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1. 发明授权

US08546088B2 Porphyrinic compounds for use in flow cytometry 有权
标题翻译：用于流式细胞术的卟啉化合物
公开(公告)号：US08546088B2
公开(公告)日：2013-10-01
申请号：US13459464
申请日：2012-04-30
申请人： Jonathan S. Lindsey
发明人： Jonathan S. Lindsey
IPC分类号： G01N33/533 , G01N21/64
CPC分类号： G01N33/582 , G01N21/643 , G01N21/6486 , G01N33/533 , G01N2021/6439 , Y02A50/53 , Y02A50/55 , Y02A50/57 , Y02A50/58 , Y10T436/145555
摘要： The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
摘要翻译：本发明提供了检测（例如，通过流式细胞术）目标化合物，细胞或颗粒的方法，其中靶标用可检测的发光化合物标记。所述方法包括使用包含卟啉大环化合物如卟啉，二氢卟酚，细菌二氢卟酚或异细菌素的化合物作为可检测的发光化合物。在具体实施方案中，可检测的发光化合物包含式A-A'-Z-B'-B的化合物，其中：A是特异性结合对的靶向基团或特异性结合对的成员，其将可检测的发光化合物特异性结合到靶化合物，细胞或颗粒; A'是连接基团或共价键; B'是连接基团或共价键; B是水溶性基团; Z是卟啉大环。

2. 发明授权

US08530459B2 Swallowtail motifs for imparting water solubility to porphyrinic compounds 有权
标题翻译：用于赋予卟啉化合物水溶性的燕尾花图案
公开(公告)号：US08530459B2
公开(公告)日：2013-09-10
申请号：US13316009
申请日：2011-12-09
申请人： K. Eszter Borbas , Jonathan S. Lindsey
发明人： K. Eszter Borbas , Jonathan S. Lindsey
IPC分类号： C07B47/00 , C07D487/22 , A01N43/36
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds compounds of Formula I: wherein: Z is a porphyrinic macrocycle, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group; R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译：描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。这些化合物的实例包括式I化合物：其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团; R3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，存在CH基团，或Alk1和Alk2直接键合到卟啉化大环Z的碳上）; 或其盐。

3. 发明申请

US20130079528A1 GEOMETRIC SYNTHESIS OF PORPHYRIN RODS 失效
标题翻译：几何组合的吡咯烷酮
公开(公告)号：US20130079528A1
公开(公告)日：2013-03-28
申请号：US13600808
申请日：2012-08-31
申请人： Jonathan S. Lindsey , Lianhe Yu , Patchanita Thamyongkit , Anil D. Bhise
发明人： Jonathan S. Lindsey , Lianhe Yu , Patchanita Thamyongkit , Anil D. Bhise
IPC分类号： C07D403/06
CPC分类号： C07D403/06 , C07D487/22
摘要： A method of making a compound of Formula I′ comprises reacting a compound of the formula DLCHO, with a compound of the formula to produce the compound of Formula I′. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.
摘要翻译：制备式I'化合物的方法包括使式DLCHO的化合物与下式的化合物反应以制备式I'的化合物。还描述了使用化合物的方法，特别是作为合成卟啉棒的中间体，其中卟啉棒又可用于（尤其）分子存储装置的生产。

4. 发明申请

US20120244551A1 PORPHYRINIC COMPOUNDS FOR USE IN FLOW CYTOMETRY 有权
标题翻译：用于流动细胞计数中的PORPHYRINIC化合物
公开(公告)号：US20120244551A1
公开(公告)日：2012-09-27
申请号：US13459464
申请日：2012-04-30
申请人： Jonathan S. Lindsey
发明人： Jonathan S. Lindsey
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/643 , G01N21/6486 , G01N33/533 , G01N2021/6439 , Y02A50/53 , Y02A50/55 , Y02A50/57 , Y02A50/58 , Y10T436/145555
摘要： The present invention provides a method of detecting (e.g., by flow cytometry) a target compound, cell or particle, wherein the target is labelled with a detectable luminescent compound. The method comprises utilizing as the detectable luminescent compound a compound comprising a porphyrinic macrocycle such as a porphyrin, chlorin, bacteriochlorin, or isobacteriochlorin. In particular embodiments, the detectable luminescent compound comprises a compound of the formula A-A′-Z-B′-B, wherein: A is a targeting group or member of a specific binding pair that specifically binds the detectable luminescent compound to the target compound, cell or particle; A′ is a linker group or covalent bond; B′ is a linker group or covalent bond; B is a water-soluble group; and Z is the porphyrinic macrocycle.
摘要翻译：本发明提供了检测（例如，通过流式细胞术）目标化合物，细胞或颗粒的方法，其中靶标用可检测的发光化合物标记。所述方法包括使用包含卟啉大环化合物如卟啉，二氢卟酚，细菌二氢卟酚或异细菌素的化合物作为可检测的发光化合物。在具体实施方案中，可检测的发光化合物包含式AA'-ZB'-B的化合物，其中：A是靶向基团或特异性结合对的成员，其特异性结合可检测的发光化合物与目标化合物，细胞或粒子; A'是连接基团或共价键; B'是连接基团或共价键; B是水溶性基团; Z是卟啉大环。

5. 发明申请

US20120232463A1 DE NOVO SYNTHESIS OF BACTERIOCHLORINS 有权
标题翻译：乙酰胆碱酯酶的合成
公开(公告)号：US20120232463A1
公开(公告)日：2012-09-13
申请号：US13443085
申请日：2012-04-10
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A61M37/00 , C07D403/06 , C07K16/00 , C07K2/00 , C07K14/00 , C07H21/00 , C07F15/00 , C07F3/02 , C07F3/06 , C07F5/06 , C07F5/00 , C07F7/22 , C07F1/08 , C07F15/04 , C07F1/12 , A61K31/409 , A61K49/00 , G01N21/64 , A61P35/00 , A61P9/00 , A61P37/06 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/10 , A61P33/02 , A61P39/02 , C07D487/22
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.
摘要翻译：通过将一对式II化合物缩合以产生细菌二氢卟酚，其中R是缩醛或醛基，从而进行制备细菌生物素的方法。缩合可以在有机溶剂中进行，优选在酸的存在下进行。细菌二氢卟酚可用于各种目的，例如光动力疗法中的活性剂，流式细胞术中的发光化合物，太阳能电池，光收集阵列和分子存储装置。

6. 发明申请

US20120209009A1 SYNTHETIC ROUTE TO ABCD-PORPHYRINS 失效
标题翻译：合成路线到ABCD-PORPHYRINS
公开(公告)号：US20120209009A1
公开(公告)日：2012-08-16
申请号：US13456482
申请日：2012-04-26
申请人： Jonathan S. Lindsey , Dilek Dogutan Kiper
发明人： Jonathan S. Lindsey , Dilek Dogutan Kiper
IPC分类号： C07D403/06
CPC分类号： C07D487/22 , C07D207/34 , C07D207/36 , Y02P20/55
摘要： A method of making a metalloporphyrin is carried out by reacting (i) a linear tetrapyrrole, said linear tetrapyrrole having a 19-acyl group and a 1-protecting group, with (ii) a metal salt under basic conditions to produce the metalloporphyrin. Products produced by such methods and intermediates useful for carrying out such methods are also described.
摘要翻译：通过使（i）在碱性条件下使（I）线性四吡咯，具有19-酰基的所述直链四吡咯和1-保护基与（ii）金属盐反应以制备金属卟啉来进行制备金属卟啉的方法。还描述了通过这种方法生产的产品和用于实施这些方法的中间体。

7. 发明授权

US08173692B2 De novo synthesis of bacteriochlorins 有权
公开(公告)号：US08173692B2
公开(公告)日：2012-05-08
申请号：US12413903
申请日：2009-03-30
申请人： Han-Je Kim , Jonathan S. Lindsey
发明人： Han-Je Kim , Jonathan S. Lindsey
IPC分类号： A01N43/38 , A61K31/40
CPC分类号： C07D487/22 , C07D207/335 , C09B47/00 , G01N21/6486
摘要： A method of making a bacteriochlorin is carried out by condensing a pair of compounds of Formula II to produce the bacteriochlorin, wherein R is an acetal or aldehyde group. The condensing may be carried out in an organic solvent, preferably in the presence of an acid. The bacteriochlorins are useful for a variety of purposes such as active agents in photodynamic therapy, luminescent compounds in flow cytometry, solar cells, light harvesting arrays, and molecular memory devices.

8. 发明申请

US20120082621A1 SWALLOWTAIL MOTIFS FOR IMPARTING WATER SOLUBILITY TO PORPHYRINIC COMPOUNDS 有权
标题翻译：用于将水溶解性转化成磷酸盐化合物的铁水运动
公开(公告)号：US20120082621A1
公开(公告)日：2012-04-05
申请号：US13316009
申请日：2011-12-09
申请人： K. Eszter Borbas , Jonathan S. Lindsey
发明人： K. Eszter Borbas , Jonathan S. Lindsey
IPC分类号： A61K49/00 , C07D403/06 , C07F9/6558 , A61M37/00 , C07F9/6561 , A61K31/675 , C12Q1/04 , A61P35/00 , C07F7/18 , C07F19/00
CPC分类号： G01N33/582 , C07D487/22 , C07F9/572 , C07F9/6524
摘要： Porphyrinic compounds that contain solubilizing groups are described, along with methods of making and using the same and compositions comprising such compounds. Examples of such compounds include compounds compounds of Formula I: wherein: Z is a porphyrinic macrocycle, Alk1 and Alk2 are each independently an alkylidene chain; L is a linking group or is absent; R1 is preferably an ionic group or polar group; R2 is an ionic group, polar group, bioconjugatable group, or targeting group; R3 is present or absent and when present is a halo group, bioconjugatable group, or targeting group, n is O or 1 (that is, the CH group is present, or Alk1 and Alk2 are bonded directly to a carbon of the porphyrinic macrocycle Z); or a salt thereof.
摘要翻译：描述含有增溶基团的卟啉化合物及其制备和使用方法以及包含这些化合物的组合物。这些化合物的实例包括式I化合物：其中：Z是卟啉大环，Alk1和Alk2各自独立地是亚烷基链; L是连接基团或不存在; R1优选为离子基团或极性基团; R2是离子基团，极性基团，生物共轭基团或靶向基团; R3存在或不存在，并且当存在卤素基团，生物共轭基团或靶向基团时，n为0或1（即，存在CH基团，或Alk1和Alk2直接键合到卟啉化大环Z的碳上）; 或其盐。

9. 发明授权

US08013149B2 Methods and intermediates for the synthesis of porphyrins 失效
标题翻译：合成卟啉的方法和中间体
公开(公告)号：US08013149B2
公开(公告)日：2011-09-06
申请号：US12494711
申请日：2009-06-30
申请人： Jonathan S. Lindsey , Masahiko Taniguchi , Arumugham Balakumar , Dazhong Fan
发明人： Jonathan S. Lindsey , Masahiko Taniguchi , Arumugham Balakumar , Dazhong Fan
IPC分类号： C07B47/00 , C07D487/22
CPC分类号： C07D487/22 , C07D403/04
摘要： A method of making a porphyrin (I) is carried out by condensing (i) a bis(imino)dipyrromethane of Formula II: with (ii) a dipyrromethaneto produce a reaction product; then (b) optionally oxidizing said reaction product with an oxidizing agent; and then (c) optionally demetallating said reaction product to produce the porphyrin. Methods of making compounds of Formula II are also described.
摘要翻译：制备卟啉（I）的方法是通过将（ⅰ）式Ⅱ的双（亚氨基）二吡咯烷与（ⅱ）二吡咯甲烷缩合制备反应产物而进行的; 然后（b）任选地用氧化剂氧化所述反应产物; 然后（c）任选地使所述反应产物脱金属以产生卟啉。还描述了制备式II化合物的方法。

10. 发明申请

US20110152515A1 NEW ROUTE TO FORMYL-PORPHYRINS 失效
标题翻译：新的路线到甲基 -
公开(公告)号：US20110152515A1
公开(公告)日：2011-06-23
申请号：US13035235
申请日：2011-02-25
申请人： Arumugham Balakumar , Kannan Muthukumaran , Jonathan S. Lindsey
发明人： Arumugham Balakumar , Kannan Muthukumaran , Jonathan S. Lindsey
IPC分类号： C07D487/22
CPC分类号： C07D487/22
摘要： A method of making a 5-formylporphyrin, comprises the steps of: condensing a 5-acetaldipyrromethane with a dipyrromethane-1,9-dicarbinol to produce a porphyrin having an acetal group substituted thereon at the 5 position; and then hydrolyzing said porphyrin to produce said 5-formylporphyrin. Products and intetinediates useful in such methods, along with methods of making such intermediates, are also described.
摘要翻译：制备5-甲酰卟啉的方法包括以下步骤：使5-乙醛二吡咯甲烷与二吡咯烷-1,9-二甲醇缩合以产生在5位上具有取代在其上的缩醛基团的卟啉; 然后水解所述卟啉以产生所述5-甲酰卟啉。还描述了可用于这些方法的产品和内联物，以及制备此类中间体的方法。

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