专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08790649B2 EGFR-binding molecules and immunoconjugates thereof 有权
标题翻译： EGFR结合分子及其免疫偶联物
公开(公告)号：US08790649B2
公开(公告)日：2014-07-29
申请号：US13284398
申请日：2011-10-28
申请人： Julianto Setiady , Peter U. Park , Lingyun Rui , Thomas Chittenden , Gillian Payne
发明人： Julianto Setiady , Peter U. Park , Lingyun Rui , Thomas Chittenden , Gillian Payne
IPC分类号： A61K39/395 , C12P21/08 , C07K16/28 , C07K16/30 , C07K16/46 , A61K47/48 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
摘要翻译：提供了与EGFR结合的新型抗癌剂，包括但不限于抗体和免疫偶联物。进一步提供使用试剂，抗体或免疫缀合物的方法，例如抑制肿瘤生长的方法。

2. 发明申请

US20120156217A1 Novel EGFR-Binding Molecules and Immunoconjugates Thereof 有权
标题翻译：新型EGFR结合分子及其免疫偶联物
公开(公告)号：US20120156217A1
公开(公告)日：2012-06-21
申请号：US13284398
申请日：2011-10-28
申请人： Julianto Setiady , Peter U. Park , Lingyun Rui , Thomas Chittenden
发明人： Julianto Setiady , Peter U. Park , Lingyun Rui , Thomas Chittenden
IPC分类号： A61K39/395 , C07K19/00 , A61P35/00 , C12N5/10 , C12P21/00 , C12N5/071 , C12N15/63 , C12N1/21 , C07K16/22 , C12N15/13
CPC分类号： C07K16/2863 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
摘要翻译：提供了与EGFR结合的新型抗癌剂，包括但不限于抗体和免疫偶联物。进一步提供使用试剂，抗体或免疫缀合物的方法，例如抑制肿瘤生长的方法。

3. 发明授权

US09238690B2 Non-antagonistic EGFR-binding molecules and immunoconjugates thereof 有权
标题翻译：非拮抗性EGFR结合分子及其免疫偶联物
公开(公告)号：US09238690B2
公开(公告)日：2016-01-19
申请号：US13882059
申请日：2011-10-28
申请人： Julianto Setiady , Rajeeva Singh , Peter U. Park , Lingyun Rui , Thomas Chittenden
发明人： Julianto Setiady , Rajeeva Singh , Peter U. Park , Lingyun Rui , Thomas Chittenden
IPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , A61K47/48 , G01N33/68 , C07K16/30 , A61K39/00
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/71 , G01N2333/912
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
摘要翻译：提供了与EGFR结合的新型抗癌剂，包括但不限于抗体和免疫偶联物。进一步提供使用试剂，抗体或免疫缀合物的方法，例如抑制肿瘤生长的方法。

4. 发明申请

US20140023662A1 NON-ANTAGONISTIC EGFR-BINDING MOLECULES AND IMMUNOCONJUGATES THEREOF 有权
标题翻译：非拮抗性EGFR结合分子及其免疫球蛋白
公开(公告)号：US20140023662A1
公开(公告)日：2014-01-23
申请号：US13882059
申请日：2011-10-28
申请人： Julianto Setiady , Rajeeva Singh , Peter U. Park , Lingyun Rui , Thomas Chittenden
发明人： Julianto Setiady , Rajeeva Singh , Peter U. Park , Lingyun Rui , Thomas Chittenden
IPC分类号： C07K16/28 , G01N33/68 , A61K47/48
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6871 , A61K2039/505 , C07K16/2863 , C07K16/30 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/74 , G01N2333/71 , G01N2333/912
摘要： Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.
摘要翻译：提供了与EGFR结合的新型抗癌剂，包括但不限于抗体和免疫偶联物。进一步提供使用试剂，抗体或免疫缀合物的方法，例如抑制肿瘤生长的方法。

5. 发明授权

US09233171B2 Method of treatment of tumors that are resistant to EGFR antibody therapies by EGFR antibody cytotoxic agent conjugate 有权
标题翻译：通过EGFR抗体细胞毒素偶联物治疗抗EGFR抗体治疗的肿瘤的方法
公开(公告)号：US09233171B2
公开(公告)日：2016-01-12
申请号：US13682948
申请日：2012-11-21
申请人： Julianto Setiady , Peter U. Park , Thomas Chittenden
发明人： Julianto Setiady , Peter U. Park , Thomas Chittenden
IPC分类号： A61K39/395 , A61K31/395 , C07K16/30 , A61K47/48 , C07K16/28 , A61K39/00
CPC分类号： A61K47/48369 , A61K39/39558 , A61K47/6803 , A61K47/6851 , A61K2039/505 , C07K16/2863 , C07K2317/24
摘要： The present invention relates to the identification that EGFR antibody immunoconjugates are effective in inhibiting the growth of tumor cells that have developed EGFR and/or ALK resistance mechanisms. Methods of administering the EGFR antibody immunoconjugates to patients having resistant tumor cells is also disclosed.
摘要翻译：本发明涉及EGFR抗体免疫缀合物有效抑制已经发展为EGFR和/或ALK抗性机制的肿瘤细胞生长的鉴定。还公开了对具有抗性肿瘤细胞的患者施用EGFR抗体免疫偶联物的方法。

6. 发明申请

US20130156796A1 Method of Treatment of Tumors That Are Resistant to EGFR Therapies by EGFR Antibody Cytotoxic Agent Conjugate 有权
标题翻译：用EGFR抗体治疗抗EGFR疗法的肿瘤治疗方法细胞毒素偶联物
公开(公告)号：US20130156796A1
公开(公告)日：2013-06-20
申请号：US13682948
申请日：2012-11-21
申请人： Julianto SETIADY , Peter U. Park , Thomas Chittenden
发明人： Julianto SETIADY , Peter U. Park , Thomas Chittenden
IPC分类号： A61K47/48
CPC分类号： A61K47/48369 , A61K39/39558 , A61K47/6803 , A61K47/6851 , A61K2039/505 , C07K16/2863 , C07K2317/24
摘要： The present invention relates to the identification that EGFR antibody immunoconjugates are effective in inhibiting the growth of tumor cells that have developed EGFR and/or ALK resistance mechanisms. Methods of administering the EGFR antibody immunoconjugates to patients having resistant tumor cells is also disclosed.
摘要翻译：本发明涉及EGFR抗体免疫缀合物有效抑制已经发展为EGFR和/或ALK抗性机制的肿瘤细胞生长的鉴定。还公开了对具有抗性肿瘤细胞的患者施用EGFR抗体免疫偶联物的方法。

7. 发明授权

US07202346B2 Antibodies to non-shed Muc1 and Muc16, and uses thereof 有权
标题翻译：非脱落Muc1和Muc16的抗体及其用途
公开(公告)号：US07202346B2
公开(公告)日：2007-04-10
申请号：US10612090
申请日：2003-07-03
申请人： Gillian Payne , Thomas Chittenden , Viktor Goldmakher , Philip Chun , Kristin Sneider-Mulready , Carol A. Vater
发明人： Gillian Payne , Thomas Chittenden , Viktor Goldmakher , Philip Chun , Kristin Sneider-Mulready , Carol A. Vater
IPC分类号： C07K16/00
CPC分类号： G01N33/57415 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K16/3092 , C07K2317/34 , C07K2317/77 , C07K2317/92 , G01N33/57449 , G01N2333/4725
摘要： The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody fragments, where the antibodies and antibody fragments recognize extracellular epitopes of plasma membrane proteins that are not released into the extracellular fluid, and to methods for the detection, monitoring and treatment of malignancies such as breast cancer and ovarian cancer using the antibodies, antibody fragments and conjugates.
摘要翻译：本发明涉及抗体，抗体片段，抗体的缀合物和具有细胞毒性剂的抗体片段，以及产生抗体和抗体片段的杂交瘤，其中抗体和抗体片段识别未释放到细胞外液中的质膜蛋白的细胞外表位以及使用抗体，抗体片段和缀合物检测，监测和治疗诸如乳腺癌和卵巢癌的恶性肿瘤的方法。

8. 发明授权

US6032912A One-piece metal cabinet base and method of construction 失效
标题翻译：一体式金属柜底座及施工方法
公开(公告)号：US6032912A
公开(公告)日：2000-03-07
申请号：US846183
申请日：1997-04-28
申请人： Francis Korn , Thomas Chittenden
发明人： Francis Korn , Thomas Chittenden
IPC分类号： A47B47/02 , A47B91/00
CPC分类号： A47B47/025 , A47B91/005
摘要： In a preferred embodiment, a one-piece cabinet base, including: a horizontal, generally rectangular, planar, cabinet receiving surface on which to place a cabinet; vertical supports at either end of the horizontal surface, formed of one piece with the horizontal surface and depending therefrom; and horizontal base plates at lower ends of the vertical supports and formed of one piece with the vertical supports.
摘要翻译：在优选实施例中，一体式机柜底座包括：水平的，大致矩形的平面机柜接收表面，在其上放置机柜; 在水平表面的任一端的垂直支撑件，由具有水平表面的一个部件形成，并且与其垂直; 垂直支架下端的水平底板与垂直支架一体形成。

9. 发明申请

US20070081987A1 Novel peptides and compositions which modulate apoptosis 失效
标题翻译：调节凋亡的新型肽和组合物
公开(公告)号：US20070081987A1
公开(公告)日：2007-04-12
申请号：US11501910
申请日：2006-08-10
申请人： Thomas Chittenden , Robert Lutz
发明人： Thomas Chittenden , Robert Lutz
IPC分类号： A61K38/48 , C12Q1/68 , C07H21/04 , A61K48/00 , C12N9/64
CPC分类号： G01N33/5008 , C07K14/4747 , C07K2319/70 , G01N33/5011 , G01N33/5017 , G01N33/68 , G01N2333/47 , G01N2500/00 , G01N2510/00
摘要： The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel peptide designated the “GD domain,” which is essential both to Bak's interaction with Bcl-xL, and to Bak's cell killing function. Methods of identifying agonists or antagonists of GD domain function are provided. The GD domain is responsible for mediating key protein/protein interactions of significance to the actions of multiple cell death regulatory molecules.
摘要翻译：本发明涉及能够调节细胞凋亡的新型肽和组合物，以及使用本发明的新肽和组合物调节凋亡的方法。一方面，本发明涉及一种称为“GD结构域”的新肽，其对于Bak与Bcl-xLa的相互作用以及Bak的细胞杀伤功能是必不可少的。提供识别GD结构域功能的激动剂或拮抗剂的方法。 GD结构域负责调控重要蛋白质/蛋白质相互作用对多种细胞死亡调节分子的作用。

10. 发明授权

US07202024B2 bbc3 Gene promoter and methods for identifying modulators of apoptosis and bbc3 gene expression using a bbc3 gene promoter 失效
标题翻译： bbc3基因启动子和使用bbc3基因启动子鉴定凋亡调节剂和bbc3基因表达的方法
公开(公告)号：US07202024B2
公开(公告)日：2007-04-10
申请号：US09953133
申请日：2001-09-17
申请人： Jia-Wen Han , Thomas Chittenden
发明人： Jia-Wen Han , Thomas Chittenden
IPC分类号： C12Q1/68
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5011 , G01N2500/20 , G01N2510/00
摘要： The present invention is directed to methods for identifying compounds that modulate apoptosis, directly or indirectly, as measured by changes in expression of the bbc3 gene or a reporter gene, or by changes in the apoptotic character of a cell. The present invention is also directed to methods for identifying compounds that modulate expression of the bbc3 gene and a method for identifying compounds that interact with a promoter of the bbc3 gene. The present invention is further directed to a method for modulating apoptosis in a cell, a method for modulating bbc3 gene expression in a cell, a process for making a modulator of apoptosis, and a process for making a modulator of bbc3 gene expression. Finally, the present invention is directed to compounds identified by each of the methods of this invention, and to promoters of the bbc3 gene and sequences homologous thereto.
摘要翻译：本发明涉及通过bbc3基因或报道基因的表达变化或细胞凋亡特性的变化来测定直接或间接调节凋亡的化合物的方法。本发明还涉及用于鉴定调节bbc3基因表达的化合物的方法和用于鉴定与bbc3基因的启动子相互作用的化合物的方法。本发明还涉及调节细胞凋亡的方法，调节细胞中bbc3基因表达的方法，制备凋亡调节剂的方法以及制备bbc3基因表达调节剂的方法。最后，本发明涉及由本发明的每种方法鉴定的化合物，以及bbc3基因的启动子和与其同源的序列。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式