专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07659055B2 Fragments of nucleic acids specific to mycobacteria which are members of the M. tuberculosis complex and their applications for the detection and the differential diagnosis of members of the M. tuberculosis complex 有权
标题翻译：作为结核分枝杆菌复合物成员的分枝杆菌特异性的核酸片段及其对结核分枝杆菌复合物成员的检测和鉴别诊断的应用
公开(公告)号：US07659055B2
公开(公告)日：2010-02-09
申请号：US10086206
申请日：2002-02-28
申请人： Juana Magdalena , Philip Supply , Camille Locht
发明人： Juana Magdalena , Philip Supply , Camille Locht
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12N15/00
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： A fragment of a nucleic acid specific to mycobacteria of M. tuberculosis complex having a nucleotide sequence of SEQ ID No: 1 and SEQ ID No: 2 and their complimentary sequences.
摘要翻译：具有核苷酸序列SEQ ID No：1和SEQ ID No：2及其互补序列的结核分支杆菌复合物分枝杆菌特异性核酸的片段。

2. 发明申请

US20050175621A9 Adjuvant composition comprising FHA protein or a fragment of FHA protein in its free form 审中-公开
标题翻译：佐剂组合物包含其自由形式的FHA蛋白或FHA蛋白的片段
公开(公告)号：US20050175621A9
公开(公告)日：2005-08-11
申请号：US10314440
申请日：2002-12-09
申请人： Andre Capron , Camille Locht , Franco Menozzi , Odile Poulain-Godefroy , Gilles Riveau
发明人： Andre Capron , Camille Locht , Franco Menozzi , Odile Poulain-Godefroy , Gilles Riveau
IPC分类号： A61K39/002 , A61K39/015 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/10 , A61K39/106 , A61K39/112 , A61K39/12 , A61K39/39 , A61P31/04 , A61P31/12 , A61P33/00 , A61P37/04 , C07K14/235 , A61K39/00 , A61K39/38
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
摘要翻译：本发明涉及FHA蛋白或游离形式的FHA蛋白的一部分作为免疫应答的佐剂或在人或动物中作为免疫刺激剂的用途。本发明还涉及包含FHA蛋白或其片段的佐剂和免疫刺激组合物，以及所述组合物用于制备疫苗的用途。

3. 发明授权

US4883761A Pertussis toxin gene: cloning and expression of protective antigen 失效
标题翻译：百日咳毒素基因：克隆和表达保护性抗原
公开(公告)号：US4883761A
公开(公告)日：1989-11-28
申请号：US843727
申请日：1986-03-25
申请人： Jerry M. Keith , Camille Locht
发明人： Jerry M. Keith , Camille Locht
IPC分类号： A61K39/00 , C07K14/235 , C12N1/21 , C12N15/31
CPC分类号： C07K14/235 , A61K39/00
摘要： The complete nucleotide sequence of the pertussis toxin gene and the deduced amino acid sequences of the individual subunits have been determined. All five subunits are coded by closely linked cistrons and possibly expressed through a polycistronic mRNA, since a promotor-like structure was found in the 5' flanking region. The order of the cistrons is S1, S2, S3, S4, S5, and S3. All subunits contain signal peptides of variable length. The calculated molecular weights of the mature subunits are 25,024 for S1, 21,924 for S2, 21,873 for S3, 12,058 for S4 and 11,013 for S5. All subunits contain signal peptides of variable length. Subunits S2 and S3 share 70% amino acid homology and 75% nucleotide homology. Subunit S1 contains two regions of eight amino acids homologous to analogous regions in the A subunit of both cholera and E. coli heat labile toxins. Functional domains in relation to the primary structure and the development of a safer, new generation vaccine against whooping cough are presented.
摘要翻译：已确定了百日咳毒素基因的完整核苷酸序列和各亚基的推导氨基酸序列。所有五个亚基由紧密连锁的顺反子编码，并且可能通过多顺反子mRNA表达，因为在5'侧翼区域发现启动子样结构。顺顺顺序为S1，S2，S3，S4，S5和S3。所有亚基含有长度可变的信号肽。成熟亚基的计算分子量为S1,025,024，S2为21,924，S3为21,873，S4为12,058，S5为11,013。所有亚基含有长度可变的信号肽。亚基S2和S3具有70％的氨基酸同源性和75％的核苷酸同源性。亚基S1含有与霍乱弧菌和大肠杆菌热不稳定毒素的A亚基中的类似区域同源的八个氨基酸的两个区域。提出了与一般结构相关的功能性领域和开发一种更安全的新一代针对百日咳的疫苗。

4. 发明申请

US20140271563A1 EFFECT OF AN ATTENUATED BORDETELLA STRAIN AGAINST ALLERGIC DISEASE 有权
标题翻译：对过敏性疾病的衰老的BORDETELLA菌株的影响
公开(公告)号：US20140271563A1
公开(公告)日：2014-09-18
申请号：US14355744
申请日：2012-11-02
申请人： Sylvie Claudette Alonso , Rui Li , Camille Locht
发明人： Sylvie Claudette Alonso , Rui Li , Camille Locht
IPC分类号： A61K35/74
CPC分类号： A61K35/74 , A61K39/39 , A61K2039/10 , A61K2039/522 , A61K2039/577 , C07K14/235 , C07K14/245 , C12N1/36
摘要： Described herein are compositions, vaccines, and methods that include use of a mutated Bordetella strain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.
摘要翻译：本文描述的是组合物，疫苗和方法，其包括使用突变的博德特氏菌菌株对抗过敏性疾病如哮喘和皮肤炎症。还描述了套件。还描述了其它组合物，疫苗和方法。

5. 发明申请

US20120121647A1 INFLUENZA VACCINE, COMPOSITION, AND METHODS OF USE 有权
标题翻译：流感疫苗，组合物和使用方法
公开(公告)号：US20120121647A1
公开(公告)日：2012-05-17
申请号：US13377070
申请日：2009-06-15
申请人： Sylvie Alonso , Rui Li , Vincent Chow , Camille Locht
发明人： Sylvie Alonso , Rui Li , Vincent Chow , Camille Locht
IPC分类号： A61K39/10 , C12N1/21 , A61P31/16
CPC分类号： A61K39/099 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , C12N2760/16134
摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.
摘要翻译：本发明涉及组合物和疫苗，其包括用于治疗或预防哺乳动物流感感染的突变的博德特氏菌属菌株。此外，本发明还提供了使用组合物或疫苗来保护哺乳动物免受流感感染和/或在哺乳动物中引发针对流感病毒的免疫应答的方法。

6. 发明申请

US20090246222A1 Live Attenuated Bordetella Strains as a Single Dose Vaccine Against Whooping cough 有权
标题翻译：生活减毒的博德特氏菌菌株作为单剂量疫苗免疫百日咳
公开(公告)号：US20090246222A1
公开(公告)日：2009-10-01
申请号：US12224895
申请日：2007-03-07
申请人： Camille Locht , Nathalie Mielcarek , Anne-Sophie Debrie , Dominique Raze , Julie Bertout
发明人： Camille Locht , Nathalie Mielcarek , Anne-Sophie Debrie , Dominique Raze , Julie Bertout
IPC分类号： A61K39/02 , C12N1/21 , A61P31/04
CPC分类号： A61K39/099 , A61K2039/522 , A61K2039/523 , A61K2039/543
摘要： A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
摘要翻译：提供了包含至少突变的ptx基因，缺失或突变的dnt基因和异源ampG基因的突变的博德氏菌属菌株。减毒的突变型博德特氏菌属菌株可用于免疫原性组合物或用于治疗或预防博德氏杆菌感染的疫苗。还提供了减毒的博德特氏菌属菌株用于制造疫苗或免疫原性组合物的用途，以及用于保护哺乳动物免受博德特氏菌感染的方法。

7. 发明申请

US20070212740A1 Detection of tuberculosis and infection by mycobacterium tuberculosis using HBHA 有权
标题翻译：使用HBHA检测结核分枝杆菌和结核分枝杆菌感染
公开(公告)号：US20070212740A1
公开(公告)日：2007-09-13
申请号：US11646299
申请日：2006-12-28
申请人： Camille Locht , Francoise Mascart , Stephane Temmerman , Jean-Michel Hougardy , Sammy Place , Christian Sergheraert
发明人： Camille Locht , Francoise Mascart , Stephane Temmerman , Jean-Michel Hougardy , Sammy Place , Christian Sergheraert
IPC分类号： G01N33/554 , G01N33/569
CPC分类号： G01N33/5695
摘要： The present invention concerns methods for in vitro detection of an infection by Mycobacterium tuberculosis in mammals, and methods for in vitro distinction between mammals infected with Mycobacterium tuberculosis in which the disease is declared (active form) and mammals which are infected but asymptomatic for tuberculosis (latent form), and a method for in vitro distinction between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis. The present invention also pertains to kits for detection and distinction between infected mammals presenting tuberculosis symptoms and infected mammals with no disease development, and a kit for distinguishing between mammals presenting an active form of tuberculosis and mammals not infected by M. tuberculosis or presenting a latent form of tuberculosis.
摘要翻译：本发明涉及用于体外检测哺乳动物结核分枝杆菌感染的方法，以及用于体外鉴别被感染疾病的结核分枝杆菌（活性形式）和感染但无症状的结核病的哺乳动物之间体外区别的方法（潜在形式），以及用于体外区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染或呈现潜在形式的结核病的哺乳动物的体外区别的方法。本发明还涉及用于检测和区分呈现结核病症状的受感染哺乳动物和没有疾病发展的感染哺乳动物的试剂盒，以及用于区分呈现活性形式的结核病的哺乳动物和未被结核分枝杆菌感染的哺乳动物或呈现潜伏形式的结核病。

8. 发明授权

US06660261B1 Bordetella strain expressing the FHA hybrid, liposomes and vaccines 失效
标题翻译：表达FHA杂交体的Bordetella菌株，脂质体和疫苗
公开(公告)号：US06660261B1
公开(公告)日：2003-12-09
申请号：US09284252
申请日：1999-09-16
申请人： Nathalie Mielcarek , Camille Locht , Gilles Riveau , Odile Poulain-Godefroy , André Capron
发明人： Nathalie Mielcarek , Camille Locht , Gilles Riveau , Odile Poulain-Godefroy , André Capron
IPC分类号： A01N6300
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
摘要翻译：本发明涉及一种缺乏毒素生产的博德氏菌菌株，并表达一种杂合蛋白质，其包含至少部分丝状血凝素（FHA）和至少部分与FHA异源的蛋白质。编码毒素的基因已被消除，或至少部分缺失或突变，以产生无活性毒素。该菌株可用作疫苗。本发明还涉及含有至少部分FHA蛋白质和至少一种与FHA蛋白质异源的蛋白质的脂质体，以及使用FHA来刺激免疫应答。

9. 发明授权

US09926346B2 Recombinant mycobacterium encoding a heparin-binding hemagglutinin (HBHA) fusion protein and uses thereof 有权
公开(公告)号：US09926346B2
公开(公告)日：2018-03-27
申请号：US14394689
申请日：2012-04-16
申请人： John Fulkerson , Michael Brennan , Kamalakannan Velmurugan , Camille Locht
发明人： John Fulkerson , Michael Brennan , Kamalakannan Velmurugan , Camille Locht
IPC分类号： C07K14/35 , A61K39/04 , A61K49/00 , A61K39/00
CPC分类号： C07K14/35 , A61K39/04 , A61K49/0006 , A61K2039/523 , A61K2039/53 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/90
摘要： Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.

10. 发明授权

US09526778B2 Influenza vaccine, composition, and methods of use 有权
标题翻译：流感疫苗，组成和使用方法
公开(公告)号：US09526778B2
公开(公告)日：2016-12-27
申请号：US13377070
申请日：2009-06-15
申请人： Sylvie Alonso , Rui Li , Vincent Chow , Camille Locht
发明人： Sylvie Alonso , Rui Li , Vincent Chow , Camille Locht
IPC分类号： A61K39/145 , A61K39/00 , A61K39/10 , A61K39/02 , A61K39/12
CPC分类号： A61K39/099 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , C12N2760/16134
摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.
摘要翻译：本发明涉及组合物和疫苗，其包括用于治疗或预防哺乳动物流感感染的突变的博德特氏菌属菌株。此外，本发明还提供了使用组合物或疫苗来保护哺乳动物免受流感感染和/或在哺乳动物中引发针对流感病毒的免疫应答的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式