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    • 1. 发明授权
    • Switching regulator and control method thereof
    • US11183928B2
    • 2021-11-23
    • US14978999
    • 2015-12-22
    • Hua Cao
    • Hua Cao
    • H02M3/158H02M3/156
    • A novel method to operate a switching regulator is presented. The method includes the generation of at least two reference signals. A first reference signal is a constant DC voltage signal and a second reference signal is a periodic ramp sawtooth signal at a given frequency. It also includes the generation of a feedback signal by using the output voltage of the switching regulator. In one method, a capacitor is either charged by a bias current or discharged by a switch. A first comparator is configured to compare a first constant DC reference voltage signal to a feedback signal. A second comparator is configured to compare a periodic ramp sawtooth signal to a voltage signal on the capacitor. In an alternative method, a comparator is configured to compare the feedback signal to either the periodic ramp sawtooth reference signal or the constant DC reference signal depending on the switching operation of the switching regulator. The periodic ramp sawtooth reference signal can be either positive or negative. The method is presented for buck switching regulators, and can be utilized also for boost, buck-boost, flyback, forward, and sepic, etc.
    • 2. 发明申请
    • SWITCHING REGULATOR AND CONTROL METHOD THEREOF
    • 切换调节器及其控制方法
    • US20160204704A1
    • 2016-07-14
    • US14978999
    • 2015-12-22
    • Hua Cao
    • Hua Cao
    • H02M3/158
    • H02M3/156H02M2003/1566
    • A novel method to operate a switching regulator is presented. The method includes the generation of at least two reference signals. A first reference signal is a constant DC voltage signal and a second reference signal is a periodic ramp sawtooth signal at a given frequency. It also includes the generation of a feedback signal by using the output voltage of the switching regulator. In one method, a capacitor is either charged by a bias current or discharged by a switch. A first comparator is configured to compare a first constant DC reference voltage signal to a feedback signal. A second comparator is configured to compare a periodic negative ramp sawtooth signal to a voltage signal on the capacitor. In an alternative method, a comparator is configured to compare the feedback signal to either the periodic ramp sawtooth reference signal or the constant DC reference signal depending on the switching operation of the switching regulator. In the alternative method, the periodic ramp sawtooth reference signal can be either positive or negative. The method is presented for buck switching regulators, and can be utilized also for boost, buck-boost, flyback, forward, and sepic, etc.
    • 介绍了一种操作开关稳压器的新方法。 该方法包括产生至少两个参考信号。 第一参考信号是恒定的直流电压信号,第二参考信号是给定频率的周期性斜坡锯齿波信号。 它还包括通过使用开关稳压器的输出电压产生反馈信号。 在一种方法中,电容器由偏置电流充电或由开关放电。 第一比较器被配置为将第一恒定DC参考电压信号与反馈信号进行比较。 第二比较器被配置为将周期性负斜坡锯齿波信号与电容器上的电压信号进行比较。 在替代方法中,比较器被配置为根据开关调节器的开关操作将反馈信号与周期性斜坡锯齿参考信号或恒定DC参考信号进行比较。 在替代方法中,周期性斜坡锯齿参考信号可以是正或负。 该方法用于降压开关稳压器,也可用于升压,降压 - 升压,反激,前进和分离等。
    • 4. 发明授权
    • Methods for preparing antiviral calanolide compounds
    • 制备抗病毒胼cal体化合物的方法
    • US06369241B1
    • 2002-04-09
    • US09557821
    • 2000-04-25
    • Ze-Qi XuHongwei YuanJennifer CrabbRaghu SamyAiling LiHua Cao
    • Ze-Qi XuHongwei YuanJennifer CrabbRaghu SamyAiling LiHua Cao
    • C07D31122
    • C07D493/04C07D493/14
    • The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy-6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (−)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.
    • 本发明涉及制备2,2-二甲基-5-酰氧基-10-丙基-2H,8H-苯并[1,2-b:3,4-b']二吡喃-8-酮(5)的方法和 2,2-二甲基-5-羟基-10-丙基-2H,8H-苯并[1,2-b:3,4-b']二吡喃-8-酮(6)及其作为合成中间体的用途 抗病毒胼cal体化合物。 例如,化合物5上的Fries重排或6上的Friedel-Crafts反应产生中间体2,2-二甲基-5-羟基-6-丙酰基-10-丙基-2H,8H-苯并[1,2-b:3, 4-b']二吡喃-8-酮(4),其依次可以转化为(+) - 卡立拉内酯A和( - ) - 甘露糖苷B。化合物6与适当的手性分子在Mitsunobu或 亲核取代导致抗病毒胼cal体化合物的不对称合成。
    • 6. 发明授权
    • Methods for preparing antiviral calanolide compounds
    • 制备抗病毒胼cal体化合物的方法
    • US06420571B2
    • 2002-07-16
    • US09918674
    • 2001-07-31
    • Ze-Qi XuHongwei YuanJennifer CrabbRaghu SamyAiling LiHua Cao
    • Ze-Qi XuHongwei YuanJennifer CrabbRaghu SamyAiling LiHua Cao
    • C07D49304
    • C07D493/04C07D493/14
    • The present invention relates to methods for preparing 2,2-dimethyl-5-acyloxy -10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (5) and 2,2-dimethyl-5-hydroxy-10 -propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (6) and their use as intermediates for the synthesis of antiviral calanolide compounds. For example, Fries rearrangement on compound 5 or Friedel-Crafts reaction on 6, yields intermediate 2,2-dimethyl-5-hydroxy -6-propionyl-10-propyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-8-one (4), which, in turn, can be converted to (+)-calanolide A and (−)-calanolide B. The coupling of compound 6 with the appropriate chiral molecule under Mitsunobu or nucleophilic displacement leads to the asymmetric synthesis of antiviral calanolide compounds.
    • 本发明涉及制备2,2-二甲基-5-酰氧基-10-丙基-2H,8H-苯并[1,2-b:3,4-b']二吡喃-8-酮(5)的方法和 2,2-二甲基-5-羟基-10-丙基-2H,8H-苯并[1,2-b:3,4-b']二吡喃-8-酮(6)及其作为合成 抗病毒胼cal体化合物。 例如,化合物5上的Fries重排或6上的Friedel-Crafts反应产生中间体2,2-二甲基-5-羟基-6-丙酰基-10-丙基-2H,8H-苯并[1,2-b:3, 4-b']二吡喃-8-酮(4),其依次可以转化为(+) - 卡立拉内酯A和( - ) - 甘露糖苷B。化合物6与适当的手性分子在Mitsunobu或 亲核取代导致抗病毒胼cal体化合物的不对称合成。
    • 7. 发明授权
    • Low dropout regulator (LDO)
    • US10345840B1
    • 2019-07-09
    • US16245568
    • 2019-01-11
    • Hua Cao
    • Hua Cao
    • G05F1/575G05F1/565
    • A novel low dropout regulator (LDO) is presented. The LDO includes the generation of a first feedback signal and a second feedback signal. The first feedback signal and a reference signal connect to a first error amplifier. The second feedback signal and the first error amplifier output signal connect to a second error amplifier. The output signal from the second error amplifier is coupled to the gate of a FET transistor. The FET transistor can be either a p-channel FET transistor, an n-channel FET transistor, a NMOS pass transistor, or a PMOS pass transistor. The positive input terminal or the negative input terminal of the first amplifier or of the second amplifier therefore need to be configured accordingly. When the source of the FET transistor is connected to the input voltage VIN, the drain of the FET transistor is the output voltage VOUT; when the drain of the FET transistor is connected to the input voltage VIN, the source of the FET transistor is the VOUT.
    • 8. 发明授权
    • Method of generating a feedback signal in a switching regulator
    • US10027221B1
    • 2018-07-17
    • US15704938
    • 2017-09-14
    • Hua Cao
    • Hua Cao
    • H02M3/156H02M1/088H02M3/158H02M1/00
    • A novel method to generate a feedback signal in a switching regulator is presented. The method includes the generation of a first feedback signal using the switching signal. The first feedback signal carries a ripple and the ripple is in phase with the switching signal. The first feedback signal does not use a control-in terminal PIN. The voltage level of the first feedback signal is regulated through a resistor and a capacitor connected between the switching node and the switching regulator controller. In an alternative method, a second feedback signal is generated using the regulator output voltage. The controller receives the second feedback through a control-in terminal PIN. In the alternative method, another resistor and another capacitor are used to connect the first feedback signal and the second feedback signal. Furthermore, the second feedback signal can adjust the regulator output voltage through two resistors connected in series. The subject invention is designed to operate in the Continuous Conduction Mode (CCM) where the load is significant and the inductor current remains positive during the entire switching period. The method is presented for buck switching regulators, and can be utilized also for boost, buck-boost, flyback, forward, and sepic, etc.