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1. 发明申请

US20080248043A1 Antibodies to SARS coronavirus 有权
标题翻译： SARS冠状病毒抗体
公开(公告)号：US20080248043A1
公开(公告)日：2008-10-09
申请号：US11805129
申请日：2007-05-21
申请人： John S. Babcook , Bellur S. Prabhakar , Melissa Coughlin
发明人： John S. Babcook , Bellur S. Prabhakar , Melissa Coughlin
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , C12N15/11 , C12N15/00 , A01K67/027 , C12P21/04 , A61P11/00
CPC分类号： C07K16/10 , A61K48/00 , C07K14/005 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C12N2770/20022
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-SARS-CoV S protein antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-SARS-CoV S protein antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合人SARS-CoV S蛋白的人抗体及其抗原结合部分的抗体，其功能是中和SARS-CoV。本发明还涉及双特异性，衍生化的单链抗体或融合蛋白部分的抗体。本发明还涉及衍生自人抗SARS-CoV S蛋白抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗SARS-CoV S蛋白抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

2. 发明授权

US07728110B2 Antibodies to SARS coronavirus 有权
标题翻译： SARS冠状病毒抗体
公开(公告)号：US07728110B2
公开(公告)日：2010-06-01
申请号：US11805129
申请日：2007-05-21
申请人： John S. Babcook , Bellur S. Prabhakar , Melissa Coughlin
发明人： John S. Babcook , Bellur S. Prabhakar , Melissa Coughlin
IPC分类号： C12P21/08 , C07K16/00
CPC分类号： C07K16/10 , A61K48/00 , C07K14/005 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C12N2770/20022
摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to human SARS-CoV S protein, and that function to neutralize SARS-CoV. The invention also relates to antibodies that are bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-SARS-CoV S protein antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-SARS-CoV S protein antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合人SARS-CoV S蛋白的人抗体及其抗原结合部分的抗体，其功能是中和SARS-CoV。本发明还涉及双特异性，衍生化的单链抗体或融合蛋白部分的抗体。本发明还涉及衍生自人抗SARS-CoV S蛋白抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗SARS-CoV S蛋白抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物或植物。

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