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1. 发明申请

US20190169612A1 Methods of Manipulating the Fate of Cells 审中-公开
公开(公告)号：US20190169612A1
公开(公告)日：2019-06-06
申请号：US16031529
申请日：2018-07-10
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/7105 , A61K31/713 , C12N15/11 , C12Q1/6886 , A61K45/06
摘要： A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding RNA species (cuR), (b) a modified cuR, or (c) a compound that modifies or affects cuR, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of RNA:RNA or RNA:DNA or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. The invention generates cell fate or cell maintenance in a subject, such as a human, so that an increase of desirable cells or a decrease in undesirable cells can be obtained in the subject. This feature can be applied to a therapeutic method of treating a condition in a subject.

2. 发明申请

US20170008968A1 NOVEL METHODS OF CANCER THERAPY TARGETED AGAINST A CANCER STEM LINE 审中-公开
标题翻译：癌症治疗方法针对癌症干细胞治疗方法
公开(公告)号：US20170008968A1
公开(公告)日：2017-01-12
申请号：US15041626
申请日：2016-02-11
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： C07K16/30 , A61K45/06 , A61K31/7088 , A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

3. 发明申请

US20070041984A1 Novel methods of cancer diagnosis and therapy targeted against a cancer stem line 审中-公开
公开(公告)号：US20070041984A1
公开(公告)日：2007-02-22
申请号：US11583859
申请日：2006-10-18
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.

4. 发明申请

US20070036804A1 Novel methods of cancer diagnosis and therapy targeted against a cancer stem line 审中-公开
公开(公告)号：US20070036804A1
公开(公告)日：2007-02-15
申请号：US11583871
申请日：2006-10-18
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.

5. 发明申请

US20070036803A1 Novel methods of cancer diagnosis and therapy targeted against a cancer stem line 审中-公开
公开(公告)号：US20070036803A1
公开(公告)日：2007-02-15
申请号：US11583860
申请日：2006-10-18
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.

6. 发明授权

US08846325B2 Methods of cancer diagnosis and therapy targeted against a cancer stem line 有权
标题翻译：针对癌症干线的癌症诊断和治疗方法
公开(公告)号：US08846325B2
公开(公告)日：2014-09-30
申请号：US12187177
申请日：2008-08-06
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： G01N33/567 , G01N33/574 , A61K49/00 , G01N33/50 , C07K16/30
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

7. 发明授权

US07608259B2 Methods of cancer diagnosis and therapy targeted against a cancer stem line 有权
标题翻译：针对癌症干线的癌症诊断和治疗方法
公开(公告)号：US07608259B2
公开(公告)日：2009-10-27
申请号：US11583744
申请日：2006-10-18
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

8. 发明申请

US20080305107A1 NOVEL METHODS OF CANCER DIAGNOSIS AND THERAPY TARGETED AGAINST A CANCER STEM LINE 审中-公开
标题翻译：癌症诊断和治疗方法针对癌症干细胞定位的新方法
公开(公告)号：US20080305107A1
公开(公告)日：2008-12-11
申请号：US12187221
申请日：2008-08-06
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395 , A61K38/00 , A61K31/7088 , A61K33/24
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

9. 发明授权

US07427400B2 Methods of cancer diagnosis and therapy targeted against a cancer stem line 有权
标题翻译：针对癌症干线的癌症诊断和治疗方法
公开(公告)号：US07427400B2
公开(公告)日：2008-09-23
申请号：US11583857
申请日：2006-10-18
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

10. 发明申请

US20060083682A1 Novel methods of cancer therapy targeted against a cancer stemline 有权
标题翻译：针对癌症干细胞的新型癌症治疗方法
公开(公告)号：US20060083682A1
公开(公告)日：2006-04-20
申请号：US11271381
申请日：2005-11-10
申请人： Ivan Bergstein
发明人： Ivan Bergstein
IPC分类号： A61K51/00 , A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/77 , G01N33/5017 , G01N33/574
摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.
摘要翻译：提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

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