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1. 发明授权

US10934519B2 Systems, methods and control laws for cell harvesting 有权
公开(公告)号：US10934519B2
公开(公告)日：2021-03-02
申请号：US13193925
申请日：2011-07-29
申请人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
发明人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
IPC分类号： C12M1/00
摘要： The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.

2. 发明申请

US20130029411A1 SYSTEMS, METHODS AND CONTROL LAWS FOR CELL HARVESTING 审中-公开
标题翻译：系统，方法和细胞收集控制法
公开(公告)号：US20130029411A1
公开(公告)日：2013-01-31
申请号：US13193925
申请日：2011-07-29
申请人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
发明人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
IPC分类号： C12N5/071 , C12M3/06
CPC分类号： C12M47/02
摘要： The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.
摘要翻译：提供了收获细胞的方法，其中所述方法包括将处理材料和源材料引入加工回路中。处理回路包括处理室和过滤装置。处理材料和源材料循环通过处理室和过滤装置，其中处理室具有质量; 通过过滤装置的渗透通量将处理材料流入处理室以将处理室的质量保持在恒定值; 并将细胞收集在收集室中。还提供细胞收集装置用于使用控制规律处理和收获细胞，以通过整个过程来平衡处理室的质量。

3. 发明授权

US09109198B2 Automated systems and methods for isolating regenerative cells from adipose tissue 有权
标题翻译：用于从脂肪组织分离再生细胞的自动系统和方法
公开(公告)号：US09109198B2
公开(公告)日：2015-08-18
申请号：US13097827
申请日：2011-04-29
申请人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
发明人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
IPC分类号： C12N5/077 , C12M1/40 , C12M1/00 , B01F5/02 , C12M1/02 , B01F5/00 , B01F5/10
CPC分类号： C12M45/09 , B01F5/0057 , B01F5/0206 , B01F5/0231 , B01F5/0256 , B01F5/10 , C12M27/00 , C12M47/04 , C12N5/0653 , C12N2501/70 , C12N2501/734 , C12N2521/00
摘要： A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.
摘要翻译：提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器; 将脂肪组织引入血管; 将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。

4. 发明申请

US20120276628A1 AUTOMATED SYSTEMS AND METHODS FOR ISOLATING REGENERATIVE CELLS FROM ADIPOSE TISSUE 有权
标题翻译：用于从ADIPOSE TISSUE分离再生细胞的自动系统和方法
公开(公告)号：US20120276628A1
公开(公告)日：2012-11-01
申请号：US13097827
申请日：2011-04-29
申请人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
发明人： Zaeem Ashraf Khan , Aaron Joseph Dulgar-Tulloch , Stefan Rakuff , Philip Alexander Shoemaker , Erik Leeming Kvam , Xiaohui Chen , Jaydeep Roy
IPC分类号： C12N5/077 , C12M1/40
CPC分类号： C12M45/09 , B01F5/0057 , B01F5/0206 , B01F5/0231 , B01F5/0256 , B01F5/10 , C12M27/00 , C12M47/04 , C12N5/0653 , C12N2501/70 , C12N2501/734 , C12N2521/00
摘要： A method of processing an adipose tissue to collect adipose derived regenerative cells is provided, wherein the method comprises providing a vessel comprising a fluid jet mixer; introducing the adipose tissue into the vessel; introducing a buffer solution into the vessel; washing the adipose tissue using the fluid jet mixer; introducing an enzyme solution into the vessel; initiating jet mixing into the vessel comprising the adipose tissue, the enzyme solution, and the buffer solution using the fluid jet mixer to digest the adipose tissue to form a digestion product; phase-separating the digestion product into a digested buoyant fat layer and a non-buoyant aqueous layer; and collecting the non-buoyant aqueous layer comprising the adipose derived regenerative cells. A system of processing an adipose tissue to collect adipose derived regenerative cells is also provided.
摘要翻译：提供了一种处理脂肪组织以收集脂肪来源的再生细胞的方法，其中所述方法包括提供包含流体喷射混合器的容器; 将脂肪组织引入血管; 将缓冲溶液引入容器中; 使用流体喷射混合器洗涤脂肪组织; 将酶溶液引入容器中; 使用流体喷射混合器将包含脂肪组织，酶溶液和缓冲溶液的射流混合到消化脂肪组织以形成消化产物; 将消化产物相分离成消化的浮力脂肪层和非浮力水层; 并收集包含脂肪来源的再生细胞的非浮力水层。还提供了一种处理脂肪组织以收集脂肪来源的再生细胞的系统。

5. 发明申请

US20130171507A1 MODULAR HIGH TEMPERATURE BATTERY ELECTRICAL CONFIGURATIONS 有权
标题翻译：模块式高温电池电气配置
公开(公告)号：US20130171507A1
公开(公告)日：2013-07-04
申请号：US13338325
申请日：2011-12-28
申请人： Kristopher John Frutschy , Reza Sarrafi-Nour , Stefan Rakuff , Sandor Istvan Hollo , Narayan Subramanian , William Patrick Waters , James Thorpe Browell , Kanthi Latha Bhamidipati
发明人： Kristopher John Frutschy , Reza Sarrafi-Nour , Stefan Rakuff , Sandor Istvan Hollo , Narayan Subramanian , William Patrick Waters , James Thorpe Browell , Kanthi Latha Bhamidipati
IPC分类号： H01M2/10
CPC分类号： H01M2/0252 , H01M2/0447 , H01M2/266
摘要： A cell module and modular cell tray apparatus for a modular electrochemical device that are more easily manufactured and serviced. A cell module is provided having a plurality of electrochemical cells. The cell module includes an electrically conductive carrier element having a plurality of apertures, wherein each aperture is configured to accept a top portion of an electrode body of an electrochemical cell. A modular cell tray apparatus is provided having a plurality of the cell modules. The cell tray apparatus includes an electrically insulating tray having rows of cell receptacles to accept the cell modules. A modular electrochemical device is provided having a plurality of the cell tray apparatuses. The modular electrochemical device includes a plurality of electrical connectors configured to electrically connect the cell modules within a cell tray apparatus, and to electrically connect the cell tray apparatuses to each other.
摘要翻译：用于模块化电化学装置的电池模块和模块化电池托盘装置，其更容易制造和维修。提供具有多个电化学电池的电池模块。电池模块包括具有多个孔的导电载体元件，其中每个孔构造成接纳电化学电池的电极体的顶部。提供具有多个单元模块的模块化电池托盘装置。细胞托盘装置包括一个电绝缘托盘，该电绝缘托盘具有一排单元容器以容纳单元模块。提供了具有多个电池托盘装置的模块化电化学装置。模块化电化学装置包括多个电连接器，其被配置为电连接电池托盘装置内的电池模块，并将电池托盘装置彼此电连接。

6. 发明授权

US08450926B2 OLED lighting devices including electrodes with magnetic material 有权
标题翻译： OLED照明装置包括具有磁性材料的电极
公开(公告)号：US08450926B2
公开(公告)日：2013-05-28
申请号：US12470067
申请日：2009-05-21
申请人： Bruce R. Roberts , Kevin C. Payne , Donald Seton Farquhar , Stefan Rakuff , Michael Scott Herzog
发明人： Bruce R. Roberts , Kevin C. Payne , Donald Seton Farquhar , Stefan Rakuff , Michael Scott Herzog
IPC分类号： H01L51/50
CPC分类号： H01L51/5203 , H01L51/5246 , H01L2251/5361
摘要： An article of manufacture comprises a thin film solid state lighting device, such as an organic light emitting diode (OLED) device, having a planar light emitting side and an opposite planar mounting side and including electrodes disposed on the planar mounting side of the thin film solid state lighting device, the electrodes including a magnetic material configured to conductively convey electrical drive current to drive the thin film solid state lighting device to emit light at the planar light emitting principal side. The article of manufacture may further comprise a fixture having a planar surface with magnets arranged to mate with the electrodes to magnetically secure the thin film solid state lighting device with the fixture and to concurrently form electrically conductive paths including the magnetic material of the electrodes configured to conductively convey electrical drive current. Thus this magnetic connection provides both mechanical support and electrical conduction path.
摘要翻译：一种制品包括具有平面发光侧和相对的平面安装侧的薄膜固态照明装置，例如有机发光二极管（OLED）装置，并且包括设置在薄膜的平面安装侧的电极固态照明装置，所述电极包括被配置为导电地传送电驱动电流以驱动所述薄膜固态照明装置在所述平面发光主面发光的磁性材料。制品可以进一步包括具有平面表面的夹具，磁体布置成与电极配合，以用固定装置固定薄膜固态照明装置，同时形成包括电极的磁性材料的导电路径，传导电驱动电流。因此，该磁连接提供机械支撑和导电路径。

7. 发明申请

US20100294526A1 HERMETIC ELECTRICAL PACKAGE 审中-公开
标题翻译：电磁电气包装
公开(公告)号：US20100294526A1
公开(公告)日：2010-11-25
申请号：US12470033
申请日：2009-05-21
申请人： Donald Seton Farquhar , Michael Scott Herzog , Stefan Rakuff
发明人： Donald Seton Farquhar , Michael Scott Herzog , Stefan Rakuff
IPC分类号： H05K5/06 , B05D5/12 , B32B3/10
CPC分类号： H01L51/5203 , H01L51/5243 , H01L51/5253 , Y10T428/24331
摘要： A hermetic electrical package includes a first transparent barrier layer; a second barrier layer bonded to the first barrier layer, and defining a plurality of feedthrough apertures; an optoelectronic device sandwiched between the first and second barrier layers, the optoelectronic device comprising an anode, a photoelectrically active layer, and a cathode; and a conductive patch electrically coupled to the cathode or anode and disposed across at least one feedthrough aperture.
摘要翻译：密封电气包装包括第一透明阻挡层; 结合到第一阻挡层的第二阻挡层，并且限定多个馈通孔; 夹在所述第一和第二阻挡层之间的光电器件，所述光电器件包括阳极，光电活性层和阴极; 以及导电贴片，其电耦合到阴极或阳极并跨过至少一个馈通孔布置。

8. 发明申请

US20110025196A1 HERMETIC PACKAGE WITH GETTER MATERIALS 审中-公开
标题翻译：含药材的包装材料
公开(公告)号：US20110025196A1
公开(公告)日：2011-02-03
申请号：US12533090
申请日：2009-07-31
申请人： Stefan Rakuff , Donald Seton Farquhar , Christian Maria Anton Heller , Ahmet Gun Erlat
发明人： Stefan Rakuff , Donald Seton Farquhar , Christian Maria Anton Heller , Ahmet Gun Erlat
IPC分类号： H01J1/62
CPC分类号： H01L51/5268 , H01L51/5246 , H01L51/5259
摘要： Organic light emitting devices include a transparent substrate, a first transparent electrode disposed on the transparent substrate, a second electrode, an electroluminescent layer sandwiched between the electrodes, and a getter layer disposed on a light emitting surface of the substrate opposite the first transparent electrode, and comprising a metal selected from beryllium, magnesium, calcium, strontium, barium, radium and titanium.
摘要翻译：有机发光器件包括透明衬底，设置在透明衬底上的第一透明电极，第二电极，夹在电极之间的电致发光层，以及设置在与第一透明电极相对的衬底的发光表面上的吸气剂层，并且包含选自铍，镁，钙，锶，钡，镭和钛的金属。

9. 发明申请

US20100295443A1 OLED LIGHTING DEVICES INCLUDING ELECTRODES WITH MAGNETIC MATERIAL 有权
标题翻译：含有磁性材料的电极的OLED照明装置
公开(公告)号：US20100295443A1
公开(公告)日：2010-11-25
申请号：US12470067
申请日：2009-05-21
申请人： Bruce R. Roberts , Kevin C. Payne , Donald Seton Farquhar , Stefan Rakuff , Michael Scott Herzog
发明人： Bruce R. Roberts , Kevin C. Payne , Donald Seton Farquhar , Stefan Rakuff , Michael Scott Herzog
IPC分类号： H01J1/62
CPC分类号： H01L51/5203 , H01L51/5246 , H01L2251/5361
摘要： An article of manufacture comprises a thin film solid state lighting device, such as an organic light emitting diode (OLED) device, having a planar light emitting side and an opposite planar mounting side and including electrodes disposed on the planar mounting side of the thin film solid state lighting device, the electrodes including a magnetic material configured to conductively convey electrical drive current to drive the thin film solid state lighting device to emit light at the planar light emitting principal side. The article of manufacture may further comprise a fixture having a planar surface with magnets arranged to mate with the electrodes to magnetically secure the thin film solid state lighting device with the fixture and to concurrently form electrically conductive paths including the magnetic material of the electrodes configured to conductively convey electrical drive current. Thus this magnetic connection provides both mechanical support and electrical conduction path.
摘要翻译：一种制品包括具有平面发光侧和相对的平面安装侧的薄膜固态照明装置，例如有机发光二极管（OLED）装置，并且包括设置在薄膜的平面安装侧的电极固态照明装置，所述电极包括被配置为导电地传送电驱动电流以驱动所述薄膜固态照明装置在所述平面发光主面发光的磁性材料。制品可以进一步包括具有平面表面的夹具，磁体布置成与电极配合，以用固定装置固定薄膜固态照明装置，同时形成包括电极的磁性材料的导电路径，传导电驱动电流。因此，该磁连接提供机械支撑和导电路径。

10. 发明授权

US08283853B2 Light-emitting device and article 有权
标题翻译：发光装置和制品
公开(公告)号：US08283853B2
公开(公告)日：2012-10-09
申请号：US12751680
申请日：2010-03-31
申请人： Min Yan , Stefan Rakuff , Xiaolei Shi , Ri-An Zhao
发明人： Min Yan , Stefan Rakuff , Xiaolei Shi , Ri-An Zhao
IPC分类号： H05B3/00 , H01L51/52 , H01L51/56 , H01J9/00
CPC分类号： H01L51/5268 , H01L51/5275 , H01L51/5284
摘要： A device including a layer comprising a light emissive area and a light non-emissive area. A light-extracting feature is disposed over the light non-emissive area. The light-extracting features can include surface aberrations and reflective index matching elements. A method of forming the device is also provided.
摘要翻译：一种装置，包括包括光发射区域和轻的非发射区域的层。光提取特征被布置在光非发射区域上。光提取特征可以包括表面像差和反射索引匹配元素。还提供了一种形成该装置的方法。

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