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1. 发明申请

US20110287429A1 USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION 有权
标题翻译：使用HAPLOID基因进行遗传诊断，修改和修复
公开(公告)号：US20110287429A1
公开(公告)日：2011-11-24
申请号：US13015968
申请日：2011-01-28
申请人： James M. Robl , Pedro Moreira
发明人： James M. Robl , Pedro Moreira
IPC分类号： C12Q1/68 , C12N5/071
CPC分类号： C12N15/873 , C12N2510/00 , C12N2517/04
摘要： Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to produce diploid nuclear transfer units. These diploid NT units e.g., human NT units, may be used to obtain pluripotent cells and differentiated cells and tissues.
摘要翻译：提供了用于繁殖男性或女性原发单倍体基因组的方法和遗传筛选及其修饰。这些单倍体基因组可用于产生单倍体胚胎和胚胎干样细胞和分化细胞。此外，这些单倍体基因组和细胞可以用作核转移供体以产生二倍体核转移单位。这些二倍体NT单位例如人NT单位可用于获得多能细胞和分化的细胞和组织。

2. 发明授权

US08551705B2 Use of haploid genomes for genetic diagnosis, modification and multiplication 有权
标题翻译：使用单倍体基因组进行遗传诊断，修饰和增殖
公开(公告)号：US08551705B2
公开(公告)日：2013-10-08
申请号：US13015968
申请日：2011-01-28
申请人： James M Robl , Pedro Moreira
发明人： James M Robl , Pedro Moreira
IPC分类号： C12Q1/68 , C12N5/071
CPC分类号： C12N15/873 , C12N2510/00 , C12N2517/04
摘要： Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to produce diploid nuclear transfer units. These diploid NT units e.g., human NT units, may be used to obtain pluripotent cells and differentiated cells and tissues.
摘要翻译：提供了用于繁殖男性或女性原发单倍体基因组的方法和遗传筛选及其修饰。这些单倍体基因组可用于产生单倍体胚胎和胚胎干样细胞和分化细胞。此外，这些单倍体基因组和细胞可以用作核转移供体以产生二倍体核转移单位。这些二倍体NT单位例如人NT单位可用于获得多能细胞和分化的细胞和组织。

3. 发明申请

US20080085517A1 USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION 审中-公开
标题翻译：使用HAPLOID基因进行遗传诊断，修改和修复
公开(公告)号：US20080085517A1
公开(公告)日：2008-04-10
申请号：US11743613
申请日：2007-05-02
申请人： James Robl , Pedro Moreira
发明人： James Robl , Pedro Moreira
IPC分类号： C12Q1/68 , C12N15/00 , C12N5/06
CPC分类号： C12N15/873 , C12N2510/00 , C12N2517/04
摘要： Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and embryonic stem-like cells and differentiated cells. Also, these haploid genomes and cells containing, may be used as nuclear transfer donors to produce diploid nuclear transfer units. These diploid NT units e.g., human NT units, may be used to obtain pluripotent cells and differentiated cells and tissues.
摘要翻译：提供了用于繁殖男性或女性原发单倍体基因组的方法和遗传筛选及其修饰。这些单倍体基因组可用于产生单倍体胚胎和胚胎干样细胞和分化细胞。此外，这些单倍体基因组和细胞可以用作核转移供体以产生二倍体核转移单位。这些二倍体NT单位例如人NT单位可用于获得多能细胞和分化的细胞和组织。

4. 发明申请

US20080268419A1 Supplementation for Embryo and/or Cell Manipulation Media 审中-公开
标题翻译：胚胎和/或细胞操纵介质的补充
公开(公告)号：US20080268419A1
公开(公告)日：2008-10-30
申请号：US11909876
申请日：2005-05-12
申请人： Andre Palasz , de la Julio Fuente Martinez , Pedro Moreira , Alfonso Gutierrez Adan
发明人： Andre Palasz , de la Julio Fuente Martinez , Pedro Moreira , Alfonso Gutierrez Adan
IPC分类号： A01N1/00 , C12N5/02 , C12N5/06
CPC分类号： C12N5/0604 , A01N1/0226 , C12N2500/36 , C12N2500/76 , C12N2501/905
摘要： The question is to increase the quality and safety of the media used in embryo and cell manipulations by means of supplementation, in the manipulation medium, by one or several of the following compounds: synthetic hyaluronan ( sHA), phospholipids or unsaturated fatty acids obtained from soybean seeds (PLFA), replacing others which are habitually added to embryo manipulation media and which produce potential damage and/or contamination by viruses, prions, endotoxins, etc., this being important with regard to the quality of the embryos or cells which it is desired to generate, both for the production of transgenic animals, for animal production, and for cell therapy or assisted reproduction; achieving a reduction in adhesiveness and an increase in viscosity, without losing the fluidity of the medium; this is essential in micro-manipulations such as ICSI, nuclear transfer, embryo biopsies, the micro-injection of cells into embryos in pre-implantational stages, or cell fusion.
摘要翻译：问题是通过在操作介质中通过一种或几种以下化合物来增加在胚胎和细胞操作中使用的培养基的质量和安全性：合成透明质酸（sHA），磷脂或不饱和脂肪酸大豆种子（PLFA），替代习惯上添加到胚胎操纵介质中并且由于病毒，朊病毒，内毒素等而产生潜在的损害和/或污染的其它物质，这对于胚胎或细胞的质量而言是重要的期望产生用于生产转基因动物，用于动物生产，以及用于细胞治疗或辅助繁殖; 实现粘合性的降低和粘度的增加，而不会损失介质的流动性; 这在微操作如ICSI，核转移，胚胎活组织检查，细胞注入胚胎在植入前阶段或细胞融合中是微不足道的。

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