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1. 发明授权

US08787519B2 System and method of optimizing a representation of dual energy spectral CT images 有权
标题翻译：优化双能谱CT图像表示的系统和方法
公开(公告)号：US08787519B2
公开(公告)日：2014-07-22
申请号：US13174825
申请日：2011-07-01
申请人： Jiahua Fan , Naveen Chandra , Bruno Kristiaan Bernard De Man
发明人： Jiahua Fan , Naveen Chandra , Bruno Kristiaan Bernard De Man
IPC分类号： A61B6/03 , A61B6/00
CPC分类号： A61B6/482 , A61B6/032 , A61B6/4241 , A61B6/5258
摘要： An imaging system includes an x-ray source, a detector, a data acquisition system (DAS) operably connected to the detector, and a computer operably connected to the DAS. The computer is programmed to obtain CT scan data with two or more incident energy spectra, decompose the obtained CT scan data into projection CT data of a first basis material and a second basis material, generate a first basis material image and a second basis material image using the decomposed projection CT data, generate a first monochromatic image from the first basis material image and the second basis material image at a first energy that is selected based on an amount of correlated noise at the first energy, noise-reduce the first monochromatic image to generate a noise-reduced first monochromatic image, and generate a final monochromatic image based at least on the noise-reduced first monochromatic image.
摘要翻译：成像系统包括可操作地连接到检测器的X射线源，检测器，数据采集系统（DAS）以及可操作地连接到DAS的计算机。计算机被编程以获得具有两个或更多个入射能谱的CT扫描数据，将获得的CT扫描数据分解成第一基材和第二基材的投影CT数据，生成第一基材图像和第二基材图像使用分解的投影CT数据，以基于第一能量处的相关噪声量选择的第一能量从第一基材图像和第二基材图像生成第一单色图像，降低第一单色图像以产生噪声减小的第一单色图像，并且至少基于噪声减小的第一单色图像生成最终单色图像。

2. 发明申请

US20120039440A1 SYSTEM AND METHOD OF OPTIMIZING A REPRESENTATION OF DUAL ENERGY SPECTRAL CT IMAGES 有权
标题翻译：优化双能谱图像的系统和方法
公开(公告)号：US20120039440A1
公开(公告)日：2012-02-16
申请号：US13174825
申请日：2011-07-01
申请人： Jiahua Fan , Naveen Chandra , Bruno Kristiaan Bernard De Man
发明人： Jiahua Fan , Naveen Chandra , Bruno Kristiaan Bernard De Man
IPC分类号： G01N23/04
CPC分类号： A61B6/482 , A61B6/032 , A61B6/4241 , A61B6/5258
摘要： An imaging system includes an x-ray source, a detector, a data acquisition system (DAS) operably connected to the detector, and a computer operably connected to the DAS. The computer is programmed to obtain CT scan data with two or more incident energy spectra, decompose the obtained CT scan data into projection CT data of a first basis material and a second basis material, generate a first basis material image and a second basis material image using the decomposed projection CT data, generate a first monochromatic image from the first basis material image and the second basis material image at a first energy that is selected based on an amount of correlated noise at the first energy, noise-reduce the first monochromatic image to generate a noise-reduced first monochromatic image, and generate a final monochromatic image based at least on the noise-reduced first monochromatic image.
摘要翻译：成像系统包括可操作地连接到检测器的X射线源，检测器，数据采集系统（DAS）以及可操作地连接到DAS的计算机。计算机被编程以获得具有两个或更多个入射能谱的CT扫描数据，将获得的CT扫描数据分解成第一基材和第二基材的投影CT数据，生成第一基材图像和第二基材图像使用分解的投影CT数据，以基于第一能量处的相关噪声量选择的第一能量从第一基材图像和第二基材图像生成第一单色图像，降低第一单色图像以产生噪声减小的第一单色图像，并且至少基于噪声减小的第一单色图像生成最终单色图像。

3. 发明授权

US08588494B2 System and method for material decomposition optimization in image domain 有权
标题翻译：图像域中物质分解优化的系统和方法
公开(公告)号：US08588494B2
公开(公告)日：2013-11-19
申请号：US12915195
申请日：2010-10-29
申请人： Bruno Kristiaan Bernard De Man , Jiang Hsieh , Naveen Chandra , Jed Douglas Pack , Jiahua Fan
发明人： Bruno Kristiaan Bernard De Man , Jiang Hsieh , Naveen Chandra , Jed Douglas Pack , Jiahua Fan
IPC分类号： G06K9/00 , A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： H04B1/1638 , G06T11/008 , G06T2211/408
摘要： A system and method for material decomposition optimization in the image domain include a non-transitory computer readable medium has stored thereon a sequence of instructions which, when executed by a computer, causes the computer to access a reconstructed basis material image. For a first voxel of the reconstructed basis material image, the instructions also cause the computer to optimize a concentration of a pair of materials (a,b) in the first voxel exclusively in the image domain and based on a first probability based on random perturbations and a second probability based on random perturbations. The optimization is further based on a third probability based on known materials and a fourth probability based on concentrations of the pair of materials in a pair of voxels neighboring the first voxel.
摘要翻译：用于图像域中的材料分解优化的系统和方法包括其上存储有一系列指令的非瞬时计算机可读介质，所述指令序列当由计算机执行时使计算机访问重建的基础材料图像。对于重建的基材图像的第一体素，指令还使计算机优化仅在图像域中的第一体素中的一对材料（a，b）的浓度，并且基于基于随机扰动的第一概率和基于随机扰动的第二概率。优化进一步基于基于已知材料的第三概率和基于邻近第一体素的一对体素中的该对材料对的浓度的第四概率。

4. 发明授权

US09326738B2 Method and system for reduced dose X-ray imaging 有权
标题翻译：降低剂量X射线成像的方法和系统
公开(公告)号：US09326738B2
公开(公告)日：2016-05-03
申请号：US13174438
申请日：2011-06-30
申请人： Zhye Yin , Roy Arnulf Helge Nilsen , Jiahua Fan , Thomas Matthew Benson , Bruno Kristiaan Bernard De Man , Jed Douglas Pack , Kai Zeng
发明人： Zhye Yin , Roy Arnulf Helge Nilsen , Jiahua Fan , Thomas Matthew Benson , Bruno Kristiaan Bernard De Man , Jed Douglas Pack , Kai Zeng
IPC分类号： A61B6/03 , A61B6/06 , A61B6/00
CPC分类号： A61B6/032 , A61B6/06 , A61B6/405 , A61B6/4085 , A61B6/4435 , A61B6/542
摘要： Approaches for acquiring CT image data corresponding to a full scan, but at a reduced dose are disclosed. In one implementation, X-ray tube current modulation is employed to reduce the effective dose. In other implementations, acquisition of sparse views, z-collimation, and two-rotation acquisition protocols may be employed to achieve a reduced dose relative to a full-scan acquisition protocol.
摘要翻译：公开了用于获取对应于全扫描但以减小剂量的CT图像数据的方法。在一个实施方案中，采用X射线管电流调制来降低有效剂量。在其他实施方案中，可采用稀疏视图，z准直和双旋转采集协议的采集来实现相对于全扫描采集协议的减少的剂量。

5. 发明申请

US20130003912A1 SYSTEM AND METHOD OF ACQUIRING COMPUTED TOMOGRAPHY DATA USING A MULTI-ENERGY X-RAY SOURCE 审中-公开
标题翻译：使用多能量X射线源获取计算机图像数据的系统和方法
公开(公告)号：US20130003912A1
公开(公告)日：2013-01-03
申请号：US13174485
申请日：2011-06-30
申请人： Bruno Kristiaan Bernard De Man , Jiang Hsieh , Naveen Stephan Chandra , Jiahua Fan , Jed Douglas Pack
发明人： Bruno Kristiaan Bernard De Man , Jiang Hsieh , Naveen Stephan Chandra , Jiahua Fan , Jed Douglas Pack
IPC分类号： A61B6/03 , G01N23/04
CPC分类号： A61B6/482 , A61B6/032 , A61B6/405
摘要： The subject matter disclosed herein relates to X-ray imaging systems, and more specifically, to multi-energy computed tomography (CT) X-ray imaging systems. In an embodiment, a multi-energy computed tomography (CT) imaging system includes an X-ray source that emits X-rays upon the application of a low stable bias, a high stable bias, and transitional biases between the low stable bias and the high stable bias. The imaging system also includes an X-ray detector configured to produce an electrical signal corresponding to the intensity of the X-rays emitted by the X-ray source that reach the X-ray detector. The imaging system also includes data processing circuitry configured to acquire a first set of data corresponding to the electrical signal produced by the X-ray detector only when the low stable bias or the high stable bias is applied to the X-ray source. The imaging system also includes a processor configured to process the first set of acquired data and construct one or more multi-energy CT images.
摘要翻译：本文公开的主题涉及X射线成像系统，更具体地，涉及多能计算机断层摄影（CT）X射线成像系统。在一个实施例中，多能量计算机断层摄影（CT）成像系统包括在施加低稳定偏压，高稳定偏差以及低稳定偏压和低稳定偏差之间的过渡偏差时发射X射线的X射线源高稳定偏差。成像系统还包括：X射线检测器，被配置为产生对应于由X射线源发射的X射线的强度的电信号，该X射线到达X射线检测器。成像系统还包括数据处理电路，其被配置为仅当低稳定偏压或高稳定偏压施加到X射线源时才获取对应于由X射线检测器产生的电信号的第一组数据。成像系统还包括被配置为处理第一组获取的数据并构造一个或多个多能CT图像的处理器。

6. 发明申请

US20130003914A1 METHOD AND SYSTEM FOR REDUCED DOSE X-RAY IMAGING 有权
标题翻译：用于减少剂量X射线成像的方法和系统
公开(公告)号：US20130003914A1
公开(公告)日：2013-01-03
申请号：US13174438
申请日：2011-06-30
申请人： Zhye Yin , Roy Arnulf Helge Nilsen , Jiahua Fan , Thomas Matthew Benson , Bruno Kristiaan Bernard De Man , Jed Douglas Pack , Kai Zeng
发明人： Zhye Yin , Roy Arnulf Helge Nilsen , Jiahua Fan , Thomas Matthew Benson , Bruno Kristiaan Bernard De Man , Jed Douglas Pack , Kai Zeng
IPC分类号： A61B6/03
CPC分类号： A61B6/032 , A61B6/06 , A61B6/405 , A61B6/4085 , A61B6/4435 , A61B6/542
摘要： Approaches for acquiring CT image data corresponding to a full scan, but at a reduced dose are disclosed. In one implementation, X-ray tube current modulation is employed to reduce the effective dose. In other implementations, acquisition of sparse views, z-collimation, and two-rotation acquisition protocols may be employed to achieve a reduced dose relative to a full-scan acquisition protocol.
摘要翻译：公开了用于获取对应于全扫描但以减小剂量的CT图像数据的方法。在一个实施方案中，采用X射线管电流调制来降低有效剂量。在其他实施方案中，可采用稀疏视图，z准直和双旋转采集协议的采集来实现相对于全扫描采集协议的减少的剂量。

7. 发明授权

US08363917B2 System and method of image artifact reduction in fast kVp switching CT 有权
标题翻译：快速kVp开关CT中图像伪影减少的系统和方法
公开(公告)号：US08363917B2
公开(公告)日：2013-01-29
申请号：US12578886
申请日：2009-10-14
申请人： Jiahua Fan , Naveen Chandra , Andrew Johnson , Jiang Hsieh , Fang Dong , Mary Sue Kulpins , Peter Crandall
发明人： Jiahua Fan , Naveen Chandra , Andrew Johnson , Jiang Hsieh , Fang Dong , Mary Sue Kulpins , Peter Crandall
IPC分类号： G06K9/00 , A61B6/00 , H05G1/64
CPC分类号： G06T11/008 , G06T2211/408
摘要： A CT system includes a generator configured to energize an x-ray source to a first kilovoltage (kVp) and to a second kVp, and a computer that is programmed to acquire a first view dataset with the x-ray source energized to the first kVp and a second view dataset with the x-ray source energized to the second kVp, generate a base correction image using the first view dataset and the second view dataset, and reconstruct a pair of base material images from the first view dataset and from the second view dataset. The computer is also programmed to estimate artifact correlation in the pair of base material images using the base correction image, generate a pair of final base material images and a final monochromatic image, and correct one of the pair of final base material images and the final monochromatic image at a keV value using the estimated artifact correlation.
摘要翻译： CT系统包括发电机，其被配置为将x射线源激励到第一千伏（kVp）和第二kVp;以及计算机，其被编程为获取第一视图数据集，其中x射线源被激励到第一kVp 以及将x射线源激励到第二kVp的第二视图数据集，使用第一视图数据集和第二视图数据集生成基本校正图像，并且从第一视图数据集和第二视图数据集重构一对基本材料图像查看数据集。计算机还被编程为使用基本校正图像来估计一对基础材料图像中的伪像相关性，生成一对最终的基底图像和最终的单色图像，并且校正一对最终基底图像和最终的基底图像中的一个使用估计的伪像相关性，以keV值的单色图像。

8. 发明申请

US20110085719A1 SYSTEM AND METHOD OF IMAGE ARTIFACT REDUCTION IN FAST KVP SWITCHING CT 有权
标题翻译：快速KVP切换CT图像缩小的系统和方法
公开(公告)号：US20110085719A1
公开(公告)日：2011-04-14
申请号：US12578886
申请日：2009-10-14
申请人： Jiahua Fan , Naveen Chandra , Andrew Johnson , Jiang Hsieh , Fang Dong , Mary Sue Kulpins , Peter Crandall
发明人： Jiahua Fan , Naveen Chandra , Andrew Johnson , Jiang Hsieh , Fang Dong , Mary Sue Kulpins , Peter Crandall
IPC分类号： G06K9/00 , H05G1/60
CPC分类号： G06T11/008 , G06T2211/408
摘要： A CT system includes a generator configured to energize an x-ray source to a first kilovoltage (kVp) and to a second kVp, and a computer that is programmed to acquire a first view dataset with the x-ray source energized to the first kVp and a second view dataset with the x-ray source energized to the second kVp, generate a base correction image using the first view dataset and the second view dataset, and reconstruct a pair of base material images from the first view dataset and from the second view dataset. The computer is also programmed to estimate artifact correlation in the pair of base material images using the base correction image, generate a pair of final base material images and a final monochromatic image, and correct one of the pair of final base material images and the final monochromatic image at a keV value using the estimated artifact correlation.
摘要翻译： CT系统包括发电机，其被配置为将x射线源激励到第一千伏（kVp）和第二kVp;以及计算机，其被编程为获取第一视图数据集，其中x射线源被激励到第一kVp 以及将x射线源激励到第二kVp的第二视图数据集，使用第一视图数据集和第二视图数据集生成基本校正图像，并且从第一视图数据集和第二视图数据集重构一对基本材料图像查看数据集。计算机还被编程为使用基本校正图像来估计一对基础材料图像中的伪像相关性，生成一对最终的基底图像和最终的单色图像，并且校正一对最终基底图像和最终的基底图像中的一个使用估计的伪像相关性，以keV值的单色图像。

9. 发明授权

US09135728B2 System and method for multi-energy computed tomography imaging 有权
标题翻译：多能计算机断层成像系统和方法
公开(公告)号：US09135728B2
公开(公告)日：2015-09-15
申请号：US13439245
申请日：2012-04-04
申请人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
发明人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
IPC分类号： G06T11/00 , A61B6/06 , A61B6/00 , G21K1/02 , A61B6/03 , G21K1/10 , H01J35/26 , H01J35/30
CPC分类号： G06T11/005 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/4241 , A61B6/4291 , A61B6/482 , A61B6/582 , G06T2211/408 , G21K1/025 , G21K1/10 , H01J35/26 , H01J35/30
摘要： A CT system includes a gantry, an x-ray source, a detector, and a grating collimator that includes alternating first and second materials. The system includes a controller configured to emit a first beam of x-rays from a first focal spot and to a first detector pixel, wherein the first beam of x-rays passes along a ray and through one of the first materials of the grating collimator, and subsequently emit a second beam of x-rays from a second focal spot and to the first detector pixel, wherein the second beam of x-rays passes substantially along the ray and through one of the second materials of the grating collimator. The system includes a computer programmed to generate first and second kVp image datasets using data acquired from the first beam and second beams of x-rays, and reconstruct a basis material image of the object.
摘要翻译： CT系统包括台架，X射线源，检测器和包括交替的第一和第二材料的光栅准直器。该系统包括控制器，该控制器被配置为从第一焦点和第一检测器像素发射第一X射线束，其中第一射线束沿着光线并通过光栅准直器的第一材料之一并且随后从第二焦点和第一检测器像素发射第二射线束，其中所述第二光束X射线基本上沿着所述光线并通过所述光栅准直器的所述第二材料之一通过。该系统包括被编程为使用从第一光束和第二光束获得的数据来生成第一和第二kVp图像数据集的计算机，并重构对象的基础材料图像。

10. 发明申请

US20130266115A1 SYSTEM AND METHOD FOR MULTI-ENERGY COMPUTED TOMOGRAPHY IMAGING 有权
标题翻译：多功能计算机图像成像系统与方法
公开(公告)号：US20130266115A1
公开(公告)日：2013-10-10
申请号：US13439245
申请日：2012-04-04
申请人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
发明人： Jiahua Fan , Jiang Hsieh , Naveen Chandra , Suresh Narayanan Narayanan , Dan Xu
IPC分类号： A61B6/08 , A61B6/03
CPC分类号： G06T11/005 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4035 , A61B6/4241 , A61B6/4291 , A61B6/482 , A61B6/582 , G06T2211/408 , G21K1/025 , G21K1/10 , H01J35/26 , H01J35/30
摘要： A CT system includes a gantry, an x-ray source, a detector, and a grating collimator that includes alternating first and second materials. The system includes a controller configured to emit a first beam of x-rays from a first focal spot and to a first detector pixel, wherein the first beam of x-rays passes along a ray and through one of the first materials of the grating collimator, and subsequently emit a second beam of x-rays from a second focal spot and to the first detector pixel, wherein the second beam of x-rays passes substantially along the ray and through one of the second materials of the grating collimator. The system includes a computer programmed to generate first and second kVp image datasets using data acquired from the first beam and second beams of x-rays, and reconstruct a basis material image of the object.
摘要翻译： CT系统包括台架，X射线源，检测器和包括交替的第一和第二材料的光栅准直器。该系统包括控制器，该控制器被配置为从第一焦点和第一检测器像素发射第一X射线束，其中第一射线束沿着光线并通过光栅准直器的第一材料之一并且随后从第二焦点和第一检测器像素发射第二射线束，其中所述第二光束X射线基本上沿着所述光线并通过所述光栅准直器的所述第二材料之一通过。该系统包括被编程为使用从第一光束和第二光束获得的数据来生成第一和第二kVp图像数据集的计算机，并重构对象的基础材料图像。

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