CPC分类号： C07C217/60 , C07C213/10
摘要： The present invention relates to a crystalline polymorph of 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl]amino]ethyl]phenoxy]acetic acid having strong diffraction peaks (diffraction angle: 2&thgr;±0.1°) at 10.8, 19.1, 19.3, 19.8, 20.6 and 27.0° in powder X-ray diffraction pattern, which has potent &bgr;2- and &bgr;3-adrenoceptor stimulating effects and is useful as an agent for relieving pain and promoting the removal of calculi in urolithiasis, and the like. For example, the crystalline polymorph can be prepared by hydrolyzing ethyl 2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]phenoxy]acetate phosphate by sodium hydroxide, adding an aqueous phosphoric acid solution at 40° C. and over, adding a mixed solvent of water and methanol or methanol to the resulting compound, and stirring the suspension at 40° C. to reflux temperature for 30 minutes to several hours.
摘要翻译：本发明涉及2- [4- [2 - [[（1S，2R）-2-羟基-2-（4-羟基 - 苯基）-1-甲基乙基]氨基]乙基]苯氧基]乙酸的结晶多晶型物在其粉末X射线衍射图中，在10.8,19.1,19.3,19.8,20.6和27.0°处具有强衍射峰（衍射角：2θ±0.1°）的酸，其具有有效的β2-和β3-肾上腺素受体刺激作用，并且是有用的作为缓解疼痛并促进尿石结石中的结石的去除的药剂等。例如，结晶多晶型物可以通过水解2- [4- [2 - [[（1S，2R）-2-羟基-2-（4-羟基苯基）-1-甲基乙基] - 氨基]乙基]苯氧基 ]乙酸磷酸盐与氢氧化钠反应，在40℃加入磷酸水溶液，过滤，向所得化合物中加入水和甲醇或甲醇的混合溶剂，并在40℃下将悬浮液在回流温度下搅拌30 几分钟到几个小时。

10. 发明授权

US06176524B1 Oil well pipe threaded joint 失效
标题翻译：油井管螺纹接头
公开(公告)号：US06176524B1
公开(公告)日：2001-01-23
申请号：US08688483
申请日：1996-07-30
申请人： Eiji Tsuru , Masaharu Oka , Kazushi Maruyama
发明人： Eiji Tsuru , Masaharu Oka , Kazushi Maruyama
IPC分类号： F16L914
CPC分类号： F16L15/004 , E21B17/042 , F16L15/003 , Y10S285/91
摘要： This invention provides an oil well pipe threaded joint capable of preventing looping and squeezing of a soft synthetic resin ring and consequently, preventing catching of a tool during a logging operation and damage such as corrosion by a corrosive fluid, the oil well pipe threaded joint employs the construction wherein a soft synthetic resin ring is interposed between distal end surfaces of pins, each step surface of a shoulder portion on an inner peripheral side of a coupling and a step surface of each pin are brought into abuttment, and each inside thread of the coupling of the coupling and each outside thread of each pin are engaged, wherein a compressive ratio of the soft synthetic resin ring in an axial direction falls within the range expressed by an inequality 18,000/E≦compressive ratio (%)
摘要翻译：本发明提供了一种油井管螺纹接头，能够防止软质合成树脂环的缠绕和挤压，从而防止在测井作业期间抓住工具以及腐蚀性液体腐蚀等损坏，油井管螺纹接头采用在软管合成树脂环插入在销的前端面之间的结构中，联接器的内周侧的肩部的每个台阶表面和每个销的台阶表面被抵接，并且每个内螺纹每个销的联接器和每个外螺纹的联接被接合，其中软合成树脂环在轴向上的压缩比落在由不等式表示的范围内（其中d1：销的内径，d2：内径软合成树脂环，t1：针脚末端厚度）。

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