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1. 发明授权

US08338372B2 Dehydroxy vancomycin, the preparation, pharmaceutical composition and the use 有权
标题翻译：脱羟万古霉素，制剂，药物组合物及用途
公开(公告)号：US08338372B2
公开(公告)日：2012-12-25
申请号：US12680650
申请日：2008-08-25
申请人： Bingxiang Xu , Haisong Xie , Huan Yu , Wei Mao , Weidong Ye
发明人： Bingxiang Xu , Haisong Xie , Huan Yu , Wei Mao , Weidong Ye
IPC分类号： A61K38/14 , C07K9/00 , C07K1/22 , A61P31/04
CPC分类号： C07K9/008 , A61K38/14 , C12P19/46 , C12P19/60
摘要： The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations of Amycolatopsis Orientalis with Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.
摘要翻译：本发明提供了一种脱羟基万古霉素化合物，其制备方法和包含药学有效量的脱羟万古霉素的药物组合物，以及所述组合物在制备用于治疗易感细菌感染的药物中的用途。该方法包括以下步骤：（1）通过发酵具有沉积物号CGMCCNO.1183的Amycolatopsis Orientalis的发酵制备含有脱羟万古霉素的浓缩万古霉素溶液; （2）分离纯化浓缩的万古霉素溶液，通过柱色谱法得到含有脱羟万古霉素的万古霉素盐酸盐精制滤液; 和（3）进一步分离和纯化精制滤液，通过色谱法获得脱羟万古霉素。其中分离纯化在含有盐水流动相的凝胶色谱柱中通过柱色谱法处理，分离和纯化在含有缓冲液 - 甲醇流动相的大孔吸附树脂色谱柱中通过色谱法处理。

2. 发明申请

US20100222252A1 DESHYDROXY VANCOMYCIN, THE PREPARATION, PHARMACEUTICAL COMPOSITION AND THE USE 有权
标题翻译：脱乙酰甘氨酸，制剂，药物组合物及其用途
公开(公告)号：US20100222252A1
公开(公告)日：2010-09-02
申请号：US12680650
申请日：2008-08-25
申请人： Bingxiang Xu , Haisong Xie , Huan Yu , Wei Mao , Weidong Ye
发明人： Bingxiang Xu , Haisong Xie , Huan Yu , Wei Mao , Weidong Ye
IPC分类号： A61K38/14 , C07K9/00 , C07K1/22 , A61P31/04
CPC分类号： C07K9/008 , A61K38/14 , C12P19/46 , C12P19/60
摘要： The present invention provides a deshydroxy vancomycin compound,a method of its preparation and a pharmaceutical composition comprising a pharmaceutically effective amount of the deshydroxy vancomycin and the use of the said composition in the preparation of drugs for the treatment of susceptible bacteria infections. The method includes the following steps: (1) preparing a concentrated vancomycin solution containing the deshydroxy vancomycin by fermentations of Amycolatopsis Orientalis with Deposit No. CGMCCNO.1183; (2) separating and purifing the concentrated vancomycin solution to obtain a refined filtrate of vancomycin hydrochloride containing the deshydroxy vancomycin by column chromatography; and (3) further separating and purifing the refined filtrate to obtain the deshydroxy vancomycin by chromatography. Wherein, separation and purification is processed by column chromatography in a gel chromatography column containing a salt-water mobile phase, separation and purification is processed by chromatography in a macroporous adsorption resin chromatography column containing a buffer-methanol mobile phase.
摘要翻译：本发明提供了一种脱羟基万古霉素化合物，其制备方法和包含药学有效量的脱羟万古霉素的药物组合物，以及所述组合物在制备用于治疗易感细菌感染的药物中的用途。该方法包括以下步骤：（1）通过发酵具有沉积物号CGMCCNO.1183的Amycolatopsis Orientalis的发酵制备含有脱羟万古霉素的浓缩万古霉素溶液; （2）分离纯化浓缩的万古霉素溶液，通过柱色谱法得到含有脱羟万古霉素的万古霉素盐酸盐精制滤液; 和（3）进一步分离和纯化精制滤液，通过色谱法获得脱羟万古霉素。其中分离纯化在含有盐水流动相的凝胶色谱柱中通过柱色谱法处理，分离和纯化在含有缓冲液 - 甲醇流动相的大孔吸附树脂色谱柱中通过色谱法处理。

3. 外观设计

USD924492S1 Pet water filter fountain 有权
公开(公告)号：USD924492S1
公开(公告)日：2021-07-06
申请号：US29666375
申请日：2018-10-12
申请人： Huan Yu
设计人： Huan Yu

4. 发明授权

US08884976B2 Image processing apparatus that enables to reduce memory capacity and memory bandwidth 有权
标题翻译：能够降低存储容量和存储器带宽的图像处理装置
公开(公告)号：US08884976B2
公开(公告)日：2014-11-11
申请号：US13446431
申请日：2012-04-13
申请人： Huan Yu
发明人： Huan Yu
IPC分类号： G09G5/39 , G09G5/00 , H04N5/76 , H04N7/01
CPC分类号： H04N7/0105 , G09G5/005 , G09G5/39 , G09G2320/106 , G09G2340/02 , G09G2340/0428 , G09G2340/0435 , G09G2350/00 , H04N7/0132 , H04N7/014
摘要： An image processing apparatus includes a memory control circuit that stores pixel data in a frame memory, an image processing circuit that processes the pixel data stored in the frame memory, and an output circuit that outputs processed pixel data. The memory control circuit divides the pixel data into upper bit portions and lower bit portions, and a lower bit processing circuit stores the lower bit portions in the frame memory by one of (i) dividing lower bit portion of each of the pixel data into n unit portions and storing corresponding one of n unit portions in the frame memory during each of n successive frame periods, and (ii) dividing pixels constituting each of the frames into n groups and storing the lower bit portions of the pixel data of pixels in corresponding one of n groups in the frame memory during each of n successive frame periods.
摘要翻译：图像处理装置包括：存储器控制电路，其存储帧存储器中的像素数据;图像处理电路，处理存储在帧存储器中的像素数据;以及输出电路，输出经处理的像素数据。存储器控制电路将像素数据分割为高位部分和低位部分，低位处理电路通过以下步骤之一将下位部分存储在帧存储器中：（i）将每个像素数据的较低位部分分成n 单元部分，并且在n个连续帧周期中的每一个期间将n个单元部分中的相应一个存储在帧存储器中，以及（ii）将构成每个帧的像素划分为n组，并将像素的像素数据的低位部分存储在相应的在n个连续帧周期的每一个期间帧存储器中的n个组中的一个。

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