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1. 发明申请

US20130029936A1 Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same 审中-公开
公开(公告)号：US20130029936A1
公开(公告)日：2013-01-31
申请号：US13414215
申请日：2012-03-07
申请人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
发明人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
IPC分类号： C08B37/16 , A61P35/00 , A61P35/04 , A61K31/724
CPC分类号： A61K47/6951 , A61K9/0019 , A61K31/336 , A61K47/02 , B82Y5/00 , C07D303/16 , C07D303/20 , C07D303/28 , C07D407/14 , C08B37/0015 , C08L5/16
摘要： The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.

2. 发明申请

US20110034550A1 Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same 审中-公开
标题翻译：烟草衍生物或其盐的包含化合物和包含其的药物组合物
公开(公告)号：US20110034550A1
公开(公告)日：2011-02-10
申请号：US12756372
申请日：2010-04-08
申请人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
发明人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
IPC分类号： A61K31/336
CPC分类号： A61K47/6951 , A61K9/0019 , A61K31/336 , A61K47/02 , B82Y5/00 , C07D303/16 , C07D303/20 , C07D303/28 , C07D407/14 , C08B37/0015 , C08L5/16
摘要： The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.
摘要翻译：本发明涉及烟曲霉醇衍生物或其盐与羟丙基 - 环糊精或磺丁基醚-7 - 和 - 环糊精的包合物，以及包含其的药物组合物。根据本发明的包合物具有优异的水溶性和稳定性，同时显示出低毒性，使其作为肿瘤转移的抗癌剂或抑制剂是有价值的。

3. 发明申请

US20140155348A1 Inclusion Compounds of Fumagillol Derivative or its Salt, and Pharmaceutical Compositions Comprising the Same 审中-公开
标题翻译：烟草衍生物或其盐的包含化合物和包含其的药物组合物
公开(公告)号：US20140155348A1
公开(公告)日：2014-06-05
申请号：US13924768
申请日：2013-06-24
申请人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
发明人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
IPC分类号： A61K47/48 , A61K31/336
CPC分类号： A61K47/6951 , A61K9/0019 , A61K31/336 , A61K47/02 , B82Y5/00 , C07D303/16 , C07D303/20 , C07D303/28 , C07D407/14 , C08B37/0015 , C08L5/16
摘要： The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.
摘要翻译：本发明涉及烟曲霉醇衍生物或其盐与羟丙基 - 环糊精或磺丁基醚-7 - 和 - 环糊精的包合物，以及包含其的药物组合物。根据本发明的包合物具有优异的水溶性和稳定性，同时显示出低毒性，使其作为肿瘤转移的抗癌剂或抑制剂是有价值的。

4. 发明授权

US07718695B2 Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same 有权
标题翻译：烟曲霉醇衍生物或其盐的包合物和包含其的药物组合物
公开(公告)号：US07718695B2
公开(公告)日：2010-05-18
申请号：US11828025
申请日：2007-07-25
申请人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
发明人： Jae Hyun Kim , Su Kyung Lee , Won Kyu Choi , Jong Lae Lim , Soon Kil Ahn , Hee Jong Shin , Chung Il Hong
IPC分类号： A61K31/336 , C07D303/12
CPC分类号： A61K47/48969 , A61K9/0019 , A61K31/336 , A61K47/02 , A61K47/6951 , B82Y5/00 , C07D303/16 , C07D303/20 , C07D303/28 , C07D407/14 , C08B37/0015 , C08L5/16
摘要： The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.
摘要翻译：本发明涉及烟曲霉醇衍生物或其盐与羟丙基 - 环糊精或磺丁基醚-7 - 和 - 环糊精的包合物，以及包含其的药物组合物。根据本发明的包合物具有优异的水溶性和稳定性，同时显示出低毒性，使其作为肿瘤转移的抗癌剂或抑制剂是有价值的。

5. 发明授权

US07622857B2 Electron emission display 失效
标题翻译：电子发射显示
公开(公告)号：US07622857B2
公开(公告)日：2009-11-24
申请号：US11264739
申请日：2005-10-31
申请人： Seung Joon Yoo , Jong Sick Choi , Zin Min Park , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
发明人： Seung Joon Yoo , Jong Sick Choi , Zin Min Park , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
IPC分类号： H01J1/62 , H01J63/04
CPC分类号： H01J31/123
摘要： An electron emission display including a first substrate having at least one electron emission device and a second substrate opposite the first substrate. The second substrate is formed with an effective region and a non-effective region. The effective region includes a fluorescent layer for emitting light by collision with electrons emitted from the electron emission device. The non-effective region includes a region in which a light-shielding layer has a transparent conductive layer and a metal layer. The transparent conductive layer is formed in the effective region where the fluorescent layer is absent. The second substrate improves the brightness of light emitted from the fluorescent layer and prevents a power supply layer, to which a high voltage is applied, from being damaged, because the transparent conductive layer is not formed under the effective region.
摘要翻译：一种电子发射显示器，包括具有至少一个电子发射器件的第一衬底和与第一衬底相对的第二衬底。第二衬底形成有效区域和非有效区域。有效区域包括用于通过与从电子发射装置发射的电子碰撞而发射光的荧光层。非有效区域包括其中遮光层具有透明导电层和金属层的区域。透明导电层形成在荧光层不存在的有效区域中。由于透明导电层没有形成在有效区域之下，所以第二衬底提高了从荧光层发出的光的亮度，并且防止施加高电压的电源层被损坏。

6. 发明授权

US07400084B2 Electron emission display 失效
标题翻译：电子发射显示
公开(公告)号：US07400084B2
公开(公告)日：2008-07-15
申请号：US11286148
申请日：2005-11-22
申请人： Zin Min Park , Jong Sick Choi , Seung Joon Yoo , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
发明人： Zin Min Park , Jong Sick Choi , Seung Joon Yoo , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
IPC分类号： H01J1/62
CPC分类号： H01J29/34 , H01J29/325 , H01J31/127
摘要： An electron emission display including an electron emission substrate having at least one electron emission device formed thereon and an image forming substrate spaced apart from the electron emission substrate. The image forming substrate includes an effective region where electrons emitted from the electron emission device collide with the effective region to form images and a black region surrounding the effective region. The effective region includes a fluorescent layer formed in an arbitrary pattern and a metal layer formed on the fluorescent layer. The metal layer has a structure extending onto at least a portion of the black region.
摘要翻译：一种电子发射显示器，包括其上形成有至少一个电子发射器件的电子发射衬底和与电子发射衬底间隔开的成像衬底。图像形成基板包括从电子发射装置发射的电子与有效区域碰撞以形成图像的周围的有效区域和围绕有效区域的黑色区域。有效区域包括以任意图案形成的荧光层和形成在荧光层上的金属层。金属层具有延伸到黑色区域的至少一部分的结构。

7. 发明授权

US07514858B2 Electron emission display device with electron collector or metal member 失效
标题翻译：具有电子收集器或金属构件的电子发射显示装置
公开(公告)号：US07514858B2
公开(公告)日：2009-04-07
申请号：US11291101
申请日：2005-11-29
申请人： Seung Joon Yoo , Jong Sick Choi , Zin Min Park , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
发明人： Seung Joon Yoo , Jong Sick Choi , Zin Min Park , Soo Joung Lee , Jung Ho Kang , Su Kyung Lee
IPC分类号： G09G3/22 , G09G3/36 , H01J63/04 , H01K1/62 , H01K1/34
CPC分类号： H01J29/085 , H01J31/127
摘要： An electron emission display comprising an electron collector or metal member is provided. The electron emission display comprises an electron emission substrate comprising at least one electron emission device and an image forming substrate comprising at least one emission region and at least one non-emission region. Images are formed in the emission regions by the collision of electrons emitted from the electron emission devices with the emission regions. The image forming substrate further comprises a metal layer positioned on at least the emission regions, and at least one electron collector positioned in the non-emission region. The electron collector may comprise first and second ends, wherein the first end is attached to the image forming substrate and the second end faces the electron emission substrate. The electron collector stabilizes the metal layer and fluorescent layers, thereby reducing arc and maintaining uniform brightness by re-directing scattered electrons toward the fluorescent layers.
摘要翻译：提供了包括电子收集器或金属构件的电子发射显示器。电子发射显示器包括包括至少一个电子发射器件和包括至少一个发射区域和至少一个非发射区域的成像衬底的电子发射衬底。通过与电子发射装置发射的电子与发射区域的碰撞，在发射区域中形成图像。图像形成基板还包括位于至少发射区域上的金属层和位于非发射区域中的至少一个电子收集器。电子收集器可以包括第一端和第二端，其中第一端附着到成像衬底上，第二端面向电子发射衬底。电子收集器稳定金属层和荧光层，从而通过将散射电子重新引向荧光层来减少电弧并保持均匀的亮度。

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