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1. 发明授权

US08588908B2 System, method and computer program product for detection of changes in health status and risk of imminent illness 有权
标题翻译：系统，方法和计算机程序产品，用于检测健康状况和即将发生的疾病风险
公开(公告)号：US08588908B2
公开(公告)日：2013-11-19
申请号：US12866056
申请日：2009-02-04
申请人： J. Randall Moorman , Douglas E. Lake
发明人： J. Randall Moorman , Douglas E. Lake
IPC分类号： A61N1/365
CPC分类号： A61B5/02405 , A61B5/0006 , A61B5/0245 , A61B5/04012 , A61B5/044 , A61B5/0452 , A61B5/0468 , A61B5/412
摘要： A method for analysis of cardiac rhythm and RR interval time series based on entropy related data and entropy based measures. The information is related to but distinct from entropy, and is derived from histograms of interval match counts in which the y-axis is the frequency of intervals of length in that have the match count given on the x-axis. The phenotype of the histogram informs on the presence of atrial fibrillation or, in the presence of sinus rhythm, the degree of congestive heart failure.
摘要翻译：基于熵相关数据和基于熵的测量方法分析心律和RR间期时间序列。该信息与熵相关，但不同于熵，并且是从间隔匹配计数的直方图导出的，其中y轴是具有在x轴上给出的匹配计数的长度间隔的频率。直方图的表型表明心房颤动的存在，或者在窦性心律的存在下充血性心力衰竭的程度。

2. 发明授权

US08983584B2 Method, system and computer program product for non-invasive classification of cardiac rhythm 有权
标题翻译：方法，系统和计算机程序产品用于心脏节律的非侵入性分类
公开(公告)号：US08983584B2
公开(公告)日：2015-03-17
申请号：US12594842
申请日：2008-04-11
申请人： J. Randall Moorman , Douglas E. Lake
发明人： J. Randall Moorman , Douglas E. Lake
IPC分类号： A61B5/04 , A61B5/048 , A61B5/00 , G06K9/00 , A61B5/0452 , A61N1/39 , G06F19/00
CPC分类号： A61B5/0456 , A61B5/0452 , A61B5/046 , A61B5/048 , A61B5/412 , A61B5/7242 , A61B5/7264 , A61N1/395 , G06K9/00523 , G16H50/20
摘要： The invention relates to a method for analysis of cardiac rhythms, based on calculations of entropy and moments of interbeat intervals. The invention provides an optimal determination of segments of data that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each segment with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated and provided as a continuous variable, providing dynamical information of fundamental importance in diagnosis and analysis. Through the present invention, standard histograms, thresholds, and categories can be avoided.
摘要翻译：本发明涉及一种基于熵和间隔时间的计算的心律分析方法。本发明提供了显示统计均匀性的数据段的最佳确定，具体地关于力矩和熵。本发明还涉及以心律的诊断为目标计算每个片段的时刻和熵。更具体地说，绝对熵测量被计算并提供为连续变量，提供在诊断和分析中具有根本重要性的动态信息。通过本发明，可以避免标准直方图，阈值和类别。

3. 发明申请

US20100324436A1 System, Method and Computer Program Product for Detection of Changes in Health Status and Risk of Imminent Illness 有权
标题翻译：系统，方法和计算机程序产品，用于检测健康状况和即将发生的疾病风险
公开(公告)号：US20100324436A1
公开(公告)日：2010-12-23
申请号：US12866056
申请日：2009-02-04
申请人： J. Randall Moorman , Douglas E. Lake
发明人： J. Randall Moorman , Douglas E. Lake
IPC分类号： A61B5/0402
CPC分类号： A61B5/02405 , A61B5/0006 , A61B5/0245 , A61B5/04012 , A61B5/044 , A61B5/0452 , A61B5/0468 , A61B5/412
摘要： A method for analysis of cardiac rhythms and the clinical status of a patient, based on calculations of entropy and moments of time series intervals. An optimal determination is made of segments of data that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each interval segments with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated, providing dynamic information of fundamental importance in diagnosis and analysis.
摘要翻译：基于时间序列间隔的熵和时刻的计算，分析心脏节律和患者临床状态的方法。最终确定显示统计均匀性的数据段，特别是关于时刻和熵。本发明还涉及以每个间隔段计算时间和熵，目的是诊断心律。更具体地说，计算绝对熵测量，提供诊断和分析中基本重要性的动态信息。

4. 发明授权

US07774050B2 Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：用于早期诊断亚急性潜在灾难性疾病的方法和装置
公开(公告)号：US07774050B2
公开(公告)日：2010-08-10
申请号：US11000630
申请日：2004-12-01
申请人： M. Pamela Griffin , J. Randall Moorman
发明人： M. Pamela Griffin , J. Randall Moorman
IPC分类号： A61B5/0402 , A61B5/0456 , A61B5/0444
CPC分类号： A61B5/0444 , A61B5/02405 , A61B5/02411 , A61B5/412 , A61B5/4362 , G06F19/00 , G06F19/3456 , G16H10/40 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect of the present invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.
摘要翻译：在本发明的一个方面，提供了一种用于在早产新生儿中早期发现亚急性，潜在的灾难性感染性疾病的方法和装置。该方法包括：（a）连续监测早产新生儿心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。在本发明的另一方面，提供了一种用于在患者中早期发现亚急性潜在的灾难性感染性疾病的方法和装置。该方法包括：（a）持续监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

5. 发明授权

US06856831B2 Method for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：早期诊断亚急性，潜在灾难性疾病的方法
公开(公告)号：US06856831B2
公开(公告)日：2005-02-15
申请号：US09770653
申请日：2001-01-29
申请人： M. Pamela Griffin , J. Randall Moorman
发明人： M. Pamela Griffin , J. Randall Moorman
IPC分类号： A61B5/024 , A61B5/0444 , G06F17/00 , G06F19/00 , A61B5/0452
CPC分类号： A61B5/0444 , A61B5/02405 , A61B5/02411 , A61B5/412 , A61B5/4362 , G06F19/00 , G06F19/3456 , G16H10/40 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect of the invention, there is provided a method for early detection of subacute, potentially catastrophic illness in an infant. The method comprises: (a) monitoring heart rate variability in the infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be used to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect of the present invention, there is provided a method for early detection of subacute, potentially catastrophic illness in an infant, which comprises: (a) monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.
摘要翻译：在本发明的一个方面，提供了一种用于在婴儿中早期检测亚急性潜在的灾难性疾病的方法。该方法包括：（a）监测婴儿的心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。在本发明的另一方面，提供了一种用于早期检测婴儿中亚急性潜在灾难性疾病的方法，其包括：（a）监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

6. 发明授权

US07519417B2 Quantitative fetal heart rate and cardiotocographic monitoring system and related method thereof 有权
标题翻译：定量胎心率和心脏造影监测系统及其相关方法
公开(公告)号：US07519417B2
公开(公告)日：2009-04-14
申请号：US10545257
申请日：2004-02-12
申请人： James E. Ferguson, II , M. Pamela Griffin , J. Randall Moorman
发明人： James E. Ferguson, II , M. Pamela Griffin , J. Randall Moorman
IPC分类号： A61B5/04
CPC分类号： A61B5/412 , A61B5/02411 , A61B5/033 , A61B5/0444 , A61B5/0452 , A61B5/0456 , A61B5/4356 , A61B5/4362 , G16H50/20
摘要： A method, system, and computer program product are provide for, among other things, quantitative analysis of heart rate characteristics from fetal heart rate and cardiotocogram monitors that gives information about the well-being of the fetus and the risk of poor fetal outcome. The method comprises (a) continuously measuring fetal heart rate and cardiotocographic characteristics and (b) identifying at least one characteristic abnormality in the heart rate characteristics that is associated with fetal distress. Benefits are appreciated by the fetus and the mother and during the antepartum and intrapartum periods.
摘要翻译：提供方法，系统和计算机程序产品，其中包括从胎儿心率和心电图监测器的心率特征的定量分析，其提供关于胎儿福利的信息和胎儿结果不良的风险。该方法包括（a）连续测量胎儿心率和心脏图形特征，以及（b）鉴定与胎儿窘迫相关的心率特征中的至少一个特征异常。胎儿和母亲以及在产后和产后时期都能感受到好处。

7. 发明授权

US06804551B2 Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：用于早期诊断亚急性潜在灾难性疾病的方法和装置
公开(公告)号：US06804551B2
公开(公告)日：2004-10-12
申请号：US09793653
申请日：2001-02-27
申请人： M. Pamela Griffin , J. Randall Moorman , Boris P. Kovatchev
发明人： M. Pamela Griffin , J. Randall Moorman , Boris P. Kovatchev
IPC分类号： A61B50456
CPC分类号： A61B5/02405 , A61B5/02411 , A61B5/0444 , A61B5/0452 , A61B5/412 , A61B5/4362 , A61B5/7275 , G06F19/00 , G16H10/60 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic illness in a patient. The method comprises: (a) monitoring heart rate variability in the patient; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis, as well as noninfectious illnesses. In another aspect of the present invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic illness in a patient. The method comprises: (a) monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the second and higher moments, including the standard deviation (ii) percentile values of the data set, (iii) sample entropy, and (iv) sample asymmetry; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments, the percentile values, sample entropy, and sample asymmetry analysis.
摘要翻译：在本发明的一个方面，提供了一种用于在患者中早期检测亚急性潜在灾难性疾病的方法和装置。该方法包括：（a）监测患者的心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎以及非感染性疾病。在本发明的另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性疾病的方法和装置。该方法包括：（a）监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第二和更高的时刻选择的数据集的时刻的一个或多个，包括数据集的标准偏差（ii）百分位数值，（iii）样本熵，以及（iv）样本不对称性 ; 和（d）基于一个或多个时刻，百分位数值，样本熵和样本不对称分析来识别与疾病相关的异常心率变异性。

8. 发明授权

US06923763B1 Method and apparatus for predicting the risk of hypoglycemia 有权
标题翻译：用于预测低血糖风险的方法和装置
公开(公告)号：US06923763B1
公开(公告)日：2005-08-02
申请号：US10069674
申请日：2000-08-21
申请人： Boris P. Kovatchev , J. Randall Moorman , William L. Clarke , Martin Straume
发明人： Boris P. Kovatchev , J. Randall Moorman , William L. Clarke , Martin Straume
IPC分类号： A61B5/00 , G06F19/00
CPC分类号： A61B5/7275 , A61B5/14532 , A61B5/4035 , G06F19/00 , G06F19/3468 , G16H10/60 , G16H50/20 , G16H50/50 , Y10S128/92
摘要： The invention relates to a method which utilizes blood glucose (“BG”) sampling, insulin infusion/injection records, heart rate (“HR”) information and heart rate varability (“HRV”) information to estimate BG in the near future and to estimate of the risk of the onset of hypoglycemia. The invention also relates to an apparatus for predicting BG levels and for assessing the risk of the onset of hypoglycemia in the near future. The invention is based on two predetermined bio-mathematical routines: a network model of BG fluctuations and a BG profile for assessment of the risk of hypoglycemia.
摘要翻译：本发明涉及利用血糖（“BG”）采样，胰岛素输注/注射记录，心率（“HR”）信息和心率可变性（“HRV”）信息在近期内估计BG的方法，估计发生低血糖的风险。本发明还涉及一种用于预测BG水平并用于评估在不久的将来发生低血糖风险的装置。本发明基于两个预定的生物数学程序：BG波动的网络模型和用于评估低血糖风险的BG简档。

9. 发明授权

US06330469B1 Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：用于早期诊断亚急性潜在灾难性疾病的方法和装置
公开(公告)号：US06330469B1
公开(公告)日：2001-12-11
申请号：US09668309
申请日：2000-09-25
申请人： M. Pamela Griffin , J. Randall Moorman
发明人： M. Pamela Griffin , J. Randall Moorman
IPC分类号： A61B50468
CPC分类号： A61B5/0444 , A61B5/02405 , A61B5/02411 , A61B5/412 , A61B5/4362 , G06F19/00 , G06F19/3456 , G16H10/40 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.
摘要翻译：在本发明的一个方面，提供了一种用于在早产新生儿中早期发现亚急性，潜在的灾难性感染性疾病的方法和装置。该方法包括：（a）连续监测早产新生儿心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性感染性疾病的方法和装置。该方法包括：（a）持续监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

10. 发明授权

US06216032B1 Method and apparatus for the early diagnosis of subacute, potentially catastrophic illness 有权
标题翻译：用于早期诊断亚急性潜在灾难性疾病的方法和装置
公开(公告)号：US06216032B1
公开(公告)日：2001-04-10
申请号：US09271279
申请日：1999-03-17
申请人： M. Pamela Griffin , J. Randall Moorman
发明人： M. Pamela Griffin , J. Randall Moorman
IPC分类号： A61B50468
CPC分类号： A61B5/0444 , A61B5/02405 , A61B5/02411 , A61B5/412 , A61B5/4362 , G06F19/00 , G06F19/3456 , G16H10/40 , G16H15/00 , G16H50/20 , G16H50/50
摘要： In one aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient. The method comprises: (a) continuously monitoring the patient's RR intervals; (b) generating a normalized data set of the RR intervals; (c) calculating one or more of (i) moments of the data set selected from the third and higher moments and (ii) percentile values of the data set; and (d) identifying an abnormal heart rate variability associated with the illness based on one or more of the moments and the percentile values.
摘要翻译：在一方面，提供了一种用于在早产新生儿中早期发现亚急性潜在的潜在感染性疾病的方法和装置。该方法包括：（a）连续监测早产新生儿心率变异性; 和（b）确定与疾病相关的心率变异性中的至少一种特征异常。该方法可用于诊断疾病，例如但不限于败血症，坏死性小肠结肠炎，肺炎和脑膜炎。另一方面，提供了一种用于在患者中早期检测亚急性潜在的灾难性感染性疾病的方法和装置。该方法包括：（a）持续监测患者的RR间期; （b）生成RR间隔的归一化数据集; （c）计算（i）从第三和更高时刻选择的数据集的时刻和（ii）数据集的百分位数值中的一个或多个; 和（d）基于一个或多个时刻和百分位数值来识别与疾病相关的异常心率变异性。

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