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1. 发明授权

US07829644B2 Gel-forming reagents and uses thereof for preparing microarrays 有权
标题翻译：凝胶形成试剂及其用于制备微阵列的用途
公开(公告)号：US07829644B2
公开(公告)日：2010-11-09
申请号：US11550730
申请日：2006-10-18
申请人： Julia Golova , Boris Chernov , Alexander Perov
发明人： Julia Golova , Boris Chernov , Alexander Perov
IPC分类号： C08L20/58 , C08L20/68
CPC分类号： C08F220/56 , C08F220/58 , C08F222/385
摘要： New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers and cross-linker reagents are described herein. New co-polymerization compositions and cross-linkers with variable length linker groups between unsaturated C═C bonds that participate in the formation of gel networks are disclosed.
摘要翻译：公开了包括单体和交联剂在内的新的凝胶形成试剂，其可以通过使用共聚方法应用于凝胶滴微阵列制备。本文描述了用新型凝胶形成单体和交联剂试剂制备共聚合混合物的组合物。公开了参与凝胶网络形成的不饱和C = C键之间具有可变长度连接基团的新型共聚合组合物和交联剂。

2. 发明申请

US20070249797A1 GEL-FORMING REAGENTS AND USES THEREOF FOR PREPARING MICROARRAYS 有权
标题翻译：凝胶成型试剂及其制备微量元素的用途
公开(公告)号：US20070249797A1
公开(公告)日：2007-10-25
申请号：US11550730
申请日：2006-10-18
申请人： Julia Golova , Boris Chernov , Alexander Perov
发明人： Julia Golova , Boris Chernov , Alexander Perov
IPC分类号： C08L47/00 , B29C65/00
CPC分类号： C08F220/56 , C08F220/58 , C08F222/385
摘要： New gel-forming reagents including monomers and cross-linkers, which can be applied to gel-drop microarray manufacturing by using co-polymerization approaches are disclosed. Compositions for the preparation of co-polymerization mixtures with new gel-forming monomers and cross-linker reagents are described herein. New co-polymerization compositions and cross-linkers with variable length linker groups between unsaturated C═C bonds that participate in the formation of gel networks are disclosed.
摘要翻译：公开了包括单体和交联剂在内的新的凝胶形成试剂，其可以通过使用共聚方法应用于凝胶滴微阵列制备。本文描述了用新型凝胶形成单体和交联剂试剂制备共聚合混合物的组合物。公开了参与凝胶网络形成的不饱和C-C键之间具有可变长度连接基团的新型共聚合组合物和交联剂。

3. 发明申请

US20070072213A1 Method and apparatus for implementing non-destructive quality control of substrates and printed biological microarrays, and for implementing quality control and visualizing gel-based microarrays prepared by dispensing gel-forming composition on solid surfaces 有权
标题翻译：用于实施基底和印刷生物微阵列的非破坏性质量控制的方法和装置，以及用于实施质量控制和可视化通过在固体表面上分配凝胶形成组合物制备的基于凝胶的微阵列
公开(公告)号：US20070072213A1
公开(公告)日：2007-03-29
申请号：US11485203
申请日：2006-07-12
申请人： Alexander Perov , Darrell Chandler
发明人： Alexander Perov , Darrell Chandler
IPC分类号： C12Q1/68 , G06T7/00
CPC分类号： G06T7/0004 , C12Q1/6837 , G06T2207/30072
摘要： A method and apparatus are provided for implementing non-destructive quality control of substrates and printed biological microarrays. A method and apparatus are provided for implementing quality control of gel-based microarrays prepared by dispensing a gel-forming composition on a solid substrate. The method utilizes the difference between the wettability properties of a supporting substrate and a gel, where the gel is hydrophilic. Condensation of vapor of a chemically inert water-soluble liquid, such as water or glycerol, on the surface of a substrate under inspection creates a layer of tiny droplets that affect both transmission and scattering of light on the surface. A pattern of condensation, characterized by spatial distribution, average size of the droplets and spacing between the droplets, reflects variation in wetting properties of the substrate. The pattern of condensation circumscribes printed microarray features to be non-destructively imaged and analyzed.
摘要翻译：提供了一种用于实现基板和印刷生物微阵列的非破坏性质量控制的方法和装置。提供了一种方法和装置，用于实施通过将凝胶形成组合物分散在固体基质上制备的基于凝胶的微阵列的质量控制。该方法利用支撑基底和凝胶的润湿性能之间的差异，其中凝胶是亲水的。化学惰性的水溶性液体如水或甘油的蒸气在被检查的基底表面上的冷凝产生影响表面上的光的透射和散射的微小液滴层。以空间分布，液滴的平均尺寸和液滴之间的间隔为特征的冷凝图案反映了基材的润湿性能的变化。凝胶图案限制印刷的微阵列特征，以便对其进行非破坏性成像和分析。

4. 发明授权

US06407395B1 Portable biochip scanner device 失效
标题翻译：便携式生物芯片扫描仪装置
公开(公告)号：US06407395B1
公开(公告)日：2002-06-18
申请号：US09515290
申请日：2000-02-29
申请人： Alexander Perov , Alexei Sharonov , Andrei D. Mirzabekov
发明人： Alexander Perov , Alexei Sharonov , Andrei D. Mirzabekov
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01J2219/00657 , B01J2219/00707 , G01N2201/0221
摘要： A portable biochip scanner device used to detect and acquire fluorescence signal data from biological microchips (biochips) is provided. The portable biochip scanner device employs a laser for emitting an excitation beam. An optical fiber delivers the laser beam to a portable biochip scanner. A lens collimates the laser beam, the collimated laser beam is deflected by a dichroic mirror and focused by an objective lens onto a biochip. The fluorescence light from the biochip is collected and collimated by the objective lens. The fluorescence light is delivered to a photomultiplier tube (PMT) via an emission filter and a focusing lens. The focusing lens focuses the fluorescence light into a pinhole. A signal output of the PMT is processed and displayed.
摘要翻译：提供了用于从生物微芯片（生物芯片）检测和获取荧光信号数据的便携式生物芯片扫描器装置。便携式生物芯片扫描仪装置采用激光发射激发光束。光纤将激光束传送到便携式生物芯片扫描仪。透镜准直激光束，准直激光束被分色镜偏转并被物镜聚焦到生物芯片上。来自生物芯片的荧光被物镜收集和准直。荧光通过发射滤光片和聚焦透镜传送到光电倍增管（PMT）。聚焦透镜将荧光聚焦到针孔中。处理并显示PMT的信号输出。

5. 发明授权

US06329661B1 Biochip scanner device 失效
标题翻译：生物芯片扫描仪装置
公开(公告)号：US06329661B1
公开(公告)日：2001-12-11
申请号：US09515814
申请日：2000-02-29
申请人： Alexander Perov , Alexander I. Belgovskiy , Andrei D. Mirzabekov
发明人： Alexander Perov , Alexander I. Belgovskiy , Andrei D. Mirzabekov
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01J2219/00527 , B01J2219/00529 , B01J2219/00596 , B01J2219/00608 , B01J2219/00621 , B01J2219/00644 , B01J2219/00659 , B01J2219/00707
摘要： A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.
摘要翻译：提供了用于检测和获取来自生物微芯片或生物芯片的荧光信号数据的生物芯片扫描器装置和使用方法。生物芯片扫描器装置包括用于发射激光束的激光器。诸如光斩波器的调制器调制激光束。扫描头接收调制的激光束，并且耦合到扫描头的扫描机构使扫描头相对于生物芯片移动。光纤将调制的激光束传送到扫描头。扫描头收集来自生物芯片的荧光，将其发射到相同的光纤中，其将荧光传递到诸如光电二极管的光电检测器中。生物芯片扫描器装置以行扫描方式使用以与固定位置的尺寸相匹配的激光束尺寸扫描生物芯片的选定行。

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